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1. 发明授权

US08260404B1 Systems and methods for employing multiple filters to detect T-wave oversensing and to improve tachyarrhythmia detection within an implantable medical device 有权
标题翻译：使用多个滤波器来检测T波过度感知并改善可植入医疗装置内的快速性心律失常检测的系统和方法
公开(公告)号：US08260404B1
公开(公告)日：2012-09-04
申请号：US11776275
申请日：2007-07-11
申请人： Rupinder Bharmi , Jeffery D. Snell , Gene A. Bornzin , Joseph J. Florio , Peter Boileau
发明人： Rupinder Bharmi , Jeffery D. Snell , Gene A. Bornzin , Joseph J. Florio , Peter Boileau
IPC分类号： A61B5/0452 , A61B5/0456
CPC分类号： A61B5/0456 , A61B5/0464 , A61B5/725 , A61N1/3702 , A61N1/395
摘要： Techniques for detecting tachyarrhythmia and also for preventing T-wave oversensing use signals filtered by a narrowband bradycardia filter in combination with signals filtered by a narrowband tachycardia filter. A separate wideband filter may also be used.
摘要翻译：用于检测快速性心律失常并且还用于预防T波超检的技术使用由窄带心动过缓过滤器滤波的信号与由窄带心动过速过滤器过滤的信号组合。也可以使用单独的宽带滤波器。

2. 发明申请

US20120158078A1 IMPLANTABLE MEDICAL DEVICE VOLTAGE DIVIDER CIRCUIT FOR MITIGATING ELECTROMAGNETIC INTERFERENCE 有权
标题翻译：用于减少电磁干扰的可植入医疗设备电压分路器电路
公开(公告)号：US20120158078A1
公开(公告)日：2012-06-21
申请号：US12968563
申请日：2010-12-15
申请人： J. Christopher Moulder , Peter Boileau
发明人： J. Christopher Moulder , Peter Boileau
IPC分类号： A61N1/362
CPC分类号： A61N1/36125 , A61N1/36142 , A61N1/362 , A61N1/37 , A61N1/3718
摘要： An RF protection circuit mitigates potentially adverse effects that may otherwise result from electromagnetic interference (e.g., due to MRI scanning of a patient having an implanted medical device). The RF protection circuit may comprise a voltage divider that is deployed across a pair of cardiac electrodes that are coupled to internal circuitry of the implantable medical device. Each leg of the voltage divider may be referenced to a ground of the internal circuit, whereby the different legs are deployed in parallel across different circuits of the internal circuitry. In this way, when an EMI-induced (e.g., MRI-induced) signal appears across the cardiac electrodes, the voltages appearing across these circuits and the currents flowing through these circuits may be reduced. The RF protection circuit may be used in an implantable medical device that employs a relatively low capacitance feedthrough to reduce EMI-induced (e.g., MRI-induced) current flow in a cardiac lead.
摘要翻译： RF保护电路减轻了可能由电磁干扰引起的潜在不利影响（例如，由于具有植入的医疗装置的患者的MRI扫描）。 RF保护电路可以包括分压器，其分布在耦合到可植入医疗装置的内部电路的一对心脏电极上。分压器的每个支路可以参考内部电路的接地，由此不同的支路并联地布置在内部电路的不同电路上。以这种方式，当在心电极上出现EMI诱发（例如，MRI诱发的）信号时，可以减少跨越这些电路的电压和流过这些电路的电流。 RF保护电路可以用在可植入医疗装置中，其采用相对低电容的馈通以减少心脏导联中的EMI诱发（例如，MRI诱发的）电流。

3. 发明授权

US08180439B2 Ischemia detection using intra-cardiac signals 有权
标题翻译：使用心脏内信号的缺血检测
公开(公告)号：US08180439B2
公开(公告)日：2012-05-15
申请号：US12846387
申请日：2010-07-29
申请人： Jong Gill , Peter Boileau , Gene A. Bornzin , Joseph J. Florio , Mohssen Fard
发明人： Jong Gill , Peter Boileau , Gene A. Bornzin , Joseph J. Florio , Mohssen Fard
IPC分类号： A61B5/0452
CPC分类号： A61B5/0452 , A61B5/7203 , A61B5/7264 , Y10S128/92
摘要： An implanted cardiac rhythm management device is disclosed that is operative to detect myocardial ischemia. This is done by evaluating electrogram features to detect an electrocardiographic change; specifically, changes in electrogram segment during the early part of an ST segment. The early part of the ST segment is chosen to avoid the T-wave.
摘要翻译：公开了可用于检测心肌缺血的植入式心律管理装置。这通过评估电描记图特征来检测心电图变化来完成; 具体来说，在ST段的早期部分，电描绘片段的变化。选择ST段的早期部分以避免T波。

4. 发明授权

US08019417B2 PAC therapy 有权
标题翻译： PAC疗法
公开(公告)号：US08019417B2
公开(公告)日：2011-09-13
申请号：US12851515
申请日：2010-08-05
申请人： Gene A. Bornzin , Peter Boileau
发明人： Gene A. Bornzin , Peter Boileau
IPC分类号： A61N1/37
CPC分类号： A61N1/3627 , A61N1/3624 , A61N1/3712 , A61N1/3714
摘要： An implantable cardiac device is programmed to detect and classify premature atrial contractions (PACs) and administer responsive pacing therapy. The responsive pacing therapy is in the form of an atrial extrastimulus, which is intended to preempt initiation of a reentrant tachycardia. The atrial extrastimulus is timed to occur late enough after a PAC to ensure atrial capture, but early enough that the resulting atrial depolarization does not conduct through the AV node to the ventricles if the PAC has already done so. If both of these criteria cannot be met, the device may be configured to inhibit the atrial extrastimulus.
摘要翻译：可植入心脏装置被编程以检测和分类早产性心房收缩（PAC）并进行响应性起搏治疗。响应性起搏治疗是以心房超激发的形式，其旨在抢先引发折返性心动过速。房间超激发定时发生在PAC后足够晚，以确保心房捕获，但足够早，如果PAC已经这样做，所产生的心房去极化不会通过AV节点进入心室。如果这两个标准都不能满足，则可以将该装置配置成抑制心房再刺激。

5. 发明申请

US20110112599A1 MRI SIGNAL FILTERING FOR IMPLANTABLE MEDICAL DEVICE 有权
标题翻译：用于可植入医疗器械的MRI信号滤波
公开(公告)号：US20110112599A1
公开(公告)日：2011-05-12
申请号：US12617532
申请日：2009-11-12
申请人： Zin Zhang , J. Christopher Moulder , George I. Isaac , Gabriel A. Mouchawar , Peter Boileau , Ingmar Viohl
发明人： Zin Zhang , J. Christopher Moulder , George I. Isaac , Gabriel A. Mouchawar , Peter Boileau , Ingmar Viohl
IPC分类号： A61N1/08
CPC分类号： G01R33/288 , A61N1/36521 , A61N1/3718 , A61N1/3754 , G01R33/3685
摘要： A filtering scheme for an implantable medical device mitigates potentially adverse effects that may be caused by MRI-induced signals. In some aspects filtering is provided to attenuate MRI-induced signals on an implanted cardiac lead that is coupled to an implanted device. In some aspects the filter may be configured to complement a capacitor circuit (e.g., a feedthrough capacitor) that reduces the amount of EMI that enters the implanted device via the cardiac lead. In some implementations the filter consists of a LC tank circuit and a series LC circuit, where the LC tank circuit is in series with the cardiac lead and a cardiac stimulation circuit and the series LC circuit is in a shunt configuration across the cardiac stimulation circuit.
摘要翻译：用于可植入医疗装置的过滤方案减轻了可能由MRI诱导的信号引起的潜在的不利影响。在一些方面，提供过滤以减少与植入装置耦合的植入心脏引线上的MRI诱导信号。在一些方面，滤波器可以被配置为补充通过心脏引线减少进入植入装置的EMI量的电容器电路（例如，馈通电容器）。在一些实施方式中，滤波器由LC谐振电路和串联LC电路组成，其中LC谐振电路与心脏引线和心脏刺激电路串联，并且串联LC电路处于穿过心脏刺激电路的分流配置。

6. 发明授权

US07848809B1 PAC therapy 有权
标题翻译： PAC疗法
公开(公告)号：US07848809B1
公开(公告)日：2010-12-07
申请号：US11735860
申请日：2007-04-16
申请人： Gene A. Bornzin , Peter Boileau
发明人： Gene A. Bornzin , Peter Boileau
IPC分类号： A61N1/08
CPC分类号： A61N1/3627 , A61N1/3624 , A61N1/3712 , A61N1/3714
摘要： An implantable cardiac device is programmed to detect and classify premature atrial contractions (PACs). In the described implementation, the device uses timing based techniques to distinguish PACs from native sinus P-waves. The device is also able to detect and count a salvo of consecutive PACs for diagnostic purposes.
摘要翻译：可植入心脏装置被编程以检测和分类早发性心房收缩（PAC）。在所描述的实现中，该设备使用基于定时的技术来区分PAC和本地窦性P波。该装置还能够检测和计数连续的PAC用于诊断目的。

7. 发明申请

US20100249862A1 System and Method for Controlling Ventricular Pacing During AF Based on Underlying Ventricular Rates Using an Implantable Medical Device 有权
标题翻译：使用植入式医疗器械，在基于心室率的房颤期间控制心室起搏的系统和方法
公开(公告)号：US20100249862A1
公开(公告)日：2010-09-30
申请号：US12410386
申请日：2009-03-24
申请人： Peter Boileau , Michael E. Benser
发明人： Peter Boileau , Michael E. Benser
IPC分类号： A61N1/365
CPC分类号： A61N1/3622 , A61N1/3702
摘要： Techniques are provided for controlling ventricular pacing during an episode of atrial fibrillation (AF) for use by a pacemaker, implantable cardioverter-defibrillator (ICD) or other implantable medical device. In one example, upon detection of AF, the underlying intrinsic ventricular rate of the patient is determined prior to delivering any ventricular pacing. Then, a ventricular pacing procedure—such as dynamic ventricular overdrive (DVO) pacing—is activated to reduce ventricular rate variability to mitigate the adverse effects of AF. The ventricular pacing procedure employed during AF is controlled based on a maximum ventricular rate set relative to the underlying intrinsic ventricular rate so as to keep an overall ventricular rate below the maximum rate.
摘要翻译：提供技术用于在心房颤动（AF）发作期间控制心室起搏，以供起搏器，可植入式心律转复除颤器（ICD）或其他可植入医疗装置使用。在一个实例中，在检测到AF后，在递送任何心室起搏之前确定患者的潜在内在心室率。然后，启动心室起搏手术，例如动态心室超速（DVO）起搏 - 以减少心室率变异性，以减轻AF的不良反应。在AF期间使用的心室起搏过程基于相对于潜在的内部心室率设定的最大心室率进行控制，以保持总体心率低于最大速率。

8. 发明申请

US20100125305A1 USE OF IMPEDANCE TO ASSESS ELECTRODE LOCATIONS 有权
标题翻译：使用阻抗来评估电极位置
公开(公告)号：US20100125305A1
公开(公告)日：2010-05-20
申请号：US12273286
申请日：2008-11-18
申请人： Gene A. Bornzin , Peter Boileau , John W. Poore
发明人： Gene A. Bornzin , Peter Boileau , John W. Poore
IPC分类号： A61N1/00 , A61N1/08
CPC分类号： A61N1/36521 , A61N1/3706
摘要： A process for determining whether the location of a stimulation electrode meets a selected heart performance criteria includes providing stimulation to the heart through the electrode and obtaining an impedance measurement during stimulation delivery using an impedance sensing vector formed by electrodes that do not include the stimulation electrode. The impedance measurements are processed, either alone or in combination with an electrogram, also obtained during stimulation, to obtain a measure of hemodynamic performance.
摘要翻译：用于确定刺激电极的位置是否满足所选择的心脏性能标准的过程包括通过电极向心脏提供刺激，并且使用由不包括刺激电极的电极形成的阻抗感测向量在刺激递送期间获得阻抗测量。阻抗测量单独地或与刺激期间获得的电描绘图结合进行处理，以获得血液动力学性能的量度。

9. 发明授权

US07460900B1 Method and apparatus for detecting ischemia using changes in QRS morphology 有权
标题翻译：使用QRS形态变化检测缺血的方法和装置
公开(公告)号：US07460900B1
公开(公告)日：2008-12-02
申请号：US11227856
申请日：2005-09-14
申请人： Jong Gill , Peter Boileau , Gene A. Bornzin
发明人： Jong Gill , Peter Boileau , Gene A. Bornzin
IPC分类号： A61B5/04
CPC分类号： A61B5/04525 , A61B5/024 , A61N1/3627 , A61N1/36507
摘要： A method for operating an implantable medical device includes determining the difference of the absolute value of the voltage of a test QRS complex and the voltage of a baseline QRS template at a plurality of corresponding sample points and detecting ischemia if the sum of the differences at the plurality of sample points is greater than an ischemia detection threshold.
摘要翻译：一种用于操作可植入医疗装置的方法包括确定测试QRS复合物的电压的绝对值与基准QRS模板在多个对应采样点的电压之间的差异，并检测缺血，如果在多个采样点大于缺血检测阈值。

10. 发明授权

US07386343B1 Spectrum-driven arrhythmia treatment method 有权
标题翻译：频谱驱动心律失常治疗方法
公开(公告)号：US07386343B1
公开(公告)日：2008-06-10
申请号：US11240950
申请日：2005-09-30
申请人： Mark W. Kroll , Peter Boileau
发明人： Mark W. Kroll , Peter Boileau
IPC分类号： A61N1/36
CPC分类号： A61N1/3622
摘要： A method and apparatus for treating an arrhythmia is provided. The method includes the steps of: (a) sensing at least one electrical signal from the patient's heart; (b) calculating a frequency spectrum of each electrical signal; (c) calculating a center frequency for each frequency spectrum; and (d) selecting an electro-therapy for delivery to the patient's heart based on the center frequency. The electro-therapy can be a pre-programmed anti-tachycardia pacing (ATP) therapy, a shock therapy, or no therapy at all. The method is performed through the use of an implantable cardioverter defibrillator (ICD). Also provided is a method of determining the optimal location to deliver the electro-therapy.
摘要翻译：提供了一种治疗心律失常的方法和装置。该方法包括以下步骤：（a）感测来自患者心脏的至少一个电信号; （b）计算每个电信号的频谱; （c）计算每个频谱的中心频率; 以及（d）根据中心频率选择电疗以传送到患者的心脏。电疗可以是预先编程的抗心动过速起搏（ATP）治疗，休克疗法，或根本没有治疗。该方法通过使用植入式心律转复除颤器（ICD）进行。还提供了确定递送电疗的最佳位置的方法。

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