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1. 发明申请

US20070192906A1 Rice plant having vaccine gene transferred thereinto 审中-公开
标题翻译：具有转移疫苗基因的水稻植物
公开(公告)号：US20070192906A1
公开(公告)日：2007-08-16
申请号：US11547910
申请日：2005-04-08
申请人： Yoshikazu Yuki , Hiroshi Kiyono , Takachika Hiroi , Tomonori Nochi , Fumio Takaiwa , Hidenori Takagi , Lijyun Yang , Kazuya Suzuki , Hiroyasu Ebinuma , Koichi Sugita , Saori Kasahara
发明人： Yoshikazu Yuki , Hiroshi Kiyono , Takachika Hiroi , Tomonori Nochi , Fumio Takaiwa , Hidenori Takagi , Lijyun Yang , Kazuya Suzuki , Hiroyasu Ebinuma , Koichi Sugita , Saori Kasahara
IPC分类号： A01H5/00 , A61K39/00 , C12N15/82
CPC分类号： A61K39/08 , A23L7/196 , A23V2002/00 , A61K39/107 , A61K39/12 , A61K39/21 , C07K14/005 , C07K2319/55 , C12N15/8258 , C12N2740/16122 , C12N2740/16134 , A23V2300/21
摘要： To provide a transgenic rice plant that can produce rice which can be used as an “edible vaccine”, i.e., rice capable of inducing a desired immune response when mucosally administered such as an oral administration. There is provided a transgenic rice plant including a genomic DNA, wherein a DNA construct is incorporated into the genomic DNA so that the DNA construct is capable of being expressed, wherein the DNA construct includes a DNA encoding an antigenic protein, and a rice endosperm specific promoter linked upstream thereof.
摘要翻译：提供可以产生可以用作“可食用疫苗”的水稻的转基因水稻植物，即当粘膜给药如口服给药时能够诱导所需免疫应答的水稻。提供了包括基因组DNA的转基因水稻植物，其中将DNA构建体并入基因组DNA中，使得DNA构建体能够被表达，其中所述DNA构建体包括编码抗原蛋白的DNA和水稻胚乳特异性启动子连接上游。

2. 发明申请

US20110206729A1 MUCOSAL VACCINE USING CATIONIC NANOGEL 审中-公开
标题翻译：使用阳离子纳米粒的胶原疫苗
公开(公告)号：US20110206729A1
公开(公告)日：2011-08-25
申请号：US13126357
申请日：2009-10-30
申请人： Kazunari Akiyoshi , Hiroshi Kiyono , Yoshikazu Yuki , Tomonori Nochi
发明人： Kazunari Akiyoshi , Hiroshi Kiyono , Yoshikazu Yuki , Tomonori Nochi
IPC分类号： A61K39/12 , A61K39/00 , A61K39/02 , A61K39/002 , A61P37/00
CPC分类号： A61K39/08 , A61K9/0043 , A61K9/006 , A61K9/06 , A61K9/5161 , A61K39/39 , A61K47/36 , A61K47/554 , A61K47/61 , A61K47/6903 , A61K2039/541 , A61K2039/543 , A61K2039/55583 , A61K2039/6087
摘要： A mucosal vaccine for the prevention or treatment of microbial infections is described that is capable of inducing vaccine antigen-specific immune responses in an organism without the addition of a mucosal adjuvant. The mucosal vaccine comprises a composite of a nanogel comprising a hydrophilic polysaccharide having a cationic functional group and a hydrophobic cholesterol added thereto as a side chain and a vaccine antigen. The vaccine is administered via a mucosal route.
摘要翻译：描述了用于预防或治疗微生物感染的粘膜疫苗，其能够在没有添加粘膜佐剂的情况下在生物体中诱导疫苗抗原特异性免疫应答。粘膜疫苗包含纳米凝胶的复合物，其包含具有阳离子官能团的亲水性多糖和作为侧链加入的疏水性胆固醇作为侧链和疫苗抗原。疫苗通过粘膜途径给药。

3. 发明授权

US08144412B2 Magnetic disk device having mechanism for detecting projections on recording medium 有权
标题翻译：具有用于检测记录介质上的投影的机构的磁盘装置
公开(公告)号：US08144412B2
公开(公告)日：2012-03-27
申请号：US12591562
申请日：2009-11-24
申请人： Hiroshi Kiyono
发明人： Hiroshi Kiyono
IPC分类号： G11B5/02 , G11B27/36 , G11B5/127 , G11B5/60 , G11B15/64 , G11B17/32 , G11B21/20
CPC分类号： G11B5/40 , G11B5/6005
摘要： A thin film magnetic head includes a medium projection detection mechanism that detects a projection on the surface of a recording medium. The medium projection detection mechanism has a discharging electrode, a capacitor, and an input line and an output line that are connected to the discharging electrode. The discharging electrode is configured to receive a voltage applied through the input line, and the capacitor is configured to store electric charge by the applied voltage. The output line is connected to a projection detection processing system and is connected to the charging electrode and the projection detection processing system to detect the location of the projection that is a detection target by detecting voltage change that is caused by discharging between the discharging electrode and the projection when the projection is detected.
摘要翻译：薄膜磁头包括检测记录介质表面上的突起的介质投影检测机构。介质投影检测机构具有连接到放电电极的放电电极，电容器，输入线和输出线。放电电极被配置为接收通过输入线施加的电压，并且电容器被配置为通过施加的电压来存储电荷。输出线连接到投影检测处理系统，并连接到充电电极和投影检测处理系统，通过检测由放电电极和放电电极之间的放电引起的电压变化来检测作为检测对象的投影的位置检测投影时的投影。

4. 发明授权

US07894168B2 Thin-film magnetic head comprising a magneto-resistive effect device of a CPP structure and having a shunting layer 有权
标题翻译：薄膜磁头包括CPP结构的磁阻效应器件并具有分流层
公开(公告)号：US07894168B2
公开(公告)日：2011-02-22
申请号：US11846170
申请日：2007-08-28
申请人： Hiroshi Kiyono , Tetsuya Kuwashima
发明人： Hiroshi Kiyono , Tetsuya Kuwashima
IPC分类号： G11B5/39
CPC分类号： G11B5/398 , B82Y25/00 , G01R33/093
摘要： The invention provides a thin-film magnetic head having a magneto-resistive effect device of the CPP (current perpendicular to plane) structure comprising a multilayer film in which a fixed magnetization layer, a nonmagnetic layer and a free layer are stacked together in order. The fixed magnetization layer, nonmagnetic layer and free layer extend away from an air bearing surface that is a plane in opposition to a medium, the length of the fixed magnetization layer in a depth direction normal to said air bearing surface is greater than the length of the free layer in the depth direction. A shunt layer for shunting the sense current is located at a farther distance in the depth direction than the free layer, and the shunt layer is separated from the free layer by a constant gap in the depth direction.
摘要翻译：本发明提供一种具有CPP（电流垂直于平面）结构的磁阻效应器件的薄膜磁头，其包括多层膜，其中固定磁化层，非磁性层和自由层按顺序堆叠在一起。固定磁化层，非磁性层和自由层远离与介质相反的平面的空气轴承表面延伸，固定磁化层在垂直于所述空气轴承表面的深度方向上的长度大于自由层在深度方向。用于分流感测电流的并联层位于深度方向上比自由层更远的距离，并且分流层在深度方向上通过恒定的间隙与自由层分离。

5. 发明申请

US20090059436A1 THIN-FILM MAGNETIC HEAD HAVING CPP STRUCTURE MAGNETO-RESISTIVE EFFECT DEVICE 有权
标题翻译：具有CPP结构磁电阻效应器件的薄膜磁头
公开(公告)号：US20090059436A1
公开(公告)日：2009-03-05
申请号：US11846170
申请日：2007-08-28
申请人： Hiroshi Kiyono , Tetsuya Kuwashima
发明人： Hiroshi Kiyono , Tetsuya Kuwashima
IPC分类号： G11B5/33
CPC分类号： G11B5/398 , B82Y25/00 , G01R33/093
摘要： The invention provides a thin-film magnetic head having a magneto-resistive effect device of the CPP (current perpendicular to plane) structure comprising a multilayer film in which a fixed magnetization layer, a nonmagnetic layer and a free layer are stacked together in order. The fixed magnetization layer, nonmagnetic layer and free layer extend rearward from an air bearing surface that is a plane in opposition to a medium, the length of the depth-wise side of the fixed magnetization layer is longer than that of the free layer, and a shunt layer for shunting a sense current is formed more on the depth-wise side of, and kept constantly away from, the free layer. There are thus much more favorable advantages obtained: even when device size is further reduced and narrowed, degradation of frequency characteristics is hold back, any increase in the thermal magnetic noise is stayed off, and performance fluctuations are minimized.
摘要翻译：本发明提供一种具有CPP（电流垂直于平面）结构的磁阻效应器件的薄膜磁头，其包括多层膜，其中固定磁化层，非磁性层和自由层按顺序堆叠在一起。固定磁化层，非磁性层和自由层从作为与介质相反的平面的空气轴承表面向后延伸，固定磁化层的深度方向的长度比自由层的长度长，用于分流感测电流的并联层更多地形成在自由层的深度方面并且保持不断地远离自由层。因此，获得了更多有利的优点：即使当器件尺寸进一步减小和变窄时，频率特性的劣化被阻止，热磁噪声的任何增加都将被停止，并且性能波动最小化。

6. 发明授权

US07359149B2 Composite type thin-film magnetic head with reduced capacitance between leads for read and write head elements 有权
标题翻译：复合型薄膜磁头，用于读写头元件引线之间的电容降低
公开(公告)号：US07359149B2
公开(公告)日：2008-04-15
申请号：US11079735
申请日：2005-03-15
申请人： Hiroshi Kiyono , Yosuke Antoku , Tsuyoshi Umehara , Yoshikazu Sawada
发明人： Hiroshi Kiyono , Yosuke Antoku , Tsuyoshi Umehara , Yoshikazu Sawada
IPC分类号： G11B5/39 , G11B5/127
CPC分类号： G11B5/3967
摘要： A composite type thin-film magnetic head is provided, which comprises: a write head element; a pair of terminal pads for the write head element; a pair of lead conductors for the write head element, electrically connecting the write head element to the pair of terminal pads for the write head element; a read head element; a pair of terminal pads for the read head element; and a pair of lead conductors for the read head element, electrically connecting the read head element to the pair of terminal pads for the read head element. The pair of lead conductors for the write head element and the pair of lead conductors for the read head element are formed into patterns that have no overlapped portions with each other through only an insulating layer.
摘要翻译：提供一种复合型薄膜磁头，其包括：写头元件; 用于写入头元件的一对端子焊盘; 用于写头元件的一对引线导体，用于将写入头元件电连接到用于写入头元件的一对端子焊盘; 读头元件; 用于读头元件的一对端子焊盘; 以及用于读头元件的一对引线导体，用于将读头元件电连接到用于读头元件的一对端子焊盘。用于读头元件的写头元件和一对引线导体的一对引线导体被形成为仅通过绝缘层彼此不重叠的图案。

7. 发明申请

US20050219765A1 Composite type thin-film magnetic head 有权
标题翻译：复合型薄膜磁头
公开(公告)号：US20050219765A1
公开(公告)日：2005-10-06
申请号：US11079677
申请日：2005-03-15
申请人： Hiroshi Kiyono , Nozomu Hachisuka , Shunji Saruki , Noriaki Kasahara
发明人： Hiroshi Kiyono , Nozomu Hachisuka , Shunji Saruki , Noriaki Kasahara
IPC分类号： G11B5/31 , G11B5/127 , G11B5/33 , G11B5/39
CPC分类号： B82Y25/00 , B82Y10/00 , G11B5/3909 , G11B5/3912 , G11B5/3967 , G11B2005/3996
摘要： A composite type thin-film magnetic head is provided, which comprises: a MR read head element having an upper shield layer, a lower shield layer, an MR layer in which a sense current flows in a direction perpendicular to a surface of the layer through the upper shield layer and the lower shield layer; an inductive write head element formed on the MR read head element, having an upper magnetic pole layer, a recording gap layer, a lower magnetic pole layer where end portion is opposed to an end portion of the upper magnetic pole layer through the recording gap layer, and a write coil; and a capacitance C12 between the write coil and the upper shield layer, set to 0.1 pF or less.
摘要翻译：提供一种复合型薄膜磁头，其包括：MR读取头元件，具有上屏蔽层，下屏蔽层，MR层，其中感测电流沿垂直于该层的表面的方向流动上屏蔽层和下屏蔽层; 形成在MR读头元件上的感应写头元件，具有上磁极层，记录间隙层，下磁极层，其端部通过记录间隙层与上磁极层的端部相对和写入线圈; 和写入线圈和上部屏蔽层之间的电容C 12 12设定为0.1pF以下。

8. 发明授权

US6004802A Oral administration of pneumococcal antigens 失效
标题翻译：口服肺炎球菌抗原
公开(公告)号：US6004802A
公开(公告)日：1999-12-21
申请号：US657751
申请日：1996-05-30
申请人： David E. Briles , Larry S. McDaniel , Masafumi Yamamoto , Hiroshi Kiyono
发明人： David E. Briles , Larry S. McDaniel , Masafumi Yamamoto , Hiroshi Kiyono
IPC分类号： A61K20060101 , A61K39/09 , C12N15/00
CPC分类号： A61K39/092
摘要： Oral or peroral administration, including intragastrically, of killed whole pneumococci, lysate of pneumococci and isolated and purified PspA, as well as immunogenic fragments thereof, particularly when administered with an adjuvant such as cholera toxin provides protection in a host, animal or human, against pneumococcal infection, including colonization, and systemic infection, such as sepsis. The ability to elicit protection against pneumococcal colonization in a host prevents carriage among immunized individuals, which can lead to elimination of disease from the population as a whole.
摘要翻译：口服或口服给药，包括胃内杀死的全肺炎球菌，肺炎球菌的裂解物和分离和纯化的PspA，以及其免疫原性片段，特别是当与佐剂如霍乱毒素一起施用时，在宿主，动物或人中提供保护，肺炎球菌感染，包括定植和全身感染，如败血症。在宿主中引发针对肺炎球菌定居的保护的能力防止免疫个体携带，这可导致整体上消除人群的疾病。

9. 发明授权

US08666692B2 Method of estimating curie temperature distribution in a magnetic recording layer 有权
标题翻译：估计磁记录层中居里温度分布的方法
公开(公告)号：US08666692B2
公开(公告)日：2014-03-04
申请号：US13044976
申请日：2011-03-10
申请人： Tomohito Mizuno , Koji Shimazawa , Hiroshi Kiyono
发明人： Tomohito Mizuno , Koji Shimazawa , Hiroshi Kiyono
IPC分类号： G06F17/18
CPC分类号： G11B5/64 , G11B2005/0021
摘要： In exemplary embodiments, first and second parameters are obtained for each of different temperatures of the magnetic recording layer. The absolute value of the first parameter for each magnetic grain has a minimum value when the temperature of each magnetic grain reaches a predetermined temperature that increases as the Curie temperature increases, and decreases as the Curie temperature decreases. The second parameter is related to the standard deviation of the coercivity distribution of the magnetic grains divided by the coercivity of the magnetic recording layer. The method calculates a value where the absolute measurement value of the first parameter has a minimum value and the temperature of the magnetic recording layer at which the standard deviation of the coercivity distribution of the magnetic grains divided by the coercivity of the magnetic recording layer has a maximum value.
摘要翻译：在示例性实施例中，针对磁记录层的不同温度的每一个获得第一和第二参数。当每个磁性颗粒的温度达到随着居里温度升高而增加的预定温度时，每个磁性颗粒的第一参数的绝对值具有最小值，并且随着居里温度降低而降低。第二参数与磁性颗粒的矫顽力分布的标准偏差除以磁记录层的矫顽力相关。该方法计算第一参数的绝对测量值具有最小值的值，并且磁记录层的矫顽力的矫顽力分布的标准偏差除以磁记录层的矫顽力的标准偏差为最大值。

10. 发明申请

US20110122533A1 Magnetic disk device having mechanism for detecting projections on recording medium 有权
标题翻译：具有用于检测记录介质上的投影的机构的磁盘装置
公开(公告)号：US20110122533A1
公开(公告)日：2011-05-26
申请号：US12591562
申请日：2009-11-24
申请人： Hiroshi Kiyono
发明人： Hiroshi Kiyono
IPC分类号： G11B5/56 , G11B15/60 , G11B21/16
CPC分类号： G11B5/40 , G11B5/6005
摘要： A thin film magnetic head includes a medium projection detection mechanism that detects a projection on the surface of a recording medium. The medium projection detection mechanism has a discharging electrode, a capacitor, and an input line and an output line that are connected to the discharging electrode. The discharging electrode is configured to receive a voltage applied through the input line, and the capacitor is configured to store electric charge by the applied voltage. The output line is connected to a projection detection processing system and is connected to the charging electrode and the projection detection processing system to detect the location of the projection that is a detection target by detecting voltage change that is caused by discharging between the discharging electrode and the projection when the projection is detected.
摘要翻译：薄膜磁头包括检测记录介质表面上的突起的介质投影检测机构。介质投影检测机构具有连接到放电电极的放电电极，电容器，输入线和输出线。放电电极被配置为接收通过输入线施加的电压，并且电容器被配置为通过施加的电压来存储电荷。输出线连接到投影检测处理系统，并连接到充电电极和投影检测处理系统，通过检测由放电电极和放电电极之间的放电引起的电压变化来检测作为检测对象的投影的位置检测投影时的投影。

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