基本信息:
- 专利标题： CHIMERIC NKG2D PROTEIN
- 申请号：PCT/EP2021/063699 申请日：2021-05-21
- 公开(公告)号：WO2021234163A1 公开(公告)日：2021-11-25
- 发明人： MAHER, John , DAVIES, David Marc , KAUSAR, Fahima , LARCOMBE-YOUNG, Daniel
- 申请人： KING'S COLLEGE LONDON , LEUCID BIO LTD
- 申请人地址： Strand; 30 Broad Street
- 专利权人： KING'S COLLEGE LONDON,LEUCID BIO LTD
- 当前专利权人： KING'S COLLEGE LONDON,LEUCID BIO LTD
- 当前专利权人地址： Strand; 30 Broad Street
- 代理机构： SPINNER, David
- 优先权： GB2007655.0 2020-05-22
- 主分类号： C12N5/0783
- IPC分类号： C12N5/0783 ; C12N5/0787 ; C12N5/0786 ; A61K35/15 ; A61K35/17 ; C07K14/705 ; C12N15/63
摘要：
This invention relates to an immunoresponsive cell comprising a chimeric NKG2D protein. The immunoresponsive cell is a T-cell, natural killer (NK) cell, macrophage or neutrophil and the chimeric NKG2D protein comprises a human NKG2D extracellular domain or a variant thereof, and a murine NKG2D transmembrane domain or a variant thereof. The disclosure also relates to isolated polynucleotide(s) encoding the chimeric NKG2D protein and the use of the immunoresponsive cells or isolated polynucleotides in therapy or the treatment of cancer.