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    • 1. 发明申请
    • Skin External Preparation
    • 皮肤外用制剂
    • US20090197948A1
    • 2009-08-06
    • US12301769
    • 2007-05-22
    • Reiji MiyaharaKouzou HiwatariKei WatanabeTakashi OkaKei-ichi MaruyamaKeiichi Yokozawa
    • Reiji MiyaharaKouzou HiwatariKei WatanabeTakashi OkaKei-ichi MaruyamaKeiichi Yokozawa
    • A61K31/375C07C43/13A61K47/10A61K31/05
    • A61Q19/00A61K8/90A61K47/34
    • The present invention is to provide a skin external preparation with good moisture retention, a rough skin improving effect, and an improved feeling in use. A skin external preparation comprising a polyoxyalkylene glycol/polyethylene glycol copolymer alkyl ether derivative represented by the below-described general formula (I):(formula I) Y—{O(EO)a/(AO)b—R}k  (I) (In the formula, Y is the residue given by removing hydroxyl groups from a polyhydric alcohol having 3 to 6 hydroxyl groups, and k is the number of hydroxyl groups of the polyhydric alcohol. EO is an oxyethylene group; AO is an oxyalkylene group having 3 to 4 carbon atoms, and 1≦a≦70, 1≦b≦70. The percentage of the oxyethylene groups with respect to the sum of the oxyalkylene groups having 3 to 4 carbon atoms and the oxyethylene groups is 20 to 100 mass %. The oxyalkylene group having 3 to 4 carbon atoms and the oxyethylene group are added randomly. Rs are either identical to or different from each other, and they are hydrocarbon groups having 1 to 4 carbon atoms.)
    • 本发明提供一种具有良好的保湿性,粗糙的皮肤改善效果和改善的使用感的皮肤外用剂。 包含由下述通式(I)表示的聚氧化亚烷基二醇/聚乙二醇共聚物烷基醚衍生物的皮肤外用制剂:(式I)<?in-line-formula description =“In-line Formulas”end =“lead “?”Y- {O(EO)a /(AO)bR} k(I)<?in-line-formula description =“In-line Formulas”end =“tail”?>(在公式中,Y是 通过从具有3〜6个羟基的多元醇除去羟基而得到的残基,k为多元醇的羟基数,EO为氧化乙烯基,AO为碳原子数3〜4的氧化烯基, 1 <= a <= 70,1 <= b <= 70,氧化乙烯基相对于具有3〜4个碳原子的氧化烯和氧化乙烯基的总和的比例为20〜100质量%,氧化烯 随机添加3〜4个碳原子的基团和氧化乙烯基,Rs可以相同也可以不同,它们是具有1〜4个碳原子的烃基 n原子)