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1. 发明申请

WO2009149546A8 METHOD OF OPERATING TANDEM ION TRAPS 审中-公开
标题翻译：工作台灯的操作方法
公开(公告)号：WO2009149546A8
公开(公告)日：2011-02-17
申请号：PCT/CA2009000805
申请日：2009-06-08
申请人： DH TECHNOLOGIES DEV PTE LTD , GUNA MIRCEA , LONDRY FRANK
发明人： GUNA MIRCEA , LONDRY FRANK
IPC分类号： H01J49/42
CPC分类号： H01J49/4265 , H01J49/0031 , H01J49/004
摘要： A method for operating tandem ion traps is provided, involving a) accumulating ions in the first ion trap at a first time; b) transmitting a first plurality of ions out of the first ion trap and into the second ion trap at a second time, the first plurality of ions having masses within a first mass range; c) retaining a second plurality of ions in the first ion trap at the second time, the second plurality of ions having masses within a second mass range different from the first mass range; d) transmitting the first plurality of ions out of the second ion trap at a third time; and, e) transmitting the second plurality of ions out of the first ion trap and into the second ion trap at the third time.
摘要翻译：提供了一种用于操作串联离子阱的方法，包括：a）在第一时间将第一离子阱中的离子累积; b）在第二时间将第一多个离子从第一离子阱中传输到第二离子阱中，第一多个离子具有在第一质量范围内的质量; c）在第二时间将第二多个离子保留在第一离子阱中，第二多个离子具有在与第一质量范围不同的第二质量范围内的质量; d）第三次将第一多个离子从第二离子阱中传出; 以及e）第三次将第二多个离子从第一离子阱中传出并进入第二离子阱。

2. 发明专利

CA2925728A1 SYSTEMS AND METHODS FOR ARBITRARY QUADRUPOLE TRANSMISSION WINDOWING 未知
公开(公告)号：CA2925728A1
公开(公告)日：2015-04-23
申请号：CA2925728
申请日：2014-10-07
申请人： DH TECHNOLOGIES DEV PTE LTD
发明人： HAGER JAMES W , LONDRY FRANK , BLOOMFIELD NIC G
IPC分类号： H01J49/26
摘要： Systems and methods are provided for shaping an effective transmission window used to select precursor ions for a precursor mass range of a sequential windowed acquisition experiment. For at least one precursor mass range, an ion transfer function is selected that is a function of mass using a processor. A quadrupole mass filter that transmits ions from a sample is instructed to produce two or more transmission windows over time using the processor. The two or more transmission windows are produced to cumulatively create an effective transmission window for the at least one precursor mass range with a shape described by the ion transfer function.

3. 发明专利

CA2720248A1 METHOD OF OPERATING TANDEM ION TRAPS 未知
公开(公告)号：CA2720248A1
公开(公告)日：2009-12-17
申请号：CA2720248
申请日：2009-06-08
申请人： DH TECHNOLOGIES DEV PTE LTD
发明人： GUNA MIRCEA , LONDRY FRANK
IPC分类号： H01J49/42
摘要： A method for operating tandem ion traps is provided, involving a) accumulating ions in the first ion trap at a first time; b) transmitting a first plurality of ions out of the first ion trap and into the second ion trap at a second time, the first plurality of ions having masses within a first mass range; c) retaining a second plurality of ions in the first ion trap at the second time, the second plurality of ions having masses within a second mass range different from the first mass range; d) transmitting the first plurality of ions out of the second ion trap at a third time; and, e) transmitting the second plurality of ions out of the first ion trap and into the second ion trap at the third time.

4. 发明专利

CA2720248C METHOD OF OPERATING TANDEM ION TRAPS 未知
公开(公告)号：CA2720248C
公开(公告)日：2016-10-04
申请号：CA2720248
申请日：2009-06-08
申请人： DH TECHNOLOGIES DEV PTE LTD
发明人： GUNA MIRCEA , LONDRY FRANK
IPC分类号： H01J49/42
摘要： A method for operating tandem ion traps is provided, involving a) accumulating ions in the first ion trap at a first time; b) transmitting a first plurality of ions out of the first ion trap and into the second ion trap at a second time, the first plurality of ions having masses within a first mass range; c) retaining a second plurality of ions in the first ion trap at the second time, the second plurality of ions having masses within a second mass range different from the first mass range; d) transmitting the first plurality of ions out of the second ion trap at a third time; and, e) transmitting the second plurality of ions out of the first ion trap and into the second ion trap at the third time.

5. 发明专利

CA2720249A1 A MULTIPOLE ION GUIDE FOR PROVIDING AN AXIAL ELECTRIC FIELD WHOSE STRENGTH INCREASES WITH RADIAL POSITION, AND A METHOD OF OPERATING A MULTIPOLE ION GUIDE HAVING SUCH AN AXIAL ELECTRIC FIELD 未知
公开(公告)号：CA2720249A1
公开(公告)日：2009-12-17
申请号：CA2720249
申请日：2009-06-09
申请人： DH TECHNOLOGIES DEV PTE LTD
发明人： LONDRY FRANK
IPC分类号： H01J49/26 , H01J49/10
摘要： A mass spectrometer having an elongated rod set, the rod set having a first end, a second end, a plurality of rods and a central longitudinal axis is described as is a method operating same. Embodiments involve a) admitting ions into the rod set; b) producing an RF field between the plurality of rods to radially confine the ions in the rod set, wherein the RF field varies along at least a portion of a length of the rod set to provide, for each of the ions, a corresponding first axial force acting on the ion to push the ion in a first axial direction; and, c) for each of the ions, providing a corresponding second axial force to push the ion in a second axial direction opposite to the first axial direction; wherein the corresponding first axial force increases relative to the corresponding second axial force with radial displacement of the ion from the central longitudinal axis in any direction orthogonal to the central longitudinal axis such that the first corresponding axial force is less than the corresponding second axial force when the ion is less than a threshold radial distance from the central longitudinal axis and the corresponding first axial force exceeds the corresponding second axial force when the ion is radially displaced from the central longitudinal axis by more than the threshold radial distance in any direction orthogonal to the central longitudinal axis.

6. 发明专利

CA2754664C FRAGMENTATION OF IONS BY RESONANT EXCITATION IN HIGH ORDER MULTIPOLE FIELD, LOW PRESSURE ION TRAP 未知
公开(公告)号：CA2754664C
公开(公告)日：2013-08-20
申请号：CA2754664
申请日：2003-04-02
申请人： DH TECHNOLOGIES DEV PTE LTD
发明人： LONDRY FRANK , COLLINGS BRUCE A , STOTT WILLIAM R
IPC分类号： G01N27/62 , H01J49/42 , H01J49/00
摘要： In the field of mass spectrometry, a method and apparatus for fragmenting ions with a relatively high degree of resolution and efficiency. The technique includes trapping the ions in a linear ion trap, in which the background or neutral gas pressure is preferably on the order of 10-5 Torr. The trapped ions are resonantly excited for a relatively extended period of time, e.g., exceeding 50 ms, at relatively low excitation levels, e.g., less than 1 Volt (0-pk). The technique allows selective dissociation of ions with a high discrimination. High fragmentation efficiency may be achieved by superimposing a higher order multipole field onto the quadrupolar RF field used to trap the ions. The multipole field, preferably an octopole field, dampens the radial oscillatory motion of resonantly excited ions at the periphery of the trap. This reduces the probability that ions will eject radially from the trap thus increasing the probability of collision induced dissociation.

7. 发明专利

CA2720249C A MULTIPOLE ION GUIDE FOR PROVIDING AN AXIAL ELECTRIC FIELD WHOSE STRENGTH INCREASES WITH RADIAL POSITION, AND A METHOD OF OPERATING A MULTIPOLE ION GUIDE HAVING SUCH AN AXIAL ELECTRIC FIELD 未知
公开(公告)号：CA2720249C
公开(公告)日：2015-12-08
申请号：CA2720249
申请日：2009-06-09
申请人： DH TECHNOLOGIES DEV PTE LTD
发明人： LONDRY FRANK
IPC分类号： H01J49/26 , H01J49/10
摘要： A mass spectrometer having an elongated rod set, the rod set having a first end, a second end, a plurality of rods and a central longitudinal axis is described as is a method operating same. Embodiments involve a) admitting ions into the rod set; b) producing an RF field between the plurality of rods to radially confine the ions in the rod set, wherein the RF field varies along at least a portion of a length of the rod set to provide, for each of the ions, a corresponding first axial force acting on the ion to push the ion in a first axial direction; and, c) for each of the ions, providing a corresponding second axial force to push the ion in a second axial direction opposite to the first axial direction; wherein the corresponding first axial force increases relative to the corresponding second axial force with radial displacement of the ion from the central longitudinal axis in any direction orthogonal to the central longitudinal axis such that the first corresponding axial force is less than the corresponding second axial force when the ion is less than a threshold radial distance from the central longitudinal axis and the corresponding first axial force exceeds the corresponding second axial force when the ion is radially displaced from the central longitudinal axis by more than the threshold radial distance in any direction orthogonal to the central longitudinal axis.

8. 发明专利

CA2925853A1 SYSTEMS AND METHODS FOR IDENTIFYING PRECURSOR IONS FROM PRODUCT IONS USING ARBITRARY TRANSMISSION WINDOWING 未知
公开(公告)号：CA2925853A1
公开(公告)日：2015-04-23
申请号：CA2925853
申请日：2014-10-07
申请人： DH TECHNOLOGIES DEV PTE LTD
发明人： BLOOMFIELD NIC G , LONDRY FRANK
IPC分类号： H01J49/26
摘要： A transmission window that has a constant rate of precursor ion transmission for each precursor ion is stepped across a mass range, producing a series of overlapping transmission windows across the mass range. The precursor ions produced at each step are fragmented. Resulting product ions are analyzed, producing a product ion spectrum for each step of the transmission window and a plurality of product ion spectra for the mass range. For at least one product ion of the plurality of product ion spectra, a function that describes how an intensity of the at least one product ion from the plurality of product ion spectra varies with precursor ion mass as the transmission window is stepped across the mass range is calculated. A precursor ion of the at least one product ion is identified from the function. An elution profile can also be determined from the function.

9. 发明专利

CA2754664A1 FRAGMENTATION OF IONS BY RESONANT EXCITATION IN HIGH ORDER MULTIPOLE FIELD, LOW PRESSURE ION TRAP 未知
公开(公告)号：CA2754664A1
公开(公告)日：2003-10-23
申请号：CA2754664
申请日：2003-04-02
申请人： DH TECHNOLOGIES DEV PTE LTD
发明人： LONDRY FRANK , COLLINGS BRUCE A , STOTT WILLIAM R
IPC分类号： G01N27/62 , H01J49/42 , H01J49/00
摘要： In the field of mass spectrometry, a method and apparatus for fragmenting ions with a relatively high degree of resolution and efficiency. The technique includes trapping the ions in a linear ion trap, in which the background or neutral gas pressure is preferably on the order of 10-5 Torr. The trapped ions are resonantly excited for a relatively extended period of time, e.g., exceeding 50 ms, at relatively low excitation levels, e.g., less than 1 Volt (0-pk). The technique allows selective dissociation of ions with a high discrimination. High fragmentation efficiency may be achieved by superimposing a higher order multipole field onto the quadrupolar RF field used to trap the ions. The multipole field, preferably an octopole field, dampens the radial oscillatory motion of resonantly excited ions at the periphery of the trap. This reduces the probability that ions will eject radially from the trap thus increasing the probability of collision induced dissociation.

10. 发明公开

EP3210234A4 METHODS AND SYSTEMS FOR CROSS-TALK ELIMINATION IN CONTINUOUS BEAM MOBILITY-BASED SPECTROMETERS 审中-公开
公开(公告)号：EP3210234A4
公开(公告)日：2018-06-27
申请号：EP15851667
申请日：2015-10-21
申请人： DH TECHNOLOGIES DEV PTE LTD
发明人： COVEY THOMAS R , KANG YANG , LONDRY FRANK , SCHNEIDER BRADLEY B
IPC分类号： H01J49/04 , G01N27/62 , H01J49/00 , H01J49/06 , H01J49/24
CPC分类号： G01N27/624 , H01J49/0031 , H01J49/004 , H01J49/04 , H01J49/06 , H01J49/24
摘要： A sample analysis system having a continuous beam ion mobility filter incorporates an ion removal mechanism for removing residual ions from the ion mobility filter to reduce cross-talk. A sample to be analyzed by the sample analysis system can be entered into the continuous beam ion mobility filter, which filters the ions of the sample and passes the filtered group of ions to a detector or a mass analyzer (e.g., via an ion optics assembly disposed between the mass analyzer and the ion mobility filter), where some or all of the ions in the group are detected. The ion removal mechanism then removes all or a substantial portion of the residual ions from the ion mobility filter that are left over from the first filtered group before a second filtered group is passed through. In some aspects, the ion removal mechanism can be operated concurrent with an ion removal mechanism for removing residual ions from an ion optics assembly.

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