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1. 发明授权

US07321792B1 Pacing therapy and acupuncture 失效
标题翻译：起搏治疗和针灸
公开(公告)号：US07321792B1
公开(公告)日：2008-01-22
申请号：US10392619
申请日：2003-03-19
申请人： Xiaoyi Min , Gene A. Bornzin , Mark W. Kroll , Xing Pei
发明人： Xiaoyi Min , Gene A. Bornzin , Mark W. Kroll , Xing Pei
IPC分类号： A61N1/08 , A61N1/36
CPC分类号： A61N1/3962 , A61H39/002 , A61H39/02 , A61N1/37252 , A61N1/3925 , Y10S128/907
摘要： Exemplary methods, devices and/or systems for detecting one or more needs and for requesting the delivery of power to one or more acupoints. Other methods, devices and/or systems are also disclosed.
摘要翻译：用于检测一个或多个需求并请求向一个或多个穴位传递电力的示例性方法，装置和/或系统。还公开了其它方法，装置和/或系统。

2. 发明授权

US07295873B1 Anti-tachycardia pacing method and apparatus for multi-chamber pacing 有权
标题翻译：用于多室起搏的抗心动过速起搏方法和装置
公开(公告)号：US07295873B1
公开(公告)日：2007-11-13
申请号：US10893710
申请日：2004-07-15
申请人： Xiaoyi Min , Gene A. Bornzin , Mark W. Kroll
发明人： Xiaoyi Min , Gene A. Bornzin , Mark W. Kroll
IPC分类号： A61N1/362
CPC分类号： A61N1/3622
摘要： Improved methods and devices perform tachycardia detection and anti-tachycardia pacing (ATP) to convert a tachycardia (e.g., VT or AT) to normal sinus rhythm. According to one embodiment, an anti-tachycardia pacing method includes sensing, during sinus rhythm, first and second cardiac signals at first and second sites, respectively, in a patient's heart. The first and second sites include left and right ventricles or left and right atria, for example. The method further includes sensing third and fourth cardiac signals at the first and second sites, respectively, during a tachycardia (e.g., ventricular tachycardia or atrial tachycardia). The cardiac signals are processed to provide respective values. One or more anti-tachycardia pacing pulses are delivered at the site closest to the reentrant circuit based on a comparison of a first ratio of the first and third values and a second ratio of the second and fourth values. Unipolar sensing of the cardiac signals may be employed by, for example, shorting together pairs of electrodes implanted at each site.
摘要翻译：改进的方法和装置执行心动过速检测和抗心动过速起搏（ATP）以将心动过速（例如VT或AT）转换为正常窦性心律。根据一个实施例，抗心动过速起搏方法包括在病人心脏中分别在窦性心律期间感测第一和第二部位的第一和第二心脏信号。第一和第二个地点包括左心室和右心室，例如左心房和右心房。该方法还包括在心动过速（例如，室性心动过速或心房心动过速）期间分别在第一和第二位置处感测第三和第四心脏信号。处理心脏信号以提供相应的值。基于第一值和第三值的第一比率以及第二和第四值的第二比率的比较，在最靠近可重入电路的位置处递送一个或多个抗心动过速起搏脉冲。可以通过例如将植入在每个部位的电极对短路来采用心脏信号的单极性感测。

3. 发明授权

US06748261B1 Implantable cardiac stimulation device for and method of monitoring progression or regression of heart disease by monitoring interchamber conduction delays 有权
标题翻译：通过监测车间传导延迟，可植入心脏刺激装置和监测心脏病进展或消退的方法
公开(公告)号：US06748261B1
公开(公告)日：2004-06-08
申请号：US09675462
申请日：2000-09-28
申请人： Mark W. Kroll , Joseph J. Florio , Gene A. Bornzin , Euljoon Park , Kerry A. Bradley
发明人： Mark W. Kroll , Joseph J. Florio , Gene A. Bornzin , Euljoon Park , Kerry A. Bradley
IPC分类号： A61B504
CPC分类号： A61N1/3627 , A61B5/0031 , A61B5/0456 , A61B5/046 , A61N1/3684
摘要： A system and method, for use in an implantable cardiac stimulation device, monitors progression or regression in heart disease such as congestive heart failure. The system includes a sensing circuit that derives an electrogram signal indicative of the electrical activity of the patient's heart. A processor processes the electrogram signal to determine interchamber conduction delays which are then stored in memory. The stored interchamber conduction delays may be later retrieved by way of a telemetry circuit. Relative changes in the interchamber conduction delays, over time, are indicative of progression or regression in the heart disease. The relative changes in the interchamber conduction delays may be further used to automatically adjust pacing parameters of the implantable cardiac stimulation device.
摘要翻译：用于可植入心脏刺激装置的系统和方法监测心脏疾病如充血性心力衰竭的进展或消退。该系统包括感测电路，其导出指示患者心脏的电活动的电描绘信号。处理器处理电描记图信号以确定然后存储在存储器中的车间传导延迟。存储的车间传导延迟可以稍后通过遥测电路检索。随着时间的推移，间歇传导延迟的相对变化表明心脏病发展或消退。室间传导延迟的相对变化可以进一步用于自动调整可植入心脏刺激装置的起搏参数。

4. 发明授权

US08121680B2 Subcutaneous cardiac stimulation device providing anti-tachycardia pacing therapy and method 有权
标题翻译：皮下心脏刺激装置提供抗心动过速起搏治疗和方法
公开(公告)号：US08121680B2
公开(公告)日：2012-02-21
申请号：US12113895
申请日：2008-05-01
申请人： Eric Falkenberg , Mark W. Kroll , Gene A. Bornzin
发明人： Eric Falkenberg , Mark W. Kroll , Gene A. Bornzin
IPC分类号： A61N1/39
CPC分类号： A61N1/0504 , A61N1/3622 , A61N1/37252
摘要： An implantable subcutaneous cardiac device includes at least two subcutaneous electrodes adapted for placement external to a heart beneath the skin of a patient. The device further includes an arrhythmia detector that detects a sustained tachyarrhythmia of the heart and a pulse generator that delivers anti-tachycardia pacing pulses to the subcutaneous electrodes in response to detection of a sustained tachyarrhythmia. The pacing pulses preferably have waveforms devoid of any exponential voltage decay and include rounded or substantially constant portions to minimize pain.
摘要翻译：植入式皮下心脏装置包括至少两个皮下电极，其适于放置在患者皮肤下方的心脏外部。该装置还包括检测心脏持续快速性心律失常的心律失常检测器和响应于持续快速性心律失常的检测而向皮下电极递送抗心动过速起搏脉冲的脉冲发生器。起搏脉冲优选具有没有任何指数电压衰减的波形，并且包括圆形或基本恒定的部分以最小化疼痛。

5. 发明授权

US07260433B1 Subcutaneous cardiac stimulation device providing anti-tachycardia pacing therapy and method 有权
公开(公告)号：US07260433B1
公开(公告)日：2007-08-21
申请号：US10937656
申请日：2004-09-08
申请人： Eric Falkenberg , Mark W. Kroll , Gene A. Bornzin
发明人： Eric Falkenberg , Mark W. Kroll , Gene A. Bornzin
IPC分类号： A61N1/00 , A61B5/02 , A61B5/04
CPC分类号： A61N1/3627 , A61N1/0504 , A61N1/3702 , A61N1/37288 , A61N1/3756
摘要： An implantable subcutaneous cardiac device includes at least two subcutaneous electrodes adapted for placement external to a heart beneath the skin of a patient. The device further includes an arrhythmia detector that detects a sustained tachyarrhythmia of the heart and a pulse generator that delivers anti-tachycardia pacing pulses to the subcutaneous electrodes in response to detection of a sustained tachyarrhythmia. The pacing pulses preferably have waveforms devoid of any exponential voltage decay and include rounded or substantially constant portions to minimize pain.

6. 发明授权

US07123961B1 Stimulation of autonomic nerves 有权
标题翻译：刺激自主神经
公开(公告)号：US07123961B1
公开(公告)日：2006-10-17
申请号：US10841094
申请日：2004-05-07
申请人： Mark W. Kroll , Gene A. Bornzin
发明人： Mark W. Kroll , Gene A. Bornzin
IPC分类号： A61N1/362
CPC分类号： A61N1/362 , A61B5/4035 , A61N1/36114
摘要： An exemplary method for stimulating an autonomic nerve that includes delivering power to, for example, an electrode at a set power level, determining whether the delivering achieved an autonomic response that affected cardiac function, and delivering power to the electrode at a reduced power level if the delivering affected the cardiac function. An exemplary device for performing such an exemplary method. Other exemplary methods and exemplary devices are also disclosed.
摘要翻译：一种用于刺激自主神经的示例性方法，其包括将功率传递到例如设定功率水平的电极，确定输送是否实现影响心脏功能的自主反应，以及如果传递影响心脏功能。用于执行这种示例性方法的示例性装置。还公开了其它示例性方法和示例性装置。

7. 发明授权

US06625493B2 Orientation of patient's position sensor using external field 有权
标题翻译：患者位置传感器使用外部场的方向
公开(公告)号：US06625493B2
公开(公告)日：2003-09-23
申请号：US09939197
申请日：2001-08-24
申请人： Mark W. Kroll , Chris Sorensen , Gene A. Bornzin
发明人： Mark W. Kroll , Chris Sorensen , Gene A. Bornzin
IPC分类号： A61N1362
CPC分类号： A61N1/36585 , A61N1/36521 , A61N1/36542
摘要： An implantable cardiac stimulation device is equipped with an accelerometer-based sensor to sense a patient's movement and produce a vertical acceleration component indicative of a patient's acceleration in a vertical direction. A vertical velocity component is computed from the vertical acceleration component. The device may be further equipped with a magnetic field sensor to sense the earth's magnetic field as a way to obtain a true vertical orientation, against which the accelerometer-based sensor can be calibrated.
摘要翻译：可植入心脏刺激装置配备有基于加速度计的传感器，以感测患者的运动并产生指示患者在垂直方向上的加速度的垂直加速度分量。从垂直加速度分量计算垂直速度分量。该装置可以进一步配备有磁场传感器，以感测地球的磁场，作为获得真正的垂直取向的方式，基于加速度计的传感器可被校准。

8. 发明授权

US07813798B2 Systems and methods for preventing, detecting, and terminating pacemaker mediated tachycardia in biventricular implantable cardiac stimulation systems 有权
标题翻译：起搏器介入性心动过速在双心室可植入心脏刺激系统中的预防，检测和终止的系统和方法
公开(公告)号：US07813798B2
公开(公告)日：2010-10-12
申请号：US11734130
申请日：2007-04-11
申请人： Gene A. Bornzin , Mark W. Kroll
发明人： Gene A. Bornzin , Mark W. Kroll
IPC分类号： A61N1/362
CPC分类号： A61N1/368 , A61N1/3622 , A61N1/3684 , A61N1/3956
摘要： Various techniques are described for preventing pacemaker mediated tachycardia (PMT) within biventricular pacing systems and for detecting and terminating PMT should it nevertheless arise. In a first prevention technique, refractory periods applied to the atrial channel are synchronized to begin with a second of a pair of ventricular pacing pulses to more effectively prevent T-wave oversensing on the atrial channel. In a second prevention technique, the sensitivity of the atrial channel is reduced during T-waves also to prevent T-wave oversensing. In a third prevention technique, template matching is performed on the ventricular channels to prevent T-wave oversensing. In a fourth prevention technique, T-wave detection windows are applied to both the ventricular and atrial channels subsequent to any paced or sensed events.
摘要翻译：描述了用于在双心室起搏系统中预防起搏器介导的心动过速（PMT）的各种技术，并且如果仍然出现则检测和终止PMT。在第一预防技术中，应用于心房通道的不应期同步于开始于一对心室起搏脉冲的第二个，以更有效地防止心房通道上的T波过度感觉。在第二种预防技术中，在T波期间心房通道的灵敏度降低，以防止T波过度感染。在第三种预防技术中，对心室通道进行模板匹配以防止T波过度感染。在第四种预防技术中，T波检测窗口被应用于任何节奏或感测事件之后的心室和心房通道。

9. 发明申请

US20080234769A1 SUBCUTANEOUS CARDIAC STIMULATION DEVICE PROVIDING ANTI-TACHYCARDIA PACING THERAPY AND METHOD 有权
标题翻译：提供抗惊厥药治疗和方法的免疫性心脏刺激装置
公开(公告)号：US20080234769A1
公开(公告)日：2008-09-25
申请号：US12113895
申请日：2008-05-01
申请人： Eric Falkenberg , Mark W. Kroll , Gene A. Bornzin
发明人： Eric Falkenberg , Mark W. Kroll , Gene A. Bornzin
IPC分类号： A61N1/39 , A61N1/362
CPC分类号： A61N1/0504 , A61N1/3622 , A61N1/37252
摘要： An implantable subcutaneous cardiac device includes at least two subcutaneous electrodes adapted for placement external to a heart beneath the skin of a patient. The device further includes an arrhythmia detector that detects a sustained tachyarrhythmia of the heart and a pulse generator that delivers anti-tachycardia pacing pulses to the subcutaneous electrodes in response to detection of a sustained tachyarrhythmia. The pacing pulses preferably have waveforms devoid of any exponential voltage decay and include rounded or substantially constant portions to minimize pain.
摘要翻译：植入式皮下心脏装置包括至少两个皮下电极，其适于放置在患者皮肤下方的心脏外部。该装置还包括检测心脏持续快速性心律失常的心律失常检测器和响应于持续快速性心律失常的检测而向皮下电极递送抗心动过速起搏脉冲的脉冲发生器。起搏脉冲优选具有没有任何指数电压衰减的波形，并且包括圆形或基本恒定的部分以最小化疼痛。

10. 发明授权

US07369898B1 System and method for responding to pulsed gradient magnetic fields using an implantable medical device 有权
标题翻译：使用可植入医疗装置对脉冲梯度磁场进行响应的系统和方法
公开(公告)号：US07369898B1
公开(公告)日：2008-05-06
申请号：US11020438
申请日：2004-12-22
申请人： Mark W. Kroll , Gene A. Bornzin , Sergio Shkurovich , Nirav Dalal
发明人： Mark W. Kroll , Gene A. Bornzin , Sergio Shkurovich , Nirav Dalal
IPC分类号： A61N1/08 , A61B5/05
CPC分类号： A61B5/055 , A61N1/36514 , A61N1/3688 , A61N1/37 , A61N1/3718
摘要： Implantable medical devices, such as pacemakers or implantable cardioverter defibrillators (ICDs), are vulnerable to the powerful magnetic fields associated with magnetic resonance imaging (MRI). In particular, pulsed gradient components, if strong enough, can induce parasitic currents that may damage the device or cause parasitic pacing that may trigger an arrhythmia in the patient. The static magnetic field components of the MRI typically do not induce parasitic currents, even though they may be as strong as the pulsed gradient components. Accordingly, techniques are described herein for specifically addressing the pulsed gradient components of the MRI fields so as to reduce the risk of parasitic currents. In one example, a pacemaker switches to tri-state pacing outputs in the presence of strong pulsed gradient magnetic fields. The device continues with normal bi-state pacing outputs so long as the pulsed gradient fields are not strong, even in the presence of a strong static magnetic field. As an added safety feature, the pacemaker switches to fixed-rate ventricular pacing whenever strong static MRI fields are detected.
摘要翻译：可植入的医疗设备，如起搏器或植入式心律转复除颤器（ICD）易受到与磁共振成像（MRI）相关的强大磁场的影响。特别地，如果足够强的脉冲梯度分量可以引起寄生电流，这些寄生电流可能会损坏器件或引起可引发患者心律失常的寄生起搏。 MRI的静态磁场分量通常不会引起寄生电流，即使它们可能与脉冲梯度分量一样强。因此，本文描述了用于专门寻址MRI场的脉冲梯度分量的技术，以便降低寄生电流的风险。在一个示例中，起搏器在存在强脉冲梯度磁场的情况下切换到三态起搏输出。只要脉冲梯度场不强，即使在存在强静态磁场的情况下，器件将继续进行正常的双态起搏输出。作为增加的安全功能，每当检测到强静态MRI场时，起搏器就切换到固定速率心室起搏。

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