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1. 发明申请

WO2011116260A1 LABEL-FREE ON-TARGET PHARMACOLOGY METHODS 审中-公开
标题翻译：无标签目标药物方法
公开(公告)号：WO2011116260A1
公开(公告)日：2011-09-22
申请号：PCT/US2011/028947
申请日：2011-03-18
申请人： CORNING INCORPORATED , FANG, Ye , FERRIE, Ann M.
发明人： FANG, Ye , FERRIE, Ann M.
IPC分类号： G06F19/00
CPC分类号： G06F19/707 , G06F19/706
摘要： Disclosed are methods and machines to determine on-target pharmacology of molecules using label-free biosensor cellular assays and label-free biosensor integrative pharmacology.
摘要翻译：公开了使用无标签生物传感器细胞测定和无标记生物传感器综合药理学确定分子的靶向药理学的方法和机器。

2. 发明申请

WO2010060019A3 METHODS FOR CHARACTERIZING MOLECULES 审中-公开
标题翻译：表征分子的方法
公开(公告)号：WO2010060019A3
公开(公告)日：2010-08-05
申请号：PCT/US2009065483
申请日：2009-11-23
申请人： CORNING INC , FANG YE , FERRIE ANN M , LAHIRI JOYDEEP , TRAN ELIZABETH
发明人： FANG YE , FERRIE ANN M , LAHIRI JOYDEEP , TRAN ELIZABETH
IPC分类号： G01N33/543 , G01N33/50 , G06F19/00
CPC分类号： G01N33/5023 , G01N33/5041 , G01N33/54373 , G01N2800/60 , G06F19/12
摘要： Drug discovery is a complex undertaking facing many challenges, not the least of which is a high attrition rate as many promising candidates prove ineffective or toxic in the clinic owing to a poor understanding of the diseases, and thus the biological systems, they target. Therefore, it is broadly agreed that to increase the productivity of drug discovery one needs a far deeper understanding of the molecular mechanisms of diseases, taking into account the full biological context of the drug target and moving beyond individual genes and proteins. The present methods rely on the use of label-free cellular assays, particularly the DMR index, to systematically display the mode of actions, the toxicity, and the target(s) and pathway(s) of any molecules.
摘要翻译：药物发现是一项复杂的任务，面临着许多挑战，其中最重要的是耗损率高，因为许多有希望的候选人由于对疾病的了解不足以及生物系统的原因而在临床中被证明无效或有毒。因此，人们普遍认为，要提高药物开发的生产力，需要对疾病的分子机制有更深入的了解，同时考虑到药物靶点的全部生物学背景，并超越个体基因和蛋白质。本发明的方法依赖于使用无标记细胞测定法，特别是DMR指数来系统地显示任何分子的作用模式，毒性以及目标和途径。

3. 发明申请

WO2009045524A2 SYSTEM AND METHOD FOR DUAL-DETECTION OF A CELLULAR RESPONSE 审中-公开
标题翻译：用于双重检测细胞响应的系统和方法
公开(公告)号：WO2009045524A2
公开(公告)日：2009-04-09
申请号：PCT/US2008011485
申请日：2008-10-03
申请人： CORNING INC , FANG YE , FERRIE ANN M , LAHIRI JOYDEEP , MUDALIAR DEEPTI J , WU QI
发明人： FANG YE , FERRIE ANN M , LAHIRI JOYDEEP , MUDALIAR DEEPTI J , WU QI
IPC分类号： G01N21/55 , G01N21/64 , G01N33/543
CPC分类号： G01N21/648 , G01N21/7743
摘要： A system and method as defined herein for dual-detection of evanescent-wave label-free light and evanescent-wave excited-fluorescent label-emitted light in an optical biosensor.
摘要翻译：本文所定义的系统和方法，用于在光学生物传感器中双重检测ev逝波无标记光和ev逝波激发荧光标记发射光。

4. 发明申请

WO9840483A3 28 HUMAN SECRETED PROTEINS 审中-公开
标题翻译： 28人类分泌蛋白
公开(公告)号：WO9840483A3
公开(公告)日：1998-11-19
申请号：PCT/US9804858
申请日：1998-03-12
申请人： HUMAN GENOME SCIENCES INC , RUBEN STEVEN M , ROSEN CRAIG A , LI YI , ZENG ZHIZHEN , KYAW HLA , FISCHER CARRIE L , LI HAODONG , SOPPET DANIEL R , GENTZ REINER L , WEI YING FEI , MOORE PAUL A , YOUNG PAUL E , GREENE JOHN M , FERRIE ANN M
发明人： RUBEN STEVEN M , ROSEN CRAIG A , LI YI , ZENG ZHIZHEN , KYAW HLA , FISCHER CARRIE L , LI HAODONG , SOPPET DANIEL R , GENTZ REINER L , WEI YING FEI , MOORE PAUL A , YOUNG PAUL E , GREENE JOHN M , FERRIE ANN M
IPC分类号： C12N15/09 , A61K38/00 , A61K48/00 , A61P31/00 , A61P35/00 , A61P37/02 , C07K14/47 , C07K16/18 , C07K19/00 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/12 , C12P21/02 , C12Q1/68 , A61K31/70 , A61K38/17 , C12N15/11 , C12N15/62 , C12Q1/48 , G01N33/53 , G01N33/60 , G01N33/68
CPC分类号： C07K14/47 , A61K38/00 , A61K48/00 , A61K2039/53 , C07K14/4702 , C07K14/4718 , C07K2319/00 , C07K2319/02 , C12N2799/026
摘要： The present invention relates to 28 human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to these novel human secreted proteins.

5. 发明申请

WO2010060022A3 METHODS OF CREATING AN INDEX 审中-公开
标题翻译：创建索引的方法
公开(公告)号：WO2010060022A3
公开(公告)日：2011-05-19
申请号：PCT/US2009065490
申请日：2009-11-23
申请人： CORNING INC , FANG YE , FERRIE ANN M , LAHIRI JOYDEEP , TRAN ELIZABETH
发明人： FANG YE , FERRIE ANN M , LAHIRI JOYDEEP , TRAN ELIZABETH
IPC分类号： G06F19/00
CPC分类号： G06F19/709 , G01N33/5041 , G01N33/54373 , G06F19/12
摘要： Drug discovery is a complex undertaking facing many challenges, not the least of which is a high attrition rate as many promising candidates prove ineffective or toxic in the clinic owing to a poor understanding of the diseases, and thus the biological systems, they target. Therefore, it is broadly agreed that to increase the productivity of drug discovery one needs a far deeper understanding of the molecular mechanisms of diseases, taking into account the full biological context of the drug target and moving beyond individual genes and proteins. The present methods rely on the use of label-free cellular assays, particularly the DMR index, to systematically display the mode of actions, the toxicity, and the target(s) and pathway(s) of any molecules.
摘要翻译：毒品发现是一项面临许多挑战的复杂工作，其中最重要的是高消耗率，因为许多有前途的候选人在诊所中证明无效或有毒，原因是对这些疾病的认识不足，从而导致其生物系统的目标。因此，普遍同意，为了提高药物发现的生产力，需要更深入地了解疾病的分子机制，同时考虑到药物靶标的完整生物学背景，超越个别基因和蛋白质。本方法依赖于使用无标记细胞测定法，特别是DMR指数来系统显示任何分子的作用模式，毒性以及靶标和途径。

6. 发明申请

WO2006108183A3 LABEL FREE BIOSENSORS AND CELLS 审中-公开
标题翻译：标签免费生物传感器和细胞
公开(公告)号：WO2006108183A3
公开(公告)日：2009-04-16
申请号：PCT/US2006013539
申请日：2006-04-05
申请人： CORNING INC , FANG YE , FERRIE ANN M , FONTAINE NORMAN H , LAHIRI JOYDEEP , YUEN PO KI
发明人： FANG YE , FERRIE ANN M , FONTAINE NORMAN H , LAHIRI JOYDEEP , YUEN PO KI
IPC分类号： A61B5/05 , A61N1/30 , G01N33/552
CPC分类号： G01N33/5008 , G01N33/54373 , G01N33/554
摘要： Disclosed are compositions and methods for using label free optical biosensors for performing cell assays. In certain embodiments the assays can be performed in highthough put methods and can be multiplexed.
摘要翻译：公开了使用无标签光学生物传感器进行细胞测定的组合物和方法。在某些实施方案中，所述测定可以以放置方式进行并且可以被复用。

7. 发明申请

WO2008106048A1 SURFACES AND METHODS FOR BIOSENSOR CELLULAR ASSAYS 审中-公开
标题翻译：生物传感器细胞测定的表面和方法
公开(公告)号：WO2008106048A1
公开(公告)日：2008-09-04
申请号：PCT/US2008/002314
申请日：2008-02-21
申请人： CORNING INCORPORATED , FANG, Ye , FERRIE, Ann M , TRAN, Elizabeth , XI, Jun
发明人： FANG, Ye , FERRIE, Ann M , TRAN, Elizabeth , XI, Jun
IPC分类号： G01N33/543 , G01N33/554
CPC分类号： G01N33/54373 , G01N33/569
摘要： Disclosed is an apparatus for measuring ligand-induced cell activity as defined herein, the apparatus including: an optical biosensor having a contact surface including a compatibilizer zone, an optional surface modifier zone, and a live cell zone. The disclosure also provides a method of making the apparatus and methods for measuring ligand-induced live cell activity with the apparatus.
摘要翻译：本发明公开了一种如本文所定义的用于测量配体诱导的细胞活性的装置，该装置包括：光学生物传感器，其具有包括增容剂区，任选的表面改性区和活细胞区的接触表面。本公开还提供了使用该装置制备用于测量配体诱导的活细胞活性的装置和方法的方法。

8. 发明申请

WO2005115622A1 POROUS SUBSTRATE PLATES AND THE USE THEREOF 审中-公开
标题翻译：多孔基板及其使用
公开(公告)号：WO2005115622A1
公开(公告)日：2005-12-08
申请号：PCT/US2005/012040
申请日：2005-04-12
申请人： CORNING INCORPORATED , FANG, Ye , FERRIE, Ann, M. , HONG, Yulong , WEBB, Brian, Lynn
发明人： FANG, Ye , FERRIE, Ann, M. , HONG, Yulong , WEBB, Brian, Lynn
IPC分类号： B01L3/00
CPC分类号： B01L3/5085 , B01L2200/12 , B01L2300/069 , B01L2300/0829 , Y10S435/81 , Y10S436/809 , Y10T29/49885
摘要： A substrate plate or device adapted for use with biological or chemical assays is disclosed. The device may take the form of a multi-well plate having a three-dimensional, porous layer as part of a support surface within each well for immobilizing probe species. The porous layer is characterized a as having a plurality of interconnected voids defined by a matrix of contiguous solid material. A method and its variants are also described.
摘要翻译：公开了适用于生物或化学测定的底物板或装置。该装置可以采用具有三维多孔层的多孔板的形式，作为每个孔内的支撑表面的一部分，用于固定探针物质。多孔层的特征在于具有由连续的固体材料的基体限定的多个相互连接的空隙。还描述了一种方法及其变体。

9. 发明申请

WO2005010532A1 MULTIPLEXED BINDING ASSAYS FOR RECEPTOR ARRAYS 审中-公开
标题翻译：用于受体阵列的多重绑定测定
公开(公告)号：WO2005010532A1
公开(公告)日：2005-02-03
申请号：PCT/US2004/019750
申请日：2004-06-21
申请人： CORNING INCORPORATED , FANG, Ye , FERRIE, Ann M , HONG, Yulong , LAHIRI, Joydeep , LAI, Fang , PENG, Jinlin , WEBB, Brian L
发明人： FANG, Ye , FERRIE, Ann M , HONG, Yulong , LAHIRI, Joydeep , LAI, Fang , PENG, Jinlin , WEBB, Brian L
IPC分类号： G01N33/566
CPC分类号： C40B30/04 , G01N33/74 , G01N2333/726
摘要： A thematic microarray and methods for multiplexed binding assays using a cocktail solution of labeled ligands in the presence or absence of a target compound is provided. The methods enables researchers to screening compounds against multiple targets using a microarray format.
摘要翻译：提供了一种专题微阵列和在存在或不存在目标化合物的情况下使用标记配体的混合溶液进行多重结合测定的方法。这些方法使研究人员可以使用微阵列格式来筛选多个靶点的化合物。

10. 发明申请

WO2011081968A1 PI3K MODULATORS, RHO KINASE MODULATORS AND METHODS OF IDENTIFYING AND USING SAME 审中-公开
标题翻译： PI3K调节剂，RHO激酶调节剂及其鉴定和使用方法
公开(公告)号：WO2011081968A1
公开(公告)日：2011-07-07
申请号：PCT/US2010/060648
申请日：2010-12-16
申请人： CORNING INCORPORATED , FANG, Ye , SUN, Haiyan , DENG, Huayun , FERRIE, Ann, M. , TRAN, Elizabeth
发明人： FANG, Ye , SUN, Haiyan , DENG, Huayun , FERRIE, Ann, M. , TRAN, Elizabeth
IPC分类号： G01N33/543 , C12Q1/48
CPC分类号： G01N33/5041 , G01N33/54373 , G01N2333/91215
摘要： Disclosed are methods to characterize PI3K inhibitors and Rho kinase inhibitors using label-free cellular assays. Disclosed are also methods to characterize a cell whether it has a deregulated PI3K pathway or not.
摘要翻译：公开了使用无标记细胞测定来表征PI3K抑制剂和Rho激酶抑制剂的方法。还公开了表征细胞是否具有失去PI3K途径的方法。

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