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1. 发明申请

WO2006108474A2 USE OF A GALECTIN-1-TRAGETED RNAI-BASED APPROACH FOR THE TREATMENT OF CANCER 审中-公开
标题翻译： GALECTIN-1-TRAGETED基于RNAi的方法在治疗癌症中的应用
公开(公告)号：WO2006108474A2
公开(公告)日：2006-10-19
申请号：PCT/EP2006/002170
申请日：2006-03-09
申请人： UNIVERSITE LIBRE DE BRUXELLES , UNIVERSITE CATHOLIQUE DE LOUVAIN , CAMBY, Isabelle , HENRIET, Patrick , LEFRANC, Florence , COURTOY, Pierre , KISS, Robert
发明人： CAMBY, Isabelle , HENRIET, Patrick , LEFRANC, Florence , COURTOY, Pierre , KISS, Robert
IPC分类号： C12N15/11 , A61K48/00
CPC分类号： C12N15/1138 , C12N15/113 , C12N2310/111 , C12N2310/14 , C12N2310/53
摘要： The present invention relates to an RNAi molecule suitable for reducing the expression of galectin-1 containing any of the sequences of SEQ ID NOs: 1-33, and preferably the sequences of SEQ ID NO: 2, 3, or 4, and to the use thereof as a medicament, or for the manufacture of a medicament for treating and/or for delaying the progression of cancer, preferably glioma, pancreatic cancer, head and neck cancer, melanoma, non-small-cell lung cancer and non-Hodgkin's lymphoma. The present invention also relates to compositions and methods for treating and for delaying the progression of cancer, preferably glioma, pancreatic cancer, head and neck cancer, melanoma, non-small-cell lung cancer and non-Hodgkin's lymphoma, for reducing the migration of tumor cells, preferably cells of glioma, pancreatic cancer, head and neck cancer, melanoma, non-small-cell lung cancer and non-Hodgkin's lymphoma, and/or for enhancing the efficacy of cancer therapies for the treatment of cancer, preferably glioma, pancreatic cancer, head and neck cancer, melanoma, non-small-cell lung cancer and non-Hodgkin's lymphoma, selected from the group comprising chemotherapy, radiation therapy, immunotherapy, and/or gene therapy.
摘要翻译：本发明涉及适用于减少包含SEQ ID NO：1-33的任何序列，并且优选SEQ ID NO：2的序列的半乳糖凝集素-1的表达的RNAi分子， 3或4的化合物，以及其作为药物的用途，或用于制造治疗和/或延缓癌症进展的药物，优选神经胶质瘤，胰腺癌，头颈癌，黑素瘤，非小细胞肺癌，细胞肺癌和非霍奇金淋巴瘤。本发明还涉及用于治疗和延缓癌症进展的组合物和方法，所述癌症优选神经胶质瘤，胰腺癌，头颈癌，黑素瘤，非小细胞肺癌和非霍奇金淋巴瘤，用于减少肿瘤细胞，优选神经胶质瘤细胞，胰腺癌，头颈癌，黑素瘤，非小细胞肺癌和非霍奇金淋巴瘤，和/或用于增强癌症疗法治疗癌症，优选神经胶质瘤的效力，胰腺癌，头颈癌，黑素瘤，非小细胞肺癌和非何杰金氏淋巴瘤，其选自包括化学疗法，放射疗法，免疫疗法和/或基因疗法的组。

2. 发明公开

EP1874930A2 USE OF A GALECTIN-1-TRAGETED RNAI-BASED APPROACH FOR THE TREATMENT OF CANCER 有权
标题翻译：使用APPROACH ON RNAI-BASED半乳糖凝集素1作为靶的癌症治疗
公开(公告)号：EP1874930A2
公开(公告)日：2008-01-09
申请号：EP06707489.8
申请日：2006-03-09
申请人： UNIVERSITE LIBRE DE BRUXELLES , UNIVERSITE CATHOLIQUE DE LOUVAIN
发明人： CAMBY, Isabelle , HENRIET, Patrick , LEFRANC, Florence , COURTOY, Pierre , KISS, Robert
IPC分类号： C12N15/11 , A61K48/00
CPC分类号： C12N15/1138 , C12N15/113 , C12N2310/111 , C12N2310/14 , C12N2310/53
摘要： The present invention relates to an RNAi molecule suitable for reducing the expression of galectin-1 containing any of the sequences of SEQ ID NOs: 1-33, and preferably the sequences of SEQ ID NO: 2, 3, or 4, and to the use thereof as a medicament, or for the manufacture of a medicament for treating and/or for delaying the progression of cancer, preferably glioma, pancreatic cancer, head and neck cancer, melanoma, non-small-cell lung cancer and non-Hodgkin's lymphoma. The present invention also relates to compositions and methods for treating and for delaying the progression of cancer, preferably glioma, pancreatic cancer, head and neck cancer, melanoma, non-small-cell lung cancer and non-Hodgkin's lymphoma, for reducing the migration of tumor cells, preferably cells of glioma, pancreatic cancer, head and neck cancer, melanoma, non-small-cell lung cancer and non-Hodgkin's lymphoma, and/or for enhancing the efficacy of cancer therapies for the treatment of cancer, preferably glioma, pancreatic cancer, head and neck cancer, melanoma, non-small-cell lung cancer and non-Hodgkin's lymphoma, selected from the group comprising chemotherapy, radiation therapy, immunotherapy, and/or gene therapy.

3. 发明授权

EP1874930B1 USE OF A GALECTIN-1-TRAGETED RNAI-BASED APPROACH FOR THE TREATMENT OF CANCER 有权
标题翻译：使用APPROACH ON RNAI-BASED半乳糖凝集素1作为靶的癌症治疗
公开(公告)号：EP1874930B1
公开(公告)日：2011-09-07
申请号：EP06707489.8
申请日：2006-03-09
申请人： Université Libre de Bruxelles , UNIVERSITE CATHOLIQUE DE LOUVAIN
发明人： CAMBY, Isabelle , HENRIET, Patrick , LEFRANC, Florence , COURTOY, Pierre , KISS, Robert
IPC分类号： C12N15/11 , A61K48/00
CPC分类号： C12N15/1138 , C12N15/113 , C12N2310/111 , C12N2310/14 , C12N2310/53
摘要： The present invention relates to an RNAi molecule suitable for reducing the expression of galectin-1 containing any of the sequences of SEQ ID NOs: 1-33, and preferably the sequences of SEQ ID NO: 2, 3, or 4, and to the use thereof as a medicament, or for the manufacture of a medicament for treating and/or for delaying the progression of cancer, preferably glioma, pancreatic cancer, head and neck cancer, melanoma, non-small-cell lung cancer and non-Hodgkin's lymphoma. The present invention also relates to compositions and methods for treating and for delaying the progression of cancer, preferably glioma, pancreatic cancer, head and neck cancer, melanoma, non-small-cell lung cancer and non-Hodgkin's lymphoma, for reducing the migration of tumor cells, preferably cells of glioma, pancreatic cancer, head and neck cancer, melanoma, non-small-cell lung cancer and non-Hodgkin's lymphoma, and/or for enhancing the efficacy of cancer therapies for the treatment of cancer, preferably glioma, pancreatic cancer, head and neck cancer, melanoma, non-small-cell lung cancer and non-Hodgkin's lymphoma, selected from the group comprising chemotherapy, radiation therapy, immunotherapy, and/or gene therapy.

4. 发明申请

WO2009106647A1 MULTI-FUELLING AN ENGINE 审中-公开
标题翻译：多功能发动机
公开(公告)号：WO2009106647A1
公开(公告)日：2009-09-03
申请号：PCT/EP2009/052476
申请日：2009-03-02
申请人： INSPECS LIMITED , COURTOY, Pierre , SMITH, Andrew, Frances, Gamble , GREENHALGH, Douglas
发明人： COURTOY, Pierre , SMITH, Andrew, Frances, Gamble , GREENHALGH, Douglas
IPC分类号： F02D19/10 , F02D19/08 , F02D41/40 , F02D41/00
CPC分类号： F02D41/402 , F02D19/061 , F02D19/0647 , F02D19/0655 , F02D19/081 , F02D19/084 , F02D41/0025 , F02D41/0027 , Y02T10/36 , Y02T10/44
摘要： A compression ignition engine is supplied with afirst fuelin a flow of air and a second fuel is injectedinto the combustion chamber. The first fuel comprises a more volatile fuel than dieselsuch as ethanol, LPG or other combustible gas; the second fuel comprises diesel or biodiesel; and the second fuel is injected in multiple pulses in each ignition cycle with the first pulse acting as a pilot pulse to trigger ignition, and the timing of the second pulse being such as to modify the temperature through evaporation of the second fuel and thereby reduce the combustion temperature and mitigate knock susceptibility. Preferably the pilot pulse is followed by a single further pulse of the second fuel in the ignition cycle. The engine may be controlled to operate in two different modes, one mode for light and medium load conditions when there is only a pilot pulse injection of the second fuel which reduces NO x and soot emissions, and the other mode for higher load conditions when there is a pilot pulse injection followed by a main pulse injection of the second fuel. The first fuel may comprise bioethanol and or one or more ofthe following: ethanol, butanol, propanol, lpg, natural gas, hydrogen.
摘要翻译：压缩点火发动机首先向空气中供应燃料，并将第二燃料注入燃烧室。第一种燃料包括比乙醇，LPG或其他可燃气体更易挥发的燃料; 第二种燃料包括柴油或生物柴油; 并且第二燃料在每个点火循环中以多个脉冲喷射，第一脉冲用作引导脉冲以触发点火，并且第二脉冲的定时使得通过蒸发第二燃料来改变温度，从而减少燃烧温度和减轻爆震敏感性。优选地，在点火循环中，先导脉冲之后是第二燃料的单个另外的脉冲。发动机可以被控制为以两种不同的模式操作，一种用于轻和中等负载条件的模式，当仅存在第二燃料的先导脉冲喷射以减少NOx和烟尘排放时，另一种模式在较高负载条件下引导脉冲喷射，随后是第二燃料的主脉冲喷射。第一种燃料可以包括生物乙醇，或者一种或多种以下物质：乙醇，丁醇，丙醇，lpg，天然气，氢气。

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