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1. 发明授权

US07877141B1 PAC therapy 有权
标题翻译： PAC疗法
公开(公告)号：US07877141B1
公开(公告)日：2011-01-25
申请号：US11349497
申请日：2006-02-06
申请人： Gene A. Bornzin , Peter Boileau
发明人： Gene A. Bornzin , Peter Boileau
IPC分类号： A61N1/37
CPC分类号： A61N1/3627 , A61N1/3624 , A61N1/3712 , A61N1/3714
摘要： An exemplary method includes detecting a first atrial event, initiating a detection window after detecting the first atrial event, detecting a second atrial event during the detection window, classifying the second atrial event as a premature atrial contraction and calling for delivery of an atrial extrastimulus in response to the premature atrial contraction. Various other exemplary technologies are also disclosed.
摘要翻译：一种示例性方法包括检测第一心房事件，在检测到第一心房事件之后启动检测窗口，在检测窗口期间检测第二心房事件，将第二心房事件分类为过早心房收缩并呼吁将房性过度激发递送至对早产性心房收缩的反应。还公开了各种其它示例性技术。

2. 发明授权

US07856268B2 Ischemia detection for anti-arrhythmia therapy 有权
标题翻译：缺血检测用于抗心律失常治疗
公开(公告)号：US07856268B2
公开(公告)日：2010-12-21
申请号：US12501765
申请日：2009-07-13
申请人： Mark W. Kroll , Peter Boileau , Jong Gill
发明人： Mark W. Kroll , Peter Boileau , Jong Gill
IPC分类号： A61N1/362
CPC分类号： A61N1/3627 , A61N1/3962
摘要： An exemplary method includes detecting arrhythmia, detecting myocardial ischemia, determining whether the myocardial ischemia comprises local ischemia or global ischemia and, in response to the determining, calling for delivery of either a local ischemic anti-arrhythmia therapy or a global ischemic anti-arrhythmia therapy. Various other exemplary methods, devices, systems, etc., are also disclosed.
摘要翻译：示例性方法包括检测心律失常，检测心肌缺血，确定心肌缺血是否包括局部缺血或全身缺血，并且响应于确定，要求递送局部缺血性抗心律失常治疗或全身缺血性抗心律失常治疗。还公开了各种其它示例性方法，装置，系统等。

3. 发明授权

US07801607B1 PAC therapy 有权
标题翻译： PAC疗法
公开(公告)号：US07801607B1
公开(公告)日：2010-09-21
申请号：US11735872
申请日：2007-04-16
申请人： Gene A. Bornzin , Peter Boileau
发明人： Gene A. Bornzin , Peter Boileau
IPC分类号： A61N1/37
CPC分类号： A61N1/3627 , A61N1/3624 , A61N1/3712 , A61N1/3714
摘要： An implantable cardiac device is programmed to detect and classify premature atrial contractions (PACs) and administer responsive pacing therapy. The responsive pacing therapy is in the form of an atrial extrastimulus, which is intended to preempt initiation of a reentrant tachycardia. The atrial extrastimulus is timed to occur late enough after a PAC to ensure atrial capture, but early enough that the resulting atrial depolarization does not conduct through the AV node to the ventricles if the PAC has already done so. If both of these criteria cannot be met, the device may be configured to inhibit the atrial extrastimulus.
摘要翻译：可植入心脏装置被编程以检测和分类早产性心房收缩（PAC）并进行响应性起搏治疗。响应性起搏治疗是以心房超激发的形式，其旨在抢先引发折返性心动过速。房间超激发定时发生在PAC后足够晚，以确保心房捕获，但足够早，如果PAC已经这样做，所产生的心房去极化不会通过AV节点进入心室。如果这两个标准都不能满足，则可以将该装置配置成抑制心房再刺激。

4. 发明授权

US07648464B1 Detecting ischemia using an implantable cardiac device based on morphology of cardiac pressure signal 有权
标题翻译：基于心脏压力信号的形态，使用可植入心脏装置检测缺血
公开(公告)号：US07648464B1
公开(公告)日：2010-01-19
申请号：US11458617
申请日：2006-07-19
申请人： Jong Gill , Peter Boileau , Gene A. Bornzin , Joseph J. Florio , Xiaoyi Min
发明人： Jong Gill , Peter Boileau , Gene A. Bornzin , Joseph J. Florio , Xiaoyi Min
IPC分类号： A61B5/021
CPC分类号： A61B5/0215 , A61B5/0031 , A61B5/042 , A61B5/7239 , A61N1/36564
摘要： Methods and systems are presented for using an ICD to detect myocardial ischemia. In one embodiment, a method includes sensing a signal indicative of cardiac pressure, measuring a height of the sensed signal at a peak amplitude of the sensed signal, and measuring a duration of the sensed signal. The method further includes indicating an ischemia based on a comparison of a ratio of the height to the duration with a predetermined value. In another embodiment, a method includes sensing a signal indicative of cardiac pressure, determining a derivative signal that is a first derivative of the sensed signal, measuring a maximum positive value of the derivative signal, and measuring a maximum negative value of the derivative signal. The method further includes indicating an ischemia based on a comparison of a ratio of the maximum positive value to the maximum negative value with a predetermined value.
摘要翻译：提出了使用ICD检测心肌缺血的方法和系统。在一个实施例中，一种方法包括感测指示心脏压力的信号，以感测信号的峰值幅度测量感测信号的高度，以及测量感测信号的持续时间。该方法还包括基于将高度与持续时间的比率与预定值的比较来指示缺血。在另一个实施例中，一种方法包括感测指示心脏压力的信号，确定作为感测信号的一阶导数的导数信号，测量导数信号的最大正值，以及测量导数信号的最大负值。该方法还包括基于将最大正值与最大负值的比率与预定值进行比较来指示缺血。

5. 发明申请

US20090318987A1 ISCHEMIA DETECTION FOR ANTI-ARRHYTHMIA THERAPY 有权
标题翻译：用于抗精神病药物治疗的ISCHEMIA检测
公开(公告)号：US20090318987A1
公开(公告)日：2009-12-24
申请号：US12501765
申请日：2009-07-13
申请人： Mark W. Kroll , Peter Boileau , Jong Gill
发明人： Mark W. Kroll , Peter Boileau , Jong Gill
IPC分类号： A61N1/368 , A61N1/39
CPC分类号： A61N1/3627 , A61N1/3962
摘要： An exemplary method includes detecting arrhythmia, detecting myocardial ischemia, determining whether the myocardial ischemia comprises local ischemia or global ischemia and, in response to the determining, calling for delivery of either a local ischemic anti-arrhythmia therapy or a global ischemic anti-arrhythmia therapy. Various other exemplary methods, devices, systems, etc., are also disclosed.
摘要翻译：示例性方法包括检测心律失常，检测心肌缺血，确定心肌缺血是否包括局部缺血或全身缺血，并且响应于确定，要求递送局部缺血性抗心律失常治疗或全身缺血性抗心律失常治疗。还公开了各种其它示例性方法，装置，系统等。

6. 发明授权

US07613508B2 Implantable cardiac stimulation device, system and method which provides an electrogram signal facilitating measurement of slow-changing electrogram features 有权
标题翻译：可植入的心脏刺激装置，系统和方法，其提供便于测量慢变化电描记图特征的电描记图信号
公开(公告)号：US07613508B2
公开(公告)日：2009-11-03
申请号：US11871873
申请日：2007-10-12
申请人： Peter Boileau , Gene A. Bornzin , Jong Gill
发明人： Peter Boileau , Gene A. Bornzin , Jong Gill
IPC分类号： A61B5/042
CPC分类号： A61N1/3702 , A61B5/04018 , A61B5/042 , A61B5/0452 , A61N1/368
摘要： An implantable cardiac system including an implantable cardiac stimulation device provides a heart activity signal of a heart facilitating measurement of slowly changing electrogram features. The system comprises at least one implantable electrode arrangement that senses cardiac electrical activity and provides an intracardiac electrogram signal, a first high pass filter that filters the electrogram and an equalizer that filters the filtered electrogram signal. The equalizer has a transfer function that is non-decreasing for frequencies up to a lower frequency breakpoint that is less than the upper frequency breakpoint, decreasing for frequencies between the lower frequency breakpoint and the upper frequency breakpoint, and generally flat for frequencies above the upper frequency breakpoint through a bandpass region of interest.
摘要翻译：包括可植入心脏刺激装置的可植入心脏系统提供心脏的心脏活动信号，便于测量缓慢变化的电描绘图特征。该系统包括感测心脏电活动并提供心内电描记图信号的至少一个可植入电极装置，对电描记图进行滤波的第一高通滤波器和对经滤波的电描记图信号进行滤波的均衡器。均衡器具有对于低于较高频率断点的频率的频率不降低的传递函数，对于较低频率断点和较高频率断点之间的频率而言降低，并且对于高于上限频率的频率，通常平坦频率断点通过感兴趣的带通区域。

7. 发明授权

US07577478B1 Ischemia detection for anti-arrhythmia therapy 有权
标题翻译：缺血检测用于抗心律失常治疗
公开(公告)号：US07577478B1
公开(公告)日：2009-08-18
申请号：US11346859
申请日：2006-02-01
申请人： Mark W. Kroll , Peter Boileau , Jong Gill
发明人： Mark W. Kroll , Peter Boileau , Jong Gill
IPC分类号： A61N1/39
CPC分类号： A61N1/3627 , A61N1/3962
摘要： An exemplary method includes detecting arrhythmia, detecting myocardial ischemia, determining whether the myocardial ischemia comprises local ischemia or global ischemia and, in response to the determining, calling for delivery of either a local ischemic anti-arrhythmia therapy or a global ischemic anti-arrhythmia therapy. Various other exemplary methods, devices, systems, etc., are also disclosed.
摘要翻译：示例性方法包括检测心律失常，检测心肌缺血，确定心肌缺血是否包括局部缺血或全身缺血，并且响应于确定，要求递送局部缺血性抗心律失常治疗或全身缺血性抗心律失常治疗。还公开了各种其它示例性方法，装置，系统等。

8. 发明申请

US20080033499A1 IMPLANTABLE CARDIAC STIMULATION DEVICE, SYSTEM AND METHOD WHICH PROVIDES AN ELECTROGRAM SIGNAL FACILITATING MEASUREMENT OF SLOW-CHANGING ELECTROGRAM FEATURES 有权
标题翻译：可植入心脏刺激装置，系统和方法提供电子信号促进慢变化电子特征的测量
公开(公告)号：US20080033499A1
公开(公告)日：2008-02-07
申请号：US11871873
申请日：2007-10-12
申请人： Peter Boileau , Gene Bornzin , Jong Gill
发明人： Peter Boileau , Gene Bornzin , Jong Gill
IPC分类号： A61N1/37
CPC分类号： A61N1/3702 , A61B5/04018 , A61B5/042 , A61B5/0452 , A61N1/368
摘要： An implantable cardiac system including an implantable cardiac stimulation device provides a heart activity signal of a heart facilitating measurement of slowly changing electrogram features. The system comprises at least one implantable electrode arrangement that senses cardiac electrical activity and provides an intracardiac electrogram signal, a first high pass filter that filters the electrogram and an equalizer that filters the filtered electrogram signal. The equalizer has a transfer function that is non-decreasing for frequencies up to a lower frequency breakpoint that is less than the upper frequency breakpoint, decreasing for frequencies between the lower frequency breakpoint and the upper frequency breakpoint, and generally flat for frequencies above the upper frequency breakpoint through a bandpass region of interest.
摘要翻译：包括可植入心脏刺激装置的可植入心脏系统提供心脏的心脏活动信号，便于测量缓慢变化的电描绘图特征。该系统包括感测心脏电活动并提供心内电描记图信号的至少一个可植入电极装置，对电描记图进行滤波的第一高通滤波器和对经滤波的电描记图信号进行滤波的均衡器。均衡器具有对于低于较高频率断点的频率的频率不降低的传递函数，对于较低频率断点和较高频率断点之间的频率而言降低，并且对于高于上限频率的频率，通常平坦频率断点通过感兴趣的带通区域。

9. 发明授权

US07162299B1 ICD with VF prevention 有权
标题翻译： ICD与VF预防
公开(公告)号：US07162299B1
公开(公告)日：2007-01-09
申请号：US10163591
申请日：2002-06-05
申请人： Mark W. Kroll , Peter Boileau
发明人： Mark W. Kroll , Peter Boileau
IPC分类号： A61N1/39
CPC分类号： A61N1/3621
摘要： A cardiac stimulation device includes a sensing unit for monitoring the electrical activity of a heart and a controller configured to predict the onset of an arrhythmia of the heart. The controller calculates a statistical indicia relating to the immediate past four R—R intervals in the form of a sliding average thereof. Upon the prediction that the risk of the onset of an arrhythmia is high, the controller compares the current value of the R—R interval to the indicia. If the current value of the R—R interval exceeds the indicia by a predetermined amount, the controller causes a high amplitude pacing pulse to be delivered to a selected cardiac site in an attempt to forestall the initiation of ventricular fibrillation.
摘要翻译：心脏刺激装置包括用于监测心脏的电活动的感测单元和配置成预测心脏心律失常发作的控制器。控制器以其滑动平均数的形式计算与过去四个R-R间隔相关的统计标记。当预测心律失常发作的风险高时，控制器将R-R间隔的当前值与标记进行比较。如果R-R间隔的当前值超过标记预定量，则控制器将高幅度起搏脉冲输送到选定的心脏部位，以试图阻止心室颤动的开始。

10. 发明授权

US06766195B1 Method and apparatus for detecting natural electrical coherence within the heart and for administering therapy based thereon 有权
标题翻译：用于检测心脏内的自然电相干性并用于基于其进行治疗的方法和装置
公开(公告)号：US06766195B1
公开(公告)日：2004-07-20
申请号：US09686630
申请日：2000-10-10
申请人： Gene A. Bornzin , Peter Boileau , Joseph J. Florio , John W. Poore , Kelly H. McClure
发明人： Gene A. Bornzin , Peter Boileau , Joseph J. Florio , John W. Poore , Kelly H. McClure
IPC分类号： A61N0118
CPC分类号： A61N1/3962 , A61N1/395
摘要： Techniques are provided for detecting natural electrical coherence within the heart and for administering or adjusting therapy based upon whether natural electrical coherence is detected. In one example, an implantable cardioverter defibrillator (ICD), upon detecting atrial fibrillation, delays administering an atrial defibrillation pulse until a period of natural electrical coherence is detected between the left and the right atria of the heart. The ICD may further delay the pulse until the ventricles of the heart are refractory so as to help prevent triggering ventricular fibrillation. The pulses are administered at a time selected based upon the period of electrical coherence to reduce the amount of electrical energy required within the pulse to reliably defibrillate the heart. Other types of therapy besides defibrillation therapy such as anti-tachycardia pacing pulses may also be timed based upon detection periods of natural electrical coherence. Method and apparatus embodiments are described.
摘要翻译：提供了用于检测心脏内的自然电连贯性的技术，并且用于基于是否检测到自然电连贯来施用或调整治疗。在一个实例中，在检测心房颤动时，植入式心律转复除颤器（ICD）延迟施用心房除颤脉冲，直到在心脏的左心房和右心房之间检测到自然电相干的时间段。 ICD可以进一步延迟脉冲，直到心脏的心室难以耐受，以便有助于防止触发心室颤动。在基于电相干周期选择的时间施加脉冲以减少脉冲内所需的电能量以可靠地除颤心脏。除了除颤疗法之外的其他类型的治疗，如抗心动过速起搏脉冲也可以基于自然电连续性的检测周期来计时。描述了方法和设备实施例。

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