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1. 发明申请

WO2009149546A8 METHOD OF OPERATING TANDEM ION TRAPS 审中-公开
标题翻译：工作台灯的操作方法
公开(公告)号：WO2009149546A8
公开(公告)日：2011-02-17
申请号：PCT/CA2009000805
申请日：2009-06-08
申请人： DH TECHNOLOGIES DEV PTE LTD , GUNA MIRCEA , LONDRY FRANK
发明人： GUNA MIRCEA , LONDRY FRANK
IPC分类号： H01J49/42
CPC分类号： H01J49/4265 , H01J49/0031 , H01J49/004
摘要： A method for operating tandem ion traps is provided, involving a) accumulating ions in the first ion trap at a first time; b) transmitting a first plurality of ions out of the first ion trap and into the second ion trap at a second time, the first plurality of ions having masses within a first mass range; c) retaining a second plurality of ions in the first ion trap at the second time, the second plurality of ions having masses within a second mass range different from the first mass range; d) transmitting the first plurality of ions out of the second ion trap at a third time; and, e) transmitting the second plurality of ions out of the first ion trap and into the second ion trap at the third time.
摘要翻译：提供了一种用于操作串联离子阱的方法，包括：a）在第一时间将第一离子阱中的离子累积; b）在第二时间将第一多个离子从第一离子阱中传输到第二离子阱中，第一多个离子具有在第一质量范围内的质量; c）在第二时间将第二多个离子保留在第一离子阱中，第二多个离子具有在与第一质量范围不同的第二质量范围内的质量; d）第三次将第一多个离子从第二离子阱中传出; 以及e）第三次将第二多个离子从第一离子阱中传出并进入第二离子阱。

2. 发明申请

WO2009094762A1 METHODS FOR FRAGMENTING IONS IN A LINEAR ION TRAP 审中-公开
标题翻译：用于在线性离子阱中去除离子的方法
公开(公告)号：WO2009094762A1
公开(公告)日：2009-08-06
申请号：PCT/CA2009/000090
申请日：2009-01-26
申请人： MDS ANALYTICAL TECHNOLOGIES, a business unit of MDS INC., doing business through its SCIEX DIVISION , LIFE TECHNOLOGIES CORPORATION , GUNA, Mircea , COLLINGS, Bruce
发明人： GUNA, Mircea , COLLINGS, Bruce
IPC分类号： H01J49/10 , H01J49/26
CPC分类号： H01J49/005 , H01J49/063 , H01J49/4225
摘要： Methods for fragmenting ions retained in an ion trap are described. In various embodiments, a non-steady-state pressure of a neutral collision gas of less than about 5 x 10 -4 Torr and an excitation amplitude of less than about 500 mV (peak to ground) is used to fragment ions with greater than about 80% fragmentation efficiency. In various embodiments, duration of ion excitation is greater than about 25 ms.
摘要翻译：描述了保留在离子阱中的分离离子的方法。在各种实施例中，使用小于约5×10 -4乇的中性碰撞气体的非稳定状态压力和小于约500mV（峰对地）的激发振幅用于将大于约 80％的碎片效率。在各种实施例中，离子激发的持续时间大于约25ms。

3. 发明申请

WO2009094760A1 METHOD OF OPERATING A LINEAR ION TRAP TO PROVIDE LOW PRESSURE SHORT TIME HIGH AMPLITUDE EXCITATION WITH PULSED PRESSURE 审中-公开
标题翻译：操作线性离子阱的方法提供低压短时间高倍数激发与脉冲压力
公开(公告)号：WO2009094760A1
公开(公告)日：2009-08-06
申请号：PCT/CA2009/000088
申请日：2009-01-26
申请人： MDS ANALYTICAL TECHNOLOGIES, a business unit of MDS Inc., doing business through its Sciex divison , LIFE TECHNOLOGIES CORPORATION , GUNA, Mircea , COLLlNGS, Bruce , LE BLANC, Yves
发明人： GUNA, Mircea , COLLlNGS, Bruce , LE BLANC, Yves
IPC分类号： H01J49/10 , H01J49/26
CPC分类号： H01J49/426 , H01J49/0063 , H01J49/24
摘要： Methods for fragmenting ions in an ion trap are described. These methods involve a) selecting parent ions for fragmentation; b) retaining the parent ions within the ion trap for a retention time interval, the ion trap having an operating pressure of less than about 1 x 10-4 Torr; c) providing a RF trapping voltage to the ion trap to provide a Mathieu stability parameter q at an excitement level during an excitement time interval within the retention time interval; d) providing a resonant excitation voltage to the ion trap during the excitement time interval to excite and fragment the parent ions; e) providing a non- steady-state pressure increase of at least 10% of the operating pressure within the ion trap by delivering a neutral gas into the ion trap for at least a portion of the retention time interval to raise the pressure in the ion trap to a varying first elevated-pressure in the range between about 6 x 10-5 Torr to about 5 x 10-4 Torr for a first elevated-pressure duration; and f) within the retention time interval and after the excitement time interval, terminating the resonant excitation voltage and changing the RF trapping voltage applied to the ion trap to reduce the Mathieu stability parameter q to a hold level less than the excitement level to retain fragments of the parent ions within the ion trap. The excitation time interval and the first elevated-pressure duration substantially overlap in time.
摘要翻译：描述了在离子阱中分离离子的方法。这些方法包括：a）选择亲本离子进行碎裂; b）将母离子保留在离子阱内保持时间间隔，离子阱具有小于约1×10 -4 Torr的操作压力; c）向离子阱提供RF捕获电压，以在保持时间间隔内的兴奋时间间隔期间以兴奋水平提供Mathieu稳定性参数q; d）在兴奋时间间隔期间向离子阱提供共振激发电压以激发和分裂母体离子; e）通过将中性气体输送到离子阱中至少保留时间间隔的一部分来提供离子阱内至少10％的工作压力的非稳态压力增加，以提高离子中的压力在第一升高的压力持续时间内在约6×10 -5 Torr至约5×10 -4 Torr之间的范围内捕获到变化的第一升高压力; 和f）在保持时间间隔内和在兴奋时间间隔之后，终止谐振激励电压并改变施加到离子阱的RF捕获电压，以将Mathieu稳定性参数q降低到小于兴奋水平的保持水平以保留片段的离子阱内的母离子。激发时间间隔和第一升高压力时间基本上在时间上重叠。

4. 发明申请

WO2006076228A2 METHOD AND APPARATUS FOR IMPROVED SENSITIVITY IN A MASS SPECTROMETER 审中-公开
标题翻译：在质谱仪中提高灵敏度的方法和装置
公开(公告)号：WO2006076228A2
公开(公告)日：2006-07-20
申请号：PCT/US2006/000492
申请日：2006-01-05
申请人： APPLERA CORPORATION , MDS INC. , LOBODA, Alexandre, V. , COLLINGS, Bruce, A. , COVEY, Thomas, R. , GUNA, Mircea , JAVAHERI, Hassan , SCHNEIDER, Bradley, B. , THOMSON, Bruce A.
发明人： COLLINGS, Bruce, A. , COVEY, Thomas, R. , GUNA, Mircea , JAVAHERI, Hassan , SCHNEIDER, Bradley, B. , THOMSON, Bruce A.
IPC分类号： H01J49/04
CPC分类号： H01J49/067 , H01J49/063
摘要： In a mass spectrometer, ions from an ion source pass through an inlet aperture into a vacuum chamber for transmitting prior to mass analysis by the mass analyzer. The configuration of the inlet aperture forms a sonic orifice or sonic nozzle and with a predetermined vacuum chamber pressure, a supersonic free jet expansion is created in the vacuum chamber that entrains the ions within the barrel shock and Mach disc. Once formed, an ion guide with a predetermined cross-section to essentially radially confine the supersonic free jet expansion can focus the ions for transmission through the vacuum chamber. This effectively improves the ion transmission between the ion source and the mass analyzer.
摘要翻译：在质谱仪中，质子分析仪进行质量分析之前，离子源的离子通过入口孔进入真空室以进行传输。入口孔的构型形成声孔或声波喷嘴，并且在预定的真空室压力下，在真空室中产生超音速自由射流膨胀，该真空室将离子夹带在筒形冲击和马赫盘内。一旦形成，具有预定横截面以基本上径向限制超音速自由射流膨胀的离子导向器可将离子聚焦以透过真空室。这有效地改善离子源和质量分析器之间的离子传递。

5. 发明申请

WO2008037058A8 METHOD FOR AXIAL EJECTION AND IN T RAP FRAGMENTATION USING AUXILIARY ELECTRODES IN A MULTIPOLE MASS SPECTROMETER 审中-公开
公开(公告)号：WO2008037058A8
公开(公告)日：2008-04-03
申请号：PCT/CA2007/001360
申请日：2007-08-02
申请人： MDS ANALYTICAL TECHNOLOGIES, a business unit of MDS INC., doing business through its Sciex Division , APPLERA CORPORATION , GUNA, Mircea
发明人： GUNA, Mircea
IPC分类号： H01J49/10 , H01J49/42
摘要： A method of operating a mass spectrometer having an elongated rod set and a set of auxiliary electrodes is provided, the rod set having an entrance end and an exit end and a longitudinal axis. The method comprises a) admitting ions into the entrance end of the rod set; b) trapping at least some of the ions in the rod set by producing a barrier field at an exit member adjacent to the exit end of the rod set and by producing an RF field between the rods of the rod set; and, c) providing an auxiliary AC excitement voltage to the set of auxiliary electrodes to energize a first group of ions of a selected mass to charge.

6. 发明申请

WO2008037058A1 METHOD FOR AXIAL EJECTION AND IN T RAP FRAGMENTATION USING AUXILIARY ELECTRODES IN A MULTIPOLE MASS SPECTROMETER 审中-公开
标题翻译：在多重质谱仪中使用辅助电极进行轴向射出和T波段分割的方法
公开(公告)号：WO2008037058A1
公开(公告)日：2008-04-03
申请号：PCT/CA2007001360
申请日：2007-08-02
申请人： MDS ANALYTICAL TECH BU MDS INC , APPLERA CORP , GUNA MIRCEA
发明人： GUNA MIRCEA
IPC分类号： H01J49/10 , H01J49/42
CPC分类号： H01J49/4225 , H01J49/0063 , H01J49/4285
摘要： A method of operating a mass spectrometer having an elongated rod set and a set of auxiliary electrodes is provided, the rod set having an entrance end and an exit end and a longitudinal axis. The method comprises a) admitting ions into the entrance end of the rod set; b) trapping at least some of the ions in the rod set by producing a barrier field at an exit member adjacent to the exit end of the rod set and by producing an RF field between the rods of the rod set; and, c) providing an auxiliary AC excitement voltage to the set of auxiliary electrodes to energize a first group of ions of a selected mass to charge.
摘要翻译：提供一种操作具有细长杆组和一组辅助电极的质谱仪的方法，该杆组具有入口端和出射端以及纵向轴线。该方法包括：a）将离子引入棒组的入口端; b）通过在与所述杆组的出口端相邻的出口构件处产生阻挡场并通过在所述杆组的杆之间产生RF场来捕获所述杆组中的至少一些离子; 以及c）向所述一组辅助电极提供辅助AC兴奋电压，以激励所选质量的第一组离子进行充电。

7. 发明申请

WO2006076228A3 METHOD AND APPARATUS FOR IMPROVED SENSITIVITY IN A MASS SPECTROMETER 审中-公开
标题翻译：在质谱仪中提高灵敏度的方法和装置
公开(公告)号：WO2006076228A3
公开(公告)日：2007-06-21
申请号：PCT/US2006000492
申请日：2006-01-05
申请人： APPLERA CORP , MDS INC , LOBODA ALEXANDRE V , COLLINGS BRUCE A , COVEY THOMAS R , GUNA MIRCEA , JAVAHERI HASSAN , SCHNEIDER BRADLEY B , THOMSON BRUCE A
发明人： COLLINGS BRUCE A , COVEY THOMAS R , GUNA MIRCEA , JAVAHERI HASSAN , SCHNEIDER BRADLEY B , THOMSON BRUCE A
IPC分类号： H01J49/04 , B01D59/44 , H01J49/10
CPC分类号： H01J49/067 , H01J49/063
摘要： In a mass spectrometer, ions from an ion source pass through an inlet aperture into a vacuum chamber for transmitting prior to mass analysis by the mass analyzer. The configuration of the inlet aperture forms a sonic orifice or sonic nozzle and with a predetermined vacuum chamber pressure, a supersonic free jet expansion is created in the vacuum chamber that entrains the ions within the barrel shock and Mach disc. Once formed, an ion guide with a predetermined cross-section to essentially radially confine the supersonic free jet expansion can focus the ions for transmission through the vacuum chamber. This effectively improves the ion transmission between the ion source and the mass analyzer.
摘要翻译：在质谱仪中，质子分析仪进行质量分析之前，离子源的离子通过入口孔进入真空室以进行传输。入口孔的构型形成声孔或声波喷嘴，并且在预定的真空室压力下，在真空室中产生超音速自由射流膨胀，该真空室将离子夹带在筒形冲击和马赫盘内。一旦形成，具有预定横截面以基本上径向限制超音速自由射流膨胀的离子导向器可将离子聚焦以透过真空室。这有效地改善离子源和质量分析器之间的离子传递。

8. 发明申请

WO2013008086A2 METHOD TO CONTROL SPACE CHARGE IN A MASS SPECTROMETER 审中-公开
标题翻译：控制质谱仪空间电荷的方法
公开(公告)号：WO2013008086A2
公开(公告)日：2013-01-17
申请号：PCT/IB2012/001366
申请日：2012-07-11
申请人： DH TECHNOLOGIES DEVELOPMENT PTE. LTD. , GUNA, Mircea
发明人： GUNA, Mircea
IPC分类号： H01J49/26
CPC分类号： H01J49/4265 , H01J49/004 , H01J49/422 , H01J49/427
摘要： A method for operating a mass spectrometer having an ion trap over a plurality of selected mass-to-charge ranges constituting an overall mass- to-charge range is disclosed. For each of the plurality of selected mass-to- charge ranges the method comprises filling the ion trap with fragmented ions of the selected mass-to-charge ranges, cooling the fragmented ions trapped in the ion trap for a first cooling period, applying an RF voltage and a resolving direct current voltage to the ion trap for eliminating any remaining fragmented ions outside the selected ion mass-to-charge range and retaining ions within the selected ion mass-to-charge range, cooling the retained ions in the ion trap for a second cooling period, and scanning the retained ions out of the ion trap and detecting the ions released therefrom.
摘要翻译：公开了一种操作质谱仪的方法，该质谱仪在构成总体质荷比范围的多个选定质荷比范围上具有离子阱。对于多个选择的质荷比范围中的每一个，所述方法包括用选定的质荷比范围的碎片离子填充离子阱，冷却截留在离子阱中的碎片离子第一冷却时段， RF电压和解析直流电压到离子阱以消除选定离子质量电荷范围之外的任何剩余碎裂离子并将离子保持在选定离子质量电荷范围内，冷却离子阱中的保留离子进行第二冷却阶段，并将保留的离子扫描离开离子阱并检测从其释放的离子。

9. 发明申请

WO2009149546A1 METHOD OF OPERATING TANDEM ION TRAPS 审中-公开
标题翻译：工作台灯的操作方法
公开(公告)号：WO2009149546A1
公开(公告)日：2009-12-17
申请号：PCT/CA2009/000805
申请日：2009-06-08
申请人： MDS ANALYTICAL TECHNOLOGIES , LIFE TECHNOLOGIES CORPORATION, A DELAWARE CORPORATION , GUNA, Mircea , LONDRY, Frank
发明人： GUNA, Mircea , LONDRY, Frank
IPC分类号： H01J49/42
CPC分类号： H01J49/4265 , H01J49/0031 , H01J49/004
摘要： A method for operating tandem ion traps is provided, involving a) accumulating ions in the first ion trap at a first time; b) transmitting a first plurality of ions out of the first ion trap and into the second ion trap at a second time, the first plurality of ions having masses within a first mass range; c) retaining a second plurality of ions in the first ion trap at the second time, the second plurality of ions having masses within a second mass range different from the first mass range; d) transmitting the first plurality of ions out of the second ion trap at a third time; and, e) transmitting the second plurality of ions out of the first ion trap and into the second ion trap at the third time.
摘要翻译：提供了一种用于操作串联离子阱的方法，包括：a）在第一时间将第一离子阱中的离子累积; b）在第二时间将第一多个离子从第一离子阱中传输到第二离子阱中，第一多个离子具有在第一质量范围内的质量; c）在第二时间将第二多个离子保留在第一离子阱中，第二多个离子具有在与第一质量范围不同的第二质量范围内的质量; d）第三次将第一多个离子从第二离子阱中传出; 以及e）第三次将第二多个离子从第一离子阱中传出并进入第二离子阱。

10. 发明申请

WO2009094759A8 METHOD OF OPERATING A LINEAR ION TRAP TO PROVIDE LOW PRESSURE SHORT TIME HIGH AMPLITUDE EXCITATION 审中-公开
公开(公告)号：WO2009094759A8
公开(公告)日：2009-08-06
申请号：PCT/CA2009/000087
申请日：2009-01-26
申请人： MDS ANALYTICAL TECHNOLOGIES, a business unit of MDS Inc, doing business throught its SCIEX Division , LIFE TECHNOLOGIES CORPORATION , GUNA, Mircea , LE BLANC, Yves
发明人： GUNA, Mircea , LE BLANC, Yves
IPC分类号： H01J49/10 , H01J49/26
摘要： In accordance with an aspect of an embodiment of the present invention, there is provided a method for fragmenting ions in an ion trap of a mass spectrometer. The method comprises a) selecting parent ions for fragmentation; b) retaining the parent ions within the ion trap for a retention time interval, the ion trap having an operating pressure of less than about 1 x 10-4 Torr; c) providing a RF trapping voltage to the ion trap to provide a Mathieu stability parameter q at an excitement level during an excitement time interval within the retention time interval; d) providing a resonant excitation voltage to the ion trap during the excitement time interval to excite and fragment the parent ions; and, e) within the retention time interval and after the excitement time interval, terminating the resonant excitation voltage and changing the RF trapping voltage applied to the ion trap to reduce the Mathieu stability parameter q to a hold level less than the excitement level to retain fragments of the parent ions within the ion trap.

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