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1. 发明申请

WO2013116449A1 AUTOMATIC CONTINUOUS PERFUSION CELL CULTURE MICROPLATE CONSUMABLES 审中-公开
标题翻译：自动连续灌注细胞培养微生物消耗
公开(公告)号：WO2013116449A1
公开(公告)日：2013-08-08
申请号：PCT/US2013/024030
申请日：2013-01-31
申请人： CORNING INCORPORATED , GORAL, Vasiliy Nikolaevich , LAI, Fang , YUEN, Po Ki
发明人： GORAL, Vasiliy Nikolaevich , LAI, Fang , YUEN, Po Ki
IPC分类号： C12M1/32 , C12M1/00 , C12M1/42
CPC分类号： C12M29/10 , B32B37/12 , C12M23/12 , C12M29/04 , C12M35/08 , Y10T156/10 , Y10T156/1064
摘要： A microplate for culturing cells with automatic, continuous perfusion includes a well frame and a planar substrate. The well frame and the planar substrate form a first well, a second well, and a third well. The first well is fluidly connected with the second well with a first perfusion membrane and the first well is fluidly connected with the third well with a second perfusion membrane. Methods of fabricating the microplate and methods of culturing cells are also provided.
摘要翻译：用于用自动连续灌注培养细胞的微板包括井架和平面基底。井架和平面底板形成第一井，第二井和第三井。第一个井用第一个灌注膜与第二个井流体连接，第一个井用第二个灌注膜与第三个井流体连接。还提供了制备微孔板的方法和培养细胞的方法。

2. 发明申请

WO2008005292A1 FLUID HANDLING SYSTEM FOR FLOW-THROUGH ASSAY 审中-公开
标题翻译：用于流量测量的流体处理系统
公开(公告)号：WO2008005292A1
公开(公告)日：2008-01-10
申请号：PCT/US2007/015045
申请日：2007-06-28
申请人： CORNING INCORPORATED , MILLER, William J , MORRELL, Mark L , ROSWECH, Todd M , YUEN, Po Ki
发明人： MILLER, William J , MORRELL, Mark L , ROSWECH, Todd M , YUEN, Po Ki
IPC分类号： G01N35/10 , B01L3/00
CPC分类号： G01N35/1072 , B01L3/5027 , G01N35/1074
摘要： A fluid handling system for transferring fluids is disclosed. The fluid handling system incorporates a plurality of transfer units for dispensing and/or collecting fluids as part of a closed analytical system. The plurality of transfer units are capable of functioning independently and/or collectively when assembled in a unitary array format. Methods of making and using the fluid handling system are also disclosed. The fluid handling system allows a sub-array of transfer units to shift in a vertical direction independent from a position of another sub-array of transfer units that are assembled within the same fluid head. Therefore, the fluid handling system facilitates multi-port fluid delivery and collection in an array format. Further, the fluid handling system aligned with a sensing surface enables label-free detection assays to be performed in an analytical system.
摘要翻译：公开了一种用于输送流体的流体处理系统。流体处理系统包括用于分配和/或收集流体作为封闭分析系统的一部分的多个转运单元。当以单一阵列格式组装时，多个传送单元能够独立地和/或共同地起作用。还公开了制造和使用流体处理系统的方法。流体处理系统允许传送单元的子阵列在垂直方向上移动，独立于组装在同一流体头内的另一传送单元子阵列的位置。因此，流体处理系统便于以端口流体输送和以阵列格式收集。此外，与感测表面对准的流体处理系统使得能够在分析系统中进行无标记检测分析。

3. 发明申请

WO2005016532A2 AUTOMATED REACTION CHAMBER SYSTEM FOR BIOLOGICAL ASSAYS 审中-公开
标题翻译：用于生物分析的自动反应室系统
公开(公告)号：WO2005016532A2
公开(公告)日：2005-02-24
申请号：PCT/US2004/018716
申请日：2004-06-10
申请人： CORNING INCORPORATED , FANG, Ye , YUEN, Po, Ki , KUNG, Vincent, T.
发明人： FANG, Ye , YUEN, Po, Ki , KUNG, Vincent, T.
IPC分类号： B01L3/00
CPC分类号： B01F5/061 , B01F9/002 , B01F9/0021 , B01F11/0071 , B01F13/0059 , B01L3/5025 , B01L3/5027 , B01L3/502715 , B01L9/527 , B01L2200/027 , B01L2200/0689 , B01L2300/0636 , B01L2300/0877 , B01L2300/1827 , B01L2300/1844 , B01L2300/185 , B01L2400/0409 , B01L2400/0457 , B01L2400/0487 , B01L2400/0633 , G01N1/312 , G01N2035/00158 , G01N2035/00524
摘要： A device for high-capacity, multiplexed processing of a variety of solid-phase-format, biological or biochemical assays, which use fluid media, is described. The device may be part of a larger machine or system, which can be automation friendly. Generally, the device comprises a number of plates, which forms a cassette or chamber module. Each cassette or chamber module has an interior and exterior surface. At least part of an interior wall surface is displaceable. Within each cassette are a number of fluid inlet and outlet passageways and a reaction chamber for receiving at least one microarray substrate. When the cassette is ready to be used, the reaction chamber should be fluid-tight. In the larger machine, a number of cassettes are associated with a rotary drum, from which the chamber modules extend outwardly. A method relating to the use of the present device or system is also provided.
摘要翻译：描述了用于使用流体介质的各种固相格式，生物或生物化学测定的高容量多路复用处理的设备。该设备可能是大型机器或系统的一部分，可以自动控制。通常，该装置包括多个板，其形成盒或腔室模块。每个盒或腔室模块具有内部和外部表面。内墙表面的至少一部分是可移动的。在每个盒内有多个流体入口和出口通道以及用于接收至少一个微阵列基底的反应室。当盒子准备好使用时，反应室应该是流体密封的。在较大的机器中，多个盒子与旋转鼓相关联，室模块从旋转鼓向外延伸。还提供了与使用本装置或系统有关的方法。

4. 发明申请

WO2012027647A3 FLEXIBLE MICROFLUIDIC DEVICE WITH INTERCONNECTED POROUS NETWORK 审中-公开
标题翻译：具有互联多孔网络的柔性微流体装置
公开(公告)号：WO2012027647A3
公开(公告)日：2012-04-19
申请号：PCT/US2011049299
申请日：2011-08-26
申请人： CORNING INC , DEROSA MICHAEL E , YUEN PO KI
发明人： DEROSA MICHAEL E , YUEN PO KI
IPC分类号： C08J7/02 , B01L3/00
CPC分类号： C08J7/02 , B01L3/502707 , B01L2300/0887 , C08J2325/06 , Y10T428/24612
摘要： Polymeric sheets having interconnected microporous networks are generated by contacting the sheets with a composition including solvent and non-solvent in an appropriate ratio and removing the composition from the sheet. Such sheets may be advantageously used in microfluidic devices for a variety of purposes.
摘要翻译：具有互连的微孔网络的聚合物片材通过使片材与包含溶剂和非溶剂的组合物以适当的比例接触并从片材上除去组合物而产生。这种片材可以有利地用于微流体装置中用于各种目的。

5. 发明申请

WO2009117147A1 MODULAR MICROFLUIDIC SYSTEM AND METHOD FOR BUILDING A MODULAR MICROFLUIDIC SYSTEM 审中-公开
标题翻译：模块化微流体系统和建立模块化微流体系统的方法
公开(公告)号：WO2009117147A1
公开(公告)日：2009-09-24
申请号：PCT/US2009/001770
申请日：2009-03-20
申请人： CORNING INCORPORATED , YUEN, Po, Ki
发明人： YUEN, Po, Ki
IPC分类号： B01L3/00 , B01L9/00 , B01J19/00
CPC分类号： B01J19/0093 , B01J2219/00804 , B01J2219/0081 , B01J2219/00833 , B01J2219/00853 , B01J2219/00873 , B01J2219/00889 , B01J2219/00909 , B01J2219/00912 , B01L3/502715 , B01L9/527 , B01L2200/025 , B01L2200/027 , B01L2200/028 , B01L2200/10 , B01L2300/0816 , B01L2300/0874 , B33Y80/00 , Y10T29/494 , Y10T436/11 , Y10T436/25375 , Y10T436/2575
摘要： A "plug-n-play" modular microfluidic system is described herein which can be made by connecting multiple microfluidic components together to form a larger integrated system. For example, the modular microfluidic system includes a motherboard with interconnecting channels and integrated electrodes (or holes for electrodes to pass) which provide electronic connections to external data acquisition and system control devices. The modular microfluidic system can also include channel inserts (which are placed in the channels of the motherboard), heater units, actuator units, fitting components and microchips/modules with different functionalities which are placed on the motherboard.
摘要翻译：本文描述了一种“即插即用”模块化微流体系统，其可以通过将多个微流体部件连接在一起以形成更大的集成系统来制造。例如，模块化微流体系统包括具有互连通道的主板和用于提供与外部数据采集和系统控制装置的电连接的集成电极（或用于电极的通孔）。模块化微流体系统还可以包括放置在母板上的通道插入件（放置在母板的通道中），加热器单元，致动器单元，配件组件和具有不同功能的微型芯片/模块。

6. 发明申请

WO2006071696A3 POROUS SUBSTRATES AND ARRAYS COMPRISING THE SAME 审中-公开
标题翻译：多孔基片和包含它的阵列
公开(公告)号：WO2006071696A3
公开(公告)日：2009-07-23
申请号：PCT/US2005046450
申请日：2005-12-21
申请人： CORNING INC , TEPESCH PATRICK D , WIGHT JOHN F JR , YUEN PO KI , MOZDY ERIC J , COONAN EVERETT W , FANG YE , FERRIE ANN M , FU XIADONG , HONG YULONG , LESLIE THOMAS M , LI XINGHUA , MONAHAN BETH C , MUELLER DIRK , TANNER CAMERON W
发明人： TEPESCH PATRICK D , WIGHT JOHN F JR , YUEN PO KI , MOZDY ERIC J , COONAN EVERETT W , FANG YE , FERRIE ANN M , FU XIADONG , HONG YULONG , LESLIE THOMAS M , LI XINGHUA , MONAHAN BETH C , MUELLER DIRK , TANNER CAMERON W
IPC分类号： B01L3/00 , B01J19/00
CPC分类号： B01L3/5085 , B01J2219/00315 , B01J2219/00317 , B01J2219/00423 , B01J2219/00639 , B01J2219/00644 , B01J2219/00722 , B01L2300/0819
摘要： The present invention relates to arrays comprising porous substrates for attachment of nucleic acids, polypeptides, membranes, or other biological or organic materials. In many embodiments, the arrays of the present invention have a flow-through configuration such that washing buffers or samples can access to the porous substrates from at least two sides of the arrays. The present invention also features arrays comprising UV-compatible porous substrates, arrays comprising three-dimensional membranes in sol-gels, and arrays comprising silica-based porous substrates prepared using a low-temperature fusion process.
摘要翻译：本发明涉及包含用于连接核酸，多肽，膜或其它生物或有机材料的多孔底物的阵列。在许多实施例中，本发明的阵列具有流通构型，使得洗涤缓冲液或样品可以从阵列的至少两侧进入多孔基底。本发明还具有包含UV兼容的多孔基材，溶胶凝胶中包含三维膜的阵列和包含使用低温熔融法制备的基于二氧化硅的多孔基材的阵列的阵列。

7. 发明申请

WO2006107506A3 SYSTEM AND METHOD FOR PERFORMING G PROTEIN COUPLED RECEPTOR (GPCR) CELL ASSAYS USING WAVEGUIDE-GRATING SENSORS 审中-公开
标题翻译：使用波导传感器执行G蛋白偶联受体（GPCR）细胞测定的系统和方法
公开(公告)号：WO2006107506A3
公开(公告)日：2006-11-16
申请号：PCT/US2006008582
申请日：2006-03-10
申请人： CORNING INC , FANG YE , FERRIE ANN M , FONTAINE NORMAN H , YUEN PO KI , LAHIRI JOYDEEP
发明人： FANG YE , FERRIE ANN M , FONTAINE NORMAN H , YUEN PO KI , LAHIRI JOYDEEP
IPC分类号： G01N33/543 , G01N21/77 , G01N33/68
CPC分类号： G01N33/5041 , G01N21/4788 , G01N21/553 , G01N2333/726 , G01N2500/10
摘要： The present invention includes a system and method that uses optical LID biosensors to monitor in real time agonist-induced GPCR signaling events within living cells. Particularly, the present invention includes a system and method for using an optical LID biosensor to screen compounds against a target GPCR within living cells based on the mass redistribution due to agonist-induced GPCR activation. In an extended embodiment, the present invention discloses different ways for self-referencing the optical LID biosensor to eliminate unwanted sensitivity to ambient temperature, pressure fluctuations, and other environmental changes. In yet another extended embodiment, the present invention discloses different ways for screening multiple GPCRs in a single type of cell or multiple GPCRs in multiple types of cells within a single medium solution. In still yet another extended embodiment, the present invention discloses different ways to confirm the physiological or pharmacological effect of a compound against a specific GPCR within living cells.
摘要翻译：本发明包括使用光学LID生物传感器实时监测活细胞内激动剂诱导的GPCR信号事件的系统和方法。特别地，本发明包括使用光学LID生物传感器基于由于激动剂诱导的GPCR活化导致的质量再分布来筛选活细胞内的靶GPCR的化合物的系统和方法。在扩展实施例中，本发明公开了用于自参考光学LID生物传感器以消除对环境温度，压力波动和其他环境变化的不期望的灵敏度的不同方式。在又一个扩展的实施方案中，本发明公开了在单一培养基溶液中的多种类型的细胞中单种类型细胞或多种GPCR筛选多种GPCR的不同方式。在又一个延伸的实施方案中，本发明公开了确定化合物对活细胞内特异性GPCR的生理或药理作用的不同方式。

8. 发明申请

WO2006071696A9 POROUS SUBSTRATES AND ARRAYS COMPRISING THE SAME 审中-公开
标题翻译：多孔基片和包含它的阵列
公开(公告)号：WO2006071696A9
公开(公告)日：2006-10-19
申请号：PCT/US2005046450
申请日：2005-12-21
申请人： CORNING INC , TEPESCH PATRICK D , WIGHT JOHN F JR , YUEN PO KI , MOZDY ERIC J , COONAN EVERETT W , FANG YE , FERRIE ANN M , FU XIADONG , HONG YULONG , LESLIE THOMAS M , LI XINGHUA , MONAHAN BETH C , MUELLER DIRK , TANNER CAMERON W
发明人： TEPESCH PATRICK D , WIGHT JOHN F JR , YUEN PO KI , MOZDY ERIC J , COONAN EVERETT W , FANG YE , FERRIE ANN M , FU XIADONG , HONG YULONG , LESLIE THOMAS M , LI XINGHUA , MONAHAN BETH C , MUELLER DIRK , TANNER CAMERON W
IPC分类号： B01L3/00 , B01J19/00
CPC分类号： B01L3/5085 , B01J2219/00315 , B01J2219/00317 , B01J2219/00423 , B01J2219/00639 , B01J2219/00644 , B01J2219/00722 , B01L2300/0819
摘要： The present invention relates to arrays comprising porous substrates for attachment of nucleic acids, polypeptides, membranes, or other biological or organic materials. In many embodiments, the arrays of the present invention have a flow-through configuration such that washing buffers or samples can access to the porous substrates from at least two sides of the arrays. The present invention also features arrays comprising UV-compatible porous substrates, arrays comprising three-dimensional membranes in sol-gels, and arrays comprising silica-based porous substrates prepared using a low-temperature fusion process.
摘要翻译：本发明涉及包含用于连接核酸，多肽，膜或其它生物或有机材料的多孔底物的阵列。在许多实施例中，本发明的阵列具有流通构型，使得洗涤缓冲液或样品可以从阵列的至少两侧进入多孔基底。本发明还具有包含UV兼容的多孔基材，溶胶凝胶中包含三维膜的阵列和包含使用低温熔融法制备的基于二氧化硅的多孔基材的阵列的阵列。

9. 发明申请

WO2005102528A1 TRANSPARENT FILTERED CAPILLARIES 审中-公开
标题翻译：透明过滤毛巾
公开(公告)号：WO2005102528A1
公开(公告)日：2005-11-03
申请号：PCT/US2005/008061
申请日：2005-03-09
申请人： CORNING INCORPORATED , YUEN, Po, Ki , DEJNEKA, Matthew, J. , RASMUSSEN, Michael, H.
发明人： YUEN, Po, Ki , DEJNEKA, Matthew, J. , RASMUSSEN, Michael, H.
IPC分类号： B01L3/00
CPC分类号： G01N15/1484 , B01J2219/00286 , B01J2219/00423 , B01J2219/00495 , B01J2219/005 , B01J2219/00722 , B01L3/502761 , B01L2200/0668 , B01L2300/0681 , B01L2300/0809 , B01L2300/16 , G01N15/0625 , G01N15/1463
摘要： A microfluidic reactor (10) for trapping one or more particles of predetermined nominal size or range of sizes that have entered a flow inlet (12) includes a transparent reaction zone (14) which also serves as an in-situ detection zone wherein the detection zone is arranged so as substantially to correspond in shape to an optical detector (456). A porous filter (16) having a plurality of holes (160) being smaller than the nominal size or range of sizes of the particles (200) are arranged so as to trap the particles in the reaction zone (14) while a fluid (18) flows from the flow inlet (12) through the reaction zone (14) and the filter (16).
摘要翻译：用于捕获已经进入流入口（12）的预定公称尺寸或尺寸范围的一个或多个颗粒的微流体反应器（10）包括也用作原位检测区域的透明反应区（14），其中检测区域被布置成基本上与形状对应于光学检测器（456）。布置有多个孔（160）小于所述颗粒（200）的标称尺寸或尺寸范围的多孔过滤器（16），以将颗粒捕集在反应区（14）中，同时流体（18 ）从流入口（12）流过反应区（14）和过滤器（16）。

10. 发明申请

WO2012027647A2 FLEXIBLE MICROFLUIDIC DEVICE WITH INTERCONNECTED POROUS NETWORK 审中-公开
标题翻译：具有互连多孔网络的柔性微流体装置
公开(公告)号：WO2012027647A2
公开(公告)日：2012-03-01
申请号：PCT/US2011/049299
申请日：2011-08-26
申请人： CORNING INCORPORATED , DEROSA, Michael E , YUEN, Po Ki
发明人： DEROSA, Michael E , YUEN, Po Ki
IPC分类号： C08J7/02
CPC分类号： C08J7/02 , B01L3/502707 , B01L2300/0887 , C08J2325/06 , Y10T428/24612
摘要： Polymeric sheets having interconnected microporous networks are generated by contacting the sheets with a composition including solvent and non-solvent in an appropriate ratio and removing the composition from the sheet. Such sheets may be advantageously used in microfluidic devices for a variety of purposes.
摘要翻译：通过使片材与包含溶剂和非溶剂的组合物以适当的比例接触而产生具有互连的微孔网络的聚合物片材，并从片材中除去组合物。为了各种目的，这种片可有利地用于微流体装置中。

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