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1. 发明申请

WO2011063061A2 MICROWAVE COAGULATION APPLICATOR AND SYSTEM 审中-公开
标题翻译： MICROWAVE凝聚装置和系统
公开(公告)号：WO2011063061A2
公开(公告)日：2011-05-26
申请号：PCT/US2010/057127
申请日：2010-11-17
申请人： BSD MEDICAL CORPORATION , TURNER, Paul, F. , YOUD, Thomas, L. , HAMILTON, Brianne
发明人： TURNER, Paul, F. , YOUD, Thomas, L. , HAMILTON, Brianne
IPC分类号： A61B18/12 , A61B18/18 , A61N5/02 , A61B17/34 , A61M25/01
CPC分类号： A61B18/1815 , A61B2018/00023 , A61B2018/00029 , A61B2018/00577 , A61B2018/00589 , A61B2018/00815 , A61B2018/1869 , A61B2018/1892
摘要： A microwave applicator for insertion into living body tissue to provide microwave ablation treatments includes a microwave transmission line extending between an attachment end of the applicator and an antenna toward an insertion end of the applicator with an outer conductive sleeve forming an enclosed fluid space around the transmission line. Circulation of cooling fluid is guided in the fluid space by a guide sleeve. A sensor senses the approximate temperature of the cooling fluid. A portion of the fluid can be injected into tissue surrounding the applicator to hydrate tissue not to be treated. Microwave power may be provided to one or more of the applicators by a system which includes a multiplexing and power splitting circuit providing power outputs tuned for either one or a plurality of applicators and detects the number of applicators and correct connection. The system may provide microwave energy of both 915 MHz and 2450 MHz.
摘要翻译：用于插入到生物体组织中以提供微波消融治疗的微波施加器包括微波传输线，其在施用器的附接端和朝向施放器的插入端的天线之间延伸，外导电套形成围绕传输的封闭流体空间线。冷却流体的循环通过导向套筒在流体空间中被引导。传感器感测冷却液的近似温度。流体的一部分可以被注入到施用器周围的组织中以水化不被治疗的组织。微波功率可以通过系统提供给一个或多个施加器，该系统包括多路复用和功率分配电路，其提供针对一个或多个施加器调谐的功率输出，并且检测施加器的数量和正确的连接。该系统可以提供915MHz和2450MHz的微波能量。

2. 发明申请

WO1993008875A1 HYPERTHERMIA APPARATUS HAVING THREE-DIMENSIONAL FOCUSING 审中-公开
标题翻译：具有三维聚焦的超高分子装置
公开(公告)号：WO1993008875A1
公开(公告)日：1993-05-13
申请号：PCT/US1991008136
申请日：1991-11-04
申请人： BSD MEDICAL CORPORATION
发明人： BSD MEDICAL CORPORATION , TURNER, Paul, F.
IPC分类号： A61N05/00
CPC分类号： A61N5/02
摘要： A hyperthermia apparatus having a three-dimensional target positioning capability is disclosed. The apparatus includes a signal modifier (16), having electromagnetic power splitting, phase adjusting, and power gain capabilities, connected to a plurality of power connector assemblies (18) having individual antenna power and power phase adjusting capability. The power connector assemblies (18) connect power at preselected phases to a plurality of antenna groups (27) forming an applicator. Each antenna group (32) includes three antennae (34) preferably of the dipole type stacked end to end on a tube of dielectric material (54). The phase of the power applied to the three antennae (34) of the antenna groups (32) is selected to provide a target heating spot positionable or adjustable in size in a body portion in a direction along the long axis of the body portion and within the cross section perpendicular to the long axis. This adjustable size and positioning of the target along the long axis provides an additional dimension to the capability of moving the target perpendicular to the long axis in either direction from the center as provided in known applicators.
摘要翻译：公开了具有三维目标定位能力的热疗装置。该装置包括具有电磁功率分配，相位调整和功率增益能力的信号调节器（16），其连接到具有单独的天线功率和功率相位调整能力的多个功率连接器组件（18）。电源连接器组件（18）将预选相位的功率连接到形成施加器的多个天线组（27）。每个天线组（32）包括优选地由电介质材料（54）的管上叠置的偶极型的三个天线（34）。选择施加到天线组（32）的三个天线（34）的功率的相位，以在沿主体部分的长轴方向的主体部分中提供可定位或可调整的目标加热点，并且在垂直于长轴的横截面。目标沿着长轴的这种可调整的尺寸和定位提供了一个额外的尺寸，使其能够在已知的施加器中提供的从中心沿任一方向垂直于长轴移动靶。

3. 发明申请

WO1992007622A1 URETHRAL INSERTED APPLICATOR FOR PROSTATE HYPERTHERMIA 审中-公开
标题翻译： URETHRAL插入式应用程序用于前瞻性高血压
公开(公告)号：WO1992007622A1
公开(公告)日：1992-05-14
申请号：PCT/US1991008183
申请日：1991-11-04
申请人： BSD MEDICAL CORPORATION
发明人： BSD MEDICAL CORPORATION , TURNER, Paul, F. , SCHAEFERMEYER, Theron, Neal , TUMEH, Amer, Mohammad , TERRY, Philip, A.
IPC分类号： A61N05/02
CPC分类号： A61N5/0601 , A61B5/01 , A61B17/2202 , A61B18/18 , A61B18/1815 , A61B2017/00057 , A61B2017/00084 , A61B2017/00132 , A61B2017/00274 , A61B2017/22021 , A61B2018/00035 , A61B2018/00166 , A61B2018/00547 , A61F7/12 , A61M2025/0177 , A61N7/022 , A61N2005/007 , A61N2005/061
摘要： A urethral insertable applicator for prostate hyperthermia includes an energy applicator (14) in association with a multi-tube, balloon-type catheter (18). The energy applicator (14) may be a microwave applicator or an ultrasound applicator, either of which, when inserted in the prostate, will cause heating of the prostate tissue surrounding the applicator. The applicator (14), with a radiometer (11), may serve as a means to measure temperature by measuring the thermal energy radiated from the prostate tissue. Provision may be made for circulating a cooling fluid through a cooling chamber (73) between the applicator (14) and the tissue to be heated. The difference in temperature of the inlet and outlet cooling fluid may also be used to indicate prostate tissue temperature. A measure of the temperature of the prostate tissue being heated is used to control application of energy to the applicator.
摘要翻译：用于前列腺热疗的尿道可插入施加器包括与多管气囊型导管（18）相关联的能量施加器（14）。能量施加器（14）可以是微波施加器或超声波施加器，其中当插入到前列腺中时，其将引起围绕施用器的前列腺组织的加热。具有辐射计（11）的施加器（14）可以用作通过测量从前列腺组织辐射的热能来测量温度的手段。可以设置使冷却流体循环通过施加器（14）和待加热组织之间的冷却室（73）。入口和出口冷却流体的温度差异也可用于指示前列腺组织温度。使用被加热的前列腺组织的温度的量度来控制对施用器的能量的施加。

4. 发明申请

WO1993008876A1 URETHRAL INSERTED APPLICATOR FOR PROSTATE HYPERTHERMIA 审中-公开
标题翻译： URETHRAL插入式应用程序用于前瞻性高血压
公开(公告)号：WO1993008876A1
公开(公告)日：1993-05-13
申请号：PCT/US1991008137
申请日：1991-11-04
申请人： BSD MEDICAL CORPORATION
发明人： BSD MEDICAL CORPORATION , TURNER, Paul, F. , ASTRAHAN, Melvin, Alan
IPC分类号： A61N05/02
CPC分类号： A61B18/1815 , A61B18/18 , A61B2018/00166 , A61B2018/1861 , A61M2025/0177
摘要： A urethral inserted applicator for prostate electromagnetic hyperthermia includes apparatus for holding and positioning at least one electromagnetic energy applicator (14) in a urethral passage extending through a prostate gland. The apparatus includes a multipassage or multitube, balloon type urinary or Foley catheter (18) with fluid-dry passages for insertion of microwave antenna or capacitive electrode type applicators (14), and an electromagnetic compatible type temperature sensor (25) for measuring the temperature of the prostate tissue. The urinary catheter provides an open fluid receiving tube (56) enabling urine drainage from the bladder and a balloon (76) at the tip region of the catheter for engaging the bladder neck to properly position and hold the apparatus during treatment. An electromagnetic generator (12) supplies electromagnetic energy to the applicators (14). A comparator (42) is connected to the temperature sensor (25) and a temperature reference potentiometer (44) for comparing the actual tissue temperature with a desired temperature and for providing output control signals to the electromagnetic generator (12) for controlling the output of the generator to the applicators (14).
摘要翻译：用于前列腺电磁疗法的尿道插入施用器包括用于保持和定位延伸穿过前列腺的尿道中的至少一个电磁能量施加器（14）的装置。该装置包括具有用于插入微波天线或电容电极型施加器（14）的流体干燥通道的多通道或多管气囊型尿液或Foley导管（18），以及用于测量温度的电磁兼容型温度传感器（25）的前列腺组织。导尿管提供开放的液体接收管（56），使得尿液从膀胱排出，并且在导管的尖端区域处具有气囊（76），用于接合膀胱颈部，以在治疗期间适当地定位和保持装置。电磁发生器（12）向施用器（14）供应电磁能。比较器（42）连接到温度传感器（25）和用于将实际组织温度与期望温度进行比较的温度参考电位器（44），并且用于向电磁发生器（12）提供输出控制信号，以控制发电机到施加器（14）。

5. 发明申请

WO1992007621A1 URETHRAL INSERTED APPLICATOR FOR PROSTATE HYPERTHERMIA 审中-公开
标题翻译： URETHRAL插入式应用程序用于前瞻性高血压
公开(公告)号：WO1992007621A1
公开(公告)日：1992-05-14
申请号：PCT/US1991008182
申请日：1991-11-04
申请人： BSD MEDICAL CORPORATION
发明人： BSD MEDICAL CORPORATION , TURNER, Paul, F. , SCHAEFERMEYER, Theron, Neal , TUMEH, Amer, Mohammad
IPC分类号： A61N05/02
CPC分类号： A61N1/403 , A61B18/1485
摘要： A radiofrequency energy source (12) supplies electromagnetic energy to the applicator (14) which acts as an electrode. A control circuit (26) contains a comparator (42) which is connected to a temperature sensor (20) and a temperature reference device (44) for comparing the actual tissue temperature level with a desired temperautre level and provides control signals to the energy source (12) for controlling the output to the applicator. A second electrode (96) provides a current return for the heating current from applicator (14). A sheet or sheath of insulation material covers the applicator (14) insulating it from the tissue; the thickness of the sheet or sheath may be varied to provide uniform tissue heating along the length of the applicator.
摘要翻译：射频能量源（12）向用作电极的施加器（14）提供电磁能。控制电路（26）包含连接到温度传感器（20）和温度参考装置（44）的比较器（42），用于将实际组织温度水平与所需温度水平进行比较，并向能量源提供控制信号（12），用于控制施加器的输出。第二电极（96）为来自施加器（14）的加热电流提供电流返回。绝缘材料的片材或护套覆盖施加器（14），使其与组织绝缘; 可以改变片材或护套的厚度以沿着施用器的长度提供均匀的组织加热。

6. 发明申请

WO1988003823A1 HYPERTHERMIA APPARATUS 审中-公开
公开(公告)号：WO1988003823A1
公开(公告)日：1988-06-02
申请号：PCT/US1987003125
申请日：1987-11-25
申请人： BSD MEDICAL CORPORATION
发明人： BSD MEDICAL CORPORATION , TURNER, Paul, F.
IPC分类号： A61N05/00
CPC分类号： A61N5/02
摘要： Hyperthermia apparatus includes a hyperthermia treatment subsystem (12), and a receiver subsystem (16). The subsystems include, respectively, a power source (30) and radiometer (33) connected to a switch (31) controlled by a central processing unit (CPU) (20) to selectively connect either the power source and the radiometer to complete the subsystems as follows. A power divider (32) having output ports for feeding electromagnetic energy through a plurality of applicator circuits each circuit including a phase shifter (34) connected to the power divider, a power regulating switch (37) connected to the phase shifter, and an applicator (36) connected to the power control switches. The power regulating switches are controlled also by the CPU. Thus, when the CPU connects the power source to the power divider the hyperthermia subsystem is complete for operation in the tissue heating mode; however, when the CPU connects the radiometer, the receiver subsystem is complete. A second embodiment includes a separate radiometer connected to each antenna port.
摘要翻译：热疗装置包括热疗治疗子系统（12）和接收器子系统（16）。子系统分别包括连接到由中央处理单元（CPU）（20）控制的开关（31）的电源（30）和辐射计（33），以选择性地连接电源和辐射计以完成子系统如下。一种功率分配器（32），具有用于通过多个施加器电路馈送电磁能的输出端口，每个电路包括连接到功率分配器的移相器（34），连接到移相器的功率调节开关（37）（36）连接到电源控制开关。功率调节开关也由CPU控制。因此，当CPU将电源连接到功率分配器时，热疗子系统完成在组织加热模式下操作; 然而，当CPU连接辐射计时，接收器子系统就完成了。第二实施例包括连接到每个天线端口的单独的辐射计。

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