专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

WO2016119054A1 SYSTEM AND METHOD FOR DETECTION OF COLLAGEN USING MAGNETIC RESONANCE IMAGING 审中-公开
标题翻译：使用磁共振成像检测胶原的系统和方法
公开(公告)号：WO2016119054A1
公开(公告)日：2016-08-04
申请号：PCT/CA2016/050065
申请日：2016-01-27
申请人： SUNNYBROOK RESEARCH INSTITUTE
发明人： SIU, Adrienne Grace , WRIGHT, Graham A.
IPC分类号： G01R33/48 , A61B5/055 , G01R33/483 , G01R33/485
CPC分类号： A61B5/055 , A61B5/14546 , A61B5/7278 , G01R33/4816 , G01R33/50
摘要： Systems and methods are provided for detecting collagen within tissue using magnetic resonance imaging. In some embodiments, pulse sequences are employed to measure signals at multiple TE values including ultra-short echo times, and the TE dependence of the measured signal is fitted to a mathematical function including at least two decay terms, where the first (initial) decay term is modulated and is associated with the presence of collagen. In another example embodiment, spectroscopy or spectroscopic imaging is employed to measure the free induction decay within at least one region of interest, and the time-dependence of the measured signal is fitted to a mathematical function including at least two decay terms, where the first decay term is modulated and is associated with the presence of collagen. In some embodiments, the methods described herein may be employed for the detection and/or assessment of myocardial fibrosis.
摘要翻译：提供了使用磁共振成像检测组织内的胶原的系统和方法。在一些实施例中，使用脉冲序列来测量包括超短回波时间的多个TE值的信号，并且测量信号的TE依赖性拟合到包括至少两个衰减项的数学函数，其中第一（初始）衰减术语被调节并且与胶原蛋白的存在相关联。在另一示例性实施例中，使用光谱或光谱成像来测量至少一个感兴趣区域内的自由感应衰减，并且所测量的信号的时间依赖性被拟合到包括至少两个衰减项的数学函数，其中第一衰变期被调节并与胶原蛋白的存在有关。在一些实施方案中，本文所述的方法可用于检测和/或评估心肌纤维化。

IPRDB

热门服务

关于我们

友情链接

联系方式