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1. 发明申请

WO2019104241A1 SYSTEM AND METHOD FOR GUIDING INVASIVE MEDICAL TREATMENT PROCEDURES BASED UPON ENHANCED CONTRAST-MODE ULTRASOUND IMAGING 审中-公开
公开(公告)号：WO2019104241A1
公开(公告)日：2019-05-31
申请号：PCT/US2018/062348
申请日：2018-11-21
申请人： THE CHARLES STARK DRAPER LABORATORY, INC. , THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY
发明人： BERLIN, Andrew, A. , YOUNG, Mon, Y.
IPC分类号： A61B8/08 , G01N33/53 , A61K49/22 , A61B8/06
CPC分类号： G01S7/52041 , A61B8/06 , A61B8/0841 , A61B8/085 , A61B8/4483 , A61B8/481 , G01S15/8979 , G06T5/001 , G06T5/50 , G06T2207/20208 , G06T2207/20221 , G06T2207/20224
摘要： This invention provides a system and method for guiding a surgical instrument based on information obtained using enhanced contrast-mode ultrasound. The enhanced information can be added to information or images obtained in one or more imaging modes. Various pieces of information can be combined and composited, including information regarding tumors, blood vessels, location information, confidence levels, and other information, and can be composited into operative imaging.

2. 发明申请

WO2008062342A3 CONTROL AND DISPLAY OF ULTRASONIC MICROBUBBLE CAVITATION 审中-公开
标题翻译：超声波微泡空泡的控制与显示
公开(公告)号：WO2008062342A3
公开(公告)日：2008-11-20
申请号：PCT/IB2007054613
申请日：2007-11-13
申请人： KONINKL PHILIPS ELECTRONICS NV , POWERS JEFFRY E
发明人： POWERS JEFFRY E
IPC分类号： A61B8/00 , A61N7/00 , G01S7/52
CPC分类号： G01S7/52041 , A61B8/0816 , A61B8/481 , A61B2017/00106 , A61N7/00 , A61N2007/0039 , A61N2007/0052 , A61N2007/0095 , G01S7/52019 , G01S7/52038 , G01S7/52046 , G01S7/5205 , G01S7/52071 , G01S7/52073
摘要： An ultrasonic diagnostic imaging system is used to insonify a subject infused with a microbubble contrast agent. At low energy levels stable cavitation occurs as the bubbles oscillate radially without breaking up. At higher energy levels the bubbles dissolve or break up, termed inertial cavitation. Echo signals from microbubbles are bandpass filtered to produce signal components in a subharmonic band, indicative of stable cavitation, and signal component in a higher harmonic band indicative of inertial cavitation. Detection of the mode of cavitation is used to automatically or manually control the mode of cavitation by controlling the transmitted acoustic energy of the system.
摘要翻译：使用超声波诊断成像系统来对注入微泡造影剂的受试者进行声刺激。在低能量水平下，随着气泡径向振荡而不分解，发生稳定的气蚀。在较高的能量水平下，气泡溶解或分解，称为惯性空化。来自微泡的回波信号被带通滤波以产生分谐波频带中的信号分量，表示稳定的空化，以及表示惯性空化的高谐波频带中的信号分量。气穴模式的检测用于通过控制系统的透射声能来自动或手动控制气穴的模式。

3. 发明申请

WO00036980A1 ULTRASONIC DIAGNOSTIC IMAGING SYSTEMS WITH POWER MODULATION FOR CONTRAST AND HARMONIC IMAGING 审中-公开
标题翻译：超声波诊断成像系统具有对比度和谐波成像的功率调制
公开(公告)号：WO00036980A1
公开(公告)日：2000-06-29
申请号：PCT/EP1999/009611
申请日：1999-12-07
IPC分类号： A61B8/00 , G01S7/52 , G10K11/34 , H04N7/18
CPC分类号： G01S7/52038 , A61B8/481 , G01S7/52039 , G01S7/52041 , G01S15/8927 , G10K11/341
摘要： A method and ultrasonic diagnostic imaging system for contrast agent imaging or tissue harmonic imaging is described which modulates the transmit power as a function of the angle of an electronically steered beam or the location of the beam in the scan plane to compensate for the reduction in delivered energy to points in the image field resulting from off-angle steering or a reduction in the number of elements of the transmit aperture.
摘要翻译：描述了用于造影剂成像或组织谐波成像的方法和超声诊断成像系统，其将发射功率作为电子转向束的角度或光束在扫描平面中的位置的函数进行调节，以补偿递送的减少由偏角转向导致的图像场中的能量的能量或发射孔径的元素数量的减少。

4. 发明申请

WO2015150810A1 ULTRASONIC CONTRAST AGENT DETECTION AND IMAGING 审中-公开
标题翻译：超声对比剂检测和成像
公开(公告)号：WO2015150810A1
公开(公告)日：2015-10-08
申请号：PCT/GB2015/051024
申请日：2015-04-01
申请人： SINTEF TTO AS , GARDINER, Stephen
发明人： HANSEN, Rune
IPC分类号： A61B8/08 , G01S7/52
CPC分类号： A61B8/481 , A61B8/5207 , A61B8/5276 , G01S7/52022 , G01S7/52039 , G01S7/52041
摘要： A method for detection and imaging of ultrasound contrast agents using multi-pulse transmit schemes, is described. The method is based on transmitting at least two pulses along each radial image line, where the purpose is to introduce a physical movement or a change in ultrasound scattering properties for the contrast agent. The image reconstruction is based on combining the received echoes resulting from at least two transmit pulses for suppression of tissue signal and detection and imaging of contrast agent signal.
摘要翻译：描述了使用多脉冲发射方案来检测和成像超声造影剂的方法。该方法基于沿着每个径向图像线传输至少两个脉冲，其目的是引入造影剂的超声散射特性的物理运动或变化。图像重建基于组合由至少两个发射脉冲产生的接收回波，用于抑制组织信号以及造影剂信号的检测和成像。

5. 发明申请

WO2012080614A1 PROCEDE ET DISPOSITIF D'IMAGERIE ULTRASONORE 审中-公开
标题翻译：用于超声成像的方法和装置
公开(公告)号：WO2012080614A1
公开(公告)日：2012-06-21
申请号：PCT/FR2011/052810
申请日：2011-11-29
申请人： CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE - CNRS - , INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE) , UNIVERSITÉ PARIS DIDEROT - PARIS 7 , COUTURE, Olivier , TANTER, Mickael , FINK, Mathias
发明人： COUTURE, Olivier , TANTER, Mickael , FINK, Mathias
IPC分类号： G01S7/52
CPC分类号： G01S7/52 , G01S7/52041 , G01S7/52046
摘要： Procédé d'imagerie ultrasonore à haute résolution, dans lequel on fait émettre par des transducteurs (T 1 -T n ) des ondes ultrasonores dans un champ d'observations contenant des microbulles, en faisant éclater les microbulles une par une au fil des émissions d'ondes ultrasonores. A chaque tir j d'onde ultrasonore, on enregistre des signaux réverbérés bruts S j (i,t) captés par chaque transducteur i, puis on détermine des signaux différentiels V j (i,t) représentatifs de variations entre signaux bruts successifs, on ajuste une fonction parabolique P j (x) sur les signaux différentiels correspondant à chaque tir j, puis on détermine un sommet A j (x 0 ,y 0 ) de cette fonction P j , correspondant à la position de la microbulle détruite entre les tirs j-1 et j.
摘要翻译：高分辨率超声波成像方法，其中通过使微泡与超声波的发射一个接一个地突破，使得换能器（T1-Tn）在包含微气泡的观察领域中发射超声波。在超声波的每个镜头j处，记录由每个换能器i拾取的原始混响信号Sj（i，t），然后确定表示连续原始信号之间的变化的差分信号Vj（i，t），抛物线函数 Pj（x）被拟合到对应于每个镜头j的差分信号，然后确定对应于在镜头j-1和j之间破坏的微小气泡的位置的该功能Pj的顶点Aj（x0，y0）。

6. 发明申请

WO2005071437A1 CONTRAST DUAL FREQUENCY IMAGING 审中-公开
标题翻译：对比双频成像
公开(公告)号：WO2005071437A1
公开(公告)日：2005-08-04
申请号：PCT/EP2005/000668
申请日：2005-01-20
申请人： STICHTING VOOR DE TECHNISCHE WETENSCHAPPEN , DE JONG, Nicolaas , BOUAKAZ, Ayache
发明人： DE JONG, Nicolaas , BOUAKAZ, Ayache
IPC分类号： G01S15/89
CPC分类号： G01S7/52022 , G01S7/52041 , G01S15/8952 , G01S15/8961 , G01S15/8963 , G01S15/899
摘要： A method and apparatus for ultrasound imaging which uses dual frequency excitation of a target. The target is simultaneously irradiated with a relatively low frequency ultrasound conditioning signal and a relatively high frequency ultrasound detection signal. The conditioning signal modulates a physical property (e.g. size) of first structures (e.g. gas bubbles) within the target, which modulation causes changes in the echo signal response of the first structures to the detection signal. A signal processor is adapted to process the received echo signals to detect the presence of the first structures by virtue of a first magnitude of detection signal echo arising from periods when the conditioning signal is in a first phase and a second, different, magnitude of detection signal echo arising from periods when the conditioning signal is in a second phase.
摘要翻译：一种用于超声成像的方法和装置，其使用目标的双频激励。用相对较低频率的超声波调理信号和较高频率的超声波检测信号同时照射靶。调节信号调制目标内的第一结构（例如气泡）的物理性质（例如大小），该调制使得第一结构的回波信号响应变化到检测信号。信号处理器适于处理所接收的回波信号，借助于第一幅度的检测信号回波来检测第一结构的存在，所述检测信号回波是在调节信号处于第一阶段和第二，不同大小的检测当调节信号处于第二阶段时产生的信号回波。

7. 发明申请

WO2005059586A1 ULTRASONIC DIAGNOSTIC IMAGING SYSTEM WITH AUTOMATIC CONTROL OF PENETRATION, RESOLUTION AND FRAME RATE 审中-公开
标题翻译：超声波诊断成像系统具有自动控制，分辨率和帧率
公开(公告)号：WO2005059586A1
公开(公告)日：2005-06-30
申请号：PCT/IB2004/052697
申请日：2004-12-07
申请人： KONINKLIJKE PHILIPS ELECTRONICS, N.V. , JONG, Jing-Ming
发明人： JONG, Jing-Ming
IPC分类号： G01S7/52
CPC分类号： A61B8/585 , A61B5/11 , A61B8/00 , A61B8/465 , A61B8/5276 , G01S7/52038 , G01S7/52039 , G01S7/52041 , G01S7/52046 , G01S7/52073
摘要： An ultrasonic diagnostic imaging system and method are presented in which the balance between image resolution and frame rate (Res/Speed) and the balance between image resolution and penetration (Pen/Gen/Res) are automatically adjusted in response to image content. A motion detector analyzes the relative motion between successive images. If the motion content is relatively high, the imaging parameters are changed in favor of relatively greater frame rate and reduced resolution. A low motion content causes the opposite adjustment. The electronic noise between successive images is also computed with a relatively high noise content (low correlation) in the far field resulting in an adjustment to penetration as by lowering the transmit frequency. A relatively low noise content causes an adjustment in favor of increased resolution.
摘要翻译：提出了超声波诊断成像系统和方法，其中图像分辨率和帧速率（Res / Speed）之间的平衡以及图像分辨率和穿透之间的平衡（Pen / Gen / Res）根据图像内容自动调整。运动检测器分析连续图像之间的相对运动。如果运动内容相对较高，则成像参数改变，有利于相对较大的帧速率和降低的分辨率。低运动内容导致相反的调整。连续图像之间的电子噪声也在远场中以相对高的噪声含量（低相关）计算，导致通过降低发射频率来调整穿透。相对低的噪声含量导致调整以有利于增加的分辨率。

8. 发明申请

WO2008017997A3 ULTRASOUND SYSTEM FOR CEREBRAL BLOOD FLOW IMAGING AND MICROBUBBLE-ENHANCED BLOOD CLOT LYSIS 审中-公开
标题翻译：超声系统用于脑血流成像和微泡增强血栓溶解
公开(公告)号：WO2008017997A3
公开(公告)日：2008-05-08
申请号：PCT/IB2007053073
申请日：2007-08-03
申请人： KONINKL PHILIPS ELECTRONICS NV , BROWNING EDWARD J , SHI WILLIAM , POWERS JEFFRY E , AVERKIOU MICHALAKIS , GAUTHIER THOMAS
发明人： BROWNING EDWARD J , SHI WILLIAM , POWERS JEFFRY E , AVERKIOU MICHALAKIS , GAUTHIER THOMAS
IPC分类号： A61N7/00 , A61B5/026 , A61B8/00 , A61B8/06 , A61B8/08 , A61B17/22 , A61B19/00
CPC分类号： A61B8/0816 , A61B5/02007 , A61B5/6814 , A61B8/06 , A61B8/08 , A61B8/0808 , A61B8/085 , A61B8/13 , A61B8/4227 , A61B8/4281 , A61B8/481 , A61B8/483 , A61B8/488 , A61B17/22004 , A61B2017/22014 , A61B2090/502 , A61N7/00 , A61N2007/0021 , A61N2007/0039 , A61N2007/0078 , A61N2007/0082 , A61N2007/0095 , G01S7/52041 , G01S15/8981
摘要： An ultrasonic diagnostic imaging system is described which utilizes one or more transducer arrays (10a, 10b) affixed to the head of a patient to diagnose and treat stroke victims. The transducer headset (200) produces a two or three dimensional image of the vasculature (300) inside the cranium, preferably assisted by a microbubble contrast agent. A vascular flow map is produced by the system which may be diagnosed for signs of a blood clot. If a blood clot is detected, a therapeutic beam is transmitted while the contrast agent is present to break up the blood clot by the disruption of microbubbles. The headset may also be used in a monitoring application to detect the recurrence of blood clots in a stroke victim.
摘要翻译：描述了一种超声诊断成像系统，其利用固定到患者头部的一个或多个换能器阵列（10a，10b）来诊断和治疗中风患者。换能器耳机（200）在颅骨内产生脉管系统（300）的二维或三维图像，优选地由微泡造影剂辅助。血管流图由系统产生，可被诊断为血凝块的迹象。如果检测到血块，则在造影剂存在时传输治疗束以通过破坏微泡破坏血块。头戴式耳机还可以用于监测应用中，以检测中风受害者中血块的复发。

9. 发明申请

WO2006131867A1 METHOD AND APPARATUS FOR DETECTING ULTRASOUND CONTRAST AGENTS IN ARTERIOLES 审中-公开
标题翻译：用于检测超声波对比剂在异构体中的方法和装置
公开(公告)号：WO2006131867A1
公开(公告)日：2006-12-14
申请号：PCT/IB2006/051774
申请日：2006-06-02
申请人： KONINKLIJKE PHILIPS ELECTRONICS, N.V. , RAFTER, Patrick, G. , BROCK-FISHER, George, A.
发明人： RAFTER, Patrick, G. , BROCK-FISHER, George, A.
IPC分类号： A61B8/00
CPC分类号： G01S7/52041 , A61B8/0883 , A61B8/0891 , A61B8/481 , A61B8/543 , G01S7/52087 , G01S15/8959
摘要： A method and apparatus for ultrasound imaging of microbubbles of a contrast agent in arterioles while all microbubbles of the contrast agent have been eliminated in the capillaries of a patient and tissue signal response to ultrasound imaging is suppressed. This method and apparatus permits ultrasound imaging for detecting coronary artery disease without the need for a stress test.
摘要翻译：用于造影剂在小动脉中的微泡的超声成像的方法和装置，同时在患者的毛细血管中消除了造影剂的所有微泡，并抑制了对超声成像的组织信号响应。该方法和装置允许用于检测冠状动脉疾病的超声成像，而不需要进行压力测试。

10. 发明申请

WO01066015A1 METHOD OF ULTRASONIC IMAGING AND ULTRASONIC DIAGNOSTIC APPARATUS 审中-公开
标题翻译：超声成像方法和超声诊断装置
公开(公告)号：WO01066015A1
公开(公告)日：2001-09-13
申请号：PCT/US2001/005792
申请日：2001-02-23
IPC分类号： A61B8/00 , A61B8/06 , A61B8/14 , G01S7/52 , G01S15/89
CPC分类号： A61B8/481 , A61B8/06 , G01S7/52038 , G01S7/52041 , G01S7/52066 , G01S7/52073 , G01S15/8979
摘要： An ultrasonic diagnostic apparatus transmits ultrasonic waves at such a strength as to disperse the contrast agent for part of a number of sonic beams which form one frame and at such a strength as not to disperse the contrast agent for other sonic beams thereby to produce an image for a marking frame from received echo signals of ultrasonic transmission, and subsequently transmits ultrasonic waves successively at such a strength as not to disperse the contrast agent for all sonic beams thereby to produce images continuously for no-marking frames, and, after such a time length that the flow range is present within the view field, produces an image for another marking frame. These operations are repeated to display ultrasonic images by which it is possible to visually recognize at a glance the time-wise change of a blood flow.
摘要翻译：超声波诊断装置以这样的强度发射超声波，以分散形成一帧的多个声束的一部分的造影剂，并以不分散其他声波束的造影剂的强度，从而产生图像对于来自超声波传输的接收回波信号的标记帧，并且随后以不分散所有声波束的造影剂的强度连续发送超声波，从而连续地产生用于无标记帧的图像，并且在这样的时间流量范围存在于视野范围内的长度产生另一个标记框架的图像。重复这些操作以显示超声图像，通过该超声图像可以一目了然地识别血流的时间变化。

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