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51. 发明申请

US20120165892A1 SYSTEMS AND METHODS FOR OPTIMIZING AV/VV PACING DELAYS USING COMBINED IEGM/IMPEDANCE-BASED TECHNIQUES FOR USE WITH IMPLANTABLE MEDICAL DEVICES 有权
标题翻译：使用组合的IEGM /基于阻抗的技术优化AV / VV延迟的系统和方法与可植入医疗设备的使用
公开(公告)号：US20120165892A1
公开(公告)日：2012-06-28
申请号：US12976322
申请日：2010-12-22
申请人： Xiaoyi Min , Gene A. Bornzin , Martin Cholette , Kyungmoo Ryu , Catherine Tan
发明人： Xiaoyi Min , Gene A. Bornzin , Martin Cholette , Kyungmoo Ryu , Catherine Tan
IPC分类号： A61N1/365
CPC分类号： A61N1/36585 , A61N1/365 , A61N1/36521
摘要： Systems and methods are provided wherein intracardiac electrogram (IEGM) signals are used to determine a set of preliminary optimized atrioventricular (AV/PV) and interventricular (VV) pacing delays. In one example, the preliminary optimized AV/VV pacing delays are used as a starting point for further optimization based on impedance signals such as impedance signals detected between a superior vena cava (SVC) coil electrode and a device housing electrode, which are influenced by changes in stroke volume within the patient. Ventricular pacing is thereafter delivered using the AV/VV pacing delays optimized via impedance. In another example, parameters derived from IEGM signals are used to limit the scope of an impedance-based optimization search to reduce the number of pacing tests needed during impedance-based optimization. Biventricular and multi-site left ventricular (MSLV) examples are described.
摘要翻译：提供了系统和方法，其中使用心内电描记图（IEGM）信号来确定一组初步优化的房室（AV / PV）和心室间（VV）起搏延迟。在一个示例中，使用初步优化的AV / VV起搏延迟作为进一步优化的起点，其基于阻抗信号，例如在上腔静电（SVC）线圈电极和器件壳体电极之间检测到的阻抗信号，其受患者体内搏动量的变化。此后，使用通过阻抗优化的AV / VV起搏延迟来递送心室起搏。在另一个示例中，从IEGM信号导出的参数用于限制基于阻抗的优化搜索的范围，以减少基于阻抗的优化期间所需的起搏测试次数。描述了双心室和多部位左心室（MSLV）的例子。

52. 发明授权

US08180441B2 System and method for distinguishing among cardiac ischemia, hypoglycemia and hyperglycemia using an implantable medical device 有权
标题翻译：使用可植入医疗器械区分心脏缺血，低血糖和高血糖的系统和方法
公开(公告)号：US08180441B2
公开(公告)日：2012-05-15
申请号：US12360822
申请日：2009-01-27
申请人： Jong Gill , Peter Boileau , Rupinder Bharmi , Xiaoyi Min , Joseph J. Florio , Michael E. Benser , Gene A. Bornzin
发明人： Jong Gill , Peter Boileau , Rupinder Bharmi , Xiaoyi Min , Joseph J. Florio , Michael E. Benser , Gene A. Bornzin
IPC分类号： A61B5/0468
CPC分类号： A61N1/3962 , A61B5/0452 , A61B5/0468 , A61B5/14532 , A61N1/3621 , A61N1/3627 , A61N1/36557 , A61N1/3925
摘要： Techniques are described for detecting ischemia, hypoglycemia or hyperglycemia based on intracardiac electrogram (IEGM) signals. Ischemia is detected based on a shortening of the interval between the QRS complex and the end of a T-wave (QTmax), alone or in combination with a change in ST segment elevation. Alternatively, ischemia is detected based on a change in ST segment elevation combined with minimal change in the interval between the QRS complex and the end of the T-wave (QTend). Hypoglycemia is detected based on a change in ST segment elevation along with a lengthening of either QTmax or QTend. Hyperglycemia is detected based on a change in ST segment elevation along with minimal change in QTmax and in QTend. By exploiting QTmax and QTend in combination with ST segment elevation, changes in ST segment elevation caused by hypo/hyperglycemia can be properly distinguished from changes caused by ischemia.
摘要翻译：描述了基于心内电描记图（IEGM）信号检测缺血，低血糖或高血糖的技术。基于QRS复合体与T波结束（QTmax）之间的间隔的缩短单独或与ST段抬高的变化相结合来检测局部缺血。或者，基于ST段抬高的变化结合QRS复合体与T波结束（QTend）之间的间隔的最小变化来检测局部缺血。基于ST段抬高的变化以及QTmax或QTend的延长来检测低血糖。基于ST段抬高的变化以及QTmax和QTend中的最小变化来检测高血糖。通过利用QTmax和QTend与ST段抬高相结合，可以将由低/高血糖引起的ST段抬高的变化与缺血引起的变化进行适当区分。

53. 发明申请

US20110060230A1 DETERMINATION OF DIASTOLIC HEART FAILURE 有权
标题翻译：糖尿病心绞痛的确定
公开(公告)号：US20110060230A1
公开(公告)日：2011-03-10
申请号：US12943653
申请日：2010-11-10
申请人： Jong Gill , Xiaoyi Min , Gene A. Bornzin , Eric Falkenberg
发明人： Jong Gill , Xiaoyi Min , Gene A. Bornzin , Eric Falkenberg
IPC分类号： A61B5/0215 , A61B5/02
CPC分类号： A61B5/0215 , A61B5/042 , A61B5/0464 , A61B5/053 , A61B7/00 , A61N1/36578
摘要： An exemplary method includes detecting a change in state of a cardiac valve, detecting elongation of the left ventricle substantially along its major axis, determining a time difference between the change in state of the cardiac valve and the elongation of the left ventricle and, based at least in part on the time difference, deciding whether a diastolic abnormality exists. Other exemplary methods, devices, systems, etc., are also disclosed.
摘要翻译：示例性方法包括检测心脏瓣膜的状态变化，检测左心室基本上沿其长轴的伸长，确定心脏瓣膜状态变化与左心室伸长之间的时间差，并基于至少部分地基于时间差，决定是否存在舒张异常。还公开了其它示例性方法，装置，系统等。

54. 发明申请

US20100081952A1 DETECTING ISCHEMIA USING AN IMPLANTABLE CARDIAC DEVICE BASED ON MORPHOLOGY OF CARDIAC PRESSURE SIGNAL 有权
标题翻译：使用基于心脏压力信号形态的可植入心脏器械检测异常
公开(公告)号：US20100081952A1
公开(公告)日：2010-04-01
申请号：US12632689
申请日：2009-12-07
申请人： Jong Gill , Peter Boileau , Gene A. Bornzin , Joseph J. Florio , Xiaoyi Min
发明人： Jong Gill , Peter Boileau , Gene A. Bornzin , Joseph J. Florio , Xiaoyi Min
IPC分类号： A61B5/0402
CPC分类号： A61B5/0215 , A61B5/0031 , A61B5/042 , A61B5/7239 , A61N1/36564
摘要： Methods and systems are presented for using an ICD to detect myocardial ischemia. One such method includes sensing via an implantable cardiac-rhythm-management device (ICRMD) a signal indicative of cardiac pressure; determining via a processor associated with the ICRMD, a derivative signal that is a first derivative of the sensed signal; measuring via the processor, a maximum positive value of the derivative signal; measuring via the processor, a maximum negative value of the derivative signal; and indicating via the processor, an ischemia based on a comparison of a ratio of the maximum positive value to the maximum negative value with a predetermined value.
摘要翻译：提出了使用ICD检测心肌缺血的方法和系统。一种这样的方法包括通过可植入心律管理装置（ICRMD）感测指示心脏压力的信号; 通过与ICRMD相关联的处理器确定作为感测信号的一阶导数的导数信号; 通过处理器测量导数信号的最大正值; 通过处理器测量导数信号的最大负值; 并且经由处理器指示基于将最大正值与最大负值的比率与预定值进行比较的缺血。

55. 发明授权

US07363077B1 Adaptive timing interval control method for treating congestive heart failure 有权
标题翻译：用于治疗充血性心力衰竭的自适应定时间隔控制方法
公开(公告)号：US07363077B1
公开(公告)日：2008-04-22
申请号：US10986010
申请日：2004-11-09
申请人： Xiaoyi Min , Gene A. Bornzin
发明人： Xiaoyi Min , Gene A. Bornzin
IPC分类号： A61N1/362 , A61N1/37
CPC分类号： A61N1/3627 , A61N1/3682
摘要： A method of treating a heart with an implantable cardiac stimulation device involves transiently disturbing the steady state hemodynamic parameters by altering a cardiac cycle timing interval sufficient to reduce end diastolic volume for that cycle. The cardiac cycle timing interval is then adaptively controlled for successive cardiac cycles to achieve a second set of hemodynamic parameters.
摘要翻译：用可植入心脏刺激装置治疗心脏的方法包括通过改变心脏周期时间间隔来暂时干扰稳态血液动力学参数，该周期时间间隔足以减少该周期的舒张末期容积。心脏周期时间间隔然后自适应地控制连续的心脏周期以实现第二组血液动力学参数。

56. 发明授权

US07321792B1 Pacing therapy and acupuncture 失效
标题翻译：起搏治疗和针灸
公开(公告)号：US07321792B1
公开(公告)日：2008-01-22
申请号：US10392619
申请日：2003-03-19
申请人： Xiaoyi Min , Gene A. Bornzin , Mark W. Kroll , Xing Pei
发明人： Xiaoyi Min , Gene A. Bornzin , Mark W. Kroll , Xing Pei
IPC分类号： A61N1/08 , A61N1/36
CPC分类号： A61N1/3962 , A61H39/002 , A61H39/02 , A61N1/37252 , A61N1/3925 , Y10S128/907
摘要： Exemplary methods, devices and/or systems for detecting one or more needs and for requesting the delivery of power to one or more acupoints. Other methods, devices and/or systems are also disclosed.
摘要翻译：用于检测一个或多个需求并请求向一个或多个穴位传递电力的示例性方法，装置和/或系统。还公开了其它方法，装置和/或系统。

57. 发明授权

US07272443B2 System and method for predicting a heart condition based on impedance values using an implantable medical device 有权
标题翻译：基于使用可植入医疗装置的阻抗值来预测心脏病的系统和方法
公开(公告)号：US07272443B2
公开(公告)日：2007-09-18
申请号：US11014276
申请日：2004-12-15
申请人： Xiaoyi Min , Gene A. Bornzin , Euljoon Park
发明人： Xiaoyi Min , Gene A. Bornzin , Euljoon Park
IPC分类号： A61N1/365
CPC分类号： A61N1/36521 , A61B5/0538 , A61N1/3627 , A61N1/371
摘要： Techniques are provided for predicting the onset of a heart condition within a patient based on impedance measurements. Briefly, overloads in fluid levels in the thorax and in ventricular myocardial mass within the patient are detected based on impedance signals sensed using implanted electrodes. The onset of certain heart conditions is then predicted based on the overloads. For example, pulmonary edema arising due to diastolic heart failure is predicted based on the detection of on-going overloads in both fluid levels and ventricular mass. Ventricular hypertrophy is detected based on an on-going ventricular mass overload without a sustained fluid overload. Various other heart conditions may also be predicted based on specific combinations of recent or on-going overloads. Evoked response is exploited to corroborate the predictions. Appropriate warning signals are generated and preemptive therapy is initiated.
摘要翻译：提供了基于阻抗测量来预测患者心脏病状发作的技术。简单地说，基于使用植入电极感测到的阻抗信号来检测患者胸部液位水平和心室心肌质量的过载。然后基于过载来预测某些心脏状况的发作。例如，由于舒张性心力衰竭引起的肺水肿基于检测流体水平和心室质量中的持续过载而被预测。基于正在进行的心室质量超载而无持续的流体超载检测出心室肥大。还可以基于最近或正在进行的过载的特定组合来预测各种其他心脏状况。被诱发的反应被利用来证实预测。产生适当的警告信号并开始抢先治疗。

58. 发明申请

US20140039238A1 SYSTEMS AND METHODS FOR CONTROLLING NEUROSTIMULATION OF ACUPUNCTURE SITES USING AN IMPLANTABLE CARDIAC RHYTHM MANAGEMENT DEVICE 有权
标题翻译：使用可植入式心脏管理装置控制针刺部位神经细胞的系统和方法
公开(公告)号：US20140039238A1
公开(公告)日：2014-02-06
申请号：US13563417
申请日：2012-07-31
申请人： Xiaoyi Min , Stuart Rosenberg , Taraneh Ghaffari Farazi , Timothy A. Fayram
发明人： Xiaoyi Min , Stuart Rosenberg , Taraneh Ghaffari Farazi , Timothy A. Fayram
IPC分类号： A61N1/365 , A61N2/00 , A61F7/00 , A61N1/39
CPC分类号： A61N1/36139 , A61B5/0215 , A61B5/042 , A61B5/0538 , A61B5/14532 , A61B5/4818 , A61B5/4836 , A61F7/00 , A61H39/002 , A61H39/06 , A61H2201/5002 , A61H2230/045 , A61H2230/305 , A61N1/3606 , A61N1/36114 , A61N1/36117 , A61N1/3621 , A61N1/3627 , A61N1/3962 , A61N2/02
摘要： Techniques are provided for use with an implantable cardiac rhythm management (CRMD) system equipped to deliver neurostimulation to acupuncture sites within anterior regions of the neck, thorax or abdomen of the patient. Parameters associated with the health of the patient are detected, such as parameters indicative of arrhythmia, heart failure and hypertension.
摘要翻译：技术提供用于与植入式心律管理（CRMD）系统一起使用，该系统被配备用于向患者的颈部，胸部或腹部前区域内的针灸位置递送神经刺激。检测与患者健康有关的参数，例如指示心律失常，心力衰竭和高血压的参数。

59. 发明授权

US08600520B2 Implantable lead assembly having a plurality of inductors 有权
标题翻译：具有多个电感器的可植入引线组件
公开(公告)号：US08600520B2
公开(公告)日：2013-12-03
申请号：US13449897
申请日：2012-04-18
申请人： Phong D. Doan , Xiaoyi Min , Virote Indravudh
发明人： Phong D. Doan , Xiaoyi Min , Virote Indravudh
IPC分类号： A61N1/00
CPC分类号： A61N1/05 , A61N1/086 , A61N1/3605 , A61N1/362 , H01F5/02 , H01F2005/025 , Y10T29/49002 , Y10T29/49071
摘要： In accordance with an embodiment, an implantable lead assembly is provided comprised of an elongated body including a distal end, a proximal end having a header connector portion for coupling the elongated body with an implantable medical device, and an intermediate segment located between the distal and proximal ends. An intermediate electrode is disposed at the intermediate segment along the elongated body. A conductor is disposed in the elongated body and electrically coupled with the header connector portion and the intermediate electrode. The conductor wound within the intermediate segment to form first and second inductive coils that are axially separated from each other by an inter-coil gap, wherein the first and second inductive coils have different self-resonant frequencies.
摘要翻译：根据一个实施例，提供一种可植入引线组件，其包括细长主体，其包括远端，近端具有用于将细长主体与可植入医疗装置连接的插头连接器部分，以及位于远端和近端中间电极沿着细长体设置在中间部分。导体设置在细长主体中并与插头连接器部分和中间电极电耦合。导体缠绕在中间段内以形成通过线圈间隙彼此轴向分离的第一和第二感应线圈，其中第一和第二感应线圈具有不同的自谐振频率。

60. 发明授权

US08504153B2 System and method for estimating cardiac pressure based on cardiac electrical conduction delays using an implantable medical device 有权
公开(公告)号：US08504153B2
公开(公告)日：2013-08-06
申请号：US11779380
申请日：2007-07-18
申请人： Brian Jeffrey Wenzel , Dan E. Gutfinger , Mihir Naware , Xiaoyi Min , Jeffery Siou , Anders Bjorling , Dorin Panescu
发明人： Brian Jeffrey Wenzel , Dan E. Gutfinger , Mihir Naware , Xiaoyi Min , Jeffery Siou , Anders Bjorling , Dorin Panescu
IPC分类号： A61N1/365
CPC分类号： A61B5/02156 , A61B5/0215 , A61B5/72 , A61N1/365 , A61N1/36564 , A61N1/36578 , A61N1/3682 , A61N1/3684 , A61N1/37258
摘要： Techniques are provided for estimating left atrial pressure (LAP) or other cardiac performance parameters based on measured conduction delays. In particular, LAP is estimated based interventricular conduction delays. Predetermined conversion factors stored within the device are used to convert the various the conduction delays into LAP values or other appropriate cardiac performance parameters. The conversion factors may be, for example, slope and baseline values derived during an initial calibration procedure performed by an external system, such as an external programmer. In some examples, the slope and baseline values may be periodically re-calibrated by the implantable device itself. Techniques are also described for adaptively adjusting pacing parameters based on estimated LAP or other cardiac performance parameters. Still further, techniques are described for estimating conduction delays based on impedance or admittance values and for tracking heart failure therefrom.

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