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1. 发明申请

WO1997048451A1 ARTERIAL MICROWAVE APPLICATOR WITH COOLING 审中-公开
标题翻译：带冷却器的微波炉微波炉
公开(公告)号：WO1997048451A1
公开(公告)日：1997-12-24
申请号：PCT/US1997009975
申请日：1997-06-10
申请人： UROLOGIX, INC.
发明人： UROLOGIX, INC. , THOME, Scott, P. , RUDIE, Eric, N. , DANN, Mitchell , HIROSE, Teruo, T.
IPC分类号： A61N05/02
CPC分类号： A61B18/1815 , A61B18/18
摘要： A catheter (28) is adapted for insertion into a cardiovascular environment such as a cardiac chamber (14) of the heart (10) and includes a microwave antenna (34), a cooling lumen structure (76A, 76B, 78A, 78B), and an inflatable cooling balloon (36). The microwave antenna (34) delivers necrosing levels of microwave energy to deseased cardiac tissue (20) spaced from the catheter (28). The cooling lumen structure surrounds the antenna (34) and cools tissues (16) immediately surrounding the catheter (28) while selectively absorbing microwave energy emitted by the antenna (34) to achieve a preferential heating pattern in the cardiac tissue (20) spaced from the catheter (28). The cooling balloon (36) of the catheter (28) is positioned adjacent the antenna (34) and partially surrounds the cooling lumen structure (78A, 78B) on one side (62) of the catheter (28) to provide additional cooling capability and additional microwave energy absorption on the side of the catheter opposite the diseased cardiac tissue (20) to prevent unwanted heating of blood within the cardiac chamber (14).
摘要翻译：导管（28）适于插入诸如心脏（10）的心室（14）的心血管环境中，并且包括微波天线（34），冷却管腔结构（76A，76B，78A，78B）和可膨胀的冷却气球（36）。微波天线（34）将微波能量的坏死水平递送至与导管（28）间隔开的干燥心脏组织（20）。冷却管腔结构围绕天线（34）并且冷却立即围绕导管（28）的组织（16），同时选择性地吸收由天线（34）发射的微波能量，以在心脏组织（20）中间隔开的优先加热模式导管（28）。导管（28）的冷却球囊（36）位于天线（34）附近并且部分地围绕导管（28）的一侧（62）上的冷却管腔结构（78A，78B），以提供额外的冷却能力，在与病变心脏组织（20）相对的导管侧上的额外的微波能量吸收，以防止心脏腔室（14）内血液的不期望的加热。

2. 发明申请

WO1997017105A1 NEEDLE MYOLYSIS SYSTEM FOR UTERINE FIBROIDS 审中-公开
标题翻译：用于子宫纤维蛋白酶的NEEDLE MYOLYSIS系统
公开(公告)号：WO1997017105A1
公开(公告)日：1997-05-15
申请号：PCT/US1996017923
申请日：1996-11-07
申请人： FEMRX, INC.
发明人： FEMRX, INC. , SAVAGE, George, M. , WEBBER, Margaret
IPC分类号： A61N05/02
CPC分类号： A61B18/1477 , A61B18/1482 , A61B18/1485 , A61B18/1492 , A61B2017/00084 , A61B2017/00106 , A61B2018/00196 , A61B2018/1253 , A61B2090/3782 , A61N1/403
摘要： The present invention provides electrosurgical needles, needle systems, and methods for their use which will allow the surgeon to target a tumor's blood supply. Generally, the invention facilitates targeting the blood flow (B) of the tumor (T) by incorporating a doppler ultrasound transducer (17) into the needle (16) or needle sheath (34). Preferably, the surgeon will also be able to control the temperature of the needle (16) using an integral temperature sensor (22) to effect maximum transfer of the RF energy into the tissue (T), thereby maximizing the volume of tissue destroyed. Furthermore, when used (for example) in the treatment of uterine fibroid, the present invention will reduce damage to the serosa by monitoring the uterine surface temperature during myolysis through a temperature sensor (36) integrated into the sheath (34) holding the myolysis needle.
摘要翻译：本发明提供电外科手术针，针系统及其使用方法，其将允许外科医生靶向肿瘤的血液供应。通常，本发明通过将多普勒超声换能器（17）并入针（16）或针鞘（34）中来有助于靶向肿瘤（T）的血流（B）。优选地，外科医生还将能够使用积分温度传感器（22）来控制针头（16）的温度，以实现RF能量到组织（T）的最大转移，从而最大化破坏的组织的体积。此外，当使用（例如）用于治疗子宫肌瘤时，本发明将通过通过集成到保持解血针（34）的护套（34）中的温度传感器（36）监测解纤时的子宫表面温度来减少对浆膜的损伤，。

3. 发明申请

WO1997006856A1 INTRASTROMAL PHOTO-REFRACTIVE KERATECTOMY 审中-公开
标题翻译：内镜照片折射式
公开(公告)号：WO1997006856A1
公开(公告)日：1997-02-27
申请号：PCT/US1996012556
申请日：1996-07-30
申请人： ESCALON MEDICAL CORP.
发明人： ESCALON MEDICAL CORP. , JUHASZ, Tibor , BILLE, Josef, F.
IPC分类号： A61N05/02
CPC分类号： A61F9/008 , A61F9/00827 , A61F2009/00872 , A61F2009/00897
摘要： A method for performing intrastromal photo-refractive keratectomy in the cornea (12) of an eye using a pulsed laser beam, includes the initial step of focusing the beam to a focal spot at a selected starting point in the stroma (22). The starting point is located at a predetermined distance behind the epithelium (18) of the cornea. While focused on the starting point, the laser beam is pulsed to disrupt a volume of stromal tissue (36) which is substantially equal to the volume of the focal spot. Subsequently, the beam is focused in a patterned sequence to focal spots at other discrete points in the stroma. At each point the stromal tissue is photo-disrupted. With this progressive pattern of photo-disruption, each spot is placed substantially adjacent a volume of previously disrupted tissue. The resultant photo-disrupted tissue creates a layer which is substantially centro-symmetrical around the optical axis. A plurality of layers can be removed to create a cavity in the stroma. When the cavity collapses, the corneal curvature is changed as desired.
摘要翻译：用于使用脉冲激光束在眼睛的角膜（12）中进行胸腔内光折射角膜切除术的方法包括将光束聚焦到基质（22）中选定起点处的焦点的初始步骤。起始点位于角膜上皮（18）后面的预定距离处。在集中于起点时，激光束被脉冲以破坏体积基本上等于焦点体积的基质组织（36）。随后，将光束以图案化的序列聚焦到基质中其他离散点处的焦点。在每一点，基质组织被光破坏。利用这种光破坏的进行模式，每个斑点基本上邻近一定体积的先前破坏的组织。所得到的光破坏的组织产生围绕光轴大致中心对称的层。可以去除多个层以在基质中产生空腔。当腔体塌陷时，根据需要改变角膜曲率。

4. 发明申请

WO1995003089A1 LASER TREATMENT SYSTEM WITH ELECTRONIC VISUALIZATION 审中-公开
标题翻译：具有电子可视化的激光治疗系统
公开(公告)号：WO1995003089A1
公开(公告)日：1995-02-02
申请号：PCT/US1994008169
申请日：1994-07-20
申请人： LUCID TECHNOLOGIES, INC.
发明人： LUCID TECHNOLOGIES, INC. , ZAVISLAN, James, M. , EASTMAN, Jay, M.
IPC分类号： A61N05/02
CPC分类号： A61B18/203 , A61B18/20 , A61B2017/00756 , A61B2018/00452 , A61B2018/00476 , A61B2018/00904 , A61B2018/20359 , A61B2090/373
摘要： A hand held microsurgical instrument (10) for applying laser energy to selected locations in an area under the skin to provide localized thermolysis of the tissue. The area is visualized while the laser beam is steered, using a deflection system, in X and Y coordinates. A telecentric optical system, in which a mirror (54) of the deflection system is located, directs the laser light essentially perpendicular to the area to be treated as the beam is scanned over the area. The optical system also focuses illumination light reflected from the area to a sensor matrix of a CCD video camera (48). The reflected illumination light is imaged essentially parallel to the optical axis in the object space thereby providing a precise image corresponding to the area. The laser beam may be tracked as it is deflected over the area by visualization thereof on a display or monitor associated with the camera.
摘要翻译：一种手持显微外科器械（10），用于将激光能量施加到皮肤下面的区域中的选定位置，以提供组织的局部热解。在X和Y坐标下，使用偏转系统对激光束进行转向时可视化该区域。偏转系统的反射镜（54）位于其中的远心光学系统在沿着该区域扫描光束时将激光基本上垂直于待处理的区域引导。光学系统还将从该区域反射的照明光聚焦到CCD摄像机（48）的传感器矩阵。反射的照明光基本上平行于对象空间中的光轴成像，从而提供对应于该区域的精确图像。激光束可以被跟踪，因为它通过在与相机相关联的显示器或监视器上的可视化而在该区域上偏转。

5. 发明申请

WO1993008877A1 CORNEAL SURGERY DEVICE AND METHOD 审中-公开
标题翻译：角膜手术装置及方法
公开(公告)号：WO1993008877A1
公开(公告)日：1993-05-13
申请号：PCT/US1992009625
申请日：1992-11-05
申请人： LAI, Shui, T.
IPC分类号： A61N05/02
CPC分类号： B23K26/0665 , A61B2017/00694 , A61F9/00804 , A61F9/00814 , A61F2009/00846 , A61F2009/00872 , A61F2009/00897 , B23K26/0096 , B23K26/03 , B23K26/032 , B23K26/04 , B23K26/043 , B23K26/06 , B23K26/0624 , B23K26/0648 , B23K26/0652 , B23K26/704 , G02B26/10 , G02F1/37 , H01S3/005 , H01S3/06 , H01S3/101 , H01S3/235
摘要： A laser-based method and apparatus for corneal surgery. The present invention is intended to be applied primarily to ablate organic materials, and human cornea in particular. The invention uses a laser source which has the characteristics of providing a shallow ablation depth (0.2 microns or less per laser pulse), and a low ablation energy density threshold (less than or equal to about 10 mJ/cm ), to achieve optically smooth ablated corneal surfaces. The preferred laser includes a laser (102) emitting approximately 100-50,000 laser pulses per second, with a wavelength of about 198-300 nm and a pulse duration of about 1-5,000 picoseconds. Each laser pulse is directed by a highly controllable laser scanning system (104).
摘要翻译：一种基于激光的角膜手术方法和装置。本发明旨在主要用于消融有机材料，特别是人角膜。本发明使用具有提供浅消融深度（每个激光脉冲0.2微米或更小）和低消融能量密度阈值（小于或等于约10mJ / cm 2）的特征的激光源，实现光学平滑的消融角膜表面。优选的激光器包括每秒发射大约100-50,000个激光脉冲的激光器（102），波长约为198-300nm，脉冲持续时间约为1-5,000皮秒。每个激光脉冲由高度可控的激光扫描系统（104）引导。

6. 发明申请

WO1993000132A1 ADAPTIVE FOCUSING AND NULLING HYPERTHERMIA ANNULAR AND MONOPOLE PHASED ARRAY APPLICATORS 审中-公开
标题翻译：自适应聚焦和空白超高分子环状和单相相位阵列应用
公开(公告)号：WO1993000132A1
公开(公告)日：1993-01-07
申请号：PCT/US1992005464
申请日：1992-06-26
申请人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY
发明人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY , FENN, Alan, J.
IPC分类号： A61N05/02
CPC分类号： A61N5/04 , A61N5/02
摘要： An R.F. hyperthermia phased array applicator uses adaptive nulling and focusing with non-invasive electric field probes (112) to control the electric field intensity at selected positions in and around a target body (106) to provide improved heating of solid tumors (107) during hyperthermia treatment. A gradient search or matrix inversion algorithm is used to control the amplitude and phase weighting for the phased array transmit elements (104) of the hyperthermia applicator. A 915 MHz monopole phased array hyperthermia applicator for heating brain tumors has an enclosed vessel including a plurality of monopole transmit antenna elements disposed as a circular arc array on a ground plane which has an aperture for positioning the tumor in proximity to the monopole antenna elements. Adaptive focusing with non-invasive electric field probes is used to maximize the electric field at the tumor site. Parallel plate microwave waveguides are used to direct R.F. energy from the monopole phased array to the tumor site. A microwave transmit and receive module generates amplitude and phase controlled transmit signals for exciting the monopole antenna elements, and receives passive microwave signals from the monopole antenna elements for taking non-invasive radiometry temperature measurements of the tumor site.
摘要翻译：一个R.F. 高温相控阵施加器使用自适应归零和聚焦与非侵入性电场探针（112）来控制目标体（106）内和周围的选定位置处的电场强度，以在高温治疗期间提供实体瘤（107）的改善的加热。使用梯度搜索或矩阵求逆算法来控制热疗施加器的相控阵发射元件（104）的振幅和相位加权。用于加热脑肿瘤的915MHz单极相位阵列热疗施加器具有封闭容器，该容器包括在接地平面上设置为圆弧阵列的多个单极发射天线元件，所述单极天线元件具有用于将肿瘤定位在单极天线元件附近的孔。使用非侵入式电场探针进行自适应聚焦，以最大化肿瘤部位的电场。平行平板微波波导用于引导R.F. 从单极相序阵列到肿瘤部位的能量。微波发射和接收模块产生用于激发单极天线元件的振幅和相位控制的发射信号，并且从单极天线元件接收被动微波信号，以获取肿瘤部位的非侵入式辐射测量温度测量值。

7. 发明申请

WO1992007621A1 URETHRAL INSERTED APPLICATOR FOR PROSTATE HYPERTHERMIA 审中-公开
标题翻译： URETHRAL插入式应用程序用于前瞻性高血压
公开(公告)号：WO1992007621A1
公开(公告)日：1992-05-14
申请号：PCT/US1991008182
申请日：1991-11-04
申请人： BSD MEDICAL CORPORATION
发明人： BSD MEDICAL CORPORATION , TURNER, Paul, F. , SCHAEFERMEYER, Theron, Neal , TUMEH, Amer, Mohammad
IPC分类号： A61N05/02
CPC分类号： A61N1/403 , A61B18/1485
摘要： A radiofrequency energy source (12) supplies electromagnetic energy to the applicator (14) which acts as an electrode. A control circuit (26) contains a comparator (42) which is connected to a temperature sensor (20) and a temperature reference device (44) for comparing the actual tissue temperature level with a desired temperautre level and provides control signals to the energy source (12) for controlling the output to the applicator. A second electrode (96) provides a current return for the heating current from applicator (14). A sheet or sheath of insulation material covers the applicator (14) insulating it from the tissue; the thickness of the sheet or sheath may be varied to provide uniform tissue heating along the length of the applicator.
摘要翻译：射频能量源（12）向用作电极的施加器（14）提供电磁能。控制电路（26）包含连接到温度传感器（20）和温度参考装置（44）的比较器（42），用于将实际组织温度水平与所需温度水平进行比较，并向能量源提供控制信号（12），用于控制施加器的输出。第二电极（96）为来自施加器（14）的加热电流提供电流返回。绝缘材料的片材或护套覆盖施加器（14），使其与组织绝缘; 可以改变片材或护套的厚度以沿着施用器的长度提供均匀的组织加热。

8. 发明申请

WO1989011311A1 MICROWAVE BALLOON ANGIOPLASTY 审中-公开
公开(公告)号：WO1989011311A1
公开(公告)日：1989-11-30
申请号：PCT/US1989002154
申请日：1989-05-18
申请人： KASEVICH ASSOCIATES, INC.
发明人： KASEVICH ASSOCIATES, INC. , KASEVICH, Raymond, S. , McQUEENEY, James, F. , CROOKER, Ronald, H.
IPC分类号： A61N05/02
CPC分类号： H01Q21/08 , A61B18/18 , A61B18/1815 , A61B2017/00057 , A61B2017/00084 , A61B2017/00853 , A61B2017/22001 , A61B2017/22051 , A61B2017/22062 , A61B2018/00285 , A61B2018/00577 , A61B2018/00738 , A61B2018/1861 , A61M25/104
摘要： A microwave catheter system used for heating arterial plaque and including a catheter member (1) adapted for positioning in the artery and an inflatable balloon (12) supported at the distal end of the catheter member (1). Microwave energy is coupled by means of a transmission line (2) to an antenna (11). An optic fiber (3) extends through the catheter member and may be used for temperature sensing or other purposes. A channel (4) is provided through the catheter member for coupling a fluid to the balloon for inflation thereof.
摘要翻译：一种用于加热动脉斑块并包括适于定位在动脉中的导管构件（1）的微波导管系统和支撑在导管构件（1）的远端处的可充气球囊（12）。微波能量通过传输线（2）耦合到天线（11）。光纤（3）延伸穿过导管构件，并可用于温度感测或其他目的。通过导管构件提供通道（4），用于将流体耦合到球囊以使其膨胀。

9. 发明申请

WO1998018522A1 COMPOUND ASTIGMATIC MYOPIA OR HYPEROPIA CORRECTION BY LASER ABLATION 审中-公开
标题翻译：通过激光消除的化合物亚麻酸或超声波校正
公开(公告)号：WO1998018522A1
公开(公告)日：1998-05-07
申请号：PCT/US1997019241
申请日：1997-10-28
申请人： LASERSIGHT TECHNOLOGIES, INC.
发明人： LASERSIGHT TECHNOLOGIES, INC. , TANG, Fuqian , HAN, Xiaofeng
IPC分类号： A61N05/02
CPC分类号： A61F9/008 , A61F9/00804 , A61F2009/00872 , A61F2009/00897
摘要： An apparatus (50) is provided for performing corneal refractive surgery by ablating a portion of a corneal surface of any eye. The apparatus includes a pulsed laser (100) for producing a pulsed output beam of light. A scanning mechanism (120) scans the output beam (110), and the output beam is operatively associated with the scanning mechanism such that the output beam may be scanned over a predetermined surface defined by a mathematically derived ablation layer boundary curve for each ablation layer. A controller (250) is operatively associated with the scanning mechanism so as to deliver output beams to the predetermined surface (160) such that center points of output beams may be disposed within the ablation layer boundary curve, on the ablation layer boundary curve, and outside, but within a predetermined distance from a nearest point on the ablation layer boundary curve so as to integrate the edges of the ablation layer boundary curve to more closely correspond to the desired ablated shape.
摘要翻译：提供了一种通过烧蚀任何眼睛的角膜表面的一部分来进行角膜屈光手术的装置（50）。该装置包括用于产生脉冲输出光束的脉冲激光器（100）。扫描机构（120）扫描输出光束（110），并且输出光束与扫描机构可操作地相关联，使得可以在由用于每个消融层的数学导出的消融层边界曲线限定的预定表面上扫描输出光束。控制器（250）与扫描机构可操作地相关联，以将输出光束输送到预定表面（160），使得输出光束的中心点可以设置在消融层边界曲线上，在消融层边界曲线上，以及但是距离消融层边界曲线上的最近点的预定距离内，以便将消融层边界曲线的边缘整合到更接近于期望的烧蚀形状。

10. 发明申请

WO1997030752A1 NON-CONTACT SCANNING LASER SYSTEM 审中-公开
标题翻译：非接触扫描激光系统
公开(公告)号：WO1997030752A1
公开(公告)日：1997-08-28
申请号：PCT/US1996002663
申请日：1996-02-26
申请人： LASERSIGHT, INC.
发明人： LASERSIGHT, INC. , LIN, Jui-Teng
IPC分类号： A61N05/02
CPC分类号： A61F9/00827 , A61F9/008 , A61F9/00804 , A61F9/00821 , A61F2009/00853 , A61F2009/00872 , A61F2009/00882 , A61F2009/00897 , B23K26/0622 , B23K26/082
摘要： A refractive laser system is disclosed for use in refractive laser surgery and is a compact, low cost ophthalmic laser system (10, 35) which has computer controlled scanning for a non-contact delivery device for both photo-ablation and photo-coagulation in corneal reshaping. The advantages of the non-contact, scanning device (12, 37) used in the process include being safer, reduced cost, more compact and more precise. Lasers are selected with energies of 0.01-10 mJ, repetition rates of 1-10,000, pulse duration of 0.01 nanoseconds to a few hundreds of microseconds, and with spot sizes of 0.05-2 mm.
摘要翻译：公开了用于折射激光手术的折射激光系统，并且是一种紧凑，低成本的眼科激光系统（10,35），其具有计算机控制扫描用于角膜消融和光凝固的非接触递送装置整形。在该过程中使用的非接触式扫描装置（12,37）的优点包括更安全，降低成本，更紧凑和更精确。激光器选择的能量为0.01-10 mJ，重复频率为1-10,000，脉冲持续时间为0.01纳秒至几百微秒，光斑尺寸为0.05-2 mm。

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