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1. 发明申请

WO2021230304A1 ヒトプロフェッショナル抗原提示細胞の製造方法审中-公开
公开(公告)号：WO2021230304A1
公开(公告)日：2021-11-18
申请号：PCT/JP2021/018121
申请日：2021-05-12
申请人：ＡＧＣ株式会社 , 国立研究開発法人国立がん研究センター
发明人：萩谷　祐一郎 , 植村　靖史 , 福田　恭子 , 岩間　達昭
IPC分类号： C12N5/0786 , A61K35/15 , A61K35/17 , A61K35/545 , A61P35/00 , A61P37/04 , A61P43/00 , C12N5/0735 , C12N5/074 , C12N5/0783 , C12N5/0784 , C12N5/0787 , C12N5/0789 , C12N5/10 , C12N15/12
摘要：本発明は、多能性幹細胞から分化させたミエロイド細胞（ＭＣ）に、ｃ－ＭＹＣなどを発現させることにより、増殖性ミエロイド細胞（ｐＭＣ）を得ること、並びに前記ｐＭＣにＧＭ－ＣＳＦおよび／またはＭ－ＣＳＦを発現させて、プロフェッショナル抗原提示細胞（ｐＡＰＣ）を得ることを含む、プロフェッショナル抗原提示細胞の製造方法と、該方法により製造されるヒトプロフェッショナル抗原提示細胞とを提供する。

2. 发明申请

WO2017040374A1 COMPOSITIONS AND METHODS OF ENHANCING ANTI-TUMOR RESPONSE USING HYBRID NEUTROPHILS 审中-公开
标题翻译：使用混合中性粒细胞增强抗肿瘤反应的组合物和方法
公开(公告)号：WO2017040374A1
公开(公告)日：2017-03-09
申请号：PCT/US2016/049205
申请日：2016-08-29
申请人： THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA
发明人： ERUSLANOV, Evgeniy , ALBELDA, Steven
IPC分类号： C12N5/00 , C12N5/07 , C12N5/071 , C12N5/078 , C12N5/0787
CPC分类号： C12N5/0642 , A61K31/454 , A61K35/15 , A61K38/193 , A61K38/217 , A61K39/0011 , A61K2039/5158 , A61K2039/572 , C12N2501/22 , C12N2501/24 , C12N2501/599 , C12N2502/30 , A61K2300/00
摘要： The present invention relates to compositions and methods that provide novel anti-tumor therapies in cancer. In one aspect, the present invention features a hybrid neutrophil in a non-naturally occurring container, wherein the hybrid neutrophil expresses at least one neutrophil associated molecule selected from the group consisting of: Arg1, MPO, CD66b, and CD15, and at least one antigen-presenting cell (APC) associated molecule selected from the group consisting of: CD14, HLA-DR, CD32, CD64, and CD89. In another aspect, the present invention features methods of generating a hybrid neutrophil. In still another aspect, the present invention features methods of inhibiting tumor growth in a subject, treating a tumor in a subject, and increasing efficacy of an antibody against a tumor in a subject. The methods comprise (a) administering to the subject an effective amount of an anti-tumor antibody and (b) administering to or generating in the subject an effective amount of a hybrid neutrophil.
摘要翻译：本发明涉及在癌症中提供新的抗肿瘤治疗的组合物和方法。在一个方面，本发明的特征在于非天然存在的容器中的杂合嗜中性粒细胞，其中所述杂合嗜中性粒细胞表达至少一种选自以下的嗜中性粒细胞相关分子：Arg1，MPO，CD66b和CD15，以及至少一种抗原呈递细胞（APC）相关分子，选自：CD14，HLA-DR，CD32，CD64和CD89。另一方面，本发明的特征在于产生混合嗜中性粒细胞的方法。另一方面，本发明的特征在于抑制受试者的肿瘤生长，治疗受试者中的肿瘤以及提高抗体对抗肿瘤的抗体的方法。所述方法包括（a）向受试者施用有效量的抗肿瘤抗体，和（b）在受试者中施用或产生有效量的杂合性嗜中性粒细胞。

3. 发明申请

WO2016073448A1 COMBINED SORTING AND CONCENTRATING PARTICLES IN A MICROFLUIDIC DEVICE 审中-公开
标题翻译：在微流体装置中组合分选和浓缩颗粒
公开(公告)号：WO2016073448A1
公开(公告)日：2016-05-12
申请号：PCT/US2015/058785
申请日：2015-11-03
申请人： THE GENERAL HOSPITAL CORPORATION
发明人： KAPUR, Ravi , SMITH, Kyle C. , TONER, Memhet
IPC分类号： G01N35/08 , C12M1/12 , C12N5/0787 , B01L3/00
CPC分类号： B01L3/502761 , A61K35/28 , B01L3/502715 , B01L3/502746 , B01L3/502753 , B01L3/502776 , B01L2200/0631 , B01L2200/0647 , B01L2200/0652 , B01L2200/0668 , B01L2200/0684 , B01L2200/12 , B01L2300/0681 , B01L2300/0877 , B01L2300/185 , B01L2400/0409 , B01L2400/0415 , B01L2400/043 , B01L2400/0436 , B01L2400/0457 , B01L2400/0487 , B01L2400/082 , G01N1/4077 , G01N15/0255 , G01N15/0618 , G01N15/1484 , G01N2001/4088 , G01N2015/0053 , G01N2015/0065 , G01N2015/0288 , G01N2015/1486 , G01N2015/149 , G01N2015/1493
摘要： Extracting and concentrating particles from a first fluid sample includes: providing the first fluid sample to a fluid exchange module of a microfluidic device, providing a second fluid sample to the fluid exchange module, in which the first fluid sample and the second fluid sample are provided under conditions such that particle-free portions of the first fluid sample are shifted, and an inertial lift force causes the particles in the first fluid sample to cross streamlines and transfer into the second fluid sample; passing the second fluid sample containing the transferred particles to a particle concentration module under conditions such that particle-free portions of the second fluid sample are shifted, and such that the particles within the second fluid sample are focused to a streamline within the particle concentration module.
摘要翻译：提取和浓缩来自第一流体样品的颗粒包括：将第一流体样品提供给微流体装置的流体交换模块，将第二流体样品提供给流体交换模块，其中提供第一流体样品和第二流体样品在第一流体样品的无颗粒部分移动的条件下，并且惯性提升力使第一流体样品中的颗粒交叉流线并转移到第二流体样品中; 将含有转移的颗粒的第二流体样品在允许第二流体样品的无颗粒部分移动的条件下将颗粒浓度模块通过，并使第二流体样品内的颗粒聚焦到颗粒浓度模块内的流线。

4. 发明申请

WO2016018726A1 METHODS AND SYSTEMS FOR SEPARATING COMPONENTS OF A BIOLOGICAL SAMPLE WITH GRAVITY SEDIMENTATION 审中-公开
标题翻译：用于分离具有重要度的生物样品组分的方法和系统
公开(公告)号：WO2016018726A1
公开(公告)日：2016-02-04
申请号：PCT/US2015/041842
申请日：2015-07-23
申请人： BECTON, DICKINSON AND COMPANY
发明人： SUGARMAN, Jeffrey
IPC分类号： C12Q1/02 , C12Q1/24 , C12M1/26 , C12N5/078 , C12N5/0787
CPC分类号： C12N5/0087 , C12N13/00
摘要： Aspects of the present disclosure include methods for separating components having different densities from a biological sample droplet. Methods according to certain embodiments include contacting a surface of a support with a biological sample droplet that includes components of different densities; subjecting the biological sample droplet to a gravitational force to produce two or more regions in the biological sample droplet on the support surface, where each region in the biological sample droplet includes a component from the biological sample droplet having a different density; separating the biological sample droplet into two or more product droplets, wherein each product droplet includes a different region of the biological sample droplet; and collecting the one or more product droplets. Systems for practicing the subject methods are also described. Computer systems and kits are also provided.
摘要翻译：本公开的方面包括用于从生物样品液滴分离具有不同密度的组分的方法。根据某些实施方案的方法包括将载体的表面与包括不同密度的组分的生物样品液滴接触; 使生物样品液滴经受重力以在支撑表面上的生物样品液滴中产生两个或更多个区域，其中生物样品液滴中的每个区域包括具有不同密度的生物样品液滴的组分; 将生物样品液滴分离成两个或更多个产物液滴，其中每个产物液滴包括生物样品液滴的不同区域; 并收集一个或多个产品液滴。还描述了用于实践主题方法的系统。还提供计算机系统和套件。

5. 发明申请

WO2014200030A1 人工多能性幹細胞の選別方法および血球への分化誘導方法审中-公开
标题翻译：诱导的肺细胞选择方法和诱导血细胞分化的方法
公开(公告)号：WO2014200030A1
公开(公告)日：2014-12-18
申请号：PCT/JP2014/065497
申请日：2014-06-11
申请人：国立大学法人京都大学
发明人：山中　伸弥 , 吉田　善紀 , 西澤　正俊
IPC分类号： C12N5/10 , C12N5/0735 , C12N5/078 , C12N5/0781 , C12N5/0783 , C12N5/0786 , C12N5/0787 , C12Q1/02
CPC分类号： C12N5/0647 , C07K14/65 , C12N5/0696 , C12N2501/105 , C12N2501/115 , C12N2501/125 , C12N2501/14 , C12N2501/145 , C12N2501/155 , C12N2501/165 , C12N2501/2303 , C12N2501/2306 , C12N2501/2311 , C12N2501/26 , C12N2506/45 , C12N2510/00 , C12Q1/6881 , C12Q2600/158 , G01N33/56966
摘要： IGF2の存在下で多能性幹細胞を培養する工程を含む、多能性幹細胞から造血幹細胞および／または造血前駆細胞を製造する方法、TRIM58、CTSF、FAM19A5およびTCERG1L遺伝子からなる群から選択される１またはそれ以上の遺伝子の発現のレベル、または、TRIM58、CSMD1および／またはFAM19A5遺伝子のDNAメチル化状態に基づいて、造血幹細胞および／または造血前駆細胞、または血球への高い分化能を有する人工多能性幹細胞を選別する方法。
摘要翻译：一种用于从多能干细胞制造造血干细胞和/或造血前体细胞的方法，所述方法包括在IGF2存在下培养多能干细胞的方法，以及选择具有高分化能力的诱导多能干细胞的方法基于选自TRIM58，CTSF，FAM19A5和TCERG1L基因的一种或多种基因的表达水平，或TRIM58的DNA甲基化状态，将其导入造血干细胞和/或造血前体细胞或血细胞， CSMD1和/或FAM19A5基因。

6. 发明申请

WO2010103475A3 USE OF SERINE PROTEASE INHIBITORS IN THE TREATMENT OF NEUTROPENIA 审中-公开
标题翻译：使用丝氨酸蛋白酶抑制剂治疗中耳炎
公开(公告)号：WO2010103475A3
公开(公告)日：2010-11-25
申请号：PCT/IB2010051038
申请日：2010-03-10
申请人： MED DISCOVERY SA , UNIV ZUERICH , FONTANA ADRIANO , RECHER MIKE , KUNDIG CHRISTOPH
发明人： FONTANA ADRIANO , RECHER MIKE , KUNDIG CHRISTOPH
IPC分类号： A61K35/14 , A61K38/55 , A61P7/00 , C12N5/0787 , C12Q1/37
CPC分类号： A61K38/57 , A61K35/15 , A61K35/28 , A61K38/1709 , A61K2300/00
摘要： The invention relates to therapeutic compounds which are inhibitors of serine proteases, to pharmaceutical compositions thereof and to their use in the treatment of the human or animal body. More specifically, the present invention relates to a method for the treatment of neutropenia comprising the administration to a subject in need thereof of a therapeutically effective amount of a serine protease inhibitor. The invention also comprises prevention of apoptosis of myeloid cells (1) during and after transfection of bone marrow cells performed for gene therapy, (2) during blood stem cell mobilization performed for reconstitution of hematopoiesis and (3) during infusion of cells of the myeloid lineage for reconstitution of hematopoiesis for gene therapy or for treatment of neutropenia by infusion of neutrophils.
摘要翻译：本发明涉及作为丝氨酸蛋白酶抑制剂的治疗化合物，其药物组合物及其在治疗人或动物体中的用途。更具体地说，本发明涉及一种治疗嗜中性粒细胞减少症的方法，其包括向有需要的受试者施用治疗有效量的丝氨酸蛋白酶抑制剂。本发明还包括在用于基因治疗的骨髓细胞转染期间和之后预防骨髓细胞（1）的凋亡，（2）在用于重建造血细胞的血液干细胞移动过程中和（3）在髓样细胞输注期间重建血液造影用于基因治疗或通过输注嗜中性粒细胞治疗中性粒细胞减少症的血统。

7. 发明申请

WO2021234163A1 CHIMERIC NKG2D PROTEIN 审中-公开
公开(公告)号：WO2021234163A1
公开(公告)日：2021-11-25
申请号：PCT/EP2021/063699
申请日：2021-05-21
申请人： KING'S COLLEGE LONDON , LEUCID BIO LTD
发明人： MAHER, John , DAVIES, David Marc , KAUSAR, Fahima , LARCOMBE-YOUNG, Daniel
IPC分类号： C12N5/0783 , C12N5/0787 , C12N5/0786 , A61K35/15 , A61K35/17 , C07K14/705 , C12N15/63
摘要： This invention relates to an immunoresponsive cell comprising a chimeric NKG2D protein. The immunoresponsive cell is a T-cell, natural killer (NK) cell, macrophage or neutrophil and the chimeric NKG2D protein comprises a human NKG2D extracellular domain or a variant thereof, and a murine NKG2D transmembrane domain or a variant thereof. The disclosure also relates to isolated polynucleotide(s) encoding the chimeric NKG2D protein and the use of the immunoresponsive cells or isolated polynucleotides in therapy or the treatment of cancer.

8. 发明申请

WO2021041711A1 HEPARIN AND HEPARAN SULFATE FROM MODIFIED MST CELLS AND METHODS OF MAKING AND USING 审中-公开
公开(公告)号：WO2021041711A1
公开(公告)日：2021-03-04
申请号：PCT/US2020/048243
申请日：2020-08-27
申请人： TEGA THERAPEUTICS, INC.
发明人： GLASS, Charles , THACKER, Bryan , ESKO, Jeffrey D.
IPC分类号： A61K31/727 , C08B37/00 , C12N5/0787 , C12N5/09
摘要： Provided herein are methods of producing heparin and heparan sulfate from modified cells, such as modified MST cells and modified basophil neoplastic cells, and compositions comprising heparin and heparan sulfate isolated from modified cells. In some embodiments, methods herein comprise culturing a genetically modified cell line comprising at least one of a mastocytoma cell line and a basophil neoplastic cell line; and isolating the heparin or heparan sulfate from the cell line.

9. 发明申请

WO2019147187A1 NEUTROPHIL SUBTYPES 审中-公开
公开(公告)号：WO2019147187A1
公开(公告)日：2019-08-01
申请号：PCT/SG2019/050040
申请日：2019-01-25
申请人： AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH
发明人： NG, Lai Guan , EVRARD, Maximilien , KWOK, Immanuel Weng Han
IPC分类号： G01N33/50 , C12N5/0787 , A61K35/15 , A61P31/00 , A61P35/00 , A61P37/00
摘要： Disclosed is a method of characterising and/or separating neutrophils, the method comprises characterising and/or separating the neutrophils into a first population comprising proliferative neutrophils and a second population comprising mature neutrophils, according to the expression of CD101 on the neutrophils. Also disclosed are compositions comprising proliferative neutrophils that are CD10 - CD101 - , and methods of treatment, diagnostic or prognostic using neutrophils thereof, as well as kits for characterising and/or separating proliferative neutrophils based on the expression of CD101 or CD10. In a preferred embodiment, the population of neutrophils may be characterised as proliferative neutrophils if CD10 - CD101 - , as immature neutrophils if CD10 - CD101 + and as mature neutrophils if CD10 + CD101 + .

10. 发明申请

WO2017223370A1 IMMUNOMODULATORY BISPECIFIC ANTIBODIES 审中-公开
标题翻译：免疫调节双特异性抗体
公开(公告)号：WO2017223370A1
公开(公告)日：2017-12-28
申请号：PCT/US2017/038850
申请日：2017-06-22
申请人： OSBORNE, Heather, M. , BINDAL, Krithi, Rao , SIVA, Amara, C.
发明人： OSBORNE, Heather, M. , BINDAL, Krithi, Rao , SIVA, Amara, C.
IPC分类号： A61K39/395 , C07K16/28 , C07K16/46 , C12N5/0787 , G01N33/563
CPC分类号： C07K16/2845 , A61K47/65 , A61P31/00 , A61P35/00 , A61P37/06 , C07K16/2896 , C07K16/46 , C07K2317/31 , C07K2317/52 , C07K2317/55 , C07K2317/622 , C07K2317/626 , C07K2317/72 , C07K2317/94 , G01N33/56972 , G01N2333/70553 , G01N2333/70596
摘要： The present invention relates to novel multi-functional polypeptides comprising at least two antigen binding sites specific for the CD11b and CD15 cell surface markers. The present invention further relates to a polypeptide, wherein the above-described polypeptide comprises at least one further domain, preferably of pre-determined function. Furthermore, the present invention relates to polynucleotides encoding said polypeptides as well as to vectors comprising said polynucleotides and to host cells transformed therewith and their use in the production of said polypeptides. In addition, the present invention relates to compositions, preferably pharmaceutical and diagnostic compositions, comprising any of the afore-described polypeptides, polynucleotides or vectors as well as to kits comprising said compositions. A further object of the present invention is the use of said compositions for therapeutic, diagnostic and cell separation methods.
摘要翻译：本发明涉及新的多功能多肽，其包含至少两个对CD11b和CD15细胞表面标记具有特异性的抗原结合位点。本发明还涉及多肽，其中上述多肽包含至少一个其他结构域，优选预定功能。此外，本发明涉及编码所述多肽的多核苷酸以及包含所述多核苷酸的载体以及用其转化的宿主细胞及其在所述多肽的生产中的用途。此外，本发明涉及包含任何上述多肽，多核苷酸或载体的组合物，优选药物和诊断组合物，以及包含所述组合物的试剂盒。本发明的另一个目的是所述组合物用于治疗，诊断和细胞分离方法的用途。

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