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1. 发明授权

US06319225B1 Injection syringe including device for preparation of injection 有权
标题翻译：注射器包括注射装置
公开(公告)号：US06319225B1
公开(公告)日：2001-11-20
申请号：US09266916
申请日：1999-03-12
申请人： Koichi Sugita , Sei Kirihara , Hiromichi Ishikawa , Yutaka Igarashi
发明人： Koichi Sugita , Sei Kirihara , Hiromichi Ishikawa , Yutaka Igarashi
IPC分类号： A61M3700
CPC分类号： A61M5/2448 , A61M5/31553 , A61M5/31591
摘要： An injection syringe including a device for preparation of an injection in situ, useful to the injection which is liable to suffer chemical changes if left for a long time in the state of solution or dispersion ready to inject. The injection syringe is portable by a patient who may prepare a necessary injection in situ with the use of a device included in the syringe which will automatically perform an injection with a prescribed dosage. The injection syringe includes a device for preparation of an injection, whereby mechanical impacts affecting the medicine and consequently, chemical changes with a medicine would be minimized during the step of dissolving the medicine. The syringe as noted is especially useful for preparation of injection and injection of human growth hormones, interferon and various polypeptides which are of an environmentally sensitive nature and liable to suffer chemical changes if left for a long time in the state of solution or dispersion.
摘要翻译：一种注射器，其包括用于制备原位注射的装置，其用于注射，如果在准备注射的溶液或分散体的状态下长时间存在易于发生化学变化。注射器可以由患者便携，该患者可以使用包括在注射器中的装置在现场准备必要的注射器，其将以规定剂量自动进行注射。注射器包括用于制备注射器的装置，由此在溶解药物的步骤期间，影响药物的机械冲击以及因此的药物的化学变化将被最小化。如上所述，注射器特别适用于制备注射和注射人生长激素，干扰素和各种具有环境敏感性质的多肽，并且如果在溶液或分散状态下长时间使用，则易于遭受化学变化。

2. 发明授权

US5085350A Pump assembly with container for storing liquid in isolation from ambient air 失效
标题翻译：泵组件带有用于与环境空气隔离的液体的容器
公开(公告)号：US5085350A
公开(公告)日：1992-02-04
申请号：US494534
申请日：1990-03-16
申请人： Koichi Sugita
发明人： Koichi Sugita
IPC分类号： B05B11/00
CPC分类号： B05B11/0048 , B05B11/0056 , B05B11/0097 , B05B11/3049 , B05B11/3026
摘要： A pump assembly for storing and discharging a liquid such as a chemical solution includes a substantially cylindrical container for storing the liquid therein. A pump is mounted on one end of the container. The pump has a suction port for drawing the liquid from the container and an outlet port for discharging the liquid. A gasket is slidably inserted in the opposite end of the container in contact with the liquid stored in the container, for sealing the liquid in the container. The gasket is slidable toward the pump when the liquid stored in the container is reduced by the pump. A slanted portion is disposed in one end of the container and has a slanted surface extending continuously from an inner peripheral surface of the container and converging away from the gasket. The suction port of the pump communicates with the interior space of the container substantially at a converging end of the slanted surface. Any trapped air is collected between the slanted surface and the liquid contained in the container, and can be discharged from the container by the pump before the liquid is discharged from the container by the pump.
摘要翻译：用于储存和排出诸如化学溶液的液体的泵组件包括用于在其中储存液体的基本上圆柱形的容器。泵安装在容器的一端。泵具有用于从容器抽出液体的抽吸口和用于排出液体的出口。垫圈可滑动地插入与容器中存储的液体接触的容器的相对端，用于密封容器中的液体。当储存在容器中的液体被泵减少时，垫圈可朝向泵滑动。倾斜部分设置在容器的一端，并且具有从容器的内周面连续延伸的倾斜表面，并从垫圈收敛。泵的吸入口基本上在倾斜表面的收敛端与容器的内部空间连通。任何被捕获的空气被收集在倾斜表面和容纳在容器中的液体之间，并且在液体通过泵从容器排出之前可以通过泵从容器中排出。

3. 发明授权

US07947876B2 Plant and plant storage organ having GLP-1 derivative accumulated therein and method of producing the same 失效
标题翻译：蓄积有GLP-1衍生物的植物贮藏器具及其制造方法
公开(公告)号：US07947876B2
公开(公告)日：2011-05-24
申请号：US11662650
申请日：2004-09-14
申请人： Koichi Sugita , Saori Kasahara , Hiroyasu Ebinuma , Humio Takaiwa , Hiroshi Yasuda , Takahito Jomori , Yuji Hayashi , Akira Tashita
发明人： Koichi Sugita , Saori Kasahara , Hiroyasu Ebinuma , Humio Takaiwa , Hiroshi Yasuda , Takahito Jomori , Yuji Hayashi , Akira Tashita
IPC分类号： A01H5/00 , C12N15/82
CPC分类号： A61K38/26 , A23L33/105 , C12N15/8257
摘要： The present invention is regarding plants and plant storage organs thereof in which GLP-1 derivatives are accumulated, and methods of producing them. The transgenic plants and plant storage organs thereof accumulate tandem repeated GLP-1 derivatives cleavable with intestinal digestive enzyme to monomeric molecules and are produced by methods comprising: integrating into vectors linked DNAs which comprise tandem repeated DNAs encoding the GLP-1 derivative with trypsin resistance in which the amino acid in the 26th position is Gln, the amino acid in the 34th position is Asn or Asp, and C-terminal consists of Arg or Lys to produce monomeric molecules; introducing the vectors into plant cells; and redifferentiating the obtained transformants. The edible transgenic plants and plant storage organs are useful for treating diabetes and can be ingested by diabetic patients.
摘要翻译：本发明涉及其中积累GLP-1衍生物的植物和植物贮藏器官及其生产方法。其转基因植物和植物储存器官将可与肠消化酶切割的串联重复的GLP-1衍生物积聚到单体分子中，并通过以下方法产生：包括：将包含编码GLP-1衍生物的串联重复DNA与胰蛋白酶抗性的连锁DNA连接其中第26位的氨基酸是Gln，第34位的氨基酸是Asn或Asp，C末端由Arg或Lys组成以产生单体分子; 将载体导入植物细胞; 并重新分化获得的转化体。可食用的转基因植物和植物贮藏器官可用于治疗糖尿病并可被糖尿病患者摄入。

4. 发明授权

US07847063B2 GLP-1 derivative 失效
标题翻译： GLP-1衍生物
公开(公告)号：US07847063B2
公开(公告)日：2010-12-07
申请号：US10550624
申请日：2004-03-26
申请人： Koichi Sugita , Saori Kasahara , Hiroyasu Ebinuma , Fumio Takaiwa , Takahito Jomori , Yuji Hayashi , Akira Tashita , Yukari Kobara
发明人： Koichi Sugita , Saori Kasahara , Hiroyasu Ebinuma , Fumio Takaiwa , Takahito Jomori , Yuji Hayashi , Akira Tashita , Yukari Kobara
IPC分类号： A61K38/00 , C07K14/00
CPC分类号： C12N15/8257 , C07K14/605 , C12N15/8216
摘要： The present invention provides a method for highly producing a recombinant protein in a plant storage organ and a GLP-1 derivative. The plant storage organ in which the recombinant protein is highly produced is obtained by transformation with the use of a vector which comprises a recombinant protein gene, a cytokinin-related gene, a drug-resistant gene and a removable DNA element, in which the cytokinin-related gene and the drug-resistant gene exist in the positions so that they can behave together with the DNA element, while the recombinant protein to be expressed in the plant storage organ exists in the position so that it would not behave together with the DNA element. The GLP-1 is produced by using the method, and a derivative having been stabilized against enzymatic digestion is further provided.
摘要翻译：本发明提供了在植物贮藏器官和GLP-1衍生物中高度产生重组蛋白的方法。通过使用包含重组蛋白基因，细胞分裂素相关基因，耐药性基因和可移除DNA元件的载体转化获得重组蛋白质高度产生的植物贮藏器官，其中细胞分裂素相关基因和耐药基因存在于可以与DNA元件一起表现的位置，而在植物储存器官中表达的重组蛋白存在于与DNA不一致的位置元件。通过使用该方法制备GLP-1，进一步提供了稳定的酶促消化的衍生物。

5. 发明申请

US20070192906A1 Rice plant having vaccine gene transferred thereinto 审中-公开
标题翻译：具有转移疫苗基因的水稻植物
公开(公告)号：US20070192906A1
公开(公告)日：2007-08-16
申请号：US11547910
申请日：2005-04-08
申请人： Yoshikazu Yuki , Hiroshi Kiyono , Takachika Hiroi , Tomonori Nochi , Fumio Takaiwa , Hidenori Takagi , Lijyun Yang , Kazuya Suzuki , Hiroyasu Ebinuma , Koichi Sugita , Saori Kasahara
发明人： Yoshikazu Yuki , Hiroshi Kiyono , Takachika Hiroi , Tomonori Nochi , Fumio Takaiwa , Hidenori Takagi , Lijyun Yang , Kazuya Suzuki , Hiroyasu Ebinuma , Koichi Sugita , Saori Kasahara
IPC分类号： A01H5/00 , A61K39/00 , C12N15/82
CPC分类号： A61K39/08 , A23L7/196 , A23V2002/00 , A61K39/107 , A61K39/12 , A61K39/21 , C07K14/005 , C07K2319/55 , C12N15/8258 , C12N2740/16122 , C12N2740/16134 , A23V2300/21
摘要： To provide a transgenic rice plant that can produce rice which can be used as an “edible vaccine”, i.e., rice capable of inducing a desired immune response when mucosally administered such as an oral administration. There is provided a transgenic rice plant including a genomic DNA, wherein a DNA construct is incorporated into the genomic DNA so that the DNA construct is capable of being expressed, wherein the DNA construct includes a DNA encoding an antigenic protein, and a rice endosperm specific promoter linked upstream thereof.
摘要翻译：提供可以产生可以用作“可食用疫苗”的水稻的转基因水稻植物，即当粘膜给药如口服给药时能够诱导所需免疫应答的水稻。提供了包括基因组DNA的转基因水稻植物，其中将DNA构建体并入基因组DNA中，使得DNA构建体能够被表达，其中所述DNA构建体包括编码抗原蛋白的DNA和水稻胚乳特异性启动子连接上游。

6. 发明授权

US06767735B1 Vector for introducing a gene into a plant using a selectable marker 失效
标题翻译：使用可选标记将基因导入植物的载体
公开(公告)号：US06767735B1
公开(公告)日：2004-07-27
申请号：US09477730
申请日：2000-01-05
申请人： Koichi Sugita , Hiroyasu Ebinuma , Mika Kaneda
发明人： Koichi Sugita , Hiroyasu Ebinuma , Mika Kaneda
IPC分类号： C12N1582
CPC分类号： C07K14/415 , C12N15/8209 , C12N15/8291 , C12N15/8295
摘要： A vector for introducing a gene into a plant, wich comprises a desired gene, and a plant hormone signal transduction gene as a selectable marker gene.
摘要翻译：用于将基因导入植物中的载体，其包含期望的基因和作为选择性标记基因的植物激素信号转导基因。

7. 发明授权

US06294714B1 Method for introducing a gene into a plant using an adventitious bud redifferentiation gene under the control of a light-inducible promoter as a selectable marker gene, and vector for introducing a gene into a plant using the same 失效
标题翻译：使用在光诱导型启动子作为选择性标记基因的控制下的不定芽再分化基因将基因引入植物的方法，以及使用其将基因导入植物的载体
公开(公告)号：US06294714B1
公开(公告)日：2001-09-25
申请号：US09354305
申请日：1999-07-16
申请人： Etsuko Matsunaga , Takehide Kasahara , Koichi Sugita , Hiroyasu Ebinuma
发明人： Etsuko Matsunaga , Takehide Kasahara , Koichi Sugita , Hiroyasu Ebinuma
IPC分类号： C12N504
CPC分类号： A01H4/005 , C12N15/8205 , C12N15/8209
摘要： A method for introducing a gene into a plant, which comprises introducing a gene into a plant cell using a vector containing an adventitious shoot redifferentiation gene as a selectable marker gene under the control of a light-inducible promoter, and a vector for introducing a gene into a plant, which comprises a desired gene, an adventitious shoot redifferentiation gene as a selectable marker gene under the control of a light-inducible promoter, and a removable DNA element, wherein the selectable marker gene is positioned such that it behaves integrally with the removable DNA element, and wherein the desired gene is positioned such that it does not behave integrally with the removable DNA element.
摘要翻译：将基因导入植物的方法，其特征在于，在光诱导型启动子的控制下，使用含有不定芽再分化基因的载体作为选择性标记基因，将基因引入植物细胞，以及用于引入基因的载体包含所需基因的植物，作为在光诱导型启动子控制下的选择性标记基因的不定芽再分化基因和可除去的DNA元件，其中所述选择标记基因定位成使其与可去除的DNA元件，并且其中所需基因定位成使其不与可移除的DNA元件整体地表现。

8. 发明授权

US4459213A Fire-extinguisher composition 失效
标题翻译：灭火器组成
公开(公告)号：US4459213A
公开(公告)日：1984-07-10
申请号：US454594
申请日：1982-12-30
申请人： Yasuzo Uchida , Sadayuki Kawai , Koichi Sugita , Hitoshi Nagasaki , Yoichi Shirakawa
发明人： Yasuzo Uchida , Sadayuki Kawai , Koichi Sugita , Hitoshi Nagasaki , Yoichi Shirakawa
IPC分类号： A62D1/02 , A62D1/00
CPC分类号： A62D1/0078
摘要： A fire-extinguisher composition comprising a blend of at least one member selected from the group consisting of protein and protein decomposition products, at least one liquid polyhydroxy compound or an aqueous solution of at least one polyhydroxy compound, and at least one halogenated hydrocarbon. The composition can easily be emulsified or dispersed in water and exhibits a high retention of its fire-extinguishing ability, a satisfactory secondary fire-extinguishing ability, and a foaming ability sufficient to make a foaming device unnecessary.
摘要翻译：一种灭火剂组合物，其包含选自蛋白质和蛋白质分解产物中的至少一种的成分的混合物，至少一种液体多羟基化合物或至少一种多羟基化合物的水溶液和至少一种卤代烃。组合物可以容易地乳化或分散在水中，并且表现出高的保持其灭火能力，令人满意的二次灭火能力和足以使发泡装置不必要的发泡能力。

9. 发明申请

US20120054923A1 METHOD FOR CULTIVATION OF GENETICALLY-MODIFIED PLANT 有权
标题翻译：基因改造植物的培育方法
公开(公告)号：US20120054923A1
公开(公告)日：2012-03-01
申请号：US13147436
申请日：2009-08-26
申请人： Saori Kasahara , Masafumi Wasai , Koichi Sugita , Teruhisa Shimada
发明人： Saori Kasahara , Masafumi Wasai , Koichi Sugita , Teruhisa Shimada
IPC分类号： A01H5/10 , A01G31/00 , A01H5/00
CPC分类号： C12N15/8261 , C12N15/8234 , C12N15/8238 , C12N15/8251 , C12N15/8257 , Y02A40/146
摘要： The present invention provides a method for cultivation of a genetically-modified plant that can highly produce a desired protein. More specifically, the present invention provides a method for cultivation of a genetically-modified plant comprising: cultivating the genetically-modified plant in a medium, wherein the genetically-modified plant is transformed by introducing an expression vector comprising a promoter regulating expression of RNA and a seed storage protein isolated from a plant that highly expresses RNA and the seed storage protein under a high nitrogen condition; and a polynucleotide encoding an objective protein, and wherein the medium is adjusted so that nitrate nitrogen is 70 mg/L to 750 mg/L and/or ammonium nitrogen is 70 mg/L to 750 mg/L for a definite period in a period from 30 days before an expected flowering date to a date on or before flowering of the genetically-modified plant.
摘要翻译：本发明提供了能够高度产生所需蛋白质的遗传修饰植物的培养方法。更具体地说，本发明提供了一种遗传修饰植物的培养方法，包括：在培养基中培养经遗传修饰的植物，其中转基因修饰植物通过引入包含调节RNA表达的启动子的表达载体和在高氮条件下从高度表达RNA和种子储存蛋白的植物中分离的种子储存蛋白; 和编码目标蛋白质的多核苷酸，并且调节培养基使得硝酸盐氮在70mg / L至750mg / L和/或铵氮为70mg / L至750mg / L的条件下在一定期间内从预计开花日期前30天到转基因植物开花前后的日期。

10. 发明授权

US5150823A Combination container and pump having a conical piston for venting 失效
标题翻译：组合容器和泵具有用于通风的活塞式活塞
公开(公告)号：US5150823A
公开(公告)日：1992-09-29
申请号：US603618
申请日：1990-10-26
申请人： Koichi Sugita
发明人： Koichi Sugita
IPC分类号： B05B11/00 , B65D83/00
CPC分类号： B05B11/0048 , B05B11/0056 , B65D83/0033
摘要： A pump is mounted in one end of a cylindrical container for storing a liquid, for drawing the liquid stored in the cylindrical container and discharging the drawn liquid out of the cylindrical container. A piston is slidably disposed in the opposite end of the container in keeping the liquid sealed in the cylindrical container. The piston is movable toward the pump as the amount of the liquid stored in the cylindrical container is reduced when the liquid is discharged from the cylindrical container by the pump. The piston has a slanted surface facing the pump for contact with the liquid stored in the cylindrical container, the slanted surface being inclined progressively toward the second axial end. The piston also has a cylindrical surface defining a communication hole defined axially therethrough and having an inner end opening at the slanted surface. The communication hole provides communication between the interior and the exterior of the cylindrical container. A cap comprises a cap body inserted in the communication hole and a flange closes an outer end of the communication hole. At least either one of the cap body and the cylindrical surface has at least one axial groove. Air bubbles which may have been trapped in the container when the liquid is charged into the container move along slanted surface into the communication hole and then is escaped from the container through the groove.
摘要翻译：泵安装在用于储存液体的圆柱形容器的一端中，用于抽出存储在圆筒形容器中的液体并将抽出的液体排出圆筒形容器。活塞可滑动地设置在容器的相对端中，以保持液体密封在圆柱形容器中。当液体通过泵从圆筒形容器排出时，随着储存在圆筒形容器中的液体的量减少，活塞可朝向泵移动。活塞具有面向泵的倾斜表面，用于与存储在圆柱形容器中的液体接触，倾斜表面朝着第二轴向端逐渐倾斜。活塞还具有圆柱形表面，该圆柱形表面限定了轴向穿过其并且在倾斜表面具有内端开口的连通孔。连通孔提供圆柱形容器的内部和外部之间的连通。盖包括插入连通孔中的盖体，凸缘封闭连通孔的外端。盖主体和圆柱形表面中的至少一个具有至少一个轴向凹槽。当液体装入容器时可能被捕获在容器中的气泡沿倾斜的表面移动到连通孔中，然后通过凹槽从容器中逸出。

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