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1. 发明申请

WO1997008332A1 A PROCESS FOR PRODUCTION OF CITRIC ACID AND MONOVALENT CITRATE SALTS 审中-公开
标题翻译：一种生产柠檬酸和单一柠檬酸盐的方法
公开(公告)号：WO1997008332A1
公开(公告)日：1997-03-06
申请号：PCT/US1996011089
申请日：1996-06-28
申请人： NTEC, INC.
发明人： NTEC, INC. , DATTA, Rathin , BERGEMANN, Eugene, P.
IPC分类号： C12P07/48
CPC分类号： C12P7/48 , Y10S435/80 , Y10S435/917
摘要： A short process is disclosed for the production of citric acid in high yield and purtiy. Conidia of Aspergillus niger are cultured in an aqueous solution of decationized glucose syrup in a fermentation medium whose maganese (II) concentration is 2.5 to less than 20 parts per billion and whose pH value is about 1.5 to about 3.0. The fermentation medium is maintained for about 4-7 days to form citric acid and mycelia pellets in an aqueous product broth. That broth is filtered and then electrodialyzed to form a citric acid-containing aqueous broth. That broth is decolorized and ion-exchanged to remove color and inorganic ions and form an aqueous citric acid solution in which citric acid constitutes at least 98 percent of the organic acid present.
摘要翻译：公开了以高产率和纯度生产柠檬酸的简短方法。将黑曲霉的分生孢子在发酵培养基中的糖化葡萄糖浆的水溶液中培养，其发酵培养基中的骨（II）浓度为2.5至小于20十亿，pH值为约1.5至约3.0。将发酵培养基保持约4-7天，以在含水产品肉汤中形成柠檬酸和菌丝体颗粒。将该肉汤过滤，然后电渗析以形成含柠檬酸的水性肉汤。该肉汤被脱色并离子交换以除去颜色和无机离子并形成其中柠檬酸占存在的有机酸的至少98％的柠檬酸水溶液。

2. 发明申请

WO1986004612A1 TEST KIT METHOD FOR THE DETERMINATION OF STREPTOCOCCUS MUTANS 审中-公开
标题翻译：用于确定。OF。。。。。。。。。。。。。
公开(公告)号：WO1986004612A1
公开(公告)日：1986-08-14
申请号：PCT/US1986000148
申请日：1986-01-29
申请人： FORSYTH DENTAL INFIRMARY FOR CHILDREN
发明人： FORSYTH DENTAL INFIRMARY FOR CHILDREN , JORDAN, Harold, V. , MARMEL, Max
IPC分类号： C12Q01/14
CPC分类号： C12Q1/14 , G01N2333/315 , Y10S435/80 , Y10S435/801 , Y10S435/885
摘要： A test kit (Fig. 1) and method for the semi-quantitive detection of Streptococcus mutans from the oral cavity of a patient, which method comrpises introducing saliva from a patient into a diluent solution (Fig. 1, item 24) to which has been added just before the saliva a predetermined powdered amount of bacitracin (Fig. 1, item 28), and contacting the diluent solution with a sterile media-coated paddle (Fig. 1, item 22), incubating the media-coated paddle containing the diluent and test saliva, and determining semi-quantitively the amount of Streptococcus mutans in the test saliva by comparing the percent of colony density with a standard Streptococcus mutans colony density chart (Fig. 2).

3. 发明申请

WO2004091658A1 HIGH CONCENTRATION ANTIBODY AND PROTEIN FORMULATIONS 审中-公开
标题翻译：高浓度抗体和蛋白质配方
公开(公告)号：WO2004091658A1
公开(公告)日：2004-10-28
申请号：PCT/US2004/009613
申请日：2004-03-29
申请人： GENENTECH, INC. , LIU, Jun , SHIRE, Steven
发明人： LIU, Jun , SHIRE, Steven
IPC分类号： A61K39/395
CPC分类号： A61K39/39591 , A61K9/0019 , A61K9/08 , A61K39/39566 , A61K45/06 , A61K47/183 , A61K47/22 , A61K47/26 , A61K2039/505 , A61M5/20 , C07K16/4291 , C07K2317/21 , C07K2317/94 , Y10S435/80
摘要： The present application relates to highly concentrated antibody and protein formulations with reduced viscosity that are stable, relatively isotonic and are of low turbidity. The formulations are particularly suitable for subcutaneous administration. The application further describes articles of manufacture containing such formulations and method for using them to treat disorders treatable by the formulated antibody or protein. The formulations comprise arginine-HC1, histidine and polysorbate.
摘要翻译：本申请涉及具有降低的粘度的高度浓缩的抗体和蛋白质制剂，其是稳定的，相对等渗的并且具有低浊度。制剂特别适用于皮下给药。本申请进一步描述了含有这些制剂的制品及使用它们治疗由配制的抗体或蛋白质可治疗的疾病的方法。制剂包含精氨酸-HCl，组氨酸和聚山梨醇酯。

4. 发明申请

WO0204084A3 PROCESS FOR OBTAINING BIO-FUNCTIONAL FRACTIONS FROM BIOMASS 审中-公开
标题翻译：从生物质获取生物功能组分的过程
公开(公告)号：WO0204084A3
公开(公告)日：2002-06-20
申请号：PCT/US0141322
申请日：2001-07-10
申请人： THORRE TECHNOLOGIES LLC , VAN THORRE DOUG
发明人： VAN THORRE DOUG
IPC分类号： C07C229/02 , C07H1/00 , C08B1/00 , C08B16/00 , C08B37/00 , C08H8/00 , C12S3/00 , C12S3/04 , D21C5/00 , D21C7/12 , C08B11/00
CPC分类号： C08H8/00 , C08B1/00 , C08B37/006 , D21C5/00 , Y10S435/80
摘要： The present invention includes a process for extracting bio-functional materials from biomass. The method comprises providing biomass and subjecting the biomass to substantially instantaneous pressurization and depressurization to separate bio-functional materials, such as cellulose, hemicellulose, and lignin from the biomass.
摘要翻译：本发明包括从生物质提取生物功能材料的方法。该方法包括提供生物质并对生物质进行基本上瞬时的加压和减压以从生物质中分离生物功能材料，例如纤维素，半纤维素和木质素。

5. 发明申请

WO1990008193A1 METHOD FOR THE PRODUCTION OF XYLITOL FROM MIXTURES CONTAINING XYLOSE 审中-公开
标题翻译：用于从含有XYLOSE的混合物生产XYLITOL的方法
公开(公告)号：WO1990008193A1
公开(公告)日：1990-07-26
申请号：PCT/FI1990000015
申请日：1990-01-15
申请人： CULTOR LTD.
发明人： CULTOR LTD. , HEIKKILÄ, Heikki , NURMI, Juha , RAHKILA, Leena , TÖYRYLÄ, Marja
IPC分类号： C12P19/02
CPC分类号： C12P7/18 , C12R1/645 , C12R1/74 , Y10S435/80 , Y10S435/803 , Y10S435/911 , Y10S435/924
摘要： A method is disclosed for the production of xylitol from a xylose and/or xylan containing material. A solution containing xylitol and other hexoses is fermented with a yeast strain capable of converting free xylose to xylitol and other free hexoses present to ethanol, with the xylitol subsequently separated by chromatographic separation means.

6. 发明申请

WO2005010136A2 METHOD FOR PRODUCING FATS OR OILS 审中-公开
标题翻译：生产脂肪或油的方法
公开(公告)号：WO2005010136A2
公开(公告)日：2005-02-03
申请号：PCT/US2004/020061
申请日：2004-06-25
申请人： ARCHER-DANIELS-MIDLAND COMPANY , LEE, Inmok
发明人： LEE, Inmok
IPC分类号： C11C
CPC分类号： C11C3/10 , C12P7/62 , C12P7/6454 , Y10S435/80 , Y10S435/962
摘要： The present invention is directed to improving productivity of an enzymatic method for making esterified, transesterified or interesterified products. Specifically, a method that can greatly improve the productivity of enzymatic transesterification or esterification by deodorization alone, or by deodorization and purification of the initial substrate substrate to extend the useful life of the enzyme is disclosed.
摘要翻译：本发明旨在提高用于制备酯化，酯交换或酯交换产物的酶法的生产率。具体地说，公开了一种可以通过单独除臭或通过除臭和纯化初始底物底物来大大提高酶酯交换或酯化的生产力以延长酶的使用寿命的方法。

7. 发明申请

WO03049766A8 METHOD OF PURIFYING HEPATITIS A VIRUS PARTICLES AND VACCINE PREPARATION 审中-公开
标题翻译：净化乙型肝炎病毒颗粒和疫苗制剂的方法
公开(公告)号：WO03049766A8
公开(公告)日：2004-05-21
申请号：PCT/EP0214008
申请日：2002-12-10
申请人： BAXTER HEALTHCARE SA , TAUER CHRISTA , MEYER HEIDI , MITTERER ARTUR , BARRETT NOEL
发明人： TAUER CHRISTA , MEYER HEIDI , MITTERER ARTUR , BARRETT NOEL
IPC分类号： C12N15/09 , A61K39/29 , A61P31/14 , C12N7/01 , C12N7/02 , A61K39/295
CPC分类号： C12N7/00 , A61K39/12 , A61K39/29 , A61K2039/5252 , A61K2039/55505 , A61K2039/57 , C12N2770/32432 , C12N2770/32451 , Y10S435/80 , Y10S435/803 , Y10S435/814 , Y10S435/816 , Y10S435/962
摘要： The present invention provides methods of purification of Hepatitis A Virus from the supernatant of an infected cell culture and production of a preparation of purified HAV antigen. The present invention is also directed to an HAV vaccine composition comprising a preparation consisting of purified mature HAV particles in an amount sufficient to induce a protective immune in a mammal.
摘要翻译：本发明提供从感染的细胞培养物的上清液中纯化甲型肝炎病毒的方法以及纯化的HAV抗原的制备物的制备。本发明还涉及一种HAV疫苗组合物，其包含由足以在哺乳动物中诱导保护性免疫的量的纯化的成熟HAV颗粒组成的制剂。

8. 发明申请

WO02030463A2 REDUCED-VISCOSITY CONCENTRATED PROTEIN FORMULATIONS 审中-公开
标题翻译：浓缩的蛋白质配方具有降低的粘度
公开(公告)号：WO02030463A2
公开(公告)日：2002-04-18
申请号：PCT/US2001/042487
申请日：2001-10-04
IPC分类号： A61K9/08 , A61K38/00 , A61K38/16 , A61K39/395 , A61K47/02 , A61K47/12 , A61K47/18 , A61K47/26
CPC分类号： A61K39/39591 , A61K9/0019 , A61K47/02 , A61K47/12 , A61K47/183 , Y10S435/80
摘要： The present application concerns concentrated protein formulations with reduced viscosity, which are particularly suitable for subcutaneous administration. The application further concerns a method for reducing the visocosity of concentrated protein formulations.
摘要翻译：本发明涉及特别适用于皮下给药的浓度降低的浓缩蛋白质制剂。本发明还涉及用于降低浓缩蛋白质制剂的粘度的方法。

9. 发明申请

WO1990008816A1 PROCESS AND DEVICE FOR SEQUENTIAL MICROBIAL ENRICHMENT IN A SINGLE APPARATUS 审中-公开
标题翻译：用于单个装置中的顺序微生物培养的方法和装置
公开(公告)号：WO1990008816A1
公开(公告)日：1990-08-09
申请号：PCT/US1990000586
申请日：1990-01-26
申请人： BIOCONTROL SYSTEMS, INCORPORATED
发明人： BIOCONTROL SYSTEMS, INCORPORATED , WARD, N., Robert, Jr. , LOZIER, Philip, J.
IPC分类号： C12M01/24
CPC分类号： C12M23/08 , C12M29/20 , Y10S435/80 , Y10S435/813 , Y10S435/819
摘要： There is disclosed an apparatus, a device, and a method using the inventive device and apparatus for the sequential enrichment of a particular microorganism to a threshold level to allow for its detection. The use of the apparatus for sequential microbial enrichment shortens the time period normally spent to enrich samples to permit the growth of enough microorganisms to detect the particular microorganism(s) of interest. The invention eliminates the need for multiple manual transfers of potentially biohazardous materials.

10. 发明申请

WO1990006109A1 ADHESION OF MYCOPLASMA PNEUMONIAE AND MYCOPLASMA HOMINUS TO SULFATIDE 审中-公开
标题翻译： MYCOPLASMA PNEUMONIAE和MYCOPLASMA HOMINUS对SULFATIDE的粘附
公开(公告)号：WO1990006109A1
公开(公告)日：1990-06-14
申请号：PCT/US1989005313
申请日：1989-11-28
申请人： THE UNITED STATES OF AMERICA, represented by THE ...
发明人： THE UNITED STATES OF AMERICA, represented by THE ... , KRIVAN, Howard, C. , GINSBURG, Victor , ROBERTS, David, D.
IPC分类号： A61K31/13
CPC分类号： A61K31/7004 , C12Q1/24 , G01N33/56933 , Y10S435/80 , Y10S435/87
摘要： The invention is a carbohydrate receptor for Mycoplasma pneumoniae and Mycoplasma hominus and its use to detect mycoplasma in biological fluids and diseased tissue and cells. The receptor can be included in a composition having a pharmaceutically acceptable carrier. Methods are provided for purifying, detecting, or removing mycoplasma from diseased tissue or fluids. The receptor includes sulfatides, dextran sulfate, sialyloligosaccharides, and mixtures thereof.

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