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1. 发明授权

US08750981B2 Systems and methods for assessing heart failure and controlling cardiac resynchronization therapy using hybrid impedance measurement configurations 有权
标题翻译：用于评估心力衰竭并使用混合阻抗测量配置控制心脏再同步治疗的系统和方法
公开(公告)号：US08750981B2
公开(公告)日：2014-06-10
申请号：US13217554
申请日：2011-08-25
申请人： Gene A. Bornzin , Xiaoyi Min , Laurence S. Sloman , Steve Koh
发明人： Gene A. Bornzin , Xiaoyi Min , Laurence S. Sloman , Steve Koh
IPC分类号： A61B5/05 , A61B5/053 , A61N1/36 , A61N1/368 , A61B5/0205
CPC分类号： A61B5/053 , A61B5/0205 , A61B5/0538 , A61B5/686 , A61N1/36185 , A61N1/3627 , A61N1/3686
摘要： Techniques are provided for use with an implantable medical device for detecting and assessing heart failure and for controlling cardiac resynchronization therapy (CRT) based on impedance signals obtained using hybrid impedance configurations. The hybrid configurations exploit right atrial (RA)-based impedance measurement vectors and/or left ventricular (LV)-based impedance measurement vectors. In one example, current is injected between the device case and a ring electrode in the right ventricle (RV) or RA. RA-based impedance values are measured along vectors between the device case and an RA electrode. LV-based impedance values are measured along vectors between the device case and one or more electrodes of the LV. Heart failure and other cardiac conditions are detected and tracked using the measured impedance values. CRT delay parameters are also optimized based impedance. In this manner, multiple hybrid impedance measurement configurations are exploited whereby different vectors are used to inject current and measure impedance.
摘要翻译：提供技术用于可植入医疗装置，用于基于使用混合阻抗配置获得的阻抗信号来检测和评估心力衰竭并用于控制心脏再同步治疗（CRT）。混合配置利用基于右心房（RA）的阻抗测量向量和/或左心室（LV））的阻抗测量向量。在一个示例中，电流注入到装置壳体和右心室（RV）或RA中的环形电极之间。基于RA的阻抗值是沿器件壳体和RA电极之间的矢量测量的。基于LV的阻抗值在器件壳体和LV的一个或多个电极之间的矢量上测量。使用测量的阻抗值检测和跟踪心力衰竭和其他心脏状况。 CRT延迟参数也是基于阻抗的优化。以这种方式，利用多个混合阻抗测量配置，由此使用不同的矢量来注入电流并测量阻抗。

2. 发明申请

US20130110127A1 MULTI-PIECE DUAL-CHAMBER LEADLESS INTRA-CARDIAC MEDICAL DEVICE AND METHOD OF IMPLANTING SAME 有权
公开(公告)号：US20130110127A1
公开(公告)日：2013-05-02
申请号：US13352005
申请日：2012-01-17
申请人： Gene A. Bornzin , John W. Poore , Zoltan Somogyi , Xiaoyi Min
发明人： Gene A. Bornzin , John W. Poore , Zoltan Somogyi , Xiaoyi Min
IPC分类号： A61N1/05 , A61B19/00
CPC分类号： A61N1/059 , A61N1/0573 , A61N1/36521 , A61N1/37288 , A61N1/3756
摘要： A leadless intra-cardiac medical device (LIMD) includes an electrode assembly configured to be anchored within a first wall portion of a first chamber of a heart. The electrode assembly includes an electrode main body having a first securing helix, an electrode wire segment extending from the body, and a first segment-terminating contact positioned on the electrode wire segment. The device further includes a housing assembly configured to be anchored within a second wall portion of a second chamber of the heart. The housing assembly includes a body having a second securing helix, a housing wire segment extending from the body, and a second segment-terminating contact positioned on the housing wire segment. The device also includes a connector block that electrically connects the electrode wire segment to the housing wire segment by retaining the first and second segment-terminating contacts.

3. 发明授权

US08090435B2 System and method for distinguishing among cardiac ischemia, hypoglycemia and hyperglycemia using an implantable medical device 有权
公开(公告)号：US08090435B2
公开(公告)日：2012-01-03
申请号：US12360826
申请日：2009-01-27
申请人： Jong Gill , Peter Boileau , Rupinder Bharmi , Xiaoyi Min , Joseph J. Florio , Michael E. Benser , Gene A. Bornzin
发明人： Jong Gill , Peter Boileau , Rupinder Bharmi , Xiaoyi Min , Joseph J. Florio , Michael E. Benser , Gene A. Bornzin
IPC分类号： A61B5/0402
CPC分类号： A61N1/3962 , A61B5/0452 , A61B5/0468 , A61B5/14532 , A61N1/3621 , A61N1/3627 , A61N1/36557 , A61N1/3925
摘要： Techniques are described for detecting ischemia, hypoglycemia or hyperglycemia based on intracardiac electrogram (IEGM) signals. Ischemia is detected based on a shortening of the interval between the QRS complex and the end of a T-wave (QTmax), alone or in combination with a change in ST segment elevation. Alternatively, ischemia is detected based on a change in ST segment elevation combined with minimal change in the interval between the QRS complex and the end of the T-wave (QTend). Hypoglycemia is detected based on a change in ST segment elevation along with a lengthening of either QTmax or QTend. Hyperglycemia is detected based on a change in ST segment elevation along with minimal change in QTmax and in QTend. By exploiting QTmax and QTend in combination with ST segment elevation, changes in ST segment elevation caused by hypo/hyperglycemia can be properly distinguished from changes caused by ischemia.

4. 发明授权

US07925348B1 Extra-cardiac impedance based hemodynamic assessment method and system 有权
标题翻译：基于心外阻抗的血液动力学评估方法及系统
公开(公告)号：US07925348B1
公开(公告)日：2011-04-12
申请号：US12694078
申请日：2010-01-26
申请人： Gene A. Bornzin , Xiaoyi Min
发明人： Gene A. Bornzin , Xiaoyi Min
IPC分类号： A61N1/00
CPC分类号： A61N1/36521 , A61B5/02028 , A61B5/029 , A61B5/0295 , A61B5/0422 , A61B5/0452 , A61B5/0538 , A61B5/686 , A61N1/3622 , A61N1/3956
摘要： A medical device is provided that comprises a lead assembly configured to be at least partially located proximate to the heart. The lead assembly includes an extra-cardiac (EC) electrode to be positioned proximate to at least one of a superior vena cava (SVC) and a left ventricle (LV) of a heart. The lead assembly includes a subcutaneous remote-cardiac (RC) electrode configured to be located remote from the heart such that at least a portion of the greater vessels are interposed between the RC electrode and the EC electrode to establish an extra-cardiac impedance (ECI) vector. The processor module measures extra-cardiac impedance along the ECI vector to obtain ECI measurements. The processor module assesses a hemodynamic performance based on the ECI measurements.
摘要翻译：提供了一种医疗装置，其包括构造成至少部分地定位成靠近心脏的引线组件。引线组件包括心脏（EC）电极，其被定位成接近心脏的上腔静脉（SVC）和左心室（LV）中的至少一个。引线组件包括构造成远离心脏的皮下远心电（RC）电极，使得至少一部分更大的血管置于RC电极和EC电极之间以建立心外阻抗（ECI ）矢量。处理器模块测量沿着ECI向量的心脏外阻抗以获得ECI测量值。处理器模块基于ECI测量来评估血液动力学性能。

5. 发明申请

US20110066028A1 SYSTEMS AND METHODS FOR REMOTE MONITORING OF IMPLANTABLE MEDICAL DEVICE LEAD TEMPERATURES DURING AN MRI PROCEDURE 审中-公开
标题翻译：在MRI程序中远程监测可植入医疗设备引导温度的系统和方法
公开(公告)号：US20110066028A1
公开(公告)日：2011-03-17
申请号：US12558366
申请日：2009-09-11
申请人： Xiaoyi Min , Gene A. Bornzin
发明人： Xiaoyi Min , Gene A. Bornzin
IPC分类号： A61B5/01 , A61N1/08 , A61B5/055
CPC分类号： G01R33/288 , A61B5/01 , A61N1/056 , A61N1/08
摘要： Systems and methods are provided for detecting and responding to excessive heating of implantable medical device leads, such as leads used with pacemakers or implantable cardioverter-defibrillators (ICDs), during a magnetic resonance imaging (MRI) procedure. In one example, a critical temperature is determined for the lead that is representative, e.g., of the temperature at which tissue damage might occur or pacing/sensing might be significantly impaired. A temperature threshold is then set based on the critical temperature by subtracting a predetermined safety margin. Lead temperatures are then sensed during the MRI procedure. The lead temperatures are compared against the threshold and suitable warnings are transmitted to an external monitoring system if lead temperatures exceed their thresholds so that the attending personnel can take corrective action. The implantable device may also be programmed to take corrective action, such as automatically changing pacing modes, adjusting pulse magnitudes or sensitivity values, etc.
摘要翻译：提供了系统和方法，用于在磁共振成像（MRI）过程期间检测和响应可植入医疗装置引线的过度加热，例如与起搏器或植入式心律转复除颤器（ICD）一起使用的引线。在一个实例中，确定代表性的导线的临界温度，例如组织损伤可能发生的温度，或起搏/感测可能受到显着损害。然后通过减去预定的安全裕度，基于临界温度设定温度阈值。然后在MRI过程中检测铅温度。将引导温度与阈值进行比较，如果引线温度超过其阈值，则合适的警告将传输到外部监控系统，以便主管人员能够采取纠正措施。也可以将可植入装置编程为采取校正动作，例如自动改变起搏模式，调节脉冲幅度或灵敏度值等。

6. 发明授权

US07643872B2 System and method for detecting cardiac ischemia based on T-Waves using an implantable medical device 有权
标题翻译：用于使用可植入医疗装置检测基于T波的心脏缺血的系统和方法
公开(公告)号：US07643872B2
公开(公告)日：2010-01-05
申请号：US11686784
申请日：2007-03-15
申请人： Xiaoyi Min , Yougandh Chitre , Jeffery D. Snell , Gene A. Bornzin , Jong Kil
发明人： Xiaoyi Min , Yougandh Chitre , Jeffery D. Snell , Gene A. Bornzin , Jong Kil
IPC分类号： A61B5/0452 , A61N1/36
CPC分类号： A61B5/0452 , A61B5/0456 , A61B5/046 , A61B5/0464 , A61B5/7242 , A61N1/3627 , A61N1/3702
摘要： A technique is provided for detecting episodes of cardiac ischemia based on an examination of the total energy of T-waves. Since cardiac ischemia is often a precursor to acute myocardial infarction (AMI) or ventricular fibrillation (VF), the technique thereby provides a method for predicting the possible onset of AMI or VF. Briefly, the technique integrates internal electrical cardiac signals occurring during T-waves and then compares the result against a running average. If the result exceeds the average by some predetermined amount, ischemia is thereby detected and a warning signal is provided to the patient. The maximum slope of the T-wave is also exploited. Techniques are also set forth herein for reliably detecting T-waves, which help prevent P-waves from being misinterpreted as T-waves on unipolar sensing channels. The T-wave detection technique may be used in conjunction with ischemia detection or for other purposes.
摘要翻译：提供了一种基于对T波总能量的检查来检测心脏缺血发作的技术。由于心脏缺血通常是急性心肌梗死（AMI）或心室颤动（VF）的前兆，因此该技术提供了一种预测AMI或VF可能发作的方法。简而言之，该技术集成了T波期间发生的内部电心脏信号，然后将结果与运行平均值进行比较。如果结果超过平均预定量，则由此检测到缺血，并向患者提供警告信号。 T波的最大斜率也被利用。本文还阐述了可靠地检测T波的技术，这有助于防止P波被单解为单极感测通道上的T波。 T波检测技术可以与缺血检测或其他目的结合使用。

7. 发明申请

US20090177105A1 System and Method for Distinguishing Among Cardiac Ischemia, Hypoglycemia and Hyperglycemia Using an Implantable Medical Device 有权
公开(公告)号：US20090177105A1
公开(公告)日：2009-07-09
申请号：US12360826
申请日：2009-01-27
申请人： Jong Gill , Peter Boileau , Rupinder Bharmi , Xiaoyi Min , Joseph J. Florio , Michael E. Benser , Gene A. Bornzin
发明人： Jong Gill , Peter Boileau , Rupinder Bharmi , Xiaoyi Min , Joseph J. Florio , Michael E. Benser , Gene A. Bornzin
IPC分类号： A61B5/04
CPC分类号： A61N1/3962 , A61B5/0452 , A61B5/0468 , A61B5/14532 , A61N1/3621 , A61N1/3627 , A61N1/36557 , A61N1/3925
摘要： Techniques are described for detecting ischemia, hypoglycemia or hyperglycemia based on intracardiac electrogram (IEGM) signals. Ischemia is detected based on a shortening of the interval between the QRS complex and the end of a T-wave (QTmax), alone or in combination with a change in ST segment elevation. Alternatively, ischemia is detected based on a change in ST segment elevation combined with minimal change in the interval between the QRS complex and the end of the T-wave (QTend). Hypoglycemia is detected based on a change in ST segment elevation along with a lengthening of either QTmax or QTend. Hyperglycemia is detected based on a change in ST segment elevation along with minimal change in QTmax and in QTend. By exploiting QTmax and QTend in combination with ST segment elevation, changes in ST segment elevation caused by hypo/hyperglycemia can be properly distinguished from changes caused by ischemia.

8. 发明授权

US07155282B1 Automatic sensitivity control and method for use in an implantable cardiac stimulation device 有权
标题翻译：自动灵敏度控制和用于可植入心脏刺激装置的方法
公开(公告)号：US07155282B1
公开(公告)日：2006-12-26
申请号：US10719307
申请日：2003-11-21
申请人： Xiaoyi Min , Gene A. Bornzin , Jeffery D. Snell
发明人： Xiaoyi Min , Gene A. Bornzin , Jeffery D. Snell
IPC分类号： A61N1/362
CPC分类号： A61N1/3704 , A61B5/0452 , A61B5/0456
摘要： A threshold sensing control for use in an implantable cardiac stimulation device controls the sensing of cardiac activity during a current cardiac cycle of a heart while avoiding sensing a T wave. The system includes a sensing circuit that senses cardiac activity of the heart during a cardiac cycle preceding the current cardiac cycle, a detector that measures selected T wave and R wave characteristics of the cardiac activity and a control circuit that varies the sensing threshold based upon the measured selected R wave and T wave characteristics. The sensing threshold control may be implemented for both intrinsic and paced beats.
摘要翻译：用于可植入心脏刺激装置的阈值感测控制器控制在心脏的当前心动周期期间对心脏活动的感测，同时避免感测T波。该系统包括感测电路，该感测电路在当前心动周期之前的心动周期期间感测心脏的心脏活动，测量心脏活动的所选T波和R波特征的检测器以及基于测量选定的R波和T波特性。感测阈值控制可以针对内部节奏和节奏节拍实现。

9. 发明授权

US09017341B2 Multi-piece dual-chamber leadless intra-cardiac medical device and method of implanting same 有权
标题翻译：多片双室无引线心脏内心脏医疗器械及其植入方法
公开(公告)号：US09017341B2
公开(公告)日：2015-04-28
申请号：US13352005
申请日：2012-01-17
申请人： Gene A. Bornzin , John W. Poore , Zoltan Somogyi , Xiaoyi Min
发明人： Gene A. Bornzin , John W. Poore , Zoltan Somogyi , Xiaoyi Min
IPC分类号： A61B19/00 , A61N1/05 , A61N1/375 , A61N1/372 , A61N1/365
CPC分类号： A61N1/059 , A61N1/0573 , A61N1/36521 , A61N1/37288 , A61N1/3756
摘要： A leadless intra-cardiac medical device (LIMD) includes an electrode assembly configured to be anchored within a first wall portion of a first chamber of a heart. The electrode assembly includes an electrode main body having a first securing helix, an electrode wire segment extending from the body, and a first segment-terminating contact positioned on the electrode wire segment. The device further includes a housing assembly configured to be anchored within a second wall portion of a second chamber of the heart. The housing assembly includes a body having a second securing helix, a housing wire segment extending from the body, and a second segment-terminating contact positioned on the housing wire segment. The device also includes a connector block that electrically connects the electrode wire segment to the housing wire segment by retaining the first and second segment-terminating contacts.
摘要翻译：无引线心脏内心脏医疗装置（LIMD）包括被配置为锚定在心脏的第一腔室的第一壁部分内的电极组件。电极组件包括具有第一固定螺旋线的电极主体，从主体延伸的电极线段和位于电极线段上的第一段终止触点。该装置还包括壳体组件，其构造成锚固在心脏的第二腔室的第二壁部分内。壳体组件包括具有第二固定螺旋的主体，从主体延伸的壳体线段和位于壳体线段上的第二段终止触点。该装置还包括连接器块，其通过保持第一和第二段终止触点将电极线段电连接到壳体线段。

10. 发明授权

US09008777B2 Leadless intra-cardiac medical device with reduced number of feed-thrus 有权
标题翻译：无铅心脏内心脏医疗器械，饲料数量减少
公开(公告)号：US09008777B2
公开(公告)日：2015-04-14
申请号：US13529226
申请日：2012-06-21
申请人： Ali Dianaty , Gabriel A. Mouchawar , Gene A. Bornzin , John W. Poore , Xiaoyi Min , Zoltan Somogyi , Richard Williamson
发明人： Ali Dianaty , Gabriel A. Mouchawar , Gene A. Bornzin , John W. Poore , Xiaoyi Min , Zoltan Somogyi , Richard Williamson
IPC分类号： A61N1/00 , A61N1/375 , A61N1/368
CPC分类号： A61N1/3756 , A61B5/042 , A61N1/362 , A61N1/368 , Y10T29/49002
摘要： A leadless implantable medical device (LIMD) includes a housing formed from a battery and an end cap. A proximal end of the end cap forms an LIMD proximal end and a distal end of the battery case forms an LIMD distal end. A non-conductive coupler mechanically secures a terminal end of the battery case to a mating end of the end cap, while maintaining the battery case and end cap electrically separated. A first electrode projects from the proximal end of the end cap. An intra-cardiac (IC) device extension projects from the distal end of the battery case. The extension includes a second electrode that is electrically connected to the battery case. The second electrode is located remote from the LIMD distal end. An electronics module is located within an internal cavity of the end cap and communicates with the first and second electrodes.
摘要翻译：无引线植入式医疗装置（LIMD）包括由电池和端盖形成的壳体。端盖的近端形成LIMD近端，并且电池壳体的远端形成LIMD远端。非导电耦合器将电池壳体的终端机械地固定到端盖的配合端，同时保持电池壳体和端盖电气分离。第一电极从端盖的近端突出。心脏内（IC）装置延伸部从电池盒的远端伸出。该延伸部包括电连接到电池壳体的第二电极。第二电极远离LIMD远端。电子模块位于端盖的内部空腔内并与第一和第二电极连通。

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