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1. 发明申请

WO2011149743A1 MULTIPLY FLUORESCENTLY LABELED CALCIUM PHOSPHATE-PROTEIN SURFACES 审中-公开
标题翻译：多孔荧光标记磷酸钙蛋白表面
公开(公告)号：WO2011149743A1
公开(公告)日：2011-12-01
申请号：PCT/US2011/037043
申请日：2011-05-18
申请人： CORNING INCORPORATED , LAHIRI, Joydeep , RAO, Hongwei H. , TAN, Jian
发明人： LAHIRI, Joydeep , RAO, Hongwei H. , TAN, Jian
IPC分类号： C12N5/00 , G01N33/58 , C12N5/078
CPC分类号： C12N5/0068 , C12N5/0643 , C12N2533/18 , C12N2533/54 , G01N33/533
摘要： Described herein are multiply-fluorescently-labeled calcium phosphate protein substrates composed of a base coated with a fluorophore-labeled calcium phosphate coating and further having a fluorescently-labeled protein. The multiply-fluorescently-labeled substrate may be a fluorescently labeled calcium phosphate surface having a fluorescently-labeled collagen. The substrates are useful in culturing and studying the activity of a variety of cells, including bone cells. The substrates described herein can be used for both solution- and image-based analysis of cultured cells. New methods for producing and using such coated substrates are also disclosed.
摘要翻译：本文描述的是多重荧光标记的磷酸钙蛋白质底物，其由涂布有荧光团标记的磷酸钙涂层的基底组成，并且还具有荧光标记的蛋白质。多荧光标记的底物可以是具有荧光标记的胶原蛋白的荧光标记的磷酸钙表面。底物可用于培养和研究包括骨细胞在内的各种细胞的活性。本文所述的底物可用于培养细胞的基于溶液和图像的分析。还公开了用于生产和使用这种涂覆的基材的新方法。

2. 发明申请

WO2010060022A2 METHODS OF CREATING AN INDEX 审中-公开
标题翻译：创建索引的方法
公开(公告)号：WO2010060022A2
公开(公告)日：2010-05-27
申请号：PCT/US2009/065490
申请日：2009-11-23
申请人： CORNING INCORPORATED , FANG, Ye , FERRIE, Ann, M. , LAHIRI, Joydeep , TRAN, Elizabeth
发明人： FANG, Ye , FERRIE, Ann, M. , LAHIRI, Joydeep , TRAN, Elizabeth
IPC分类号： G06F19/00
CPC分类号： G06F19/709 , G01N33/5041 , G01N33/54373 , G06F19/12
摘要： Drug discovery is a complex undertaking facing many challenges, not the least of which is a high attrition rate as many promising candidates prove ineffective or toxic in the clinic owing to a poor understanding of the diseases, and thus the biological systems, they target. Therefore, it is broadly agreed that to increase the productivity of drug discovery one needs a far deeper understanding of the molecular mechanisms of diseases, taking into account the full biological context of the drug target and moving beyond individual genes and proteins. The present methods rely on the use of label-free cellular assays, particularly the DMR index, to systematically display the mode of actions, the toxicity, and the target(s) and pathway(s) of any molecules.
摘要翻译：毒品发现是一项面临许多挑战的复杂工作，其中最重要的是高消耗率，因为许多有前途的候选人在诊所中证明是无效或有毒的，因为对疾病的认识不足，从而导致其生物系统的目标。因此，普遍同意，为了提高药物发现的生产力，需要更深入地了解疾病的分子机制，同时考虑到药物靶标的完整生物学背景，超越个别基因和蛋白质。本方法依赖于使用无标记细胞测定法，特别是DMR指数来系统显示任何分子的作用模式，毒性以及靶标和途径。

3. 发明申请

WO2006107506A3 SYSTEM AND METHOD FOR PERFORMING G PROTEIN COUPLED RECEPTOR (GPCR) CELL ASSAYS USING WAVEGUIDE-GRATING SENSORS 审中-公开
标题翻译：使用波导传感器执行G蛋白偶联受体（GPCR）细胞测定的系统和方法
公开(公告)号：WO2006107506A3
公开(公告)日：2006-11-16
申请号：PCT/US2006008582
申请日：2006-03-10
申请人： CORNING INC , FANG YE , FERRIE ANN M , FONTAINE NORMAN H , YUEN PO KI , LAHIRI JOYDEEP
发明人： FANG YE , FERRIE ANN M , FONTAINE NORMAN H , YUEN PO KI , LAHIRI JOYDEEP
IPC分类号： G01N33/543 , G01N21/77 , G01N33/68
CPC分类号： G01N33/5041 , G01N21/4788 , G01N21/553 , G01N2333/726 , G01N2500/10
摘要： The present invention includes a system and method that uses optical LID biosensors to monitor in real time agonist-induced GPCR signaling events within living cells. Particularly, the present invention includes a system and method for using an optical LID biosensor to screen compounds against a target GPCR within living cells based on the mass redistribution due to agonist-induced GPCR activation. In an extended embodiment, the present invention discloses different ways for self-referencing the optical LID biosensor to eliminate unwanted sensitivity to ambient temperature, pressure fluctuations, and other environmental changes. In yet another extended embodiment, the present invention discloses different ways for screening multiple GPCRs in a single type of cell or multiple GPCRs in multiple types of cells within a single medium solution. In still yet another extended embodiment, the present invention discloses different ways to confirm the physiological or pharmacological effect of a compound against a specific GPCR within living cells.
摘要翻译：本发明包括使用光学LID生物传感器实时监测活细胞内激动剂诱导的GPCR信号事件的系统和方法。特别地，本发明包括使用光学LID生物传感器基于由于激动剂诱导的GPCR活化导致的质量再分布来筛选活细胞内的靶GPCR的化合物的系统和方法。在扩展实施例中，本发明公开了用于自参考光学LID生物传感器以消除对环境温度，压力波动和其他环境变化的不期望的灵敏度的不同方式。在又一个扩展的实施方案中，本发明公开了在单一培养基溶液中的多种类型的细胞中单种类型细胞或多种GPCR筛选多种GPCR的不同方式。在又一个延伸的实施方案中，本发明公开了确定化合物对活细胞内特异性GPCR的生理或药理作用的不同方式。

4. 发明申请

WO2013036746A1 ANTIMICROBIAL COMPOSITE MATERIAL 审中-公开
标题翻译：抗微生物复合材料
公开(公告)号：WO2013036746A1
公开(公告)日：2013-03-14
申请号：PCT/US2012/054126
申请日：2012-09-07
申请人： CORNING INCORPORATED , CHEN, Guohua , JIANG, Dayue David , LAHIRI, Joydeep , VERRIER, Florence , WANG, Jianguo , WEI, Ying
发明人： CHEN, Guohua , JIANG, Dayue David , LAHIRI, Joydeep , VERRIER, Florence , WANG, Jianguo , WEI, Ying
IPC分类号： A01N57/20 , A01N25/08 , A01N25/10 , A01P1/00 , A01P3/00 , C09D5/16
CPC分类号： A01N59/20 , A01N25/34 , C09D5/14 , C09D7/68 , C09D7/69 , A01N25/08 , A01N25/10 , A01N2300/00
摘要： The present disclosure is directed to an antimicrobial composite material, and more particularly to an antimicrobial composite material comprising particles having a metal or metal alloy core and a porous inorganic material shell, coatings including the antimicrobial composite material, and methods of making the same. In some embodiments, Cu-SiO 2 core-shell particles are disclosed in which the Cu core provides antimicrobial activity and the porous SiO 2 shell functions as a barrier for the Cu core, thus preventing the Cu core from being directly exposed to air or moisture.
摘要翻译：本公开涉及抗微生物复合材料，更具体地涉及包含具有金属或金属合金芯和多孔无机材料壳的颗粒的抗微生物复合材料，包括抗微生物复合材料的涂层及其制备方法。在一些实施方案中，公开了Cu-SiO2核 - 壳颗粒，其中Cu芯提供抗微生物活性，并且多孔SiO 2壳体用作Cu芯的屏障，从而防止Cu芯直接暴露于空气或水分。

5. 发明申请

WO2011123424A1 SCREENING METHODS FOR MITOCHONDRIA KATP MODULATORS USING CELL LINES 审中-公开
标题翻译：使用细胞线的MITOCHONDRIA KATP调制器的筛选方法
公开(公告)号：WO2011123424A1
公开(公告)日：2011-10-06
申请号：PCT/US2011/030284
申请日：2011-03-29
申请人： CORNING INCORPORATED , FANG, Ye , LAHIRI, Joydeep , SUN, Haiyan , WEI, Ying
发明人： FANG, Ye , LAHIRI, Joydeep , SUN, Haiyan , WEI, Ying
IPC分类号： G01N33/50
CPC分类号： G01N33/6872 , G01N21/553 , G01N21/7703 , G01N33/48714 , G01N33/54373 , Y02A50/60 , Y02A90/26
摘要： Disclosed are compositions and methods related to modulation of K ATP channels and methods of treating liver disorders by modulating K ATP and mito-K ATP channels.
摘要翻译：公开了与调节KATP通道有关的组合物和方法以及通过调节KATP和mito-KATP通道治疗肝脏疾病的方法。

6. 发明申请

WO2011066097A9 VARIABLE PENETRATION DEPTH BIOSENSOR AND METHODS 审中-公开
标题翻译：可变渗透深度生物传感器和方法
公开(公告)号：WO2011066097A9
公开(公告)日：2011-08-04
申请号：PCT/US2010055950
申请日：2010-11-09
申请人： CORNING INC , COUILLARD JAMES G , FONTAINE NORMAN H , LAHIRI JOYDEEP , LI GUANGSHAN , LIU ANPING , PENG JINLIN , WALTON DONNELL T
发明人： COUILLARD JAMES G , FONTAINE NORMAN H , LAHIRI JOYDEEP , LI GUANGSHAN , LIU ANPING , PENG JINLIN , WALTON DONNELL T
IPC分类号： G02B6/00
CPC分类号： G01N21/553
摘要： A surface plasmon resonance sensor system including a high refractive index prism, a sensor chip, a light source having multiple wavelengths over a broad range of wavelengths, optical lenses, a photodetector, a data acquisition unit, and as defined herein. The sensor chip can include, for example, a thin layer of silicon and gold on one face of a transparent substrate and the prism adjacent to the opposite face of the transparent substrate. Such an arrangement provides variable penetration depths up to about 1.5 micrometers with a dynamic range for sensing index of refraction changes in a sample that are several times greater than that of a conventional SPR sensor. The disclosure provides methods for using the surface plasmon resonance sensor system for cell assay or chemical assay related applications.
摘要翻译：一种表面等离子体共振传感器系统，包括高折射率棱镜，传感器芯片，在宽波长范围内具有多个波长的光源，光学透镜，光电检测器，数据采集单元，如本文所定义。传感器芯片例如可以包括在透明基板的一个面上的硅和金的薄层和邻近透明基板的相对面的棱镜。这种布置提供高达约1.5微米的可变穿透深度，具有用于感测样品中的折射改变的动态范围，其比常规SPR传感器的折射数倍大几倍。本公开提供了使用表面等离子体共振传感器系统用于细胞测定或化学测定相关应用的方法。

7. 发明申请

WO2011066097A1 VARIABLE PENETRATION DEPTH BIOSENSOR AND METHODS 审中-公开
标题翻译：可变穿透深度生物传感器和方法
公开(公告)号：WO2011066097A1
公开(公告)日：2011-06-03
申请号：PCT/US2010/055950
申请日：2010-11-09
申请人： CORNING INCORPORATED , COUILLARD, James G , FONTAINE, Norman H , LAHIRI, Joydeep , LI, Guangshan , LIU, Anping , PENG, Jinlin , WALTON, Donnell T
发明人： COUILLARD, James G , FONTAINE, Norman H , LAHIRI, Joydeep , LI, Guangshan , LIU, Anping , PENG, Jinlin , WALTON, Donnell T
IPC分类号： G02B6/00
CPC分类号： G01N21/553
摘要： A surface plasmon resonance sensor system including a high refractive index prism, a sensor chip, a light source having multiple wavelengths over a broad range of wavelengths, optical lenses, a photodetector, a data acquisition unit, and as defined herein. The sensor chip can include, for example, a thin layer of silicon and gold on one face of a transparent substrate and the prism adjacent to the opposite face of the transparent substrate. Such an arrangement provides variable penetration depths up to about 1.5 micrometers with a dynamic range for sensing index of refraction changes in a sample that are several times greater than that of a conventional SPR sensor. The disclosure provides methods for using the surface plasmon resonance sensor system for cell assay or chemical assay related applications.
摘要翻译：表面等离子体共振传感器系统包括高折射率棱镜，传感器芯片，在宽波长范围内具有多个波长的光源，光学透镜，光电探测器，数据采集单元和如本文所定义的。传感器芯片可以包括例如在透明基板的一个面上的硅和金的薄层以及与透明基板的相对面相邻的棱镜。这样的布置提供了可变的穿透深度达约1.5微米，并具有用于感测样本中的折射率变化的动态范围，其比传统的SPR传感器的折射率的数倍大。本公开提供了使用表面等离子体共振传感器系统进行细胞测定或化学测定相关应用的方法。

8. 发明申请

WO2009067174A1 NORMALIZATION METHODS FOR G-PROTEIN COUPLED RECEPTOR MEMBRANE ARRAY 审中-公开
标题翻译： G蛋白偶联受体膜阵列的正常化方法
公开(公告)号：WO2009067174A1
公开(公告)日：2009-05-28
申请号：PCT/US2008/012805
申请日：2008-11-14
申请人： CORNING INCORPORATED , DONG, Longying , HONG, Yulong , LAHIRI, Joydeep , LAI, Fang , LIU, Li , LYNN, Jeffrey G
发明人： DONG, Longying , HONG, Yulong , LAHIRI, Joydeep , LAI, Fang , LIU, Li , LYNN, Jeffrey G
IPC分类号： G01N33/50
CPC分类号： G01N33/554 , G01N2333/726 , G01N2500/10
摘要： Reference membrane components are either pre-labeled or labeled during assays for purposes of normalizing signals associated with binding or functional assays employing G-protein coupled receptor microarrays. A reference component may be included in a membrane in which the target GPCR is embedded or may be present in another membrane printed in conjunction with the target membrane on a microspot. Or, a GPCR microarray may be pre-labeled by incorporating a label on an exposed substrate in a defect in the printed microspot.
摘要翻译：参考膜组分在测定期间被预标记或标记，目的是使与G-蛋白偶联受体微阵列的结合或功能测定相关的信号归一化。参考组分可以包含在其中嵌入目标GPCR的膜中，或者可以存在于与微孔上的靶膜结合印刷的另一膜中。或者，GPCR微阵列可以通过在印刷的微点的缺陷中的暴露的基底上并入标签来进行预标记。

9. 发明申请

WO2010060019A3 METHODS FOR CHARACTERIZING MOLECULES 审中-公开
标题翻译：表征分子的方法
公开(公告)号：WO2010060019A3
公开(公告)日：2010-08-05
申请号：PCT/US2009065483
申请日：2009-11-23
申请人： CORNING INC , FANG YE , FERRIE ANN M , LAHIRI JOYDEEP , TRAN ELIZABETH
发明人： FANG YE , FERRIE ANN M , LAHIRI JOYDEEP , TRAN ELIZABETH
IPC分类号： G01N33/543 , G01N33/50 , G06F19/00
CPC分类号： G01N33/5023 , G01N33/5041 , G01N33/54373 , G01N2800/60 , G06F19/12
摘要： Drug discovery is a complex undertaking facing many challenges, not the least of which is a high attrition rate as many promising candidates prove ineffective or toxic in the clinic owing to a poor understanding of the diseases, and thus the biological systems, they target. Therefore, it is broadly agreed that to increase the productivity of drug discovery one needs a far deeper understanding of the molecular mechanisms of diseases, taking into account the full biological context of the drug target and moving beyond individual genes and proteins. The present methods rely on the use of label-free cellular assays, particularly the DMR index, to systematically display the mode of actions, the toxicity, and the target(s) and pathway(s) of any molecules.
摘要翻译：药物发现是一项复杂的任务，面临着许多挑战，其中最重要的是耗损率高，因为许多有希望的候选人由于对疾病的了解不足以及生物系统的原因而在临床中被证明无效或有毒。因此，人们普遍认为，要提高药物开发的生产力，需要对疾病的分子机制有更深入的了解，同时考虑到药物靶点的全部生物学背景，并超越个体基因和蛋白质。本发明的方法依赖于使用无标记细胞测定法，特别是DMR指数来系统地显示任何分子的作用模式，毒性以及目标和途径。

10. 发明申请

WO2010060066A1 SUBSTRATE AND METHOD FOR CULTURING BREAST CELLS 审中-公开
标题翻译：用于培养乳腺细胞的基质和方法
公开(公告)号：WO2010060066A1
公开(公告)日：2010-05-27
申请号：PCT/US2009/065612
申请日：2009-11-24
申请人： CORNING INCORPORATED , DENG, Huayun , LAHIRI, Joydeep , SU, Hui
发明人： DENG, Huayun , LAHIRI, Joydeep , SU, Hui
IPC分类号： C12N5/00
CPC分类号： C12N5/0075 , C12N5/0062 , C12N5/0068
摘要： A cell culture article includes a porous substrate having a plurality of pores and a plurality of interstices in communication with the pores. At least some of the plurality of pores and interstices are sufficiently large for two or more mammary epithelial cells to cluster within the pores or interstices. Non-malignant mammary epithelial cells or breast cancer cells may not attach strongly to the substrate surface, which may encourage cell-cell interaction. In many cases, the article is desirably free of components of unknown origin. The articles may be capable of maintaining culture of malignant and non-malignant mammary epithelial cells and allowing for development of in vivo-like morphologies or characteristics of such cells.
摘要翻译：细胞培养物包括具有多个孔和与孔连通的多个间隙的多孔基材。多个孔和间隙中的至少一些孔和间隙对于两个或更多个乳腺上皮细胞聚集在孔或间隙内是足够大的。非恶性乳腺上皮细胞或乳腺癌细胞可能不会强烈附着于底物表面，这可能促进细胞 - 细胞相互作用。在许多情况下，该物品理想地不含未知来源的成分。这些制品可能能够维持恶性和非恶性乳腺上皮细胞的培养，并允许发展体内样的形态或这些细胞的特征。

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