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1. 发明申请

WO2016182446A1 DETECTING MAGNETIC OBJECTS IN MAGNETIC RESONANCE IMAGES USING PHASE SADDLES 审中-公开
标题翻译：使用相位角检测磁共振图像中的磁性物体
公开(公告)号：WO2016182446A1
公开(公告)日：2016-11-17
申请号：PCT/NL2016/050345
申请日：2016-05-13
申请人： UMC UTRECHT HOLDING B.V.
发明人： BOUWMAN, Johannes Gijsbertus , SEEVINCK, Peter Roland
IPC分类号： G01R33/28 , G01R33/56
CPC分类号： G01R33/286 , G01R33/5608
摘要： A method of object detection in MRI comprises determining a filter representing an effect of an object in a frequency domain with respect to phase of a plurality of sampled data points of an MRI dataset (401) based on at least one phase saddle in a combined phase gradient field that is a combination of a phase gradient field caused by the object based on a shape and material of the object and a phase gradient field caused by an image sequence used to generate the MRI dataset. The filter is applied to a phase component of the sampled data points in the frequency domain. The effect of the object can comprise a change of the phase caused by the object.
摘要翻译： MRI中的物体检测方法包括基于组合阶段中的至少一个相位坐标来确定表示相对于MRI数据集（401）的多个采样数据点的相位的频域中的对象的影响的滤波器梯度场，其是由基于物体的形状和材料的对象引起的相位梯度场的组合以及由用于生成MRI数据集的图像序列引起的相位梯度场。滤波器被应用于频域中的采样数据点的相位分量。对象的效果可以包括由对象引起的相位的改变。

2. 发明申请

WO2014142772A9 ENHANCEMENT OF MAGNETIC RESONANCE IMAGE RESOLUTION BY USING BIO-COMPATIBLE, PASSIVE RESONATOR HARDWARE 审中-公开
标题翻译：通过使用生物兼容的被动谐振器硬件来增强磁共振图像分辨率
公开(公告)号：WO2014142772A9
公开(公告)日：2015-02-12
申请号：PCT/TR2014000083
申请日：2014-03-14
申请人： DEMIR HILMI VOLKAN
发明人： DEMIR HILMI VOLKAN , UNAL EMRE , GOKYAR SAYIM
IPC分类号： G01R33/28 , G01R33/34 , G01R33/36
CPC分类号： G01R33/34053 , G01R33/286 , G01R33/287 , G01R33/34007 , G01R33/34084 , G01R33/3628
摘要： Embodiments of the present invention address the problems with previously known MRI enhancement resonators. The embodiments provide capacitances that are sufficiently large to result in resonance frequencies that are sufficiently low for medical MRI applications in devices that are sufficiently small for implantation into the body. Further, the capacitance and resonance frequency of the MRI enhancement resonator may be easily adjusted to particular desired values by selecting corresponding thin-film dielectrics, or thicknesses of such thin-film dielectrics. Moreover, the design and geometry of the embodiments provide MRI enhancement resonators with high Q-factors. The construction and material of such MRI enhancement resonators also yield flexible and biocompatible devices that are appropriate for applications involving implantation into the body.
摘要翻译：本发明的实施例解决了先前已知的MRI增强谐振器的问题。这些实施例提供足够大的电容，以产生对于植入体内足够小的装置中的医疗MRI应用来说足够低的共振频率。此外，通过选择相应的薄膜电介质或这种薄膜电介质的厚度，可以容易地将MRI增强谐振器的电容和谐振频率调整到特定的期望值。此外，实施例的设计和几何形状提供具有高Q因子的MRI增强谐振器。这种MRI增强谐振器的结构和材料也产生适于涉及植入人体内的应用的柔性和生物相容性装置。

3. 发明申请

WO2012143021A1 SPATIALLY ENCODED PHASE-CONTRAST MRI 审中-公开
标题翻译：空间编码相位对比MRI
公开(公告)号：WO2012143021A1
公开(公告)日：2012-10-26
申请号：PCT/EP2011/002054
申请日：2011-04-21
申请人： MAX-PLANCK-GESELLSCHAFT ZUR FÖRDERUNG DER WISSENSCHAFTEN E. V. , MERBOLDT, Klaus-Dietmar , FRAHM, Jens , UECKER, Martin , VOIT, Dirk
发明人： MERBOLDT, Klaus-Dietmar , FRAHM, Jens , UECKER, Martin , VOIT, Dirk
IPC分类号： G01R33/48
CPC分类号： G01R33/48 , G01R33/286 , G01R33/4826 , G01R33/5613 , G01R33/56316 , G01R33/56325
摘要： A method of collecting magnetic resonance data for imaging an object with a predetermined spin density being arranged in a static magnetic field, comprises the steps subjecting said object to at least one radiofrequency pulse and magnetic field gradients for creating spatially encoded magnetic resonance signals, including at least two settings of spatially encoding phase-contrast gradients differently encoding the phase of said magnetic resonance signals in at least one field of view in a predetermined spatial dimension, acquiring at least two magnetic resonance signals, each with one of said at least two settings of different spatially encoding phase-contrast gradients, and determining at least one mean spin density position of said object along said spatial dimension by calculating the phase difference between said signals. Furthermore, a control device and a magnetic resonance imaging (MRI) device implementing the method are described.
摘要翻译：收集用于对静电磁场中预定的自旋密度进行成像的磁共振数据的方法包括以下步骤：对所述物体进行至少一个射频脉冲和磁场梯度，以产生空间编码的磁共振信号，包括在空间编码相位对比度梯度的至少两个设置在预定的空间维度中以至少一个视野不同地编码所述磁共振信号的相位，获取至少两个磁共振信号，每个磁共振信号具有所述至少两个设置中的一个不同的空间编码相位对比度梯度，以及通过计算所述信号之间的相位差来确定所述物体沿着所述空间维度的至少一个平均自旋密度位置。此外，描述了实现该方法的控制装置和磁共振成像（MRI）装置。

4. 发明申请

WO2011089551A3 SUSCEPTIBILITY GRADIENT MAPPING 审中-公开
标题翻译：可疑梯度映射
公开(公告)号：WO2011089551A3
公开(公告)日：2011-11-10
申请号：PCT/IB2011050230
申请日：2011-01-19
申请人： KONINKL PHILIPS ELECTRONICS NV , PHILIPS INTELLECTUAL PROPERTY , SENEGAS JULIEN , PERKINS THOMAS
发明人： SENEGAS JULIEN , PERKINS THOMAS
IPC分类号： G01R33/565
CPC分类号： G01R33/56536 , G01R33/286 , G01R33/5601 , G01R33/5615
摘要： The invention relates to a method of determining a susceptibility gradient map, the method comprising acquiring (300) a magnetic resonance k- space dataset, said dataset comprising magnetic resonance echo data, wherein a recursive iteration is used to determine the susceptibility gradient map. Further, the invention relates to a method of determining a susceptibility gradient map, the method comprising acquiring a magnetic resonance k-space dataset, said dataset comprising magnetic resonance echo data, wherein the acquired dataset comprises magnetic resonance echo data of multiple echoes with different echo times, wherein a susceptibility gradient map is determined separately for each echo time resulting in a temporary susceptibility gradient map, wherein the method further comprises calculating a total susceptibility gradient map by combining all determined temporary susceptibility gradient maps.
摘要翻译：本发明涉及一种确定磁敏度梯度图的方法，所述方法包括获取（300）磁共振k空间数据集，所述数据集包括磁共振回波数据，其中使用递归迭代来确定磁敏度梯度图。此外，本发明涉及一种确定磁敏度梯度图的方法，所述方法包括获取磁共振k空间数据集，所述数据集包括磁共振回波数据，其中所获取的数据集包括具有不同回波的多个回波的磁共振回波数据时间，其中针对导致临时磁敏度梯度图的每个回波时间分别确定敏感度梯度图，其中所述方法还包括通过组合所有确定的临时磁敏度梯度图来计算总磁敏度梯度图。

5. 发明申请

WO2010148088A3 MRI-GUIDED DEVICES AND MRI-GUIDED INTERVENTIONAL SYSTEMS THAT CAN TRACK AND GENERATE DYNAMIC VISUALIZATIONS OF THE DEVICES IN NEAR REAL TIME 审中-公开
标题翻译： MRI引导设备和MRI导引的传统系统可以在实时跟踪和生成设备的动态可视化
公开(公告)号：WO2010148088A3
公开(公告)日：2011-03-31
申请号：PCT/US2010038824
申请日：2010-06-16
申请人： SURGIVISION INC , JENKINS KIMBLE L , PIFERI PETER , VIJ KAMAL , GHIDOLI DANIELE , FLORES JESSE
发明人： JENKINS KIMBLE L , PIFERI PETER , VIJ KAMAL , GHIDOLI DANIELE , FLORES JESSE
IPC分类号： A61B5/055 , G06T15/10
CPC分类号： A61B5/062 , A61B5/0044 , A61B5/042 , A61B5/0422 , A61B5/053 , A61B5/055 , A61B5/065 , A61B5/415 , A61B5/418 , A61B18/02 , A61B18/18 , A61B34/10 , A61B34/20 , A61B2090/365 , A61B2090/374 , A61B2090/3954 , A61M5/00 , A61M25/01 , A61M25/0127 , A61M29/00 , A61M2025/0089 , A61M2025/0166 , A61M2025/0681 , A61M2025/09175 , G01R33/286 , G01R33/287
摘要： An MRI-compatible catheter includes an elongated flexible shaft having opposite distal and proximal end portions. A handle is attached to the proximal end portion and includes an actuator in communication with the shaft distal end portion that is configured to articulate the shaft distal end portion. The distal end portion of the shaft may include an ablation tip and includes at least one RF tracking coil positioned adjacent the ablation tip that is electrically connected to an MRI scanner. The at least one RF tracking coil is electrically connected to a circuit that reduces coupling when the at least one RF tracking coil is exposed to an MRI environment. Each RF tracking coil is a 1-10 turn solenoid coil, and has a length along the longitudinal direction of the catheter of between about 0.25 mm and about 4 mm.
摘要翻译： MRI兼容导管包括具有相对的远端和近端部分的细长柔性轴。手柄附接到基端部，并且包括与轴远端部连通的致动器，该致动器构造成铰接轴远端部。轴的远端部分可以包括消融尖端，并且包括邻近消融尖端定位的至少一个RF跟踪线圈，其被电连接到MRI扫描器。当至少一个RF跟踪线圈暴露于MRI环境时，至少一个RF跟踪线圈电连接到减少耦合的电路。每个RF跟踪线圈是1-10圈电磁线圈，并且沿着导管的纵向方向具有在约0.25mm和约4mm之间的长度。

6. 发明申请

WO2010053609A9 SYSTEM AND METHOD USING COUPLER-RESONATORS FOR ELECTRON PARAMAGNETIC RESONANCE SPECTROSCOPY 审中-公开
标题翻译：用耦合共振器进行电子顺磁共振谱的系统和方法
公开(公告)号：WO2010053609A9
公开(公告)日：2010-08-26
申请号：PCT/US2009052261
申请日：2009-07-30
申请人： DARTMOUTH COLLEGE , SWARTZ HAROLD M , LESNIEWSKI PIOTR , LI HONG BIN
发明人： SWARTZ HAROLD M , LESNIEWSKI PIOTR , LI HONG BIN
IPC分类号： A61B5/05 , A61B5/055 , G05F1/00
CPC分类号： G01R33/341 , G01R33/286 , G01R33/287 , G01R33/34084 , G01R33/3415 , G01R33/58 , G01R33/60
摘要： A coupler-resonator for electron paramagnetic resonance (EPR) spectroscopy in subjects has a wire loop formed into a coupling loop, a central transmission portion, and sensor loops. The sensor loops hold EPR sensor materials and are coated with biocompatible plastic. The coupler-resonator is implanted in a subject, the subject in a nonuniform magnetic field with a pickup coil for RF response measurement apparatus near the subject's skin and inductively coupled to the coupling loop. Resonances are measured at multiple sensor loops distinguished by sweeping magnetic field or radio frequency. A biopsy sampler has an outer needle with sensor loop and a central sampling needle with cavity for biopsy samples and EPR sensor material. A device for EPR of fingernails has sensor loops in a partial glove for holding loops next to fingertips. A device for EPR of teeth has sensor loops in plastic chips that can be held between the teeth.
摘要翻译：用于受试者中电子顺磁共振（EPR）光谱学的耦合器 - 谐振器具有形成耦合环路，中心传输部分和传感器环路的导线环路。传感器环路保持EPR传感器材料并涂有生物相容性塑料。耦合谐振器植入受试者体内，受试者处于非均匀磁场中，在受试者皮肤附近具有用于RF响应测量装置的拾取线圈并且与耦合回路感应耦合。谐振是在多个传感器回路测量的，通过扫描磁场或射频来区分。活检采样器具有带传感器环的外针和带有用于活检样本和EPR传感器材料的腔的中央采样针。用于手指甲的EPR的装置在部分手套中具有传感器环，用于将指尖附近的环扣住。用于牙齿EPR的装置具有塑料片中的传感器环，其可以保持在牙齿之间。

7. 发明申请

WO2008106201A1 VOLTAGE STANDING WAVE SUPPRESSION FOR MR-GUIDED THERAPEUTIC INTERVENTIONS 审中-公开
标题翻译：用于MR导向治疗干预的电压波形抑制
公开(公告)号：WO2008106201A1
公开(公告)日：2008-09-04
申请号：PCT/US2008/002655
申请日：2008-02-28
申请人： WISCONSIN ALUMNI RESEARCH FOUNDATION , KURPAD, Krishna, N. , UNAL, Orhan
发明人： KURPAD, Krishna, N. , UNAL, Orhan
IPC分类号： A61B5/055 , A61B5/06 , A61B19/00 , G01R33/28 , G01R33/36
CPC分类号： G01R33/34053 , A61B5/06 , A61B34/20 , A61B90/36 , A61B2034/2051 , A61B2090/374 , A61B2090/3954 , G01R33/286 , G01R33/287 , G01R33/34084 , G01R33/3657 , G01R33/3685
摘要： A system and method of tracking a medical device and generating an image of a target area. The medical device includes a tracking device to create an imaging field-of-view that extends beyond the tip of the medical device while allowing the tip of the medical device to be visualized. The medical device further includes an imaging/visualization device to create an imaging field from the point of view of the medical device. A voltage standing wave suppression device is formed on the exterior surface of the medical device to prevent the formation of voltage standing waves and localized tissue heating. The voltage standing wave suppression device includes two cable traps spaced apart from one another with each cable trap being formed of a closely packed coiled region of a conductor extending the length of the medical device.
摘要翻译：一种跟踪医疗装置并产生目标区域的图像的系统和方法。该医疗装置包括跟踪装置，用于产生延伸超过医疗装置的尖端的成像视场，同时允许医疗装置的尖端可视化。医疗装置还包括成像/可视化装置，用于从医疗装置的角度创建成像场。在医疗装置的外表面上形成电压驻波抑制装置，以防止电压驻波和局部组织加热的形成。电压驻波抑制装置包括彼此间隔开的两个电缆陷阱，每个电缆陷阱由延伸医疗装置的长度的导体的密集卷绕区域形成。

8. 发明申请

WO2008094855A1 INTERVENTIONAL MULTI-MODE MEDICAL SYSTEM WITH THERMAL ABLATION CAPABILITY 审中-公开
标题翻译：具有热吸收能力的传统多模式医疗系统
公开(公告)号：WO2008094855A1
公开(公告)日：2008-08-07
申请号：PCT/US2008/052178
申请日：2008-01-28
申请人： WISCONSIN ALUMNI RESEARCH FOUNDATION , UNAL, Orhan , KURPAD, Krishna, N. , BRACE, Christopher, L.
发明人： UNAL, Orhan , KURPAD, Krishna, N. , BRACE, Christopher, L.
IPC分类号： G01R33/28 , A61B5/055 , A61B18/14
CPC分类号： G01R33/286 , A61B5/055 , A61B5/064 , A61B18/1492 , A61B34/20 , A61B34/25 , A61B2034/2051 , A61B2090/374 , G01R33/287 , G01R33/34084
摘要： A multi-mode medical device system (500) and method of using same to perform an interventional procedure. The multi-mode medical device system includes a medical device (502) and an electrical circuit (504) coupled to the medical device (502). The electrical circuit includes an integrated- tracking device (506) (e.g., a solenoid) and an imaging/visualizing device (508) (e.g., a resonant loop). The multi-mode medical device system also includes a thermal ablation device (510) coupled to the medical device (502) and to the tracking device (506).
摘要翻译：一种多模式医疗装置系统（500）及其使用方法，进行介入手术。多模式医疗设备系统包括耦合到医疗设备（502）的医疗设备（502）和电路（504）。电路包括集成跟踪装置（506）（例如，螺线管）和成像/可视化装置（508）（例如，谐振回路）。多模式医疗装置系统还包括耦合到医疗装置（502）和跟踪装置（506）的热消融装置（510）。

9. 发明申请

WO2008035759A1 磁気共鳴画像視認性と表面潤滑性とを有する重合体および医療用器具审中-公开
标题翻译：具有磁共振图像和表面润滑性和医疗设备可见性的聚合物
公开(公告)号：WO2008035759A1
公开(公告)日：2008-03-27
申请号：PCT/JP2007/068367
申请日：2007-09-21
申请人：テルモ株式会社 , 栗田朋香
发明人：栗田朋香
IPC分类号： C08F8/00 , A61B5/055 , A61F2/06 , A61L29/00 , A61L31/00 , A61M1/14 , A61M25/00 , C08F265/04
CPC分类号： A61L31/18 , A61B5/055 , A61B5/06 , A61L29/18 , A61L2400/10 , A61M1/10 , A61M1/1008 , A61M1/14 , A61M25/0127 , C08F265/00 , C08F265/04 , C08F293/00 , C08F293/005 , C08L51/003 , C08L53/00 , C09D151/003 , C09D153/00 , G01R33/286 , C08L2666/02 , C08L2666/04
摘要：　磁気共鳴画像診断および治療に用いる医療用器具を湿潤時に磁気共鳴画像下で容易に視認でき、かつ表面潤滑性を同時に発現する重合体と、それを被覆してなる医療用器具を提供する。　磁気共鳴にて検出可能な核種の緩和時間を短縮する物質、および反応性基を有する部位と潤滑性を発現する部位とからなる共重合体を含む重合体を医療用器具に被覆することにより、優れた耐剥離製、高い潤滑性と磁気共鳴下での視認性、容易な塗布操作および高い安全性が得られる。
摘要翻译：旨在提供一种聚合物，其使得在磁共振成像下使用在湿润状态下高度可见的磁共振成像进行诊断和治疗的医疗装置，同时显示表面润滑性，涂覆有医疗器械的医疗器械。通过用包含能够缩短通过磁共振检测到的核物质的松弛时间的物质和包含具有反应性基团的部分和表现出表面润滑性的另一部分的共聚物的聚合物涂覆医疗装置，可以获得高的耐剥离性，高润滑性，在磁共振下的高可见度，易于涂布处理性和高安全性。

10. 发明申请

WO2007064739A3 MRI-GUIDED LOCALIZATION AND/OR LEAD PLACEMENT SYSTEMS, RELATED METHODS, DEVICES AND COMPUTER PROGRAM PRODUCTS 审中-公开
标题翻译： MRI指导的本地化和/或铅放置系统，相关方法，设备和计算机程序产品
公开(公告)号：WO2007064739A3
公开(公告)日：2007-12-21
申请号：PCT/US2006045752
申请日：2006-11-29
申请人： SURGIVISION INC , KARMARKAR PARAG V , JENKINS KIMBLE
发明人： KARMARKAR PARAG V , JENKINS KIMBLE
IPC分类号： A61B5/0476 , A61B5/055 , A61B19/00 , A61N1/18 , G01R33/28 , G01R33/341
CPC分类号： A61B90/11 , A61B5/0476 , A61B5/055 , A61B5/6847 , A61B5/6864 , A61B5/6865 , A61B5/7435 , A61B19/5244 , A61B34/10 , A61B34/20 , A61B90/14 , A61B2017/00039 , A61B2034/107 , A61B2034/2051 , A61B2090/374 , A61B2090/3954 , A61M39/08 , A61N1/0529 , A61N1/0534 , A61N1/0539 , A61N1/08 , A61N1/086 , A61N1/3718 , A61N1/372 , A61N2001/086 , G01R33/285 , G01R33/286 , G01R33/287 , G01R33/288 , G01R33/34084 , G01R33/4808
摘要： MRI compatible localization and/or guidance systems for facilitating placement of an interventional therapy and/or device in vivo include: (a) a mount adapted for fixation to a patient; (b) a targeting cannula with a lumen configured to attach to the mount so as to be able to controllably translate in at least three dimensions; and (c) an elongate probe configured to snugly slidably advance and retract in the targeting cannula lumen, the elongate probe comprising at least one of a stimulation or recording electrode. In operation, the targeting cannula can be aligned with a first trajectory and positionally adjusted to provide a desired internal access path to a target location with a corresponding trajectory for the elongate probe. Automated systems for determining an MR scan plane associated with a trajectory and for determining mount adjustments are also described.
摘要翻译：用于促进介入治疗和/或装置体内放置的MRI兼容的定位和/或引导系统包括：（a）适于固定于患者的安装座; （b）具有被配置为附接到所述安装件以便能够可控地平移至少三个维度的内腔的靶向插管; 以及（c）细长探针，其被配置为在所述靶向插管腔中紧密地滑动地前进和缩回，所述细长探针包括刺激或记录电极中的至少一个。在操作中，瞄准套管可以与第一轨迹对准，并且被位置调节以便为具有针对细长探针的对应轨迹的目标位置提供期望的内部通路。还描述了用于确定与轨迹相关联并用于确定安装调整的MR扫描平面的自动化系统。

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