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1. 发明授权

US08923965B2 Systems and methods for optimizing AV/VV pacing delays using combined IEGM/impedance-based techniques for use with implantable medical devices 有权
标题翻译：使用组合的基于IEGM /阻抗的技术优化AV / VV起搏延迟的系统和方法，用于可植入医疗设备
公开(公告)号：US08923965B2
公开(公告)日：2014-12-30
申请号：US12976322
申请日：2010-12-22
申请人： Xiaoyi Min , Gene A. Bornzin , Martin Cholette , Kyungmoo Ryu , Catherine Tan
发明人： Xiaoyi Min , Gene A. Bornzin , Martin Cholette , Kyungmoo Ryu , Catherine Tan
IPC分类号： A61B1/00 , A61N1/365
CPC分类号： A61N1/36585 , A61N1/365 , A61N1/36521
摘要： Systems and methods are provided wherein intracardiac electrogram (IEGM) signals are used to determine a set of preliminary optimized atrioventricular (AV/PV) and interventricular (VV) pacing delays. In one example, the preliminary optimized AV/VV pacing delays are used as a starting point for further optimization based on impedance signals such as impedance signals detected between a superior vena cava (SVC) coil electrode and a device housing electrode, which are influenced by changes in stroke volume within the patient. Ventricular pacing is thereafter delivered using the AV/VV pacing delays optimized via impedance. In another example, parameters derived from IEGM signals are used to limit the scope of an impedance-based optimization search to reduce the number of pacing tests needed during impedance-based optimization. Biventricular and multi-site left ventricular (MSLV) examples are described.
摘要翻译：提供了系统和方法，其中使用心内电描记图（IEGM）信号来确定一组初步优化的房室（AV / PV）和心室间（VV）起搏延迟。在一个示例中，使用初步优化的AV / VV起搏延迟作为进一步优化的起点，其基于阻抗信号，例如在上腔静电（SVC）线圈电极和器件壳体电极之间检测到的阻抗信号，其受患者体内搏动量的变化。此后，使用通过阻抗优化的AV / VV起搏延迟来递送心室起搏。在另一个示例中，从IEGM信号导出的参数用于限制基于阻抗的优化搜索的范围，以减少基于阻抗的优化期间所需的起搏测试次数。描述了双心室和多部位左心室（MSLV）的例子。

2. 发明申请

US20120165892A1 SYSTEMS AND METHODS FOR OPTIMIZING AV/VV PACING DELAYS USING COMBINED IEGM/IMPEDANCE-BASED TECHNIQUES FOR USE WITH IMPLANTABLE MEDICAL DEVICES 有权
标题翻译：使用组合的IEGM /基于阻抗的技术优化AV / VV延迟的系统和方法与可植入医疗设备的使用
公开(公告)号：US20120165892A1
公开(公告)日：2012-06-28
申请号：US12976322
申请日：2010-12-22
申请人： Xiaoyi Min , Gene A. Bornzin , Martin Cholette , Kyungmoo Ryu , Catherine Tan
发明人： Xiaoyi Min , Gene A. Bornzin , Martin Cholette , Kyungmoo Ryu , Catherine Tan
IPC分类号： A61N1/365
CPC分类号： A61N1/36585 , A61N1/365 , A61N1/36521
摘要： Systems and methods are provided wherein intracardiac electrogram (IEGM) signals are used to determine a set of preliminary optimized atrioventricular (AV/PV) and interventricular (VV) pacing delays. In one example, the preliminary optimized AV/VV pacing delays are used as a starting point for further optimization based on impedance signals such as impedance signals detected between a superior vena cava (SVC) coil electrode and a device housing electrode, which are influenced by changes in stroke volume within the patient. Ventricular pacing is thereafter delivered using the AV/VV pacing delays optimized via impedance. In another example, parameters derived from IEGM signals are used to limit the scope of an impedance-based optimization search to reduce the number of pacing tests needed during impedance-based optimization. Biventricular and multi-site left ventricular (MSLV) examples are described.
摘要翻译：提供了系统和方法，其中使用心内电描记图（IEGM）信号来确定一组初步优化的房室（AV / PV）和心室间（VV）起搏延迟。在一个示例中，使用初步优化的AV / VV起搏延迟作为进一步优化的起点，其基于阻抗信号，例如在上腔静电（SVC）线圈电极和器件壳体电极之间检测到的阻抗信号，其受患者体内搏动量的变化。此后，使用通过阻抗优化的AV / VV起搏延迟来递送心室起搏。在另一个示例中，从IEGM信号导出的参数用于限制基于阻抗的优化搜索的范围，以减少基于阻抗的优化期间所需的起搏测试次数。描述了双心室和多部位左心室（MSLV）的例子。

3. 发明授权

US09427579B2 System and method for performing renal denervation verification 有权
标题翻译：进行肾去神经支配验证的系统和方法
公开(公告)号：US09427579B2
公开(公告)日：2016-08-30
申请号：US13248818
申请日：2011-09-29
申请人： Eric S. Fain , Martin Cholette , Gary R. Dulak , Gene A. Bornzin , John W. Poore
发明人： Eric S. Fain , Martin Cholette , Gary R. Dulak , Gene A. Bornzin , John W. Poore
IPC分类号： A61B18/12 , A61N1/36 , A61B5/00 , A61B5/04 , A61N1/05 , A61B18/00 , A61B18/14
CPC分类号： A61B18/1492 , A61B5/04001 , A61B5/7203 , A61B2018/00404 , A61B2018/00434 , A61B2018/00511 , A61B2018/00577 , A61B2018/00839 , A61N1/0551 , A61N1/36007
摘要： A renal denervation feedback method is described that performs a baseline measurement of renal nerve plexus electrical activity at a renal vessel; denervates at least some tissue proximate the renal vessel after performing the baseline measurement; performs a post-denervation measurement of renal nerve plexus electrical activity at the renal vessel, after the denervating; and assesses denervation of the renal vessel based on a comparison of the baseline measurement and the post-denervation measurement of renal nerve plexus electrical activity at the renal vessel.
摘要翻译：描述了肾去神经反馈方法，其执行肾血管的肾神经丛电活动的基线测量; 在进行基线测量后，至少接近肾血管的一些组织去神经细胞; 在去神经元后，对肾血管进行肾神经丛电活动的去神经后测量; 并且基于在肾血管上的肾神经丛电活动的基线测量和去神经后测量的比较来评估肾血管的去神经支配。

4. 发明申请

US20130085489A1 SYSTEM AND METHOD FOR PERFORMING RENAL DENERVATION VERIFICATION 有权
标题翻译：用于执行肾衰竭验证的系统和方法
公开(公告)号：US20130085489A1
公开(公告)日：2013-04-04
申请号：US13248818
申请日：2011-09-29
申请人： Eric S. Fain , Martin Cholette , Gary R. Dulak , Gene A. Bornzin , John W. Poore
发明人： Eric S. Fain , Martin Cholette , Gary R. Dulak , Gene A. Bornzin , John W. Poore
IPC分类号： A61B18/12
CPC分类号： A61B18/1492 , A61B5/04001 , A61B5/7203 , A61B2018/00404 , A61B2018/00434 , A61B2018/00511 , A61B2018/00577 , A61B2018/00839 , A61N1/0551 , A61N1/36007
摘要： A renal denervation feedback method is described that performs a baseline measurement of renal nerve plexus electrical activity at a renal vessel; denervates at least some tissue proximate the renal vessel after performing the baseline measurement; performs a post-denervation measurement of renal nerve plexus electrical activity at the renal vessel, after the denervating; and assesses denervation of the renal vessel based on a comparison of the baseline measurement and the post-denervation measurement of renal nerve plexus electrical activity at the renal vessel.
摘要翻译：描述了肾去神经反馈方法，其执行肾血管的肾神经丛电活动的基线测量; 在进行基线测量后，至少接近肾血管的一些组织去神经细胞; 在去神经元后，对肾血管进行肾神经丛电活动的去神经后测量; 并且基于在肾血管上的肾神经丛电活动的基线测量和去神经后测量的比较来评估肾血管的去神经支配。

5. 发明申请

US20120215271A1 SYSTEMS AND METHODS FOR DISCONNECTING ELECTRODES OF LEADS OF IMPLANTABLE MEDICAL DEVICES DURING AN MRI TO REDUCE LEAD HEATING 审中-公开
标题翻译：用于断开MRI中的可植入医疗器械引线电极的系统和方法，以减少引线加热
公开(公告)号：US20120215271A1
公开(公告)日：2012-08-23
申请号：US13450127
申请日：2012-04-18
申请人： Xiaoyi Min , Martin Cholette , J. Christopher Moulder
发明人： Xiaoyi Min , Martin Cholette , J. Christopher Moulder
IPC分类号： A61N1/37 , A61N1/39
CPC分类号： A61N1/3718 , A61N1/086
摘要： Systems and methods are provided for reducing heating within pacing/sensing leads of a pacemaker or implantable, cardioverter-defibrillator that occurs due to induced loop currents during a magnetic resonance imaging (MRI) procedure, or in the presence of other sources of strong radio frequency (RF) fields. For example, bipolar coaxial leads are described herein wherein the ring conductor of the lead is disconnected from the ring electrode in response to detection of MRI fields so as to convert the ring conductor into an RF shield for shielding the inner tip conductor of the lead so as to reduce the strength of loop currents induced therein and hence reduce tip heating.
摘要翻译：提供的系统和方法用于减少起搏器或可植入的心律转复除颤器的起搏/感测引线内的加热，由于在磁共振成像（MRI）程序期间由于感应回路电流而发生，或者存在其他强射频源（RF）领域。例如，这里描述了双极同轴引线，其中响应于MRI场的检测，引线的环形导体与环形电极断开，以便将环形导体转换成用于屏蔽引线的内部尖端导体的RF屏蔽以减少其中引起的环路电流的强度，从而减少尖端加热。

6. 发明申请

US20100106227A1 Systems and Methods for Disconnecting Electrodes of Leads of Implantable Medical Devices During an MRI to Reduce Lead Heating 审中-公开
标题翻译：在MRI期间断开可植入医疗器械引线电极的系统和方法，以减少引线加热
公开(公告)号：US20100106227A1
公开(公告)日：2010-04-29
申请号：US12257245
申请日：2008-10-23
申请人： Xiaoyi Min , Martin Cholette , J. Christopher Moulder
发明人： Xiaoyi Min , Martin Cholette , J. Christopher Moulder
IPC分类号： A61N1/05 , A61N1/372 , A61N1/36
CPC分类号： A61N1/3718 , A61N1/086
摘要： Systems and methods are provided for reducing heating within pacing/sensing leads of a pacemaker or implantable cardioverter-defibrillator that occurs due to induced loop currents during a magnetic resonance imaging (MRI) procedure, or in the presence of other sources of strong radio frequency (RF) fields. For example, bipolar coaxial leads are described herein wherein the ring conductor of the lead is disconnected from the ring electrode in response to detection of MRI fields so as to convert the ring conductor into an RF shield for shielding the inner tip conductor of the lead so as to reduce the strength of loop currents induced therein and hence reduce tip heating. Techniques are also described herein for selectively disconnecting the tip electrode of the lead during an MRI procedure, except during actual delivery of pacing pulses, so as to permit delivery of individual pacing pulses to pacemaker dependent patients during the MRI. Still other techniques describe the use of both RF shielding and tip switching.
摘要翻译：提供了系统和方法，用于减少起搏器或植入式心律转复除颤器的起搏/感应引线内的加热，由于在磁共振成像（MRI）程序期间由于感应回路电流而发生，或者存在其他强射频源（ RF）字段。例如，这里描述了双极同轴引线，其中响应于MRI场的检测，引线的环形导体与环形电极断开，以便将环形导体转换成用于屏蔽引线的内部尖端导体的RF屏蔽以减少其中引起的环路电流的强度，从而减少尖端加热。本文还描述了在MRI过程期间选择性地断开引线的尖端电极的技术，除了在实际递送起搏脉冲之前，以便允许在MRI期间将起搏器依赖患者的单个起搏脉冲输送到起搏器依赖患者。其他技术还描述了使用RF屏蔽和尖端切换。

7. 发明申请

US20100049290A1 MRI COMPATIBLE LEAD 有权
标题翻译： MRI兼容导联
公开(公告)号：US20100049290A1
公开(公告)日：2010-02-25
申请号：US12197957
申请日：2008-08-25
申请人： Xiaoyi Min , J. Christopher Moulder , Yong D. Zhao , Kevin L. Morgan , Martin Cholette , Phong D. Doan
发明人： Xiaoyi Min , J. Christopher Moulder , Yong D. Zhao , Kevin L. Morgan , Martin Cholette , Phong D. Doan
IPC分类号： A61N1/05
CPC分类号： A61N1/0563 , A61N1/086
摘要： Disclosed herein is an implantable medical lead. In one embodiment, the lead includes a ring electrode, a tip electrode, first and second helically wound coaxial conductor coils, and a distal coil transition. The coils extend between the proximal and distal ends of the lead. The distal coil transition is proximal to the ring electrode and near the distal end and is where the first coil transitions from being outside the second coil proximal of the distal coil transition to being inside the second coil distal of the distal coil transition.
摘要翻译：本文公开了可植入医疗引线。在一个实施例中，引线包括环形电极，尖端电极，第一和第二螺旋缠绕的同轴导体线圈和远端线圈转变。线圈在引线的近端和远端之间延伸。远侧线圈转变靠近环形电极并且靠近远端，并且是第一线圈从远端线圈过渡处的第二线圈的外侧转变到远端线圈转变远端的第二线圈内部的位置。

8. 发明授权

US08244375B2 MRI compatible lead 有权
标题翻译： MRI兼容铅
公开(公告)号：US08244375B2
公开(公告)日：2012-08-14
申请号：US12197957
申请日：2008-08-25
申请人： Xiaoyi Min , J. Christopher Moulder , Yong D. Zhao , Kevin L. Morgan , Martin Cholette , Phong D. Doan
发明人： Xiaoyi Min , J. Christopher Moulder , Yong D. Zhao , Kevin L. Morgan , Martin Cholette , Phong D. Doan
IPC分类号： A61N1/05
CPC分类号： A61N1/0563 , A61N1/086
摘要： Disclosed herein is an implantable medical lead. In one embodiment, the lead includes a ring electrode, a tip electrode, first and second helically wound coaxial conductor coils, and a distal coil transition. The coils extend between the proximal and distal ends of the lead. The distal coil transition is proximal to the ring electrode and near the distal end and is where the first coil transitions from being outside the second coil proximal of the distal coil transition to being inside the second coil distal of the distal coil transition.
摘要翻译：本文公开了可植入医疗引线。在一个实施例中，引线包括环形电极，尖端电极，第一和第二螺旋缠绕的同轴导体线圈和远端线圈转变。线圈在引线的近端和远端之间延伸。远侧线圈转变靠近环形电极并且靠近远端，并且是第一线圈从远端线圈过渡处的第二线圈的外侧转变到远端线圈转变远端的第二线圈内部的位置。

9. 发明授权

US08521291B1 Dual therapy electrical stimulation system for treating metabolic and eating disorders 有权
标题翻译：用于治疗代谢和进食障碍的双重治疗电刺激系统
公开(公告)号：US08521291B1
公开(公告)日：2013-08-27
申请号：US11555166
申请日：2006-10-31
申请人： Martin Cholette , Ruth Lyons
发明人： Martin Cholette , Ruth Lyons
IPC分类号： A61N1/00
CPC分类号： A61N1/36053 , A61N1/0509 , A61N1/36007
摘要： An exemplary method for treating an eating or metabolism disorder includes calling for delivery of energy to the stomach using a pulse train that includes use of pulses with a pulse width less than approximately 20 ms, a duty cycle greater than approximately 20% and a pulse train duration of less than approximately 10 seconds and calling for delivery of energy to a vagal nerve. Various other methods, devices, systems, etc., are also disclosed.
摘要翻译：用于治疗进食或代谢紊乱的示例性方法包括：使用包括使用脉冲宽度小于约20ms，占空比大于约20％的脉冲和脉冲串的脉冲串来呼叫将能量递送至胃持续时间少于约10秒，并呼吁将能量输送至迷走神经。还公开了各种其它方法，装置，系统等。

10. 发明授权

US08255051B2 Skin response monitoring for neural and cardiac therapies 有权
标题翻译：神经和心脏治疗的皮肤反应监测
公开(公告)号：US08255051B2
公开(公告)日：2012-08-28
申请号：US12783427
申请日：2010-05-19
申请人： Martin Cholette
发明人： Martin Cholette
IPC分类号： A61N1/36
CPC分类号： A61N1/36585 , A61B5/01 , A61B5/1455 , A61B5/4082 , A61B5/686 , A61N1/36071 , A61N1/36082 , A61N1/36135
摘要： An exemplary method includes emitting radiation subcutaneously; sensing at least some of the emitted radiation as reflected cutaneously; detecting an abnormal physiologic condition; and, based at least in part on the sensing, adjusting a stimulation therapy to treat the detected abnormal condition. In such a method, the abnormal condition may be an abnormal cardiac condition, an abnormal neural condition or other condition. Various other methods, devices, systems, etc., are also disclosed.
摘要翻译：一种示例性的方法包括：皮下发射辐射; 感测至少一些所发射的辐射，如皮肤反射; 检测异常生理状况; 并且至少部分地基于感测，调整刺激疗法以治疗检测到的异常状况。在这种方法中，异常状态可能是异常心脏病，异常神经病或其他状况。还公开了各种其它方法，装置，系统等。

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