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1. 发明申请

WO2023038859A1 CHARACTERIZATION AND LOCALIZATION OF PROTEIN MODIFICATIONS 审中-公开
公开(公告)号：WO2023038859A1
公开(公告)日：2023-03-16
申请号：PCT/US2022/042499
申请日：2022-09-02
申请人： NAUTILUS BIOTECHNOLOGY, INC.
发明人： JOLY, James Henry , RINKER, Torri Elise , INMAN, Christina E.
IPC分类号： G01N33/68 , C12Q1/68 , C40B20/02 , C40B20/04 , C40B70/00
摘要： A method for characterizing proteins, including steps of (a) detecting a plurality of proteins, wherein individual proteins of the plurality are associated with unique identifiers, wherein the detecting distinguishes the identities of the individual proteins and the unique identifiers associated with the individual proteins; (b) digesting the proteins to form peptides, wherein the peptides from each protein are associated with the unique identifiers for the respective individual protein; (c) detecting the peptides and associated unique identifiers, wherein the detecting distinguishes characteristics of individual peptides, and wherein the detecting distinguishes unique identifiers associated with the individual peptides; and (d) correlating characteristics detected in step (c) with individual proteins detected in step (a) based on the unique identifiers associated with the individual proteins and the peptides.

2. 发明申请

WO02016903A3 MICROFLUIDIC DEVICE AND METHOD WITH TRAPPING OF SAMPLE IN CARITIES HAVING LIDS THAT CAN BE OPENED OR CLOSED 审中-公开
标题翻译：微型流体装置和方法，在具有可以打开或关闭的小狗的货物中捕捉样品
公开(公告)号：WO02016903A3
公开(公告)日：2002-05-30
申请号：PCT/SE2001/001798
申请日：2001-08-23
IPC分类号： G01N1/00 , B01J19/00 , B01L3/00 , B03C1/035 , C12M1/00 , C12Q1/68 , C40B20/02 , C40B40/06 , C40B60/14 , G01N1/02 , G01N27/00 , G01N27/22 , G01N33/543 , G01N37/00 , B03C1/00 , C12Q1/00
CPC分类号： B01J19/0093 , B01J19/0046 , B01J2219/00317 , B01J2219/0034 , B01J2219/00439 , B01J2219/00459 , B01J2219/005 , B01J2219/00585 , B01J2219/0059 , B01J2219/00596 , B01J2219/00605 , B01J2219/00608 , B01J2219/00612 , B01J2219/00621 , B01J2219/00648 , B01J2219/00659 , B01J2219/00689 , B01J2219/00722 , B01J2219/00783 , B01J2219/00822 , B01J2219/00828 , B01J2219/00833 , B01J2219/00914 , B01J2219/00918 , B01J2219/0093 , B01J2219/00934 , B01J2219/0095 , B01L3/502761 , B01L3/50853 , B01L2200/0647 , B01L2300/049 , B01L2300/0819 , B01L2400/043 , B01L2400/0433 , B03C1/035 , C12Q1/6825 , C40B40/06 , C40B60/14 , G01N33/54333
摘要： The present invention relates to a sample preparing arrangement (10) submergible in a liquid medium, comprising a carrier structure (11), at least one cavity (12) in said carrier, in communication with said cavity an arrangement (13) for controllable generation of a magnetic filed through influence of a control signal. The sample preparing arrangement comprises a magnetic covering structure (4) for covering/uncovering said cavity in operative interaction with said magnetic field.
摘要翻译：本发明涉及在液体介质中可浸没的样品制备装置（10），其包括载体结构（11），所述载体中的至少一个空腔（12），与所述空腔连通，用于可控产生的装置（13）的磁场通过控制信号的影响。样品制备装置包括用于覆盖/揭开与所述磁场有效相互作用的所述空腔的磁性覆盖结构（4）。

3. 发明申请

WO0216904A3 MICROFLUIDIC DEVICE AND METHOD WITH TRANSPORT OF MAGNETIC PARTICLES INTO AND OUT OF WELLS 审中-公开
标题翻译：微流体装置和方法将磁性颗粒运输到和流出
公开(公告)号：WO0216904A3
公开(公告)日：2002-05-23
申请号：PCT/SE0101799
申请日：2001-08-23
申请人： IMEGO AB , STOREK DAVID , SCHNEEBERGER NIKLAUS , OTILLAR ROBERT P , KROZER ANATOL
发明人： STOREK DAVID , SCHNEEBERGER NIKLAUS , OTILLAR ROBERT P , KROZER ANATOL
IPC分类号： G01N1/00 , B01J19/00 , B01L3/00 , B03C1/035 , C12M1/00 , C12Q1/68 , C40B20/02 , C40B40/06 , C40B60/14 , G01N1/02 , G01N27/00 , G01N27/22 , G01N33/543 , G01N37/00 , B03C1/00 , C12Q1/00
CPC分类号： B01J19/0093 , B01J19/0046 , B01J2219/00317 , B01J2219/0034 , B01J2219/00439 , B01J2219/00459 , B01J2219/005 , B01J2219/00585 , B01J2219/0059 , B01J2219/00596 , B01J2219/00605 , B01J2219/00608 , B01J2219/00612 , B01J2219/00621 , B01J2219/00648 , B01J2219/00659 , B01J2219/00689 , B01J2219/00722 , B01J2219/00783 , B01J2219/00822 , B01J2219/00828 , B01J2219/00833 , B01J2219/00914 , B01J2219/00918 , B01J2219/0093 , B01J2219/00934 , B01J2219/0095 , B01L3/502761 , B01L3/50853 , B01L2200/0647 , B01L2300/049 , B01L2300/0819 , B01L2400/043 , B01L2400/0433 , B03C1/035 , C12Q1/6825 , C40B40/06 , C40B60/14 , G01N33/54333
摘要： The present invention relates to an arrangement (10, 20) for preparing samples (15, 27), submergible in a liquid medium. The arrangement comprises a section provided with a device (13, 23) for controllable generation of a magnetic filed through influence of a control signal, said magnetic field being generated to attract at least part of said at least first and second type of samples (15, 27) at one stage and to repel at least one of said first or second type of samples in a second stage.
摘要翻译：本发明涉及一种用于制备在液体介质中浸没的样品（15,27）的装置（10,20）。该装置包括具有通过控制信号的影响可控地产生磁场的装置（13,23）的部分，所述磁场被产生以吸引至少部分所述至少第一和第二类型的样品（15 ，27），并且在第二阶段排斥所述第一或第二类型样品中的至少一个。

4. 发明申请

WO02024324A2 FOCUSED ACOUSTIC ENERGY IN THE PREPARATION AND SCREENING OF COMBINATORIAL LIBRARIES 审中-公开
标题翻译：在组合图书馆的准备和筛选中聚焦的声能
公开(公告)号：WO02024324A2
公开(公告)日：2002-03-28
申请号：PCT/US2001/030094
申请日：2001-09-25
IPC分类号： G01N33/53 , B01J4/02 , B01J19/00 , B01J19/10 , B01J19/12 , B05B17/04 , B05B17/06 , B41J2/04 , B41J2/14 , C07B61/00 , C40B20/02 , C40B40/06 , C40B40/10 , C40B60/14 , G01N35/10 , G01N37/00
CPC分类号： B41J2/04 , B01J19/0046 , B01J2219/00351 , B01J2219/00378 , B01J2219/00497 , B01J2219/00527 , B01J2219/00585 , B01J2219/0059 , B01J2219/00596 , B01J2219/00605 , B01J2219/00608 , B01J2219/0061 , B01J2219/00612 , B01J2219/00626 , B01J2219/00637 , B01J2219/00641 , B01J2219/00659 , B01J2219/00722 , B01J2219/00725 , B01L2400/0433 , B05B17/0607 , B05B17/0615 , B41J2/14008 , C07B2200/11 , C40B40/06 , C40B40/10 , C40B60/14
摘要： The present invention provides a method for the acoustic ejection of fluid droplets (49) from each of a plurality of fluid-containing reservoirs (13, 15) to prepare combinatorial libraries in the form of microarrays. An acoustic ejection device (11) is used comprised of a plurality of fluid reservoirs (13, 15), an ejector (33) for generating acoustic radiation and focusing the acoustic radiation generated at a focal point sufficiently near the fluid surface (17, 19) in each of the reservoirs (13, 15) such that a fluid droplet (49) is ejected therefrom toward a site on a substrate surface (51), and a means for positioning (43) the ejector (33) in acoustically coupled relationship to each of the reservoirs (13, 15). The combinatorial libraries may comprise biological or nonbiological moieties.
摘要翻译：本发明提供了一种用于从多个含液体储存器（13,15）中的每一个的声弹出液体（49）的方法，以制备微阵列形式的组合文库。使用由多个流体储存器（13,15）组成的声学喷射装置（11），用于产生声辐射的喷射器（33）并且聚焦在足够靠近流体表面（17,19）的焦点处产生的声辐射），使得流体液滴（49）从其中朝向基板表面（51）上的位置喷射，并且用于将喷射器（33）定位（43）为声耦合关系的装置到每个储存器（13,15）。组合文库可以包括生物或非生物部分。

5. 发明申请

WO01068236A2 PROCESS AND APPARATUS FOR THE COMBINATORIAL PRODUCTION AND TESTING OF MATERIAL LIBRARIES BY USING AT LEAST TWO ANALYTICAL METHODS 审中-公开
标题翻译：利用两种分析方法组合制作和测试材料图书的过程和装置
公开(公告)号：WO01068236A2
公开(公告)日：2001-09-20
申请号：PCT/EP2001/002953
申请日：2001-03-15
IPC分类号： G01J3/44 , B01J19/00 , C40B20/02 , C40B30/08 , C40B40/18 , G01J3/45 , G01J5/48 , G01N1/36 , G01N21/78 , G01N25/22 , G01N27/62 , G01N30/72 , G01N31/10 , G01N31/22 , G01N37/00
CPC分类号： G01N31/10 , B01J19/0046 , B01J2219/00286 , B01J2219/00313 , B01J2219/00495 , B01J2219/00585 , B01J2219/00596 , B01J2219/00689 , B01J2219/00704 , B01J2219/00745 , B01J2219/00747 , C40B30/08 , C40B40/18 , Y10T436/21 , Y10T436/212 , Y10T436/214 , Y10T436/216 , Y10T436/24 , Y10T436/25875
摘要： A process is disclosed for testing material libraries, in particular catalysts, by means of coupled use of at least two analytical methods, preferably IR thermography and mass spectrometry. The rapid integrated determination of potentially "good" materials via IR thermography prevents an excessive loss of time by needing to test all materials of a library successively with the mass spectrometer. The reactor design permits, firstly, the integral recording of the entire reactor through a window which is transparent for the corresponding method and, secondly, permits the simultaneous, automated application of a second analytical method (for example mass sepectrometry) to selected materials of material library, which have been rated as active by the optical method. In the case described, the optical method provides information on the material activity for a set problem, and the second analytical method determines the selectivity of the materials.
摘要翻译：公开了通过耦合使用至少两种分析方法，优选IR热成像和质谱法来测试材料库，特别是催化剂的方法。通过红外热像仪快速综合测定潜在的“良好”材料，可以通过质谱连续测试所有材料，从而防止时间过多。反应器设计首先通过对于相应方法是透明的窗口整体记录整个反应器，其次允许同时自动应用第二种分析方法（例如质量分离法）到所选择的材料材料图书馆，通过光学方法被评为活跃。在所描述的情况下，光学方法提供关于集合问题的材料活性的信息，第二分析方法确定材料的选择性。

6. 发明申请

WO2017205686A1 OLIGONUCLEOTIDE PROBES AND USES THEREOF 审中-公开
公开(公告)号：WO2017205686A1
公开(公告)日：2017-11-30
申请号：PCT/US2017/034567
申请日：2017-05-25
申请人： CARIS SCIENCE, INC.
发明人： DOMENYUK, Valeriy , HORNUNG, Tassilo , MIGLARESE, Mark , SPETZLER, David
IPC分类号： C12N15/115 , C12Q1/68 , C40B20/02 , C40B20/04 , C40B40/08
摘要： Methods and compositions are provided to identify oligonucleotides that bind targets of interest. The targets include tissues, cells, circulating biomarkers such as microvesicles, including those derived from various diseases. The oligonucleotides can be used in diagnostic and therapeutic applications.

7. 发明申请

WO2009140802A8 TEST PROBES, COMMON OLIGONUCLEOTIDE CHIPS, NUCLEIC ACID DETECTION METHOD, AND THEIR USES 审中-公开
标题翻译：测试探针，通用寡核苷酸芯片，核酸检测方法及其用途
公开(公告)号：WO2009140802A8
公开(公告)日：2010-12-09
申请号：PCT/CN2008001695
申请日：2008-10-06
申请人： SHAAN XI LIFEGEN CO LTD , TANG YITONG , CHEN CHAO , CUI YALI , ZHU JUANLI , YU LONGLIN , GAO YIWEN , LI ZHENG
发明人： TANG YITONG , CHEN CHAO , CUI YALI , ZHU JUANLI , YU LONGLIN , GAO YIWEN , LI ZHENG
IPC分类号： C40B40/06 , C12Q1/68 , C40B20/02 , C40B20/04
CPC分类号： C12Q1/6827 , C12Q2533/107 , C12Q2525/197
摘要： High-throughput detection for the interesting base or the mutation site in the nucleic acid sample can be achieved by the linear test probe pairs P1 and P2. The test probe pairs P1 and P2 respectively comprise either of the flanking complementary sequences which are adjacent to the interesting base or the mutation site in the nucleic acid sample. When the test probe pairs P1, P2 are annealed and hybridized to the nucleic acid sample, a gap will be generated at the interesting base or the mutation site position between the probe pairs and the sample. Divide the annealed hybrid sample into four equal reaction systems to which add dATP, dTTP, dCTP, dGTP, respectively. The test probe pairs P1 and P2 will be ligated into one single probe when adding the complementary nucleotide system under the DNA polymerase or ligase. After purified and amplified, the generated single probes are hybridized to the corresponding area in a common oligonucleotide microarray. The generated single probe will give a signal in the hybrid area, and therefore detect and analyze the hybrid signal to determine the base type or the mutation genotype at the detection position. The invention can be applied to the re-sequencing the target nucleic acid sequence, the detection and analysis for the mutation, insertion, or deletion sites of a known nucleic acid sequence, and the genotyping of the pathogenic microorganism.
摘要翻译：可以通过线性测试探针对P1和P2来实现核酸样品中感兴趣碱基或突变位点的高通量检测。测试探针对P1和P2分别包含与感兴趣碱基或核酸样品中突变位点相邻的侧翼互补序列之一。当测试探针对P1，P2退火并与核酸样品杂交时，将在探针对和样品之间的感兴趣的碱基或突变位点位置产生间隙。将退火的混合样品分成四个相等的反应体系，分别加入dATP，dTTP，dCTP，dGTP。当在DNA聚合酶或连接酶下添加互补核苷酸系统时，测试探针对P1和P2将被连接到一个单个探针中。纯化和扩增后，产生的单个探针与普通寡核苷酸微阵列中的相应区域杂交。所产生的单个探针将在混合区域中产生信号，因此检测和分析混合信号以确定检测位置的基因型或突变基因型。本发明可以应用于重新测序目标核酸序列，检测和分析已知核酸序列的突变，插入或缺失位点，以及病原微生物的基因分型。

8. 发明申请

WO00062919A1 MODULAR CHEMICAL MICROSYSTEM 审中-公开
标题翻译：模块化化学MICROSYSTEMS
公开(公告)号：WO00062919A1
公开(公告)日：2000-10-26
申请号：PCT/EP2000/003222
申请日：2000-04-11
IPC分类号： G01N37/00 , B01J19/00 , B81B7/00 , C40B20/02 , C40B60/10 , G01N35/00
CPC分类号： G01N35/00871 , B01J19/004 , B01J19/0093 , B01J2219/0081 , B01J2219/00871 , B01J2219/00986 , G01N2035/00237 , G01N2035/00881
摘要： The invention relates to a modular chemical microsystem for carrying out preferably chemical processes. Said modular microsystem consists of at least one coupling bar (1) and a plurality of modules (2). The coupling bar is provided with a plurality of gates (3) that connect the microsystem to a control unit (10) and with a system bus that communicates with the plurality of gates (3) and that transmits control signals within the microsystem. The coupling bar further comprises a plurality of connections (4) for substances that connect the microsystem to a storage and/or collection reservoir and a channel system for said substances that communicates with the plurality of connections (4) and that carries substances within the microsystem. Also provided is a plurality of geometrically defined module interfaces (5) of the same kind that communicate with the system bus and the channel system for the substances. The substances are subject to controlled processes in said modules. The modules have a connecting area (6) that is complementary to the module interfaces (5) and they can be arranged on the at least one coupling bar (1) in random order.
摘要翻译：本发明涉及一种模块化微系统用于进行化学过程，优选由至少一个连接轨道（1）和多个模块（2）中的。耦合轨道具有服务于微系统的控制单元（10），系统总线，其与所述多个控制端子（3）和微系统内的控制信号的传输通信的连接多个控制端子（3）被使用时，多种织物连接（4），其用于连接所述微到供给和/或收集容器（13），燃料通道系统，其与所述多个织物端口进行通信（4）和传质是微系统内，与多个类似的，几何定义的接口模块（5），其连接到系统总线和燃料通道系统。在模块中的物质控制的过程受试者，其中所述模块具有模块到所述接口（5）互补的连接区域（6），并且可以在所述至少一个连接轨道布置成任何顺序（1）。

9. 发明申请

WO0033084A3 ARRAYS OF ORGANIC COMPOUNDS ATTACHED TO SURFACES 审中-公开
标题翻译：有机化合物连接到表面的阵列
公开(公告)号：WO0033084A3
公开(公告)日：2000-08-10
申请号：PCT/US9928021
申请日：1999-11-23
申请人： SYNTRIX BIOCHIP INC , ZEBALA JOHN A
发明人： ZEBALA JOHN A
IPC分类号： G01N37/00 , B01J19/00 , C07B61/00 , C07H21/00 , C07K1/04 , C07K14/00 , C12M1/00 , C12N15/09 , C12Q1/37 , C12Q1/68 , C40B20/02 , C40B40/02 , C40B40/06 , C40B40/10 , C40B50/00 , C40B50/06 , C40B50/14 , C40B60/10 , C40B60/14 , G03F7/00 , G03F7/40 , G01N33/68
CPC分类号： B82Y30/00 , B01J19/0046 , B01J2219/00432 , B01J2219/00497 , B01J2219/00527 , B01J2219/00585 , B01J2219/0059 , B01J2219/00596 , B01J2219/00605 , B01J2219/00608 , B01J2219/00612 , B01J2219/00617 , B01J2219/00621 , B01J2219/00626 , B01J2219/00637 , B01J2219/00644 , B01J2219/00659 , B01J2219/00675 , B01J2219/00702 , B01J2219/00711 , B01J2219/0072 , B01J2219/00722 , B01J2219/00725 , B01J2219/00729 , C07B2200/11 , C07H21/00 , C07K1/047 , C07K14/003 , C12Q1/6809 , C12Q1/6841 , C40B40/06 , C40B40/10 , C40B50/14 , C40B60/14 , G03F7/00 , G03F7/0035 , G03F7/40
摘要： Compositions and methods are provided for performing regionally selective solid-phase chemical synthesis of organic compounds. Such methods may employ solvent-resistant photoresist compositions to prepare arrays of organic compounds, such as ligands, for use within a variety of diagnostic and drug discovery assays. Ligand-arrays may comprise, for example, nucleobase polymers that are resistant to degradative enzymes.
摘要翻译：提供组合物和方法用于进行有机化合物的区域选择性固相化学合成。这样的方法可以使用耐溶剂光致抗蚀剂组合物来制备用于多种诊断和药物发现测定中的有机化合物阵列，例如配体。配体阵列可以包含例如耐降解酶的核碱基聚合物。

10. 发明申请

WO00033084A2 METHODS AND COMPOSITIONS FOR PERFORMING AN ARRAY OF CHEMICAL REACTIONS ON A SUPPORT SURFACE 审中-公开
标题翻译：用于在支撑表面上实施化学反应的阵列的方法和组合物
公开(公告)号：WO00033084A2
公开(公告)日：2000-06-08
申请号：PCT/US1999/028021
申请日：1999-11-23
IPC分类号： G01N37/00 , B01J19/00 , C07B61/00 , C07H21/00 , C07K1/04 , C07K14/00 , C12M1/00 , C12N15/09 , C12Q1/37 , C12Q1/68 , C40B20/02 , C40B40/02 , C40B40/06 , C40B40/10 , C40B50/00 , C40B50/06 , C40B50/14 , C40B60/10 , C40B60/14 , G03F7/00 , G03F7/40 , G01N33/68
CPC分类号： B82Y30/00 , B01J19/0046 , B01J2219/00432 , B01J2219/00497 , B01J2219/00527 , B01J2219/00585 , B01J2219/0059 , B01J2219/00596 , B01J2219/00605 , B01J2219/00608 , B01J2219/00612 , B01J2219/00617 , B01J2219/00621 , B01J2219/00626 , B01J2219/00637 , B01J2219/00644 , B01J2219/00659 , B01J2219/00675 , B01J2219/00702 , B01J2219/00711 , B01J2219/0072 , B01J2219/00722 , B01J2219/00725 , B01J2219/00729 , C07B2200/11 , C07H21/00 , C07K1/047 , C07K14/003 , C12Q1/6809 , C12Q1/6841 , C40B40/06 , C40B40/10 , C40B50/14 , C40B60/14 , G03F7/00 , G03F7/0035 , G03F7/40
摘要： Compositions and methods are provided for performing regionally selective solid-phase chemical synthesis of organic compounds. Such methods may employ solvent-resistant photoresist compositions to prepare arrays of organic compounds, such as ligands, for use within a variety of diagnostic and drug discovery assays. Ligand-arrays may comprise, for example, nucleobase polymers that are resistant to degradative enzymes.
摘要翻译：提供组合物和方法用于进行有机化合物的区域选择性固相化学合成。这样的方法可以使用耐溶剂光致抗蚀剂组合物来制备用于多种诊断和药物发现测定中的有机化合物阵列，例如配体。配体阵列可以包含例如耐降解酶的核碱基聚合物。

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