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1. 发明授权

US5547945A Remitting agent for nephrotic syndrome and hepatopathy symptoms 失效
标题翻译：肾病综合征和肝病症状的补救剂
公开(公告)号：US5547945A
公开(公告)日：1996-08-20
申请号：US271795
申请日：1994-07-07
申请人： Guoji Ye , Jun-ichi Kajihara , Sei Kirihara , Kazuo Kato , Hiroko Abe
发明人： Guoji Ye , Jun-ichi Kajihara , Sei Kirihara , Kazuo Kato , Hiroko Abe
IPC分类号： A61K36/537 , A61P1/16 , A61P13/00 , C08B37/00 , A61K31/715 , C07H1/00 , C07H1/08 , C08B37/06
CPC分类号： A61K31/715 , C08B37/006
摘要： A remitting agent for nephrotic syndrome and hepatopathy symptoms is provided that which comprises water-soluble polysaccharides having poly-D-galacturonic acid as an effective constituent; polysaccharides having the following characteristic properties which are extractable from Tanjin with water or an aqueous solvent:A. Sugar content: 60 to 100%.(1) Sugar composition:40 to 80% of uronic acid (composed almost entirely of D-galacturonic acid) and10 to 30% of neutral sugars(2) Neutral sugar composition:0 to 15% of rhamnose0 to 15% of glucose25 to 55% of galactose30 to 60% of arabinose0 to 15% of mannoseB. Molecular weight: 150,000 to 300,000; the invention also provides a process for producing the above-described polysaccharides which comprises allowing an aqueous extract of Tanjin to pass through a porous polymeric resin, followed by purification through gel filtration chromatography.
摘要翻译：提供了一种肾病综合征和肝病症状的缓解剂，其包含具有多聚-D半乳糖醛酸作为有效成分的水溶性多糖; 具有以下特征的多糖，其可用水或水溶剂从Tanjin提取：A.糖含量：60〜100％。（1）糖组成：40〜80％的糖醛酸（几乎全部由D-半乳糖醛酸组成）和10〜30％的中性糖（2）中性糖成分：0〜15％的鼠李糖0〜15％的葡萄糖 25至55％的半乳糖30至60％的阿拉伯糖0至15％的甘露糖B.分子量：15万至30万; 本发明还提供了一种制备上述多糖的方法，其包括使Tanjin的水提取物通过多孔聚合物树脂，然后通过凝胶过滤层析纯化。

2. 发明申请

US20110105734A1 METHOD FOR PRODUCTION OF HUMAN ERYTHROPOIETIN 审中-公开
标题翻译：生产人ERYTHROPOIETIN的方法
公开(公告)号：US20110105734A1
公开(公告)日：2011-05-05
申请号：US12517936
申请日：2006-12-19
申请人： Atsuko Kawasaki , Keisuke Mukai , Sei Kirihara
发明人： Atsuko Kawasaki , Keisuke Mukai , Sei Kirihara
IPC分类号： C12P21/00 , C07K1/22
CPC分类号： C07K14/505
摘要： Disclosed is a method for production of human erythropoietin. By the method, the cells are cultured in a serum-free medium with repetitive medium exchanges, in which medium exchange is carried out either by collecting 80 to 95% of the culture when viable cell density has reached at 2×106˜4×106 cells/mL, or by adjusting the amount of the exchanged medium so that the initial density of the viable cells may be 1.5×105˜2.5×105 cells/mL.
摘要翻译：公开了一种生产人促红细胞生成素的方法。通过该方法，将细胞在具有重复培养基交换的无血清培养基中培养，当存活细胞密度达到2×106〜4×106时，通过收集80〜95％的培养物进行培养基交换细胞/ mL，或通过调节交换培养基的量使活细胞的初始密度为1.5×105〜2.5×10 5个细胞/ mL。

3. 发明授权

US06319225B1 Injection syringe including device for preparation of injection 有权
标题翻译：注射器包括注射装置
公开(公告)号：US06319225B1
公开(公告)日：2001-11-20
申请号：US09266916
申请日：1999-03-12
申请人： Koichi Sugita , Sei Kirihara , Hiromichi Ishikawa , Yutaka Igarashi
发明人： Koichi Sugita , Sei Kirihara , Hiromichi Ishikawa , Yutaka Igarashi
IPC分类号： A61M3700
CPC分类号： A61M5/2448 , A61M5/31553 , A61M5/31591
摘要： An injection syringe including a device for preparation of an injection in situ, useful to the injection which is liable to suffer chemical changes if left for a long time in the state of solution or dispersion ready to inject. The injection syringe is portable by a patient who may prepare a necessary injection in situ with the use of a device included in the syringe which will automatically perform an injection with a prescribed dosage. The injection syringe includes a device for preparation of an injection, whereby mechanical impacts affecting the medicine and consequently, chemical changes with a medicine would be minimized during the step of dissolving the medicine. The syringe as noted is especially useful for preparation of injection and injection of human growth hormones, interferon and various polypeptides which are of an environmentally sensitive nature and liable to suffer chemical changes if left for a long time in the state of solution or dispersion.
摘要翻译：一种注射器，其包括用于制备原位注射的装置，其用于注射，如果在准备注射的溶液或分散体的状态下长时间存在易于发生化学变化。注射器可以由患者便携，该患者可以使用包括在注射器中的装置在现场准备必要的注射器，其将以规定剂量自动进行注射。注射器包括用于制备注射器的装置，由此在溶解药物的步骤期间，影响药物的机械冲击以及因此的药物的化学变化将被最小化。如上所述，注射器特别适用于制备注射和注射人生长激素，干扰素和各种具有环境敏感性质的多肽，并且如果在溶液或分散状态下长时间使用，则易于遭受化学变化。

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