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1. 发明申请

WO2009094784A8 HIGH-THROUGHPUT SCREENING OF METABOLIC DISORDERS USING A LASER DESORPTION ION SOURCE COUPLED TO A MASS ANALYZER 审中-公开
标题翻译：使用激光解吸离子源与质谱分析仪相结合的代谢性疾病的高通量筛选
公开(公告)号：WO2009094784A8
公开(公告)日：2009-10-01
申请号：PCT/CA2009000126
申请日：2009-01-30
申请人： MDS ANALYTICAL TECH BU MDS INC , LIFE TECHNOLOGIES CORP , CORR JOHN J , QUINN ZOE A , SHUSHAN BORI
发明人： CORR JOHN J , QUINN ZOE A , SHUSHAN BORI
IPC分类号： H01J49/10 , C40B30/10 , G01N27/00 , G01N30/02 , G01N30/72 , H01J49/26
CPC分类号： H01J49/401 , G01N30/7233 , G01N2030/8411
摘要： Methods and kits for high throughput screening and analysis of metabolic disorders using a laser desorption ion source coupled to a mass analyzer (for example, MALDI) are provided. The metabolic disorders can be amino acid, organic acid or fatty acid oxidation disorders. A panel of disorders can be analyzed at high speeds. The methods and kits are particularly useful for newborn screening (NBS) of metabolic disorders.
摘要翻译：提供了使用耦合到质量分析器（例如MALDI）的激光解吸离子源进行高通量筛选和代谢紊乱分析的方法和试剂盒。代谢紊乱可以是氨基酸，有机酸或脂肪酸氧化失调。可以高速分析一组障碍。这些方法和试剂盒对代谢紊乱的新生儿筛查（NBS）特别有用。

2. 发明申请

WO2011094529A3 MASS ANALYSIS SYSTEM WITH LOW PRESSURE DIFFERENTIAL MOBILITY SPECTROMETER 审中-公开
标题翻译：低压微分移动光谱仪质谱分析系统
公开(公告)号：WO2011094529A3
公开(公告)日：2011-10-06
申请号：PCT/US2011022905
申请日：2011-01-28
申请人： MDS ANALYTICAL TECH BU MDS INC , APPLIED BIOSYSTEMS CANADA LTD , COVEY THOMAS R , SCHNEIDER BRADLEY B
发明人： COVEY THOMAS R , SCHNEIDER BRADLEY B
IPC分类号： H01J49/00
CPC分类号： H01J49/26 , G01N27/624 , H01J49/004 , Y10T436/24
摘要： A mass analysis system including a low pressure dissociation region and a differential mobility spectrometer. The differential mobility spectrometer including at least one pair of filter electrodes defining an ion flow path where the filter electrodes generate an electric field for passing through a selected portion of the sample ions based on the mobility characteristics of the sample ions. The differential mobility spectrometer also includes a voltage source that provides DC and RF voltages to at least one of the filter electrodes to generate the electric field, an ion inlet that receives sample ions that have passed through the low pressure dissociation region, and an ion outlet that outputs the selected portion of the sample ions. A mass spectrometer receives some or all of the selected portion of the sample ions.
摘要翻译：质量分析系统，包括低压解离区域和差分迁移谱仪。所述差分迁移率谱仪包括至少一对滤波器电极，所述至少一对滤波器电极限定离子流路径，其中所述滤波器电极基于所述样本离子的迁移率特性产生用于穿过样本离子的选定部分的电场。差分迁移率谱仪还包括电压源，该电压源向至少一个滤波器电极提供DC和RF电压以产生电场;离子入口，其接收已经通过低压离解区的样品离子;以及离子出口输出样本离子的选定部分。质谱仪接收部分或全部样本离子的选定部分。

3. 发明申请

WO2006104839A3 MULTIWELL SAMPLE PLATE WITH INTEGRATED IMPEDANCE ELECTRODES AND CONNECTION SCHEME 审中-公开
标题翻译：具有集成阻抗电极和连接方案的多芯片样品板
公开(公告)号：WO2006104839A3
公开(公告)日：2007-10-11
申请号：PCT/US2006010574
申请日：2006-03-24
申请人： MDS ANALYTICAL TECH BU MDS INC , FULLER CHRIS K , SUGARMAN JEFFREY H
发明人： FULLER CHRIS K , SUGARMAN JEFFREY H
IPC分类号： C12Q1/70 , G01N33/00
CPC分类号： B01L3/5085 , B01L2200/0647 , B01L2300/021 , B01L2300/0645 , B01L2300/1827 , G01N33/48728
摘要： As disclosed within, the present device is directed to a multi-well sample module having integrated impedance measuring electrodes (which allow for the generation of an electric field within each well and the measuring of the change in impedance of each of the well's contents) and an electrical connection scheme allowing simultaneous measurement of each well's change in impedance.
摘要翻译：如本文所公开的，本装置涉及具有集成阻抗测量电极（其允许在每个阱内产生电场和测量每个井的内容物的阻抗的变化）的多阱采样模块，以及一个允许同时测量每个井的阻抗变化的电气连接方案。

4. 发明申请

WO2008086618A8 APPARATUS AND METHOD FOR COOLING IONS 审中-公开
标题翻译：用于冷却离子的装置和方法
公开(公告)号：WO2008086618A8
公开(公告)日：2008-09-25
申请号：PCT/CA2008000094
申请日：2008-01-18
申请人： MDS ANALYTICAL TECH BU MDS INC , APPLERA CORP , LOBODA ALEXANDRE V
发明人： LOBODA ALEXANDRE V
IPC分类号： H01J49/02 , H01J49/10 , H01J49/26
CPC分类号： H01J49/142 , H01J49/0481
摘要： An apparatus for secondary ion mass spectrometry is provided having a target surface for supporting a sample on the target surface and an ion source configured to direct a beam of primary ions toward the sample to sputter secondary ions and neutral particles from the sample, A first chamber having an inlet provides gas to maintain high pressure at the sample for cooling the secondary ions and neutral particles, the high pressure being in the range of about 10 -3 to about 1000 Torr. A method of secondary ion mass spectrometry is provided having a target surface for supporting a sample, directing a beam of primary ions toward the sample to sputter secondary ions and neutral particles from the sample, and providing a high pressure at the sample for cooling the secondary ions and neutral particles, the high pressure being in the range of about 10 -3 to about 1000 Torr.
摘要翻译：提供了一种用于二次离子质谱的装置，其具有用于在样品表面上支撑样品的目标表面和被配置为将一次离子束引向样品以从样品溅射二次离子和中性粒子的离子源。第一室具有入口提供气体以在样品处保持高压以冷却次级离子和中性粒子，高压在约10 -3至约1000乇的范围内。提供了一种二次离子质谱法，其具有用于支撑样品的靶表面，将一次离子束导向样品以从样品溅射次级离子和中性粒子，并在样品处提供高压以冷却次级离子和中性粒子，高压在大约10 -3至大约1000托的范围内。

5. 发明申请

WO2008037058A1 METHOD FOR AXIAL EJECTION AND IN T RAP FRAGMENTATION USING AUXILIARY ELECTRODES IN A MULTIPOLE MASS SPECTROMETER 审中-公开
标题翻译：在多重质谱仪中使用辅助电极进行轴向射出和T波段分割的方法
公开(公告)号：WO2008037058A1
公开(公告)日：2008-04-03
申请号：PCT/CA2007001360
申请日：2007-08-02
申请人： MDS ANALYTICAL TECH BU MDS INC , APPLERA CORP , GUNA MIRCEA
发明人： GUNA MIRCEA
IPC分类号： H01J49/10 , H01J49/42
CPC分类号： H01J49/4225 , H01J49/0063 , H01J49/4285
摘要： A method of operating a mass spectrometer having an elongated rod set and a set of auxiliary electrodes is provided, the rod set having an entrance end and an exit end and a longitudinal axis. The method comprises a) admitting ions into the entrance end of the rod set; b) trapping at least some of the ions in the rod set by producing a barrier field at an exit member adjacent to the exit end of the rod set and by producing an RF field between the rods of the rod set; and, c) providing an auxiliary AC excitement voltage to the set of auxiliary electrodes to energize a first group of ions of a selected mass to charge.
摘要翻译：提供一种操作具有细长杆组和一组辅助电极的质谱仪的方法，该杆组具有入口端和出射端以及纵向轴线。该方法包括：a）将离子引入棒组的入口端; b）通过在与所述杆组的出口端相邻的出口构件处产生阻挡场并通过在所述杆组的杆之间产生RF场来捕获所述杆组中的至少一些离子; 以及c）向所述一组辅助电极提供辅助AC兴奋电压，以激励所选质量的第一组离子进行充电。

6. 发明申请

WO2009114932A1 SYSTEMS AND METHODS FOR ANALYZING SUBSTANCES USING A MASS SPECTROMETER 审中-公开
标题翻译：用质谱仪分析物质的系统和方法
公开(公告)号：WO2009114932A1
公开(公告)日：2009-09-24
申请号：PCT/CA2009000310
申请日：2009-03-12
申请人： MDS ANALYTICAL TECH BU MDS INC , LIFE TECHNOLOGIES CORP , LOCK CHRIS M , BLOOMFIELD NIC
发明人： LIFE TECHNOLOGIES CORPORATION , LOCK CHRIS M
IPC分类号： H01J49/26 , G01N30/72 , H01J49/10
CPC分类号： H01J49/004 , G01N30/7233 , H01J49/0027
摘要： Systems and methods for analyzing compounds in a sample. In one embodiment, the present technology is directed towards a method of analyzing a sample, comprising: emitting ions from the sample; selectively filtering the emitted ions for at least one designated trigger ion; fragmenting the designated trigger ions; scanning for a designated trigger ion fragment; and upon detecting the designated trigger ion fragment, scanning for at least one confirmatory ion fragment.
摘要翻译：用于分析样品中化合物的系统和方法。在一个实施方案中，本技术涉及分析样品的方法，包括：从样品发射离子; 针对至少一个指定的触发离子选择性地过滤所发射的离子; 使指定的触发离子碎裂; 扫描指定的触发离子片段; 并且在检测到指定的触发离子片段时，扫描至少一个确认离子片段。

7. 发明申请

WO2009085081A2 METHOD AND APPARATUS FOR REDUCING SPACE CHARGE IN AN ION TRAP 审中-公开
标题翻译：用于减少离子阱中空隙电荷的方法和装置
公开(公告)号：WO2009085081A2
公开(公告)日：2009-07-09
申请号：PCT/US2008012910
申请日：2008-11-19
申请人： MDS ANALYTICAL TECH BU MDS INC , APPLIED BIOSYSTEMS LLC , COLLINGS BRUCE A
发明人： COLLINGS BRUCE A
IPC分类号： H01J49/26 , H01J3/40 , H01J49/02
CPC分类号： H01J49/4225 , H01J49/4265
摘要： Ion trap apparatus and methods for efficiently addressing the effects of charge space caused by ion trap overfilling, useful in linear ion traps of mass spectrometers.
摘要翻译：用于有效解决由离子阱过度填充引起的电荷空间影响的离子阱设备和方法，可用于质谱仪的线性离子阱。

8. 发明申请

WO2009023946A8 METHOD FOR ENHANCING MASS ASSIGNMENT ACCURACY 审中-公开
标题翻译：提高质量分配精度的方法
公开(公告)号：WO2009023946A8
公开(公告)日：2009-04-23
申请号：PCT/CA2007001459
申请日：2007-08-21
申请人： MDS ANALYTICAL TECH BU MDS INC , APPLERA CORP , HAGER JAMES
发明人： HAGER JAMES
IPC分类号： H01J49/26 , H01J49/10
CPC分类号： H01J49/0031 , H01J49/0009 , H01J49/426
摘要： A method of operating an ion trap spectrometer system having an ion trap is provided. The method comprises a) providing a group of ions for analysis, wherein the group of ions includes a first analyte; b) providing a filtered first analyte having a first mass-to-charge ratio by filtering out ions other than the first analyte; c) storing the filtered first analyte in the ion trap; d) storing a first set of calibrant ions in the ion trap with the filtered first analyte, wherein the first set of calibrant ions has at least one calibrant ion and each calibrant ion in the first set of calibrant ions has a known mass-to-charge ratio; e) transmitting the filtered first analyte and the first set of calibrant ions from the ion trap for detection; f) detecting the filtered first analyte to generate a first analyte mass signal peak representing the filtered first analyte, and detecting each calibrant ion in the first set of calibrant ions to generate an associated calibrant mass signal peak for each calibrant ion in the first set of calibrant ions; and, g) calibrating a first mass signal derived from the first analyte mass signal peak by comparing the known mass-to-charge ratio and the associated calibrant mass signal peak for each calibrant ion in the first set of calibrant ions.
摘要翻译：提供了一种操作具有离子阱的离子阱光谱仪系统的方法。该方法包括a）提供一组用于分析的离子，其中该组离子包括第一分析物; b）通过过滤除第一分析物以外的离子来提供具有第一质荷比的过滤的第一分析物; c）将过滤的第一分析物存储在离子阱中; d）将第一组校准离子与经过滤的第一分析物一起存储在离子阱中，其中第一组校准离子具有至少一个校准离子，并且第一组校准离子中的每个校准离子具有已知的质量 - 收费比例; e）将来自离子阱的经过滤的第一分析物和第一组校准离子传送用于检测; f）检测经过滤的第一分析物以产生表示过滤的第一分析物的第一分析物质量信号峰值，并且检测第一组校准离子中的每个校准物离子以产生第一组中的每个校准离子的相关校准质量信号峰值校准离子; 以及g）通过比较第一组校准离子中的每个校准物离子的已知质量电荷比和相关联的校准质量信号峰来校准从第一分析物质量信号峰导出的第一质量信号。

9. 发明公开

EP2245450A4 METHOD OF QUANTITATION BY MASS SPECTROMETRY 有权转让
标题翻译：量化过程BY MASS
公开(公告)号：EP2245450A4
公开(公告)日：2015-11-25
申请号：EP09711367
申请日：2009-02-16
申请人： MDS ANALYTICAL TECH BU MDS INC , APPLIED BIOSYSTEMS CANADA LTD
发明人： THOMSON BRUCE A , LE BLANC YVES
IPC分类号： H01J49/00
CPC分类号： H01J49/0009
摘要： Quantitation is performed using data from a mass spectrometer. A calibration ion mass spectrum is acquired for each of a plurality of known quantities of a material. From the calibration spectra a plurality of ions that identify the material is determined, and for each ion of the plurality of ions a linear range and linear function are determined. A sample ion mass spectrum is acquired for an unknown quantity of the material. A sample intensity is measured for each ion of the plurality of ions from the sample spectrum. After acquiring the sample spectrum, one or more ions are selected from the plurality of ions such that the sample intensity of each of the one or more ions is within a linear range of the ion. The unknown quantity is calculated from the sample intensities and linear functions of the one or more ions.

10. 发明公开

EP2084730A4 METHOD FOR AXIAL EJECTION AND IN T RAP FRAGMENTATION USING AUXILIARY ELECTRODES IN A MULTIPOLE MASS SPECTROMETER 审中-公开
标题翻译：程序对AXIALAUSWURF和陷阱FRAGMENTATION利用辅助电极的多极SET-
公开(公告)号：EP2084730A4
公开(公告)日：2011-12-07
申请号：EP07785024
申请日：2007-08-02
申请人： MDS ANALYTICAL TECH BU MDS INC , APPLIED BIOSYSTEMS CANADA LTD
发明人： GUNA MIRCEA
IPC分类号： H01J49/10 , H01J49/00 , H01J49/42
CPC分类号： H01J49/4225 , H01J49/0063 , H01J49/4285
摘要： A method of operating a mass spectrometer having an elongated rod set and a set of auxiliary electrodes is provided, the rod set having an entrance end and an exit end and a longitudinal axis. The method comprises a) admitting ions into the entrance end of the rod set; b) trapping at least some of the ions in the rod set by producing a barrier field at an exit member adjacent to the exit end of the rod set and by producing an RF field between the rods of the rod set; and, c) providing an auxiliary AC excitement voltage to the set of auxiliary electrodes to energize a first group of ions of a selected mass to charge.

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