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1. 发明申请

WO2006076228A2 METHOD AND APPARATUS FOR IMPROVED SENSITIVITY IN A MASS SPECTROMETER 审中-公开
标题翻译：在质谱仪中提高灵敏度的方法和装置
公开(公告)号：WO2006076228A2
公开(公告)日：2006-07-20
申请号：PCT/US2006/000492
申请日：2006-01-05
申请人： APPLERA CORPORATION , MDS INC. , LOBODA, Alexandre, V. , COLLINGS, Bruce, A. , COVEY, Thomas, R. , GUNA, Mircea , JAVAHERI, Hassan , SCHNEIDER, Bradley, B. , THOMSON, Bruce A.
发明人： COLLINGS, Bruce, A. , COVEY, Thomas, R. , GUNA, Mircea , JAVAHERI, Hassan , SCHNEIDER, Bradley, B. , THOMSON, Bruce A.
IPC分类号： H01J49/04
CPC分类号： H01J49/067 , H01J49/063
摘要： In a mass spectrometer, ions from an ion source pass through an inlet aperture into a vacuum chamber for transmitting prior to mass analysis by the mass analyzer. The configuration of the inlet aperture forms a sonic orifice or sonic nozzle and with a predetermined vacuum chamber pressure, a supersonic free jet expansion is created in the vacuum chamber that entrains the ions within the barrel shock and Mach disc. Once formed, an ion guide with a predetermined cross-section to essentially radially confine the supersonic free jet expansion can focus the ions for transmission through the vacuum chamber. This effectively improves the ion transmission between the ion source and the mass analyzer.
摘要翻译：在质谱仪中，质子分析仪进行质量分析之前，离子源的离子通过入口孔进入真空室以进行传输。入口孔的构型形成声孔或声波喷嘴，并且在预定的真空室压力下，在真空室中产生超音速自由射流膨胀，该真空室将离子夹带在筒形冲击和马赫盘内。一旦形成，具有预定横截面以基本上径向限制超音速自由射流膨胀的离子导向器可将离子聚焦以透过真空室。这有效地改善离子源和质量分析器之间的离子传递。

2. 发明申请

WO2007075856A2 LASER DESORPTION ION SOURCE WITH ION GUIDE COUPLING FOR ION MASS SPECTROSCOPY 审中-公开
标题翻译：带离子导向的激光吸附离子源用于离子质谱
公开(公告)号：WO2007075856A2
公开(公告)日：2007-07-05
申请号：PCT/US2006/048732
申请日：2006-12-19
申请人： MDS SCIEX, INC. , APPLERA CORPORATION , COVEY, Thomas, R. , JAVAHERI, Hassan , SCHNEIDER, Bradley, B.
发明人： COVEY, Thomas, R. , JAVAHERI, Hassan , SCHNEIDER, Bradley, B.
IPC分类号： H01J49/42
CPC分类号： H01J49/063 , H01J49/164
摘要： A laser desorption ion source provides enhanced ion sampling efficiency and measurement sensitivity by using one or more ion guides to effectively capture ions in a plume emitted from the ion target and guide the ions through an aperture into a downstream vacuum chamber. In one configuration using two RF multipole ion guides, a first RF multipole ion guide disposed next to the ion target is selected to be sufficiently large to capture a substantial portion of the plume, while the second RF multipole ion guide disposed between the first multipole ion guide and the aperture has a smaller dimension to assist focusing of ions into the aperture. The first RF multipole ion guides the ions in the plume into the second RF multipole ion guide, which then focuses the ions so that they pass through the aperture into the downstream vacuum chamber.
摘要翻译：激光解吸离子源通过使用一个或多个离子引导件有效地捕获从离子靶发射的羽流中的离子并将离子引导通过孔进入下游真空室来提供增强的离子采样效率和测量灵敏度。在使用两个RF多极离子引导件的一种配置中，选择邻近离子靶设置的第一RF多极离子导向器足够大以捕获大部分羽流，而第二射频多极离子导向器设置在第一多极离子导向件和孔径具有较小的尺寸以辅助将离子聚焦到孔中。第一RF多极离子将羽流中的离子引导到第二射频多极离子导向器中，然后将离子聚焦以使它们通过孔进入下游真空室。

3. 发明申请

WO2007075856A3 LASER DESORPTION ION SOURCE WITH ION GUIDE COUPLING FOR ION MASS SPECTROSCOPY 审中-公开
标题翻译：带离子导向的激光吸附离子源用于离子质谱
公开(公告)号：WO2007075856A3
公开(公告)日：2008-04-17
申请号：PCT/US2006048732
申请日：2006-12-19
申请人： MDS SCIEX INC , APPLERA CORP , COVEY THOMAS R , JAVAHERI HASSAN , SCHNEIDER BRADLEY B
发明人： COVEY THOMAS R , JAVAHERI HASSAN , SCHNEIDER BRADLEY B
IPC分类号： H01J49/42
CPC分类号： H01J49/063 , H01J49/164
摘要： A laser desorption ion source provides enhanced ion sampling efficiency and measurement sensitivity by using one or more ion guides to effectively capture ions in a plume emitted from the ion target and guide the ions through an aperture into a downstream vacuum chamber. In one configuration using two RF multipole ion guides, a first RF multipole ion guide disposed next to the ion target is selected to be sufficiently large to capture a substantial portion of the plume, while the second RF multipole ion guide disposed between the first multipole ion guide and the aperture has a smaller dimension to assist focusing of ions into the aperture. The first RF multipole ion guides the ions in the plume into the second RF multipole ion guide, which then focuses the ions so that they pass through the aperture into the downstream vacuum chamber.
摘要翻译：激光解吸离子源通过使用一个或多个离子引导件有效地捕获从离子靶发射的羽流中的离子并将离子引导通过孔进入下游真空室来提供增强的离子采样效率和测量灵敏度。在使用两个RF多极离子引导件的一种配置中，选择邻近离子靶设置的第一RF多极离子导向器足够大以捕获大部分羽流，而第二射频多极离子导向器设置在第一多极离子导向件和孔径具有较小的尺寸以辅助将离子聚焦到孔中。第一RF多极离子将羽流中的离子引导到第二射频多极离子导向器中，然后将离子聚焦以使它们通过孔进入下游真空室。

4. 发明申请

WO02082073A3 A METHOD OF AND APPARATUS FOR IONIZING AN ANALYTE AND ION SOURCE PROBE FOR USE THEREWITH 审中-公开
标题翻译：用于分离分析仪的离子源和离子源探针的方法和装置
公开(公告)号：WO02082073A3
公开(公告)日：2003-05-22
申请号：PCT/CA0200491
申请日：2002-04-09
申请人： MDS INC DBA MDS SCIEX , COVEY THOMAS , JONG RAYMOND , JAVAHERI HASSAN
发明人： COVEY THOMAS , JONG RAYMOND , JAVAHERI HASSAN
IPC分类号： G01N27/62 , G01N30/72 , H01J49/04 , H01J49/10
CPC分类号： H01J49/04 , G01N30/724 , G01N30/7246 , G01N30/7266 , H01J49/107
摘要： A device for electrospray ionization comprises two gas sources, or an arc jet of gas, provide second and third flows, of a gas, and include heaters for heating the second and third flows. The second and third flows intersect with the first flow at a selected mixing region, to promote turbulent mixing of the first, second and third flows, the first, second and third directions being different from one another, and each of the second and third directions being selected to provide each of the second and third flows with a velocity component in the first direction and a velocity component towards the axis of the capillary tube, thereby to promote entrainment of the heated gas in the spray, with the heated gas acting to assist the evaporation of the droplets to release ions therefrom. At least some of the ions produced from the droplets are drawn through the orifice for analysis.
摘要翻译：用于电喷雾离子化的装置包括两个气源或气体的电弧射流，提供气体的第二和第三流，并且包括用于加热第二和第三流量的加热器。第二和第三流在选定的混合区域与第一流相交，以促进第一，第二和第三流的湍流混合，第一，第二和第三方向彼此不同，第二和第三方向被选择为使第二和第三流中的每一个具有在第一方向上的速度分量和朝向毛细管的轴线的速度分量，从而促进加热的气体在喷雾中的夹带，加热的气体用于辅助液滴的蒸发从其中释放离子。从液滴产生的至少一些离子被吸入孔中进行分析。

5. 发明申请

WO2006076228A3 METHOD AND APPARATUS FOR IMPROVED SENSITIVITY IN A MASS SPECTROMETER 审中-公开
标题翻译：在质谱仪中提高灵敏度的方法和装置
公开(公告)号：WO2006076228A3
公开(公告)日：2007-06-21
申请号：PCT/US2006000492
申请日：2006-01-05
申请人： APPLERA CORP , MDS INC , LOBODA ALEXANDRE V , COLLINGS BRUCE A , COVEY THOMAS R , GUNA MIRCEA , JAVAHERI HASSAN , SCHNEIDER BRADLEY B , THOMSON BRUCE A
发明人： COLLINGS BRUCE A , COVEY THOMAS R , GUNA MIRCEA , JAVAHERI HASSAN , SCHNEIDER BRADLEY B , THOMSON BRUCE A
IPC分类号： H01J49/04 , B01D59/44 , H01J49/10
CPC分类号： H01J49/067 , H01J49/063
摘要： In a mass spectrometer, ions from an ion source pass through an inlet aperture into a vacuum chamber for transmitting prior to mass analysis by the mass analyzer. The configuration of the inlet aperture forms a sonic orifice or sonic nozzle and with a predetermined vacuum chamber pressure, a supersonic free jet expansion is created in the vacuum chamber that entrains the ions within the barrel shock and Mach disc. Once formed, an ion guide with a predetermined cross-section to essentially radially confine the supersonic free jet expansion can focus the ions for transmission through the vacuum chamber. This effectively improves the ion transmission between the ion source and the mass analyzer.
摘要翻译：在质谱仪中，质子分析仪进行质量分析之前，离子源的离子通过入口孔进入真空室以进行传输。入口孔的构型形成声孔或声波喷嘴，并且在预定的真空室压力下，在真空室中产生超音速自由射流膨胀，该真空室将离子夹带在筒形冲击和马赫盘内。一旦形成，具有预定横截面以基本上径向限制超音速自由射流膨胀的离子导向器可将离子聚焦以透过真空室。这有效地改善离子源和质量分析器之间的离子传递。

6. 发明申请

WO2002082073A2 A METHOD OF AND APPARATUS FOR IONIZING AN ANALYTE AND ION SOURCE PROBE FOR USE THEREWITH 审中-公开
标题翻译：用于分离分析仪的离子源和离子源探针的方法和装置
公开(公告)号：WO2002082073A2
公开(公告)日：2002-10-17
申请号：PCT/CA2002/000491
申请日：2002-04-09
申请人： MDS INC., doing business as MDS SCIEX , COVEY, Thomas , JONG, Raymond , JAVAHERI, Hassan
发明人： COVEY, Thomas , JONG, Raymond , JAVAHERI, Hassan
IPC分类号： G01N30/72
CPC分类号： H01J49/04 , G01N30/724 , G01N30/7246 , G01N30/7266 , H01J49/107
摘要： Ions for analysis are formed from a liquid sample comprising an analyte in a solvent liquid by directing the liquid sample through a capillary tube having a free end so as to form a first flow comprising a spray of droplets of the liquid sample, to promote vaporization of the solvent liquid. An orifice member is spaced from the free-end of the capillary tube and has an orifice therein. An electric field is generated between the free-end of the capillary and the orifice member, thereby causing the droplets to be charged, and the first flow is directed in a first direction along the axis of the capillary tube. Two gas sources, or an arc jet of gas, provide second and third flows, of a gas, and include heaters for heating the second and third flows. The second and third flows intersect with the first flow at a selected mixing region, to promote turbulent mixing of the first, second and third flows, the first, second and third directions being different from one another, and each of the second and third directions being selected to provide each of the second and third flows with a velocity component in the first direction and a velocity component towards the axis of the capillary tube, thereby to promote entrainment of the heated gas in the spray, with the heated gas acting to assist the evaporation of the droplets to release ions therefrom. At least some of the ions produced from the droplets are drawn through the orifice for analysis.
摘要翻译：用于电喷雾离子化的装置包括两个气源或气体的电弧射流，提供气体的第二和第三流，并且包括用于加热第二和第三流量的加热器。第二和第三流在选定的混合区域与第一流相交，以促进第一，第二和第三流的湍流混合，第一，第二和第三方向彼此不同，第二和第三方向被选择为使第二和第三流中的每一个具有在第一方向上的速度分量和朝向毛细管的轴线的速度分量，从而促进加热的气体在喷雾中的夹带，加热的气体用于辅助液滴的蒸发从其中释放离子。从液滴产生的至少一些离子被吸入孔中进行分析。

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