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    • 2. 发明申请
    • SYSTEM AND METHOD FOR DETECTION OF COLLAGEN USING MAGNETIC RESONANCE IMAGING
    • 使用磁共振成像检测胶原的系统和方法
    • WO2016119054A1
    • 2016-08-04
    • PCT/CA2016/050065
    • 2016-01-27
    • SUNNYBROOK RESEARCH INSTITUTE
    • SIU, Adrienne GraceWRIGHT, Graham A.
    • G01R33/48A61B5/055G01R33/483G01R33/485
    • A61B5/055A61B5/14546A61B5/7278G01R33/4816G01R33/50
    • Systems and methods are provided for detecting collagen within tissue using magnetic resonance imaging. In some embodiments, pulse sequences are employed to measure signals at multiple TE values including ultra-short echo times, and the TE dependence of the measured signal is fitted to a mathematical function including at least two decay terms, where the first (initial) decay term is modulated and is associated with the presence of collagen. In another example embodiment, spectroscopy or spectroscopic imaging is employed to measure the free induction decay within at least one region of interest, and the time-dependence of the measured signal is fitted to a mathematical function including at least two decay terms, where the first decay term is modulated and is associated with the presence of collagen. In some embodiments, the methods described herein may be employed for the detection and/or assessment of myocardial fibrosis.
    • 提供了使用磁共振成像检测组织内的胶原的系统和方法。 在一些实施例中,使用脉冲序列来测量包括超短回波时间的多个TE值的信号,并且测量信号的TE依赖性拟合到包括至少两个衰减项的数学函数,其中第一(初始)衰减 术语被调节并且与胶原蛋白的存在相关联。 在另一示例性实施例中,使用光谱或光谱成像来测量至少一个感兴趣区域内的自由感应衰减,并且所测量的信号的时间依赖性被拟合到包括至少两个衰减项的数学函数,其中第一 衰变期被调节并与胶原蛋白的存在有关。 在一些实施方案中,本文所述的方法可用于检测和/或评估心肌纤维化。
    • 10. 发明申请
    • IMPROVEMENTS IN OR RELATING TO NUCLEAR MAGNETIC RESONANCE (NMR) IMAGING
    • 核磁共振(NMR)成像中的改进或相关
    • WO1995004288A1
    • 1995-02-09
    • PCT/GB1994001640
    • 1994-07-29
    • BRITISH TECHNOLOGY GROUP LIMITEDMcDONALD, Peter, JohnBENSON, Timothy, Birkett
    • BRITISH TECHNOLOGY GROUP LIMITED
    • G01R33/48
    • G01R33/4816
    • The invention describes an improved NMR imaging technique having particular application in imaging of solid objects using gradient echo techniques. By applying a so called 90 DEG rf pulse substantially at zero gradient crossing it is possible to obtain frequency encoded information about an object being imaged, using a so called gradient echo technique. However, profile degradation occurs as a result of the very large magnetic fields which are used which spoil the rf pulse. By shortening the length of pulses below 90 DEG it has been possible to improve gradient echo imaging. However, this has resulted in the reduction in the signal-to-noise ratio of the echo following each pulse. The present invention overcomes this problem by providing a rapidly oscillating magnetic field gradient and applying a radio frequency pulse away from a zero gradient crossing and by substantially phase rotating the resultant profile. The result is the surprising effect that information is preserved, the pulse bandwidth remains constant and the signal-to-noise ratio is superior to that in existing systems.
    • 本发明描述了一种改进的NMR成像技术,其具有使用梯度回波技术在固体物体成像中的特殊应用。 通过在零梯度交叉处施加所谓的90°rf脉冲,可以使用所谓的梯度回波技术来获得关于被成像对象的频率编码信息。 然而,由于使用破坏rf脉冲的非常大的磁场,导致轮廓退化。 通过缩短90度以下的脉冲长度,可以提高梯度回波成像。 然而,这导致每个脉冲之后的回波的信噪比的降低。 本发明通过提供快速振荡的磁场梯度并将射频脉冲施加在零梯度交叉之外,并通过基本上相位旋转所得到的轮廓来克服这个问题。 结果是令人惊奇的效果是信息被保留,脉冲带宽保持不变,信噪比优于现有系统。