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1. 发明申请

WO2004016771A1 MICROORGANISM PRODUCING HYALURONIC ACID AND PURIFICATION METHOD OF HYALURONIC ACID 审中-公开
标题翻译：生产HYALURONIC酸的微生物和纯化方法
公开(公告)号：WO2004016771A1
公开(公告)日：2004-02-26
申请号：PCT/KR2003/001666
申请日：2003-08-19
申请人： KOLON IND. INC. , VACCTECH CORP. , HAN, Hee-Yong , JANG, Seung-Hong , KIM, Eul-Chae , PARK, Jung-Kyung , HAN, Young-Jin , LEE, Chung , PARK, Heung-Soon , KIM, Yun-Cheul , PARK, Ho-Jin
发明人： HAN, Hee-Yong , JANG, Seung-Hong , KIM, Eul-Chae , PARK, Jung-Kyung , HAN, Young-Jin , LEE, Chung , PARK, Heung-Soon , KIM, Yun-Cheul , PARK, Ho-Jin
IPC分类号： C12N1/20
CPC分类号： C12P19/28 , C08B37/0072 , C12P19/26 , C12R1/46 , Y10S435/885
摘要： The present invention relates to a hyaluronic acid producing strain Streptococcus sp. KL0188 and a method for purifying hyaluronic acid, more particularly to a Streptococcus sp. KL0188 that does not express hyaluronidase and is non-hemolytic, and a method for purifying hyaluronic acid using an aromatic adsorption resin and an active carbon.
摘要翻译：本发明涉及产生透明质酸的菌株Streptococcus sp。 KL0188和用于纯化透明质酸的方法，更特别地涉及链球菌属。 KL0188，其不表达透明质酸酶并且是非溶血性的，以及使用芳香族吸附树脂和活性炭来净化透明质酸的方法。

2. 发明申请

WO01091711A1 USE OF EXOGENOUS LACTIC BACTERIA STRAIN AGAINST ACTINOMYCES NAESLUNDII RELATED DISEASES 审中-公开
标题翻译：使用外源性细菌细菌株与抗生素联合治疗相关疾病
公开(公告)号：WO01091711A1
公开(公告)日：2001-12-06
申请号：PCT/EP2001/006268
申请日：2001-05-30
IPC分类号： A23L1/30 , A23C9/123 , A23G4/00 , A23G4/12 , A23K1/00 , A23K1/18 , A61K8/99 , A61K35/74 , A61K38/00 , A61P1/02 , A61P31/04 , A61Q11/00 , C12N1/20 , A61K7/26
CPC分类号： A23G4/123 , A23C9/123 , A23C9/1236 , A23C9/1238 , A23C2220/206 , A23K10/18 , A23K40/30 , A23K50/40 , A23Y2240/75 , A61K8/99 , A61Q11/00 , Y10S435/822 , Y10S435/885
摘要： The use of a lactic bacteria strain that is exogenous to the oral microflora, which has been selected for its ability to adhere the pellicle of the teeth and to produce a growth inhibition factor, for the preparation of a composition intended for reducing dental plaque and for treating or preventing root caries and other diseases related to Actinomyces naeslundii in mammals.
摘要翻译：使用外源于口腔微生物群的外源性乳酸菌菌株，其已经被选择为粘附牙齿防护薄膜并产生生长抑制因子的能力，用于制备用于减少牙菌斑的组合物和在哺乳动物中治疗或预防与猕猴桃放线菌相关的根龋和其它疾病。

3. 发明申请

WO00067696A3 LACTIC ACID BACTERIA WITH ANXIOLYTIC PROPERTIES AND USES THEREOF 审中-公开
标题翻译：具有抗氧化性质的酸性细菌和其用途
公开(公告)号：WO00067696A3
公开(公告)日：2001-03-22
申请号：PCT/FR2000/001238
申请日：2000-05-05
IPC分类号： A23C9/123 , A23C9/13 , A23L1/03 , A23L1/28 , A23L1/30 , A61K35/74 , A61K35/744 , A61P25/22 , C12N1/20 , C12P1/04 , C12R1/46 , A61K35/20
CPC分类号： C12R1/46 , A23C9/1234 , A23C9/1238 , A23L29/065 , A61K35/744 , C12P1/04 , Y10S435/854 , Y10S435/885
摘要： The invention concerns lactic acid bacteria with anxiolytic properties and not inducing sedative effect. Said lactic acid bacteria are useful in particular for preparing foods or medicines.
摘要翻译：本发明涉及具有抗焦虑性质并且不诱导镇静作用的乳酸菌。所述乳酸菌特别用于制备食品或药物。

4. 发明申请

WO1990009186A1 A PHARMACEUTICAL PREPARATION IN THE TREATMENT OF TONSILLITIS 审中-公开
标题翻译：药物治疗药物的制备
公开(公告)号：WO1990009186A1
公开(公告)日：1990-08-23
申请号：PCT/SE1990000089
申请日：1990-02-12
申请人： GRAHN, Eva, Elisabeth , HOLM, Stig, Edvin, Folke
IPC分类号： A61K35/74
CPC分类号： A61K35/744 , Y10S435/885
摘要： A pharmaceutical preparation in the prophylaxis against and/or the treatment of beta -streptococcal tonsillitis is described. The preparation includes at least one viable microorganism strain selected from the group consisting of Streptococcus sanguis II strains with the deposit numbers NCIB 40104, NCIB 40105 and NCIB 40106, the Streptococcus mitis strain with the deposit number NCIB 40107 and streptococci strains with essentially the same capacity to inhibit beta -streptococci as the deposited strains, in a pharmaceutically acceptable medium wherein the microorganisms retain their viability. Use of the preparation in the prophylaxis against and/or the treatment of beta -streptococcal tonsillitis is also described.
摘要翻译：描述了预防和/或治疗β-链球菌性扁桃体炎的药物制剂。该制剂包括至少一种存活微生物菌株，其选自具有保藏号NCIB 40104，NCIB 40105和NCIB 40106的链球菌II株，具有保藏号NCIB 40107的链球菌菌株和具有基本相同容量的链球菌菌株抑制β-链球菌作为沉积的菌株，其中微生物保留其活力的药学上可接受的培养基中。还描述了用于预防和/或治疗β-链球菌性扁桃体炎的制剂的用途。

5. 发明申请

WO1984003302A1 HYALURONIC ACID FROM BACTERIAL CULTURE 审中-公开
标题翻译：来自细菌培养物的柠檬酸
公开(公告)号：WO1984003302A1
公开(公告)日：1984-08-30
申请号：PCT/US1983001428
申请日：1983-09-16
申请人： DIAGNOSTIC, INC.
发明人： DIAGNOSTIC, INC. , BRACKE, James, W. , THACKER, Kipling
IPC分类号： C12P19/04
CPC分类号： C12P19/26 , C12R1/46 , Y10S435/801 , Y10S435/885
摘要： Hyaluronic acid, a polysaccharide, is prepared in high yield from streptococcus bacteria by fermenting the bacteria under anaerobic conditions in a CO2-enriched growth medium, separating the bacteria from the resulting broth and isolating the hyaluronic acid from the remaining constituents of the broth. The bacteria may be grown free of endotoxins by filtering all ingredients through a 10K Millipore TM filter prior to inoculation of the medium and subsequently maintaining pyrogen-free conditions. Separation of the microorganisms from the polysaccharide is facilitated by killing the bacteria with trichloroacetic acid. After removal of the bacterial cells and concentration of the higher molecular weight fermentation products, the hyaluronic acid is isolated and purified by precipitation, resuspension and reprecipitation.

6. 发明申请

WO2008101428A1 嗜酸乳杆菌/粪肠球菌培养基、制剂及其工艺审中-公开
公开(公告)号：WO2008101428A1
公开(公告)日：2008-08-28
申请号：PCT/CN2008/070255
申请日：2008-02-03
申请人：信谊药厂 , 陈彬华 , 王雪松 , 张亮
发明人：陈彬华 , 王雪松 , 张亮
IPC分类号： A61K35/74 , C12N1/20 , C12P1/04 , A61P1/00 , A61P1/12 , C12R1/32 , C12R1/23 , C12R1/46
CPC分类号： C12N1/20 , A23L33/135 , A23V2002/00 , A23Y2220/03 , A23Y2240/33 , A23Y2300/55 , A61K35/744 , A61K35/745 , A61K35/747 , C12N1/04 , Y10S435/853 , Y10S435/854 , Y10S435/885 , A23V2200/3204 , A23V2200/32
摘要： A microbe composition comprising three viable and beneficial bacteria: Bifidobacterium longum, Lactobacillus acidophilus and Streptococcus faecalis. The invention further provides a method of preparing the composition with the addition of a protective medium comprising dried skimmed milk, lactulose, sodium vitamin C, sodium glutamate and starch. Furthermore, the invention provides protective medium, fermentation culture medium and seed culture medium used for the microbe composition.

7. 发明申请

WO2004059280A3 METHODS, COMPOSITIONS AND KITS FOR BIOMARKER EXTRACTION 审中-公开
标题翻译：方法，用于生物标记提取的组合物和试剂盒
公开(公告)号：WO2004059280A3
公开(公告)日：2006-07-20
申请号：PCT/US0339938
申请日：2003-12-17
申请人： MESO SCALE TECHNOLOGIES LLC , DEBAD JEFF D , LY CINDY
发明人： DEBAD JEFF D , LY CINDY
IPC分类号： G01N33/53 , C12Q1/68 , C12Q1/70 , G01N33/554 , G01N33/569
CPC分类号： C12Q1/689 , C12Q1/6806 , G01N33/5306 , G01N33/56911 , G01N33/56983 , G01N2333/11 , G01N2333/315 , Y10S435/885 , Y10S436/808 , C12Q2565/501
摘要： The present invention is directed to methods for extracting markers from biological samples, and to systems, devices, kits and reagents for use in such methods. The invention is also to methods, kits, reagents and compositions for measuring a plurality of different organism types in a sample. One of the specific advantages of the present invention is the ability to simultaneously extract more than one microorganism or viral particle marker in one volume from a single sample containing a complex biological matrix.
摘要翻译：本发明涉及用于从生物样品中提取标记物的方法以及用于这些方法的系统，装置，试剂盒和试剂。本发明还涉及用于测量样品中多种不同生物类型的方法，试剂盒，试剂和组合物。本发明的具体优点之一是能够从含有复杂生物基质的单个样品中同时提取一个体积的多于一个的微生物或病毒颗粒标记物。

8. 发明申请

WO2005030229A1 PROBIOTIC STORAGE AND DELIVERY 审中-公开
标题翻译： PROBIOTIC存储和交付
公开(公告)号：WO2005030229A1
公开(公告)日：2005-04-07
申请号：PCT/AU2004/001341
申请日：2004-09-30
申请人： COMMONWEALTH SCIENTIFIC & INDUSTRIAL RESEARCH ORGANISATION , CRITTENDEN, Ross , SANGUANSRI, Luz , AUGUSTIN, Mary, Ann
发明人： CRITTENDEN, Ross , SANGUANSRI, Luz , AUGUSTIN, Mary, Ann
IPC分类号： A61K35/74
CPC分类号： A61K47/26 , A61K9/19 , A61K35/741 , A61K35/744 , A61K35/745 , A61K35/747 , A61K36/064 , A61K47/42 , A61K47/44 , Y10S435/822 , Y10S435/853 , Y10S435/885 , Y10S435/886
摘要： Probiotic microorganisms are micro encapsulated by dispersing the probiotic microorganism in an aqueous suspension of a film forming protein and a carbohydrate;in an oil in water emulsion of a film forming protein and a carbohydrate and a fat; or in an oil which is subsequently dispersed in a film forming protein and a carbohydrate. The emulsion or suspension may be dried to form a powder. The probiotic may be dispersed in oil and then emulsified with the aqueous suspension and then dried to produce an encapsulated oil carrying probiotic. This may also be dried to produce a powder. Oil suspended probiotics may be preferred where the probiotic is water sensitive. The preferred protein is casein or whey protein and the carbohydrate may be a resistant starch or a saccharide with a reducing sugar group. Where the probiotic is oxygen sensitive the protein carbohydrate is heated to create Maillard reaction products in the encapsulating film.
摘要翻译：益生菌微生物通过将益生菌微生物分散在成膜蛋白质和碳水化合物的水悬浮液中而微胶囊化;在成膜蛋白质和碳水化合物和脂肪的水包油乳液中; 或随后分散在成膜蛋白质和碳水化合物中的油中。可以将乳液或悬浮液干燥以形成粉末。益生菌可以分散在油中，然后用水悬浮液乳化，然后干燥以产生携带益生菌的包封的油。这也可以被干燥以产生粉末。在益生菌对水敏感的地方，优选油悬浮的益生菌。优选的蛋白质是酪蛋白或乳清蛋白，碳水化合物可以是抗性淀粉或具有还原糖基团的糖。当益生菌对氧敏感时，蛋白质碳水化合物被加热以在封装膜中产生美拉德反应产物。

9. 发明申请

WO2004059280A2 METHODS, COMPOSITIONS AND KITS FOR BIOMARKER EXTRACTION 审中-公开
标题翻译：用于生物标记提取的方法，组合物和试剂盒
公开(公告)号：WO2004059280A2
公开(公告)日：2004-07-15
申请号：PCT/US2003/039938
申请日：2003-12-17
申请人： MESO SCALE TECHNOLOGIES, LLC , DEBAD, Jeff, D. , LY, Cindy
发明人： DEBAD, Jeff, D. , LY, Cindy
IPC分类号： G01N
CPC分类号： C12Q1/689 , C12Q1/6806 , G01N33/5306 , G01N33/56911 , G01N33/56983 , G01N2333/11 , G01N2333/315 , Y10S435/885 , Y10S436/808 , C12Q2565/501
摘要： The present invention is directed to methods for extracting markers from biological samples, and to systems, devices, kits and reagents for use in such methods. The invention is also to methods, kits, reagents and compositions for measuring a plurality of different organism types in a sample. One of the specific advantages of the present invention is the ability to simultaneously extract more than one microorganism or viral particle marker in one volume from a single sample containing a complex biological matrix.
摘要翻译：本发明涉及用于从生物样品中提取标记物的方法以及用于这些方法的系统，装置，试剂盒和试剂。本发明还涉及用于测量样品中多种不同生物类型的方法，试剂盒，试剂和组合物。本发明的具体优点之一是从含有复杂生物基质的单一样品中同时提取一种体积的多于一种的微生物或病毒颗粒标记物的能力。

10. 发明申请

WO98030235A1 LACTOFERRIN TABLETS 审中-公开
标题翻译： LACTOFERRIN片剂
公开(公告)号：WO98030235A1
公开(公告)日：1998-07-16
申请号：PCT/JP1998/000024
申请日：1998-01-08
IPC分类号： A61K9/20 , A61K38/40 , A61K35/74 , A61K47/26
CPC分类号： A61K9/2018 , A61K35/741 , A61K38/40 , Y10S435/822 , Y10S435/853 , Y10S435/885 , A61K2300/00
摘要： Lactoferrin tablets containing as the active ingredients lactoferrin and lactulose and having a horizontal hardness of at least 4 kg and a vertical hardness of at least 3 kg; and lactoferrin tablets containing as the active ingredients a microbial cell powder of at least one microorganism selected from among lactic acid bacteria, lactoferrin and lactulose and having a horizontal hardness of at least 4 kg and a vertical hardness of at least 3 kg. These tablets can be produced by using the conventional tableting apparatuses and yet have high hardnesses. Thus they do not adhere to the inner wall of the oral cavity and have a favorable taste. Since no excessive tableting pressure is needed in the production process, moreover, these tablets can contain much viable cells of lactic acid bacteria, though they are in the form of rigid tablets.
摘要翻译：含有作为活性成分的乳铁蛋白和乳果糖并具有至少4kg的水平硬度和至少3kg的垂直硬度的乳铁蛋白片剂; 和含有至少一种选自乳酸菌，乳铁蛋白和乳果糖中的微生物的微生物细胞粉末作为活性成分的乳铁蛋白片，其水平硬度至少为4kg，垂直硬度至少为3kg。这些片剂可以通过使用常规的压片装置制造，但是具有高硬度。因此，它们不粘附到口腔的内壁并具有良好的味道。此外，由于在生产过程中不需要过量的压片压力，所以这些片剂可以容纳许多活细胞的乳酸菌，尽管它们是刚性片剂的形式。

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