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1. 发明申请

WO2022104673A1 一种花生四烯酸的生产方法审中-公开
公开(公告)号：WO2022104673A1
公开(公告)日：2022-05-27
申请号：PCT/CN2020/130322
申请日：2020-11-20
申请人：内蒙古金达威药业有限公司 , 厦门金达威集团股份有限公司
发明人：王霄凤 , 陈必钦 , 严必能 , 刘子睿
IPC分类号： C12P7/64 , C12N1/14 , C12Q3/00 , C12R1/645
摘要：属于发酵工程领域，涉及一种花生四烯酸的生产方法，包括将高山被抱霉或其突变菌株依次进行菌株活化、种子扩大培养和发酵培养，且在发酵培养过程中，在线监测OUR并将OUR数值控制在10-100mmol／Lh，和／或，在发酵培养的第100h之后，在线监测发酵液中的ORP并将ORP数值控制在50-150mv。采用所述方法能够稳定提高发酵生产水平，使所得发酵液中花生四烯酸的含量明显提高。

2. 发明申请

WO2020002713A1 METHOD IN BIOPROCESS PURIFICATION SYSTEM 审中-公开
公开(公告)号：WO2020002713A1
公开(公告)日：2020-01-02
申请号：PCT/EP2019/067643
申请日：2019-07-01
申请人： GE HEALTHCARE BIO-SCIENCES AB
发明人： HYCKENBERG, Key , SKOGLAR, Helena , MALMQUIST, Gunnar , CARLSTEN, Mikael , LUNDQVIST, Roger , ANDERSSON, Dan , MATHIASSON, Linda , MATTSSON, Lars , SENDABO, Sara , BERG, Mikael
IPC分类号： C12M1/36 , C12P21/00 , C12Q3/00 , G06N20/00
摘要： The present invention relates to a method for optimizing a bioprocess purification system comprising a bioreactor configured to provide a harvest comprising a target composition, and a purification process arranged downstream the bioreactor and being configured for purification of the harvest to produce a target product having a desired characteristics. The method comprising: a) detecting (32) at least one quality attribute indicative of characteristics of the target product in a downstream process, b) identifying (33) correlations between the at least one quality attribute measured in the downstream process and parameters to control a cell culture process in the bioreactor, and c) controlling (34) the cell culture process to meet the desired characteristics based on the identified correlations, whereby the target characteristics is within a p re- determined range.

3. 发明申请

WO2019030186A1 USE OF FCA CONTROL BASED ON PH 审中-公开
公开(公告)号：WO2019030186A1
公开(公告)日：2019-02-14
申请号：PCT/EP2018/071311
申请日：2018-08-07
申请人： NOVOZYMES A/S
发明人： CORNELISSEN, Sjef , CASSELLS, Benny
IPC分类号： C12N1/20 , C12Q3/00 , C12N1/14 , C12N9/54
摘要： Disclosed is a method for controlling the carbon feed to a fed-batch fermenter based on the disturbance of the pH signal following the addition or a limiting substrate.

4. 发明申请

WO2018152408A1 PLEUROMUTILIN DERIVATIVES AND USES THEREOF 审中-公开
公开(公告)号：WO2018152408A1
公开(公告)日：2018-08-23
申请号：PCT/US2018/018503
申请日：2018-02-16
申请人： UNIVERSITY OF TENNESSEE RESEARCH FOUNDATION
发明人： KUROSU, Michio , MITACHI, Katsuhiko
IPC分类号： C12N1/14 , C12P15/00 , C12Q3/00
CPC分类号： A61K31/65 , A61K31/16 , A61K31/4015 , C12Q3/00 , A61K2300/00
摘要： Provided herein are pleuromutilin derivatives and analogs that are useful antimicrobial agents against Acinetobacter baumannii and Mycobacterium.

5. 发明申请

WO2018134820A1 SYSTEM AND METHOD FOR GROWING ALGAE 审中-公开
公开(公告)号：WO2018134820A1
公开(公告)日：2018-07-26
申请号：PCT/IL2018/050067
申请日：2018-01-18
申请人： ALGAENNOVATION LTD
发明人： BASHAN, Oded , BASHAN, Ohad , DRUMMEY, Stephen
IPC分类号： C12M1/04 , C12M1/02 , C12M1/34 , C12M1/36 , C12Q3/00 , C12N1/04 , C12N1/12 , B01F3/04
摘要： Some aspects of the invention may be directed to an algae cultivation container sparging system that include at least one sensor, to measure at least one parameter within the container; at least one first sparger, to distribute a first fluid into the container at a first operating flow rate; at least one second sparger, to distribute a second fluid into the container at a second operating flow rate based on the at least one measured parameter; at least one light source, to illuminate the interior of the container; and at least one controller. In some embodiments, the controller may be configured to control the first operating flow rate and the second operating flow rate. The controller may further be configured to control the at least one light source.

6. 发明申请

WO2017205705A1 SYSTEMS AND METHODS FOR CONTINUOUSLY FERMENTING C5 AND C6 SACCHARIDES 审中-公开
标题翻译：用于连续引发C5和C6糖链的系统和方法
公开(公告)号：WO2017205705A1
公开(公告)日：2017-11-30
申请号：PCT/US2017/034596
申请日：2017-05-26
申请人： API INTELLECTUAL PROPERTY HOLDINGS, LLC
发明人： SURVASE, Shrinkant , ZEBROSKI, Ryan , ADAMOS, Georgios , PYLKKANEN, Vesa
IPC分类号： C12P7/04 , C12P7/06 , C12P7/14 , C12P7/16 , C12P7/28 , C12Q3/00
CPC分类号： C12P7/10 , C12P7/04 , C12P7/16 , C12P7/28 , C12P7/52 , C12P7/54 , C12P19/02 , C12P19/14 , C12P2201/00 , C12P2203/00 , Y02E50/10 , Y02E50/16 , Y02E50/17
摘要： This invention provides optimized fermentation of cellulosic and hemicellulosic sugars. Biomass-derived hemicellulosic and cellulosic sugars are independently conditioned and separately fermented, utilizing reuse and recycle of microorganisms, metabolic intermediates, and nutrients. Conditioned sugars can be fermented in separate vessels, where excess cells from glucose fermentation are conveyed to hemicellulose sugar fermentation along with raffinate from solvent recovery, to enhance productivity and product yield. Some variations provide a method of fermenting C 5 and C 6 sugars to fermentation products, the method comprising: fermenting a C 6 -rich sugar feed to a first fermentation product; fermenting a C 5 -rich sugar feed to a second fermentation product; removing microorganism cells from the first fermentor, to maintain a cell concentration within a selected range; conveying microorganism cells to a second fermentor; and removing microorganism cells from the second fermentor, to maintain a microorganism cell concentration that is greater than that in the C 6 -rich fermentor.
摘要翻译：本发明提供了纤维素和半纤维素糖的优化发酵。利用微生物，代谢中间体和营养物质的再利用和再循环，将生物质衍生的半纤维素和纤维素糖独立调节并分别发酵。条件糖可以在单独的容器中发酵，其中来自葡萄糖发酵的过量细胞与来自溶剂回收的提余液一起被输送到半纤维素糖发酵，以提高生产率和产品产量。一些变化提供了将C 5和C 6糖发酵成发酵产物的方法，所述方法包括：发酵富含C 6的糖进料到第一发酵产物; 将第C 5高丰度糖原料发酵成第二发酵产物; 从第一发酵罐中除去微生物细胞，以将细胞浓度保持在选定范围内; 将微生物细胞输送至第二发酵罐; 并从第二发酵罐中除去微生物细胞，以保持比富含Cys6的发酵罐更高的微生物细胞浓度。

7. 发明申请

WO2017177111A1 A MULTI-LEVEL, LABORATORY-BASED SURVEILLANCE SYSTEM FOR DETECTION OF INTRAOPERATIVE "ESKAPE" BACTERIAL PATHOGENS FOR HCAI PREVENTION 审中-公开
标题翻译：一种用于检测HCAI预防“ESKAPE”细菌病原体的多级实验室监测系统
公开(公告)号：WO2017177111A1
公开(公告)日：2017-10-12
申请号：PCT/US2017/026557
申请日：2017-04-07
申请人： RDB BIOINFORMATICS, LLC
发明人： LOFTUS, Randy W.
IPC分类号： C12M1/36 , C12Q1/00 , C12Q1/68 , C12Q1/70 , C12Q3/00 , G01N33/48 , G06F7/00
CPC分类号： C12Q1/04 , C12Q1/025 , C12Q1/689 , C12Q3/00 , G01N2800/26 , G01N2800/50 , G06F7/00 , G16B10/00 , G16B40/00 , G16B50/00 , G16B99/00 , G16H50/70
摘要： The present invention provides systems and methods for surveillance, diagnosis, and evaluation of high risk bacterial transmission events. The systems and methods utilize software and computational systems that automate identification, surveillance, and communication. The invention further includes archival systems for use in the systems and methods that compile bacterial isolates linked to information about patients, pre-operative, intra-operative, or post-operative arenas, healthcare providers, and the like.
摘要翻译：本发明提供了用于监测，诊断和评估高风险细菌传播事件的系统和方法。该系统和方法利用软件和计算系统，使识别，监视和通信自动化。本发明进一步包括用于系统和方法中的档案系统，所述系统和方法编辑与关于患者，手术前，手术中或手术后场所，医疗保健提供者等等的信息相关联的细菌分离株。

8. 发明申请

WO2015003064A2 SYSTEM AND METHOD FOR HIGH-THROUGHPUT ASSESSMENT OF CELLULAR CARDIOTOXICITY, DRUG SCREENING, AND CARDIOGENIC FACTORS VIA ON-LINE PHYSIOLOGICAL MEASUREMENTS 审中-公开
标题翻译：通过在线生理测量来高密度地评估细胞毒性，药物筛选和致癌因子的系统和方法
公开(公告)号：WO2015003064A2
公开(公告)日：2015-01-08
申请号：PCT/US2014/045265
申请日：2014-07-02
申请人： THE TRUSTEES COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
发明人： TANDON, Nina , CIMETTA, Elisa , RONALDSON, Kacey , VUNJAK-NOVAKOVIC, Gordana
IPC分类号： C12Q3/00
CPC分类号： G01N33/4836 , G01N27/26 , G01N33/5008
摘要： An integrated system for detecting safety and/or efficacy issues related to potential drug compounds by combining tissue maturation, imaging and electrophysiology measurements, at high throughput, with high signal to noise ratio. Testing includes cardiotoxicity screening, drug screening, and screening for cardiogenic factors via on-line physiological measurements.
摘要翻译：通过组合成熟，成像和电生理学测量，以高通量，高信噪比来检测与潜在药物化合物相关的安全性和/或功效问题的综合系统。测试包括心脏毒性筛查，药物筛选和通过在线生理测量筛查心源性因素。

9. 发明申请

WO2013100756A3 A METHOD AND A SYSTEM FOR MASS-CULTIVATING MICROALGAE WITH ENHANCED PHOTOSYNTHETIC EFFICIENCY 审中-公开
标题翻译：用于增强光化学效率的微囊藻毒素的方法和系统
公开(公告)号：WO2013100756A3
公开(公告)日：2014-10-16
申请号：PCT/MY2012000290
申请日：2012-11-29
申请人： HO TET SHIN
发明人： HO TET SHIN
IPC分类号： C12M1/06 , C12N1/12 , C12P1/00 , C12Q3/00
CPC分类号： C12M41/46 , C12M21/02 , C12M41/36 , C12N1/12
摘要： A method for cultivating photosynthetic microorganisms with optimal photosynthetic efficiency, comprising the steps of exposing the microorganisms grown in a culture tank of culture broth to light and carbon source; circulating the culture broth vertically from the bottom of the tank up to the surface of the tank to allow momentary exposure of the microorganisms to the light and carbon source, using one or more circulating means located within the culture tank which are regulated according to a selected cultivation mode; and maintaining the cultured microorganisms at a substantially constant areal density range of 300 to 12,000 g/m2 to attain the optimal photosynthetic efficiency of the cultivation.
摘要翻译：一种培养具有最佳光合效率的光合微生物的方法，包括将生长在培养液培养槽中的微生物暴露于光和碳源的步骤; 将培养液从容器底部垂直循环到罐的表面，以允许使用位于培养槽内的一种或多种循环装置将微生物瞬间暴露于光和碳源，所述循环装置根据所选择的调节栽培模式; 并将培养的微生物保持在300至12,000g / m 2的基本恒定的面积密度范围，以获得最佳的培养光合效率。

10. 发明申请

WO2014047082A1 A PROCESS TO CONTROL CO CONCENTRATIONS IN FERMENTATIONS 审中-公开
标题翻译：控制发酵中浓缩浓度的方法
公开(公告)号：WO2014047082A1
公开(公告)日：2014-03-27
申请号：PCT/US2013/060238
申请日：2013-09-18
申请人： INEOS BIO SA , SNYDER, David Scott
发明人： SNYDER, David Scott
IPC分类号： C12P7/06 , C12Q3/00 , G01N21/75
CPC分类号： C12Q1/04 , C12P7/065 , C12P7/08 , C12Q3/00 , G01N21/31 , G01N33/84 , Y02E50/17
摘要： A process for controlling concentration of CO in a bioreactor provides a direct and real time measurement of dissolved CO in a fermentation medium. The process for controlling concentrations of CO in a bioreactor includes contacting an aliquot of fermentation medium with at least one CO binding ligand and at least one microbial inactivator.
摘要翻译：用于控制生物反应器中CO浓度的方法提供了发酵培养基中溶解的CO的直接和实时测量。用于控制生物反应器中CO浓度的方法包括将等分试样的发酵培养基与至少一种CO结合配体和至少一种微生物灭活剂接触。

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