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1. 发明申请

WO2021126142A1 ESTERIFICATION OF ACETIC ACID RECOVERED FROM WOOD ACETYLATION WITH ALCOHOLS 审中-公开
公开(公告)号：WO2021126142A1
公开(公告)日：2021-06-24
申请号：PCT/US2019/066474
申请日：2019-12-16
申请人： EASTMAN CHEMICAL COMPANY
发明人： JANKA, Mesfin, Ejerssa , FONTENOT, Kevin, John
IPC分类号： A61K47/38 , A61K9/48 , C07C67/08 , C07C69/12 , C07H3/06
摘要： An esterification process that uses an acetic acid composition from a wood acetylation process as a reactant. Even though the acetic acid composition contains impurities, such as ethyl acetate, methyl acetate, acetaldehyde, acetone, terpenes and/or terpenes derivatives, the impurities do not adversely affect the quality of the ester products. This process can be economically advantageous by using cheaper acetic acid - one sourced directly from a wood acetylation process.

2. 发明申请

WO02044110A1 AN OXIDATION REACTION PROCESS CATALYSIZED BY PHASE-TRANSFER CATALYST CONTROLLING REACTION 审中-公开
公开(公告)号：WO02044110A1
公开(公告)日：2002-06-06
申请号：PCT/CN2001/001589
申请日：2001-11-29
IPC分类号： C07D333/32 , B01J27/186 , B01J31/00 , B01J31/02 , C07B33/00 , C07B61/00 , C07C29/48 , C07C35/08 , C07C45/28 , C07C45/29 , C07C47/228 , C07C49/04 , C07C49/10 , C07C49/403 , C07C49/78 , C07C49/825 , C07C51/285 , C07C51/31 , C07C55/14 , C07C59/185 , C07C67/42 , C07C69/12 , C07C315/02 , C07C317/04 , C07C317/14 , C07D301/06 , C07D301/12 , C07D303/04 , C07D309/30 , B01J31/16 , B01J31/26
CPC分类号： B01J27/186 , B01J31/006 , B01J31/0208 , B01J31/0239 , B01J31/0244 , B01J31/1815 , B01J31/2243 , B01J2531/64 , B01J2531/66 , B01J2531/96 , B01J2531/985 , C07B33/00 , C07C29/48 , C07C45/294 , C07C51/31 , C07C315/02 , C07C2601/14 , C07D301/06 , C07D301/12 , C07D303/04 , C07D315/00 , Y02P20/584 , C07C35/08 , C07C49/78 , C07C47/228 , C07C49/10 , C07C49/403 , C07C47/575 , C07C49/04 , C07C59/347 , C07C317/14
摘要： The present invention relates to an oxidation reaction in the presence of phase-transfer catalyst controlling reaction, which may be represented by general formular [(R1) (R2) (R3) (R4) N]xH>y

3. 发明申请

WO01054682A1 REMEDIES 审中-公开
标题翻译：补救措施
公开(公告)号：WO01054682A1
公开(公告)日：2001-08-02
申请号：PCT/JP2001/000513
申请日：2001-01-26
IPC分类号： A23L1/30 , A61K31/12 , A61K31/216 , A61K31/222 , A61K31/352 , A61K31/7004 , A61P9/10 , A61P25/00 , A61P25/28 , A61P43/00 , C07C49/255 , C07C49/573 , C07C49/83 , C07C49/84 , C07C69/12
CPC分类号： A61K31/7004 , A23L33/10 , A61K31/12 , A61K31/216 , A61K31/222 , A61K31/352
摘要： Remedies or preventives for diseases with a need for the enhancement of the production of nerve growth factor which contain as the active ingredient specific compounds having an activity of enhancing the production of nerve growth factor or salts thereof, agents for enhancing the production of nerve growth factor, or foods, drinks or feeds for enhancing the production of nerve growth factor; a method of enhancing the production of nerve growth factor which comprises administering the above compounds or salts thereof to mammals; and use of the above compounds or salts thereof in remedies or preventives for diseases with a need for the enhancement of the production of nerve growth factor, agents for enhancing the production of nerve growth factor, or foods, drinks or feeds for enhancing the production of nerve growth factor. Also, novel compounds having an activity of enhancing the production of nerve growth factor are provided.
摘要翻译：需要增强神经生长因子生成的疾病的治疗或预防药物，其含有作为活性成分的具有增强神经生长因子或其盐的生成活性的特异性化合物，用于增强神经生长因子产生的药剂，或用于增强神经生长因子产生的食物，饮料或饲料; 一种增强神经生长因子产生的方法，其包括将上述化合物或其盐施用于哺乳动物; 以及上述化合物或其盐在需要增强神经生长因子的生成的疾病的补救或预防药物中的用途，用于增强神经生长因子的产生的药剂或用于增强生产神经生长因子的食品，饮料或饲料神经生长因子另外，提供具有增强神经生长因子生成活性的新化合物。

4. 发明申请

WO2015070354A1 ACETYL SALICYCLIC ACID DIMERS, SYNTHESIS THEREOF, AND USES THEREOF TO PREVENT AND TREAT COMPLEMENT-MEDIATED DISORDERS 审中-公开
标题翻译：乙酰油酸二酯，其合成及其用途，以预防和治疗补充介导的疾病
公开(公告)号：WO2015070354A1
公开(公告)日：2015-05-21
申请号：PCT/CA2014/051097
申请日：2014-11-17
申请人： AURIN BIOTECH INC.
发明人： MCGEER, Patrick L. , LEE, Moonhee , MCGEER, Edith G.
IPC分类号： C07C69/12 , A61K31/616 , A61P37/02
CPC分类号： C07C69/16 , A61K8/375 , A61K9/0014 , A61Q5/006 , A61Q7/00 , A61Q19/004 , A61Q19/008 , C07C69/017 , Y02A50/411
摘要： Dimers of acetyl salicylic acid, including 4,4'-diacetoxy-[1,1'-biphenyl]-3,3'-dicarboxylic acid (DAS-1) and 5,5'-methylenebis(2-acetoxybenzoic acid) (DAS-2) are provided. Methods of blocking the C3 convertase stage of the alternative complement pathway, preventing formation of the membrane attack complex of complement, and preventing or treating a complement-mediated disorder in a mammal including the step of administering dimers of acetyl salicylic acid are also provided.
摘要翻译：包括4,4'-二乙酰氧基 - [1,1'-联苯] -3,3'-二羧酸（DAS-1）和5,5'-亚甲基双（2-乙酰氧基苯甲酸）（DAS）的乙酰水杨酸二聚体 -2）。还提供了阻断替代补体途径的C3转化酶阶段的方法，防止补体的膜侵袭复合物的形成，以及预防或治疗哺乳动物的补体介导的病症，包括给予二乙酰水杨酸的步骤。

5. 发明申请

WO0136351A3 PLASMINOGEN ACTIVATOR INHIBITOR ANTAGONISTS RELATED APPLICATIONS 审中-公开
标题翻译： PLASMINOGEN ACTIVATOR INHIBITOR ANTAGONISTS相关申请
公开(公告)号：WO0136351A3
公开(公告)日：2002-07-11
申请号：PCT/US0031824
申请日：2000-11-17
申请人： CORVAS INT INC , MADISON EDWIN L , BRUNCK TERENCE K , SEMPLE JOSEPH EDWARD , LIM-WILBY MARGUERITA , PRYOR KENT E , LEWIS RONALD D II , DUNCAN DAVID F , LAWRENCE C MAXWELL
发明人： MADISON EDWIN L , BRUNCK TERENCE K , SEMPLE JOSEPH EDWARD , LIM-WILBY MARGUERITA , PRYOR KENT E , LEWIS RONALD D II , DUNCAN DAVID F , LAWRENCE C MAXWELL
IPC分类号： C07C59/68 , C07C59/72 , C07C59/90 , C07C65/24 , C07C69/12 , A61K31/19 , C07C39/27 , C07C49/83 , C07C59/125 , C07C59/66 , C07C69/712 , C07C69/734 , C07C69/88
CPC分类号： C07C59/72 , C07C59/68 , C07C59/90 , C07C65/24
摘要： Compounds and pharmaceutical compositions useful as plasminogen activator inhibitor (PAI) antagonists are provided. In particular, methods of antagonizing PAI with substituted and unsubstituted aryl and heteroaryl ethers and thioethers, benzils, benzyl ethers, benzoate esters, sulfones and benzophenones are provided.
摘要翻译：提供了可用作纤溶酶原激活物抑制剂（PAI）拮抗剂的化合物和药物组合物。特别地，提供了用取代和未取代的芳基和杂芳基醚和硫醚，苯偶酰，苄基醚，苯甲酸酯，砜和二苯甲酮拮抗PAI的方法。

6. 发明申请

WO01021616A1 CARBON DIOXIDE-PHILIC COMPOUNDS AND METHODS OF SYNTHESIS THEREOF 审中-公开
标题翻译：二氧化碳 - 二氧化碳化合物及其合成方法
公开(公告)号：WO01021616A1
公开(公告)日：2001-03-29
申请号：PCT/US2000/026156
申请日：2000-09-22
IPC分类号： C07C67/10 , C07B61/00 , C07C41/30 , C07C43/04 , C07C68/04 , C07C69/003 , C07C69/12 , C07C69/96 , C08F8/00 , C08G63/672 , C08G63/91 , C08G64/02 , C08G64/18 , C08G64/34 , C08G64/42 , C08G65/26 , C08G65/329 , C08G65/331 , C08G65/332 , C09K3/00 , C11D1/00 , C07D401/06
CPC分类号： C08G65/3322 , C08G63/672 , C08G63/91 , C08G63/914 , C08G64/02 , C08G64/0208 , C08G64/183 , C08G64/34 , C08G64/42 , C08G65/2603 , C08G65/2654 , C08G65/331 , C08L2205/05 , C11D1/008
摘要： A method of synthesizing a CO2-philic analog of a CO2-phobic compound, includes the step of: reacting the CO2-phobic compound with a CO2-philic compound selected from the group of a polyether substituted with at least one side group including preferably a Lewis base, a polycarbonate, a polycarbonate substituted with at least one side group including preferably a Lewis base, a vinyl polymer substituted with at least one side group including preferably a Lewis base a poly(ether-ester) or a poly(ether-ester) substituted with at least one side group including preferably a Lewis base, to create the CO2-philic analog. A method of synthesizing a CO2-phile includes the step of copolymerizing at least two monomers, wherein a polymer formed from homopolymerization of one of the monomers has a Tg of less than approximately 250 K and a steric factor less than approximately 1.8, at least one of the monomers contains a group that results in a pendant group from the CO2-phile backbone that contains a Lewis base group, and the resultant CO2-phile does not contain both hydrogen bond donors and acceptors.
摘要翻译：一种合成二氧化碳恐怕化合物的二氧化碳亲和类似物的方法包括以下步骤：使二氧化碳恐怕化合物与选自由至少一个侧基取代的聚醚组成的二氧化碳亲和化合物反应，所述至少一个侧基优选包含路易斯碱，聚碳酸酯，由至少一个优选路易斯碱的侧基取代的聚碳酸酯，由至少一个侧基取代的乙烯基聚合物，优选包含路易斯碱，聚（醚 - 酯）或聚（醚 - 酯））被至少一个包含优选路易斯碱的侧基取代，以产生CO 2亲本类似物。合成二氧化碳歧化酶的方法包括使至少两种单体共聚的步骤，其中由单体之一的均聚形成的聚合物的Tg小于约250K，空间因子小于约1.8，至少一种的单体包含导致来自含有路易斯碱基的CO 2 - 残基骨架的侧基的基团，并且所得的CO 2 - 残留物不含氢键供体和受体。

7. 发明申请

WO99010303A1 RADIATION-CURABLE PROPENYL COMPOUNDS, USES THEREOF, AND COMPOSITIONS CONTAINING THEM 审中-公开
标题翻译：可辐射固化丙烯化合物及其组合物及其组合物
公开(公告)号：WO99010303A1
公开(公告)日：1999-03-04
申请号：PCT/US1998/017110
申请日：1998-08-19
IPC分类号： C07C43/16 , C07C69/007 , C07C69/54 , C07C69/96 , C07C271/12 , C07C271/28 , C07C43/215 , C07C69/12
CPC分类号： C07C271/28 , C07C43/16 , C07C69/007 , C07C69/54 , C07C69/96 , C07C271/12
摘要： Disclosed are compounds of formula (1): R is linear, branched or cyclic alkyl containing 1 to 6 carbon atoms; R is -H or -CH3; R is -OH, alkoxy containing 1 to 20 carbon atoms which is optionally substituted with phenyl and two consecutive carbon atoms of which are optionally bonded to an oxygen atom to form an epoxy ring, phenoxy, acryloloxy, methacryloloxy, or A-(Het)0-1C(O)O- wherein A is alkyl containing 1 to 20 carbon atoms, and (Het) is -O- or -NH-; or R is -L-X-(L-R-(OCH=CH-CH2R )n)1-3 wherein X has any of the structures -Ph0-1-CaH2a-Ph0-1-Ph0-1-(cyclo-C5-20-alkyl)-Ph0-1-, -Ph-Ph-, or -Ph-, wherein Ph is phenylene and a is 1 to 20; -CfH2fC(O)CgH2g -CfH2fOCgH2g, -CfH2fC(O)OCgH2g-, -CfH2fPhCgH2g-, or -CfH2fC(O)NHCgH2g-, wherein f and g are each 1 to 12; and each L is independently a chemical bond or -C(O)O-, -OC(O)O-, -O-, or -NHC(O)O-, provided that each R is bonded to an oxygen atom of L; or X is -C(O)-, each L is a chemical bond, and i is 1. Also disclosed are methods and compositions useful in the radiation-induced polymerization of such compounds.
摘要翻译：公开了式（1）的化合物：R是含有1至6个碳原子的直链，支链或环状烷基; R 1是-H或-CH 3; R 2是-OH，含有1至20个碳原子的烷氧基，其任选被苯基取代，并且其两个连续的碳原子任选地与氧原子键合以形成环氧环，苯氧基，丙烯酰氧基，甲基丙烯酰氧基或A- （Het）0-1C（O）O-，其中A是含有1至20个碳原子的烷基，和（Het）是-O-或-NH-; 或R 2是-LX-（LR-（OCH = CH-CH 2 R 1）n）1-3，其中X具有任何结构-Ph0-1-CaH2a-Ph0-1-Ph0-1-（环-C5-20烷基）-Ph0-1-，-Ph-Ph-或-Ph-，其中Ph是亚苯基，a是1至20; （O）CgH2g -CfH2fOCgH2g，-CfH2fC（O）OCgH2g-，-CfH2fPhCgH2g-或-CfH2fC（O）NHCgH2g-，其中f和g各自为1至12; 且每个L独立地为化学键或-C（O）O-，-OC（O）O-，-O-或-NHC（O）O-，条件是每个R与L的氧原子键合 ; 或X是-C（O） - ，每个L是化学键，i是1.还公开了可用于这种化合物的辐射诱导聚合的方法和组合物。

8. 发明申请

WO99003810A1 HYDROFORMYLATION WITH UNMODIFIED RHODIUM CATALYSTS IN SUPERCRITICAL CARBON DIOXIDE 审中-公开
标题翻译：在超临界二氧化碳未改性的铑催化剂的羰基化
公开(公告)号：WO99003810A1
公开(公告)日：1999-01-28
申请号：PCT/EP1998/004319
申请日：1998-07-11
IPC分类号： B01J23/46 , B01J31/16 , B01J31/20 , B01J31/22 , C07B41/06 , C07B61/00 , C07C45/50 , C07C45/80 , C07C47/02 , C07C47/52 , C07C51/265 , C07C57/30 , C07C63/00 , C07C67/29 , C07C67/293 , C07C67/343 , C07C67/38 , C07C69/12 , C07C69/716 , C07C403/08
CPC分类号： C07C403/14 , B01J31/20 , B01J31/2226 , B01J31/2234 , B01J31/2282 , B01J31/2295 , B01J2231/321 , B01J2531/0205 , B01J2531/822 , B01J2531/922 , C07C45/50 , C07C67/293 , C07C67/343 , C07C2601/16 , Y02P20/544 , C07C69/14 , C07C69/716 , C07C47/02
摘要： The invention relates to a method for producing oxo products by hydroformylation of substrates with C=C double bonds, using unmodified rhodium catalysts in a reaction mixture consisting essentially of the substrates, the catalyst and carbon dioxide in a supercritical state (scCO2). The invention especially relates to methods of this kind for producing products containing substantial parts of branched i-oxo products. The invention further relates to methods of this kind for the hydroformylation of substrates not corresponding to the general formula C2H2n. The invention also relates to said methods in which the product and catalyst are separated using the special solubilizing properties of scCO2.
摘要翻译：本发明涉及一种用于通过使用未改性的铑催化剂在超临界状态（超临界CO2）基本上底物，催化剂，和二氧化碳组成的反应混合物与C = C双键的底物的羰基化生产氧产品的方法。特别地，本发明提供了这种用于生产含有支化的i-氧代产品相当大比例涉及包含产品的方法。此外，本发明提供这种对于不对应于通式C2H2n涉及衬底的加氢甲酰化的方法。此外，本发明涉及所述方法，其中的产物和催化剂溶液通过取超临界CO2的特殊性能的优点的分离发生。

9. 发明申请

WO2018154314A1 HEMICELLULOSE PROCESSING METHOD 审中-公开
公开(公告)号：WO2018154314A1
公开(公告)日：2018-08-30
申请号：PCT/GB2018/050474
申请日：2018-02-23
申请人： SAPPI BIOTECH UK LIMITED
发明人： MARSHALL, Edward Leslie , WAITE, Alan Geoffrey , GIBNEY, David Peter
IPC分类号： C07G1/00 , C13K13/00 , C07C51/00 , C07C59/08 , C07C69/12 , C07C67/00
摘要： A method of processing an aqueous hemicellulosic stream containing lignin, comprising: (a) contacting an aqueous hemicellulosic stream containing lignin with a C 3-8 alkyl alcohol at elevated temperature and acidic pH; (b) separating the reaction mixture obtained from step (a) into an aqueous phase containing hemicellulose-derived monosaccharide and an organic phase containing C 3-8 alkyl alcohol; (c) concentrating the organic phase obtained from step (b) to remove at least some C 3-8 alkyl alcohol; (d) treating the residue from step (c) with water or an aqueous medium having an alkaline pH; and (e) recovering C 3-8 alkyl alcohol from the product of step (d).

10. 发明申请

WO2018124172A1 アルコール化合物の製造法审中-公开
公开(公告)号：WO2018124172A1
公开(公告)日：2018-07-05
申请号：PCT/JP2017/046877
申请日：2017-12-27
申请人：株式会社カネカ
发明人：町田　康士 , 安河内　宏昭 , 西山　章
IPC分类号： C07C67/03 , C07C33/22 , C07C69/12 , C07D249/08 , C07B61/00
摘要：エステル化合物からアルコール化合物を純度よく、且つ簡便な操作で取得する方法を提供する。　エステル化合物とメタノール及び／又はエタノールを含む溶液を、メトキシド又はエトキシドをカウンター陰イオンに持つ陰イオン交換樹脂を充填したカラムに通液して、メチルエステル及び／又はエチルエステルを生成させ、これをメタノール及び／又はエタノールと一緒に留去することで、高純度のアルコール化合物が取得できる。

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