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    • 33. 发明申请
    • Solubilized Composition
    • 溶解组合物
    • US20120027712A1
    • 2012-02-02
    • US13257352
    • 2010-03-09
    • Takashi TeshigawaraHidefumi ArakiKei Watanabe
    • Takashi TeshigawaraHidefumi ArakiKei Watanabe
    • A61K8/58A61Q5/00A61Q7/00A61Q19/00
    • C08L71/02A61K8/39A61K8/585A61K8/86A61K8/891A61Q19/00C08K5/5419C08K5/549C08L83/04
    • This invention provides a solubilized composition in which a cyclic or straight silicone oil is solubilized in a large amount and stably. The solubilized composition is characterized by comprising (a) a polyoxyethylene alkyl ether type nonionic surfactant represented by the following formula (I): R1—O—(CH2CH2O)a—H  (I) wherein R1 represents a branched chain alkyl group having 8 to 18 carbon atoms; a represents an integer satisfying 3≦a≦20, (b) one or more silicone(s) selected from a cyclic silicone represented by the following formula (II) and a short chain straight silicone represented by the following formula (III): [(CH3)HSi—O—]m  (II) (CH3)3Si—O—[Si(CH3)2O]nSi(CH3)3  (III) wherein m represents an integer satisfying 3≦m≦7; and n represents an integer satisfying 0≦n≦7, and (c) water.
    • 本发明提供一种溶解组合物,其中环状或直链硅油大量且稳定地溶解。 该溶解组合物的特征在于:(a)由下式(I)表示的聚氧乙烯烷基醚型非离子表面活性剂:R1-O-(CH2CH2O)a-H(Ⅰ),其中R1表示支链烷基, 18个碳原子; a表示满足3&nlE的整数; a≦̸ 20,(b)选自由下式(II)表示的环状硅氧烷中的一种或多种硅酮和由下式(III)表示的短链直链硅氧烷:[ (CH3)HSi-O-] m(II)(CH3)3Si-O- [Si(CH3)2O] nSi(CH3)3(Ⅲ)其中m表示满足3&nlE的整数; m& n表示满足0&nlE的整数; n≦̸ 7,(c)水。
    • 37. 发明申请
    • Silica Composite Capsules Obtained By Blending Water-Soluble Silane Derivative, Composition Containg The Same, And Transparent Gel-Form Composition
    • 通过混合水溶性硅烷衍生物获得的二氧化硅复合胶囊,含有它的组合物和透明的凝胶形式组合物
    • US20100016200A1
    • 2010-01-21
    • US12440614
    • 2007-09-11
    • Yuko NagareKei WatanabeKazutami SakamotoShun TakahashiTeruhiko Hineno
    • Yuko NagareKei WatanabeKazutami SakamotoShun TakahashiTeruhiko Hineno
    • A61K8/06
    • A61Q19/10A61K8/0291A61K8/0295A61K8/042A61K8/11A61K8/25A61K8/585A61K2800/262A61K2800/412A61Q1/02
    • The present invention provides new silica composite capsules that can be easily prepared, a composition containing the silica composite capsules, and a transparent gel-form composition excellent in appearance transparency and texture in use, and in particular, a transparent gel-form composition with improved cleansing properties when used as a cleanser. Micelle/silica composite capsules can easily be obtained, in an aqueous system, by mixing a material capable of forming micelles in water and a water-soluble silane derivative having a specific structure in aqueous solution. In addition, emulsion/silica composite capsules wherein the periphery of emulsion particles in the inner phase is coated with silica, can easily be obtained by mixing a surfactant, water, an oil, and a water-soluble silane derivative having a specific structure. Moreover, a transparent gel-form composition showing excellent appearance transparency, the texture in use and cleansing properties, can be obtained by blending a water-soluble silane derivative having a specific structure into the formulation that contains a surfactant, an oil and water, and capable of taking a surfactant association structure with aqueous continuous phase or both of aqueous continuous phase and oil continuous phase in the formulation.
    • 本发明提供了可以容易地制备的新的二氧化硅复合胶囊,含有二氧化硅复合胶囊的组合物,以及外观透明性和使用质地优异的透明凝胶状组合物,特别是具有改进的透明凝胶状组合物 用作清洁剂时的清洁性能。 通过将能够在水中形成胶束的材料和在水溶液中具有特定结构的水溶性硅烷衍生物混合,可以在水性体系中容易地获得胶束/二氧化硅复合胶囊。 此外,通过混合表面活性剂,水,油和具有特定结构的水溶性硅烷衍生物,可以容易地得到内层的乳液粒子的周围用二氧化硅涂布的乳液/二氧化硅复合胶囊。 此外,通过将具有特定结构的水溶性硅烷衍生物掺入含有表面活性剂,油和水的配方中,可以获得表现出优异的外观透明度,使用质地和清洁性能的透明凝胶状组合物,以及 能够在制剂中具有含水连续相或水相连续相和油连续相的表面活性剂缔合结构。
    • 38. 发明申请
    • Skin External Preparation
    • 皮肤外用制剂
    • US20090197948A1
    • 2009-08-06
    • US12301769
    • 2007-05-22
    • Reiji MiyaharaKouzou HiwatariKei WatanabeTakashi OkaKei-ichi MaruyamaKeiichi Yokozawa
    • Reiji MiyaharaKouzou HiwatariKei WatanabeTakashi OkaKei-ichi MaruyamaKeiichi Yokozawa
    • A61K31/375C07C43/13A61K47/10A61K31/05
    • A61Q19/00A61K8/90A61K47/34
    • The present invention is to provide a skin external preparation with good moisture retention, a rough skin improving effect, and an improved feeling in use. A skin external preparation comprising a polyoxyalkylene glycol/polyethylene glycol copolymer alkyl ether derivative represented by the below-described general formula (I):(formula I) Y—{O(EO)a/(AO)b—R}k  (I) (In the formula, Y is the residue given by removing hydroxyl groups from a polyhydric alcohol having 3 to 6 hydroxyl groups, and k is the number of hydroxyl groups of the polyhydric alcohol. EO is an oxyethylene group; AO is an oxyalkylene group having 3 to 4 carbon atoms, and 1≦a≦70, 1≦b≦70. The percentage of the oxyethylene groups with respect to the sum of the oxyalkylene groups having 3 to 4 carbon atoms and the oxyethylene groups is 20 to 100 mass %. The oxyalkylene group having 3 to 4 carbon atoms and the oxyethylene group are added randomly. Rs are either identical to or different from each other, and they are hydrocarbon groups having 1 to 4 carbon atoms.)
    • 本发明提供一种具有良好的保湿性,粗糙的皮肤改善效果和改善的使用感的皮肤外用剂。 包含由下述通式(I)表示的聚氧化亚烷基二醇/聚乙二醇共聚物烷基醚衍生物的皮肤外用制剂:(式I)<?in-line-formula description =“In-line Formulas”end =“lead “?”Y- {O(EO)a /(AO)bR} k(I)<?in-line-formula description =“In-line Formulas”end =“tail”?>(在公式中,Y是 通过从具有3〜6个羟基的多元醇除去羟基而得到的残基,k为多元醇的羟基数,EO为氧化乙烯基,AO为碳原子数3〜4的氧化烯基, 1 <= a <= 70,1 <= b <= 70,氧化乙烯基相对于具有3〜4个碳原子的氧化烯和氧化乙烯基的总和的比例为20〜100质量%,氧化烯 随机添加3〜4个碳原子的基团和氧化乙烯基,Rs可以相同也可以不同,它们是具有1〜4个碳原子的烃基 n原子)
    • 39. 发明申请
    • WATER-SOLUBLE METAL ALCOHOLATE DERIVATIVES, PRODUCTION METHODS THEREOF, AND SOLID GELATINOUS EXTERNAL PREPARATIONS CONTAINING THE SAME
    • 水溶性金属醇盐衍生物,其生产方法和含有其的固体外消旋制剂
    • US20090149554A1
    • 2009-06-11
    • US12063275
    • 2006-08-11
    • Yuko IshikawaKatzutami SakamotoToshikhiko SekiIsao YajimaShun TakahashiKei Watanabe
    • Yuko IshikawaKatzutami SakamotoToshikhiko SekiIsao YajimaShun TakahashiKei Watanabe
    • A61K47/24C07F7/28C07F7/02
    • C07F7/045A61K9/0014A61K47/10C07C31/20
    • The object of the present invention is to provide a production method of water-soluble silane derivatives, the separation and purification of which are easy, and the reaction for which can be conducted under an industrially practicable temperature condition (under the temperature condition of 90° C. or lower) and to provide compounds with which solid gelatinous external preparations, with excellent stability against a temperature change and against an effect of additives and with excellent usability, can be prepared. The water-soluble silane derivative could be formed by the substitution reaction of a metal alkoxide with a polyhydric alcohol under the presence of a solid catalyst. According to this production method, the separation of the catalyst from the product is very easy, and the reaction can be carried out under the temperature condition of 90° C. or lower. The obtained water-soluble metal alcoholate derivative can satisfactory solidify an aqueous formulation of an external preparation by its blending thereinto. The obtained solid gelatinous external preparation has excellent stability against a temperature change and against the effect of additives. In addition, the external preparation is easily disintegrated during use; thus the usability such as easiness to be scooped up with fingers and spreadability during application is excellent.
    • 本发明的目的是提供一种水溶性硅烷衍生物的制造方法,其分离纯化容易,其反应可以在工业上可行的温度条件下(在90℃的温度条件下进行) C.或更低),并且可以制备具有优异的耐温度变化稳定性和抗添加剂效果以及优异可用性的固体胶状外用制剂的化合物。 水溶性硅烷衍生物可以通过金属醇盐与多元醇在固体催化剂存在下的取代反应形成。 根据该制造方法,催化剂与产物的分离非常容易,反应可以在90℃以下的温度条件下进行。 所得到的水溶性金属醇化物衍生物可以通过其混合来使外用制剂的水性制剂充分固化。 所得固体凝胶状外用制剂对温度变化和添加剂的效果具有优异的稳定性。 此外,外用制剂在使用过程中容易分解; 因此在使用时易于用手指舀起的可用性和铺展性优异。