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    • 1. 发明申请
    • DISPOSITIVO ADAPTABLE A EQUIPOS DE RADIOTERAPIA EXTERNA QUE CONCENTRA LA DOSIS EN EL BLANCO CON FOCO VARIABLE
    • WO2020021315A1
    • 2020-01-30
    • PCT/IB2018/055616
    • 2018-07-27
    • UNIVERSIDAD DE LA FRONTERA
    • FIGUEROA SAAVEDRA, Rodolfo Gabriel
    • A61N5/00G21K1/02G21K5/00H05H9/00H05H9/02H05H9/04
    • Un dispositivo concentrador de fluencia de radiación ionizante (100) de foco variable adaptable a una fuente de electrones de alta energía de un dispositivo de radioterapia externa con acelerador lineal, para focalizar y guiar el foco de manera continua y menos invasiva, dentro de una zona determinada, que comprende: una estructura de acople que une al dispositivo de radioterapia externa con acelerador lineal con una estructura exterior (101); un sistema de giro que se une a la estructura de acople con una brida de acople (8) hace girar una estructura interior (102); un sistema de deflexión (103) de electrones que está en la estructura interior (102), en donde el sistema de deflexión (103) comprende, un primer y un segundo dispositivo de deflexión magnética (13, 14); y unos elementos corrección de haz de electrones (104); un disco (26) de disipación térmica, que comprende un anillo blanco (19) en donde impactan los electrones provenientes del sistema de deflexión (103) en el perímetro del anillo, generándose allí los rayos X; un blindaje (20); un sistema de control de foco, que está en el sistema de deflexión (103) de electrones, que comprende un sistema electrónico de control (31) que controla un conjunto a los motores (12, 22) que generan desplazamientos coordinados del segundo dispositivo de deflexión magnética (14), un elemento de corrección y un colimador (25), que permiten cambiar la posición del punto focal; y al menos un diodo laser (74) ubicado en el borde del colimador (25) apuntando hacia el foco permitiendo determinar la posición de haz de rayos X generado.
    • 2. 发明申请
    • USE OF LINEAR ION ACCELERATORS FOR THE TREATMENT OF ATRIAL FIBRILLATION AND ION ACCELERATOR SYSTEM THERE FOR
    • 线性加速器用于治疗ATRIAL FIBRILLATION和离子加速器系统的应用
    • WO2015025203A1
    • 2015-02-26
    • PCT/IB2014/001514
    • 2014-08-13
    • FONDAZIONE PER ADROTERAPIA ONCOLOGICA - TERA
    • AMALDI, Ugo
    • H05H7/22H05H9/04
    • A61N5/1064A61N5/1067A61N2005/1087H05H7/22H05H9/041H05H2277/11
    • The application of a system (12) is proposed for the acceleration of ions to treat Atrial Fibrillation (AF), arteriovenous malformations (AVMS) and focal epileptic lesions; this system (12) is composed of a pulsed ion source (1), a pre-accelerator (3) and one or more linear accelerators or linacs (5, 6, 7) operating at frequencies above 1 GHz with a repetition rate between 1 Hz and 500 Hz. The particle beam coming out of the complex (12) can vary in intensity (i), (acting on the ion source (1) ), (ii) in deposition depth (by independently adjusting the radiofrequency of the power sources that feed the linac accelerators units) and (iii) transversally with respect to the central beam direction (by varying the current in the coils of two orthogonal scanning magnets placed upstream of the patient). The possibility of adjusting in a few milliseconds and in three orthogonal directions, the location of each energy deposition in the body of the patient makes that system of accelerators (12) perfectly suited to irradiation of a beating heart.
    • 提出了一种系统(12)的应用,用于加速离子以治疗心房颤动(AF),动静脉畸形(AVMS)和局灶性癫痫病变; 该系统(12)由脉冲离子源(1),预加速器(3)和一个或多个在1GHz以上的频率工作的线性加速器或线性加速器(5,6,7)组成,重复率为1 Hz和500 Hz。 从复合体(12)出来的粒子束的强度(i),(作用在离子源(1))上,(ii)沉积深度(通过独立地调整供给线性加速器的电源的射频) 加速器单元)和(iii)相对于中心束方向横向(通过改变放置在患者上游的两个正交扫描磁体的线圈中的电流)。 在几毫秒和三个正交方向调整的可能性,每个能量沉积在患者体内的位置使得加速器(12)的系统完全适合于跳动心脏的照射。
    • 4. 发明申请
    • DISPOSITIF HYPERFREQUENCES D'ACCELERATION D'ELECTRONS
    • 用于加速电子的微波器件
    • WO2011020882A1
    • 2011-02-24
    • PCT/EP2010/062110
    • 2010-08-19
    • THALESSIERRA, Serge
    • SIERRA, Serge
    • H05H7/12H05H9/04
    • H05H7/12H05H9/04
    • L'invention concerne un dispositif hyperfréquences d'accélération d'électrons comportant, un canon (50) à électrons fournissant un faisceau d'électrons (54) selon un axe ZZ' dans une structure hyperfréquence (60) d'accélération des électrons du faisceau ayant à une des extrémité (62), du côté du canon à électrons, une entrée (66) du faisceau d'électrons, à l'autre extrémité (64), une sortie (68) d'électrons accélérés, entre les deux extrémités de la structure une suite de n cavités C1, C2,... Ci,... Cx,... Cn couplées selon ledit axe ZZ', de fréquence centrale de résonance fO, une entrée (74) de signal hyperfréquences d'excitation Urf de la structure hyperfréquences par une des cavités Ci de la suite des n cavités, un générateur radiofréquences (76) fournissant le signal hyperfréquences d'excitation Urf à la structure hyperfréquence d'accélération, une unité centrale UC (90) configurée pour commander la variation d'énergie des électrons en sortie de la structure hyperfréquences. Le générateur radiofréquences (76) comporte, une entrée de contrôle (78) de fréquence pour changer la fréquence Fv du signal hyperfréquences d'excitation Urf autour de la fréquence centrale de résonance fO, le changement de la fréquence Fv du signal d'excitation produisant une variation de l'énergie des électrons accélérés du faisceau en sortie de la structure hyperfréquences (60) Application : inspection de conteneurs par irradiation de photons, radiothérapie médicale.
    • 本发明涉及一种用于加速电子的微波器件,它包括一个在微波结构(60)中沿ZZ'轴线提供电子束(54)的电子炮(50),用于加速光束的电子, 在电子枪侧的端部(62)上具有用于电子束的输入(66),在另一端(64)处,用于加速电子的输出(68)在结构的两端之间, 沿着所述轴线ZZ'耦合的一系列n腔C1,C2,... Ci,... Cx,... Cn到中心共振频率f0,用于微波信号的输入(74)用于激励 通过一系列n腔的空腔C1中的一个的微波结构,向微波加速结构提供微波激发信号Urf的射频发生器(76),配置成控制微波激发信号Urf的能量变化的中央处理单元UC(90) 电子离开微波结构。 射频发生器(76)包括频率控制输入(78),用于改变围绕中心谐振频率f0的微波激励信号Urf的频率Fv,激励信号的频率Fv的变化产生能量的变化 离开微波结构(60)的光束的加速电子。 本发明可用于通过照射光子或用于医疗放射治疗来检查容器。
    • 6. 发明申请
    • ION ACCELERATION SYSTEM FOR HADRONTHERAPY
    • 离子加速系统
    • WO2006081847A1
    • 2006-08-10
    • PCT/EP2005/011566
    • 2005-10-28
    • FONDAZIONE PER ADROTERAPIA ONCOLOGICA - TERA
    • AMALDI, UgoCRESCENTI, MassimoZENNARO, Riccardo
    • H05H9/04H05H13/00
    • H05H13/00G21K5/04H05H9/04
    • System for ion acceleration for medical purposes comprising a conventional or superconducting cyclotron, a radiofrequency linear accelerator (Linac), a Medium Energy Beam Transport line (MEBT) connected, at the low energy side, to the exit of the cyclotron, and at the other side, to the entrance of the linear radiofrequency accelerator, as well as a High Energy Beam Transport line (HEBT) connected at high energy side to the radiofrequency linear accelerator exit and at the other end, to a system for the dose distribution to the patient. The high frequency of operation of the Linac allows for a reduced consumption and a remarkable compactness facilitating its installation in hospital structures. The use of a modular LINAC allows varying in active way the energy and the current of the therapeutic beam, having a small emittance and a time structure adapted to the dose distribution based on the technique known as the "spot scanning".
    • 用于医疗用途的用于离子加速的系统包括常规或超导回旋加速器,在低能量侧连接到回旋加速器的出口的射频线性加速器(Linac),中等能量束输送线(MEBT)以及另一个 侧向线性射频加速器的入口以及在高能量侧连接到射频线性加速器出口的另一端的高能束输送线(HEBT)连接到用于剂量分配给患者的系统 。 线性面包线的高频率运行允许减少消耗和显着的紧凑性,便于其在医院结构中的安装。 使用模块化的LINAC允许主动地改变基于被称为“点扫描”的技术的具有适合于剂量分布的小的发射率和时间结构的治疗束的能量和电流。
    • 8. 发明申请
    • STANDING-WAVE ELECTRON LINEAR ACCELERATOR
    • 标准波电子线性加速器
    • WO2004033613A3
    • 2004-07-08
    • PCT/US0332447
    • 2003-10-14
    • SCANTECH HOLDINGS LLCPIROZHENKO VITALY MBOWSER GARY FBELUGIN VLADIMIR MROZANOV NIKOLAY E
    • PIROZHENKO VITALY MBOWSER GARY FBELUGIN VLADIMIR MROZANOV NIKOLAY E
    • C12M20060101H05H9/00H05H9/04
    • H05H9/04
    • A particle accelerator system, including apparatuses and methods, for producing a beam of bunched charged particles at high intensities and with minimal energy dispersion comprises a bunching section having a plurality of bunching cavities, an accelerating section having a plurality of accelerating and coupling cavities, and an electromagnetic drive subsystem having a single radio-frequency (RF) generator coupled to the accelerating section at a single location. The accelerating and bunching sections are directly coupled and share a common wall, which may have a resonant coupling cavity therein, such that charged particles bunch in the bunching section and travel through the common wall into the accelerating section where they are accelerated and exit the particle accelerator system as a beam of bunched charged particles. Preferably, a phase shift of one hundred-eighty degrees (180 DEG ) (or it radians) is created between the electric fields of successive bunching cavities in the bunching section.
    • 用于以高强度和最小能量分散生产聚束带电粒子束的粒子加速器系统包括具有多个聚束腔的聚束部分,具有多个加速和耦合空腔的加速部分,以及 具有在单个位置处耦合到加速部分的单个射频(RF)发生器的电磁驱动子系统。 加速和聚束部分被直接耦合并且共享共同的壁,其可以在其中具有谐振耦合空腔,使得带电粒子束在聚束部分中并且穿过共用壁进入加速部分,在那里它们被加速并离开颗粒 加速器系统作为聚束带电粒子束。 优选地,在聚束部分中连续的聚束空腔的电场之间产生了一百八十度(180度)(或其弧度)的相移。
    • 9. 发明申请
    • PARTICLE ACCELERATOR HAVING WIDE ENERGY CONTROL RANGE
    • 颗粒加速器具有宽的能量控制范围
    • WO2004030424A3
    • 2004-07-08
    • PCT/US0330548
    • 2003-09-29
    • SCANTECH HOLDINGS LLCZAVADTSEV ALEXANDRE ABOWSER GARY F
    • ZAVADTSEV ALEXANDRE ABOWSER GARY F
    • G21K5/04H01J3/14H01S1/00H05H7/22H05H15/00H01J37/30H05H9/00H05H9/04
    • H05H15/00G21K5/04H05H7/22
    • A particle accelerator system (100) for producing a charged particle beam having pulses of charged particles that have different energy levels from pulse to pulse. The system enables independent adjustment of the RF power delivered to first (102) and second (104) accelerating sections thereof without adjustment of the RF power generated by an RF source (106). Such independent adjustment enables the RF power provided to the first accelerating section (102) to be maintained at a level appropriate for optimal particle capturing therein and for producing a tightly, bunched beam of particles having different energy levels from pulse to pulse, while enabling; the RF power provided to the second accelerating section (104) to be varied in order to vary the energy levels of the charged particles of the charged particle beam from pulse to pulse.
    • 一种粒子加速器系统(100),用于产生具有从脉冲到脉冲具有不同能级的带电粒子的脉冲的带电粒子束。 该系统能够独立调节传送到其第一(102)和第二(104)加速部分的RF功率,而不调整由RF源(106)产生的RF功率。 这种独立调整使得能够将提供给第一加速部分(102)的RF功率保持在适合于其中的最佳粒子捕获的水平,并且在使能时产生具有不同能量水平的紧密束缚的粒子束从脉冲到脉冲; 提供给第二加速部分(104)的RF功率被改变以便改变带电粒子束的带电粒子从脉冲到脉冲的能级。
    • 10. 发明申请
    • LINAC FOR ION BEAM ACCELERATION
    • LINAC用于离子束加速
    • WO2004054331A1
    • 2004-06-24
    • PCT/EP2003/006254
    • 2003-06-13
    • FONDAZIONE PER ADROTERAPIA ONCOLOGICA - TERA
    • AMALDI, UgoCRESCENTI, MassimoZENNARO, Riccardo
    • H05H9/04
    • H05H9/00H05H7/22
    • A drift tube (15) linear accelerator (linac) (4) that can be used for the acceleration of low energy ion beams is disclosed. The particles enter the linac (4) at low energy and are accelerated and focused along a straight line in a plurality of resonant accelerating structures (8) interposed by coupling structures (9) up to the desired energy, for instance for therapeutic needs. In the accelerating structures (8), excited by an H-type resonant electromagnetic field, a plurality of accelerating gaps (20) is provided between said drift tubes (15), said drift tubes being supported by stems, for instance alternatively horizontally (16) and vertically (17) disposed. A basic module (7) is disclosed, composed of two accelerating structures (8) and an interposed coupling structure (9), or if necessary a modified coupling structure (9A) connected to a RF power generator (11), being linked if necessary to a vacuum system (13 ) and equipped if necessary with one or more quadrupoles (18). Said basic module (7) can be expanded to get modules (7A) that present an odd number n of coupling structures (9, 9A) which still if necessary are equipped with one or more quadrupoles (18), and an even number N = n + 1 of accelerating structures (8). The proposed linac (4) contains one or more modules (7, 7A) and allows obtaining a large accelerating gradient and a very compact structure.
    • 公开了一种可用于加速低能量离子束的漂移管(15)直线加速器(直线加速器)(4)。 颗粒以低能量进入直线加速器(4),并且在多个谐振加速结构(8)中沿着直线加速聚焦,所述多个谐振加速结构(8)插入通过耦合结构(9)达到期望的能量,例如用于治疗需要。 在由H型共振电磁场激发的加速结构(8)中,在所述漂移管(15)之间设置有多个加速间隙(20),所述漂移管由杆支撑,例如水平地(16 )和垂直(17)。 公开了由两个加速结构(8)和插入的耦合结构(9)组成的基本模块(7),或者如果需要,连接到RF发电机(11)的修改的耦合结构(9A),如果需要则链接 到真空系统(13)并且如果必要的话配备一个或多个四极杆(18)。 所述基本模块(7)可以被扩展以获得呈现奇数N个耦合结构(9,9A)的模块(7A),其仍然需要配备有一个或多个四极(18),偶数N = n + 1加速结构(8)。 所提出的直线加速器(4)包含一个或多个模块(7,7A),并且允许获得大的加速梯度和非常紧凑的结构。