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1. 发明申请

WO2006076228A3 METHOD AND APPARATUS FOR IMPROVED SENSITIVITY IN A MASS SPECTROMETER 审中-公开
标题翻译：在质谱仪中提高灵敏度的方法和装置
公开(公告)号：WO2006076228A3
公开(公告)日：2007-06-21
申请号：PCT/US2006000492
申请日：2006-01-05
申请人： APPLERA CORP , MDS INC , LOBODA ALEXANDRE V , COLLINGS BRUCE A , COVEY THOMAS R , GUNA MIRCEA , JAVAHERI HASSAN , SCHNEIDER BRADLEY B , THOMSON BRUCE A
发明人： COLLINGS BRUCE A , COVEY THOMAS R , GUNA MIRCEA , JAVAHERI HASSAN , SCHNEIDER BRADLEY B , THOMSON BRUCE A
IPC分类号： H01J49/04 , B01D59/44 , H01J49/10
CPC分类号： H01J49/067 , H01J49/063
摘要： In a mass spectrometer, ions from an ion source pass through an inlet aperture into a vacuum chamber for transmitting prior to mass analysis by the mass analyzer. The configuration of the inlet aperture forms a sonic orifice or sonic nozzle and with a predetermined vacuum chamber pressure, a supersonic free jet expansion is created in the vacuum chamber that entrains the ions within the barrel shock and Mach disc. Once formed, an ion guide with a predetermined cross-section to essentially radially confine the supersonic free jet expansion can focus the ions for transmission through the vacuum chamber. This effectively improves the ion transmission between the ion source and the mass analyzer.
摘要翻译：在质谱仪中，质子分析仪进行质量分析之前，离子源的离子通过入口孔进入真空室以进行传输。入口孔的构型形成声孔或声波喷嘴，并且在预定的真空室压力下，在真空室中产生超音速自由射流膨胀，该真空室将离子夹带在筒形冲击和马赫盘内。一旦形成，具有预定横截面以基本上径向限制超音速自由射流膨胀的离子导向器可将离子聚焦以透过真空室。这有效地改善离子源和质量分析器之间的离子传递。

2. 发明申请

WO2009085081A2 METHOD AND APPARATUS FOR REDUCING SPACE CHARGE IN AN ION TRAP 审中-公开
标题翻译：用于减少离子阱中空隙电荷的方法和装置
公开(公告)号：WO2009085081A2
公开(公告)日：2009-07-09
申请号：PCT/US2008012910
申请日：2008-11-19
申请人： MDS ANALYTICAL TECH BU MDS INC , APPLIED BIOSYSTEMS LLC , COLLINGS BRUCE A
发明人： COLLINGS BRUCE A
IPC分类号： H01J49/26 , H01J3/40 , H01J49/02
CPC分类号： H01J49/4225 , H01J49/4265
摘要： Ion trap apparatus and methods for efficiently addressing the effects of charge space caused by ion trap overfilling, useful in linear ion traps of mass spectrometers.
摘要翻译：用于有效解决由离子阱过度填充引起的电荷空间影响的离子阱设备和方法，可用于质谱仪的线性离子阱。

3. 发明专利

CA2481081C FRAGMENTATION OF IONS BY RESONANT EXCITATION IN A HIGH ORDER MULTIPOLE FIELD, LOW PRESSURE ION TRAP 未知
公开(公告)号：CA2481081C
公开(公告)日：2012-01-10
申请号：CA2481081
申请日：2003-04-02
申请人： MDS INC DBA MDS SCIEX , APPLERA CORP
发明人： LONDRY FRANK , COLLINGS BRUCE A , STOTT WILIAM R
IPC分类号： G01N27/62 , H01J49/42 , H01J49/00
摘要： In the field of mass spectrometry, a method and apparatus for fragmenting ions with a relatively high degree of resolution and efficiency. The technique includes trapping the ions in a linear ion trap, in which the background or neutral gas pressure is preferably on the order of 10-5 Torr. The trapped ions are resonantly excited for a relatively extended period of time, e.g., exceeding 50 ms, at relatively low excitation levels, e.g., less than 1 Volt (0-pk). The technique allows selective dissociation of ions with a high discrimination. High fragmentation efficiency may be achieved by superimposing a higher order multipole field onto the quadrupolar RF field used to trap the ions. The multipole field, preferably an octopole field, dampens the radial oscillatory motion of resonantly excited ions at the periphery of the trap. This reduces the probability that ions will eject radially from the trap thus increasing the probability of collision induced dissociation.

4. 发明申请

WO0033350A3 METHOD AND APPARATUS FOR MULTIPLE STAGES OF MASS SPECTROMETRY 审中-公开
标题翻译：方法和装置用于大量光谱的多个阶段
公开(公告)号：WO0033350A3
公开(公告)日：2000-10-26
申请号：PCT/CA9901142
申请日：1999-11-30
申请人： UNIV BRITISH COLUMBIA , DOUGLAS DONALD , CAMPBELL JENNIFER , COLLINGS BRUCE A
发明人： DOUGLAS DONALD , CAMPBELL JENNIFER , COLLINGS BRUCE A
IPC分类号： H01J49/42
CPC分类号： H01J49/4225 , H01J49/004
摘要： A method of and apparatus for analyzing a stream of ions first subjects astream of ions to a first mass analysis step, to select ions having a mass-to-charge ratio in a first desired range; this enables a mass analyzer with highresolution to be used. The selected ions are then passed into a radiofrequency linear ion trap containing a gas. The trapped ions are caused to collide with the gas, either by being injected with a high axial energy or by application of external excitation to cause fragmentation. Fragment ions of a given mass-to-charge ratio can then be isolated and excited to produce fragments of fragments. This process can be repeated to give multiple steps of mass spectrometry, MS . The fragment ions, and undissociated precursorions are then passed out of the linear ion trap and subjected to a further mass analysis step, for example in a time of flight device, to determine the mass spectrum of the ions.
摘要翻译：用于分析离子流的方法和装置首先使离子流进入第一质量分析步骤，以选择质量与电荷比在第一期望范围内的离子; 这使得能够使用具有高分辨率的质量分析器。然后将选定的离子通入含有气体的射频线性离子阱。被捕获的离子通过注入高轴向能量或通过施加外部激发而引起碎片而与气体碰撞。然后可以分离并激发给定质荷比的片段离子以产生碎片片段。这个过程可以重复进行质谱分析MS MS。然后将片段离子和未解离的前体从线性离子阱中通过，并进行进一步的质量分析步骤，例如在飞行时间装置中，以确定离子的质谱。

5. 发明申请

WO0028574A2 MASS SPECTROMETER INCLUDING MULTIPLE MASS ANALYSIS STAGES AND METHOD OF OPERATION, TO GIVE IMPROVED RESOLUTION 审中-公开
标题翻译：质谱仪包括多个质量分析阶段和操作方法，以提供改进的分辨率
公开(公告)号：WO0028574A2
公开(公告)日：2000-05-18
申请号：PCT/CA9901062
申请日：1999-11-09
申请人： UNIV BRITISH COLUMBIA , DOUGLAS DONALD J , ZHAOHUI DU , COLLINGS BRUCE A
发明人： DOUGLAS DONALD J , DU ZHAOHUI , COLLINGS BRUCE A
IPC分类号： H01J49/42
CPC分类号： H01J49/421 , H01J49/004 , H01J49/288 , H01J49/429
摘要： A method is provided of operating a mass spectrometer apparatus comprising a pair of quadrupole rod sets. Each quadrupole rod set is operated in a mass resolving mode. They may be operated in the same or different stability regions. The rod sets are operated to select essentially ions of the same mass to charge ratio, and are operated such that the combined resolution of the two rod sets is greater than the resolution of either rod set. The rod sets can be operated at relatively low resolution, with the combined peak shape from the two rod sets showing high resolution. This can make up for mechanical imperfections in the rod sets, losses due to high gas pressures, etc. A mass shift can be provided to give the desired resolution. The rod sets can be close coupled, and for this purpose neutralizing capacitors can be provided to prevent electrical interference between adjacent rod sets. The rod sets can be provided with the same frequency signal, which preferably is a phase locked and shifted, to give enhanced sensitivity.
摘要翻译：提供了一种操作包括一对四极杆组的质谱仪装置的方法。每个四极杆组以质量分辨模式运行。它们可以在相同或不同的稳定性区域中操作。操作杆组以选择基本上具有相同质荷比的离子，并且操作使得两个杆组的组合分辨率大于任一杆组的分辨率。杆组可以相对较低的分辨率操作，两个组合的组合峰形显示高分辨率。这可以弥补棒组中的机械缺陷，由于气体压力高导致的损失等。可以提供质量偏移以给出所需的分辨率。杆组可以紧密连接，为此，可以提供中和电容器以防止相邻杆组之间的电气干扰。杆组可以设置有相同的频率信号，其优选地是锁相和偏移的，以提供增强的灵敏度。

6. 发明专利

CA2483542A1 IMPROVED AXIAL EJECTION RESOLUTION IN MULTIPOLE MASS SPECTROMETERS 未知
公开(公告)号：CA2483542A1
公开(公告)日：2003-12-11
申请号：CA2483542
申请日：2003-04-02
申请人： MDS INC DBA MDS SCIEX
发明人： LONDRY FRANK , COLLINGS BRUCE A , HAGER JAMES , STOTT WILLIAM R
IPC分类号： G01N27/62 , H01J49/42
摘要： An improved method of operating a mass spectrometer having a linear ion trap wherein ions are axially ejected from the trap to a detector or subsequent mass analysis stage. The DC barrier field produced at the exit lens of the trap is scanned in conjunction with the scanning of other fields used to energize ions of select mass-to-charge ratios past the barrier field/exit lens. The technique can maximize the resolution obtainable from axial ejecti on over a wide mass range.

7. 发明专利

AU2003229212A8 Methods and apparatus for reducing artifacts in mass spectrometers 未知
公开(公告)号：AU2003229212A8
公开(公告)日：2003-12-19
申请号：AU2003229212
申请日：2003-05-29
申请人： MDS INC DBA MDS SCIEX
发明人： COLLINGS BRUCE A , STOTT WILLIAM R , LONDRY FRANK , HAGER JAMES
IPC分类号： G01N27/62 , H01J49/42
摘要： The invention solves the problem of artifact ghost peaks which can sometimes arise in mass spectrometers that employ a quadrupole rod set for both trapping and mass analyzing the trapped ions. The problem arises as a result of randomly distributed voltage gradients along the length of the rods. Three solutions are presented. The first approach involves improving the conduction characteristics of the rod sets. The second approach involves the application of at least one continuous axial DC field to the trapping quadrupole rod set in order to urge ions towards a pre-determined region of the trap, thereby avoiding voltage gradients. The third approach involves the application of one or more discrete axial fields to create one or more potential barriers along the axial dimension of the trap (in addition to the barriers used to initially trap the ions). These barriers prevent ions of differing voltage gradients from equilibrating with one another.

8. 发明专利

AU2003213946A1 FRAGMENTATION OF IONS BY RESONANT EXCITATION IN A HIGH ORDER MULTIPOLE FIELD, LOW PRESSURE ION TRAP 未知
公开(公告)号：AU2003213946A1
公开(公告)日：2003-10-27
申请号：AU2003213946
申请日：2003-04-02
申请人： MDS INC DOING BUSINESS AS MDS SCIEX
发明人： LONDRY FRANK , COLLINGS BRUCE A , STOTT WILLIAM R
IPC分类号： G01N27/62 , H01J49/00 , H01J49/42
摘要： In the field of mass spectrometry, a method and apparatus for fragmenting ions with a relatively high degree of resolution and efficiency. The technique includes trapping the ions in a linear ion trap, in which the background or neutral gas pressure is preferably on the order of 10-5 Torr. The trapped ions are resonantly excited for a relatively extended period of time, e.g., exceeding 50 ms, at relatively low excitation levels, e.g., less than 1 Volt (0-pk). The technique allows selective dissociation of ions with a high discrimination. High fragmentation efficiency may be achieved by superimposing a higher order multipole field onto the quadrupolar RF field used to trap the ions. The multipole field, preferably an octopole field, dampens the radial oscillatory motion of resonantly excited ions at the periphery of the trap. This reduces the probability that ions will eject radially from the trap thus increasing the probability of collision induced dissociation.

9. 发明专利

CA2481299A1 FRAGMENTATION OF IONS BY RESONANT EXCITATION IN A LOW PRESSURE ION TRAP 未知
公开(公告)号：CA2481299A1
公开(公告)日：2003-10-23
申请号：CA2481299
申请日：2003-04-02
申请人： MDS INC DBA MDS SCIEX
发明人： LONDRY FRANK , COLLINGS BRUCE A , STOTT WILLIAM R
IPC分类号： H01J49/42
摘要： In the field of mass spectrometry, a method and apparatus for fragmenting io ns with a relatively high degree of resolution. The technique includes trapping the ions in an ion trap, preferably a linear ion trap, in which the backgrou nd or neutral gas pressure is preferably on the order of 10-5 Torr. The trapped ions are resonantly excited for a relatively extended period of time, e.g., exceeding 50 ms, at relatively low excitation levels, e.g., less than 1V(0- pk). The technique allows selective dissociation of ions with a discriminati on of at least about 1 m/z at a practical fragmentation efficiencies. Apparatus and related methods are also disclosed for obtaining MS, MS2, MS3 and MSn spectrums at relatively high resolutions using the low pressure fragmentatio n technique.

10. 发明专利

CA2483542C IMPROVED AXIAL EJECTION RESOLUTION IN MULTIPOLE MASS SPECTROMETERS 未知
公开(公告)号：CA2483542C
公开(公告)日：2012-10-16
申请号：CA2483542
申请日：2003-04-02
申请人： MDS INC DBA MDS SCIEX
发明人： COLLINGS BRUCE A , HAGER JAMES , LONDRY FRANK , STOTT WILLIAM R
IPC分类号： G01N27/62 , H01J49/42
摘要： An improved method of operating a mass spectrometer having a linear ion trap wherein ions are axially ejected from the trap to a detector or subsequent mass analysis stage. The DC barrier field produced at the exit lens of the trap is scanned in conjunction with the scanning of other fields used to energize ions of select mass-to-charge ratios past the barrier field/exit lens. The technique can maximize the resolution obtainable from axial ejection over a wide mass range.

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