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1. 发明申请

US20090197948A1 Skin External Preparation 审中-公开
标题翻译：皮肤外用制剂
公开(公告)号：US20090197948A1
公开(公告)日：2009-08-06
申请号：US12301769
申请日：2007-05-22
申请人： Reiji Miyahara , Kouzou Hiwatari , Kei Watanabe , Takashi Oka , Kei-ichi Maruyama , Keiichi Yokozawa
发明人： Reiji Miyahara , Kouzou Hiwatari , Kei Watanabe , Takashi Oka , Kei-ichi Maruyama , Keiichi Yokozawa
IPC分类号： A61K31/375 , C07C43/13 , A61K47/10 , A61K31/05
CPC分类号： A61Q19/00 , A61K8/90 , A61K47/34
摘要： The present invention is to provide a skin external preparation with good moisture retention, a rough skin improving effect, and an improved feeling in use. A skin external preparation comprising a polyoxyalkylene glycol/polyethylene glycol copolymer alkyl ether derivative represented by the below-described general formula (I):(formula I) Y—{O(EO)a/(AO)b—R}k (I) (In the formula, Y is the residue given by removing hydroxyl groups from a polyhydric alcohol having 3 to 6 hydroxyl groups, and k is the number of hydroxyl groups of the polyhydric alcohol. EO is an oxyethylene group; AO is an oxyalkylene group having 3 to 4 carbon atoms, and 1≦a≦70, 1≦b≦70. The percentage of the oxyethylene groups with respect to the sum of the oxyalkylene groups having 3 to 4 carbon atoms and the oxyethylene groups is 20 to 100 mass %. The oxyalkylene group having 3 to 4 carbon atoms and the oxyethylene group are added randomly. Rs are either identical to or different from each other, and they are hydrocarbon groups having 1 to 4 carbon atoms.)
摘要翻译：本发明提供一种具有良好的保湿性，粗糙的皮肤改善效果和改善的使用感的皮肤外用剂。包含由下述通式（I）表示的聚氧化亚烷基二醇/聚乙二醇共聚物烷基醚衍生物的皮肤外用制剂：（式I）<？in-line-formula description =“In-line Formulas”end =“lead “？”Y- {O（EO）a /（AO）bR} k（I）<？in-line-formula description =“In-line Formulas”end =“tail”？>（在公式中，Y是通过从具有3〜6个羟基的多元醇除去羟基而得到的残基，k为多元醇的羟基数，EO为氧化乙烯基，AO为碳原子数3〜4的氧化烯基， 1 <= a <= 70，1 <= b <= 70，氧化乙烯基相对于具有3〜4个碳原子的氧化烯和氧化乙烯基的总和的比例为20〜100质量％，氧化烯随机添加3〜4个碳原子的基团和氧化乙烯基，Rs可以相同也可以不同，它们是具有1〜4个碳原子的烃基 n原子）

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