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1. 发明申请

WO2010060218A1 A COMPOSITION FOR USE AS A PEPTIDE RETENTION STANDARD AND A METHOD OF PREDICTING PEPTIDE HYDROPHOBICITY IN LIQUID CHROMATOGRAPHY 审中-公开
标题翻译：用作肽类保留标准的组合物和在液相色谱中预测肽类疏水性的方法
公开(公告)号：WO2010060218A1
公开(公告)日：2010-06-03
申请号：PCT/CA2009/001730
申请日：2009-11-30
申请人： UNIVERSITY OF MANITOBA , KROKHIN, Oleg V. , SPICER, Vic
发明人： KROKHIN, Oleg V. , SPICER, Vic
IPC分类号： G01N30/86 , C40B40/10 , G01N30/02 , C07K7/08 , C07K7/06
CPC分类号： C07K7/06 , G01N30/8668 , G01N30/8672 , G01N2030/042 , G01N2030/8831
摘要： A composition comprising synthetic peptides for use as a peptide retention standard in liquid chromatography applications is disclosed Said synthetic peptides have a broad range of hydrophobicity while maintaining low variation in their molecular weights The synthetic peptides disclosed consist of the ammo acid sequences LGGGGGGDGSR, LGGGGGGDFR, LLGGGGDFG, LLLGGDFR, LLLLDFR, LLLLLDFR A method of predicting the hydrophobicity of an unknown peptide in liquid chromatography using a composition of peptide retention standards and a method of developing a Universal Hydrophobicity Index (UHI) for the measurement of peptide hydrophobicity in liquid chromatography are also described
摘要翻译：公开了包含用于液相色谱应用中的肽保留标准的合成肽的组合物。所述合成肽具有宽范围的疏水性，同时保持其分子量的低变化。所公开的合成肽由氨基酸序列LGGGGGGDGSR，LGGGGGGDFR，LLGGGGDFG LLLGGDFR，LLLLDFR，LLLLLDFR还描述了使用肽保留标准物组合物和用于测量液相色谱中肽疏水性的通用疏水性指数（UHI）的方法在液相色谱中预测未知肽的疏水性的方法

2. 发明申请

WO2018052952A1 METHOD AND APPARATUS FOR LINEARIZING AND MITIGATING DENSITY DIFFERENCES ACROSS MULTIPLE CHROMATOGRAPHIC SYSTEMS 审中-公开
标题翻译：用于在多色谱系统之间线性化和减少密度差异的方法和设备
公开(公告)号：WO2018052952A1
公开(公告)日：2018-03-22
申请号：PCT/US2017/051293
申请日：2017-09-13
申请人： WATERS TECHNOLOGIES CORPORATION
发明人： SHREVE, Joshua, A. , HILL, Jason, F. , MICHIENZI, Joseph, D. , TARAFDER, Abhijit , FOGWILL, Michael, O.
IPC分类号： B01D15/08
CPC分类号： B01D15/40 , B01D15/163 , B01D15/1871 , G01N30/32 , G01N30/6065 , G01N30/8658 , G01N30/8672
摘要： Methods for transferring a carbon dioxide based separation procedure from a first chromatographic system to a second one involve identifying an average column pressure for the separation in the first system is identified, determining a measured average column pressure for the separation in the second system, and comparing the measured average column pressure with the identified average column pressures. To more closely match the identified average column pressure, the methods involve: (a) altering a cross-sectional area of a column packed with media in the second system; and/or (b) adding makeup fluid along the length of the column in the second system. Columns with the characteristics used in the methods and second chromatographic systems are disclosed.
摘要翻译：用于将基于二氧化碳的分离程序从第一色谱系统转移到第二色谱系统的方法涉及识别用于第一系统中的分离的平均柱压力，识别出测量的用于在第二系统中分离，并将测得的平均柱压与所确定的平均柱压进行比较。为了更接近地匹配所确定的平均柱压力，所述方法包括：（a）改变第二系统中填充有介质的柱的横截面积; 和/或（b）在第二系统中沿着柱的长度添加补充流体。公开了具有方法和第二色谱系统中所用特征的色谱柱。

3. 发明申请

WO2014065409A1 前処理決定装置、前処理法決定方法、制御プログラム、および記録媒体审中-公开
标题翻译：预处理确定装置，预处理方法确定方法，控制程序和记录介质
公开(公告)号：WO2014065409A1
公开(公告)日：2014-05-01
申请号：PCT/JP2013/079006
申请日：2013-10-25
申请人：株式会社住化分析センター
发明人：富樫　一天
IPC分类号： G01N30/14 , G01N30/06 , G01N30/86
CPC分类号： G01N30/8672 , G01N30/14
摘要：前処理決定装置（１）は、対象化合物を所定の条件でＬＣに供したときの保持時間を取得するデータ取得部（１０）と、前処理ＤＢ（２０）のデータに基づき、データ取得部（１０）が取得した保持時間から所定範囲内の保持時間の化合物に対応付けられている前処理法を、対象化合物の前処理法として決定する前処理決定部（１１）とを備えているので、知識や経験の有無にかかわらず、迅速に適切な前処理法を決定できる。
摘要翻译：该预处理确定装置（1）具有：数据获取单元（10），其在预定条件下获取目标化合物可用于LC时的保留时间; 以及预处理确定单元（11），其基于预处理数据库（20）中的数据，确定所述目标化合物的预处理方法为与具有所述化合物的化合物相关联的预处理方法保持时间在从数据获取单元（10）获取的保持时间的预定范围内。结果，无论知识或经验的存在或不存在，都可以快速确定适当的预处理方法。

4. 发明申请

WO2011147974A1 RETENTION TIME LOCKING FOR MULTI-DIMENSIONAL GAS CHROMATOGRAPHY 审中-公开
标题翻译：多维气相色谱保留时间锁定
公开(公告)号：WO2011147974A1
公开(公告)日：2011-12-01
申请号：PCT/EP2011/058753
申请日：2011-05-27
申请人： DSM IP ASSETS B.V. , MOMMERS, Johannes Helena Michael , KNOOREN, Jeroen Albert Angelicus
发明人： MOMMERS, Johannes Helena Michael , KNOOREN, Jeroen Albert Angelicus
IPC分类号： G01N30/46 , G01N30/86 , G01N30/30 , G01N30/32
CPC分类号： G01N30/463 , G01N30/30 , G01N30/32 , G01N30/465 , G01N30/8672 , G01N2030/165
摘要： The invention relates to a method for adjusting operating parameters of a multi-dimensional gas chromatograph system comprising a first oven, a primary column, and a secondary column, to match the operating parameters of a reference multi-dimensional gas chromatograph system comprising an original primary column and an original secondary column, such that measured primary and secondary retention times of a target compound in the multi-dimensional gas chromatography system are matched to the original primary and the original secondary retention times of the target compound in the reference system.
摘要翻译：本发明涉及一种用于调整多维气相色谱系统的操作参数的方法，该系统包括第一烘箱，主色谱柱和第二色谱柱，以匹配参考多维气相色谱系统的操作参数，所述参考多维气相色谱系统包括原始主要柱和原始第二柱，使得在多维气相色谱系统中目标化合物的测量的一次和二次保留时间与目标化合物在参考系统中的原始初级和原始二次保留时间相匹配。

5. 发明申请

WO2018193334A1 METHOD AND APPARATUS FOR EFFICIENTLY TRANSFERRING A CARBON DIOXIDE BASED SEPARATION PROCEDURE FROM A FIRST CHROMATOGRAPHIC SYSTEM TO A SECOND CHROMATOGRAPHIC SYSTEM 审中-公开
公开(公告)号：WO2018193334A1
公开(公告)日：2018-10-25
申请号：PCT/IB2018/052465
申请日：2018-04-09
申请人： WATERS TECHNOLOGIES CORPORATION
发明人： HILL, Jason F. , FOGWILL, Michael O. , MICHIENZI, Joseph D. , SHREVE, Joshua A. , TARAFDER, Abhijit
IPC分类号： G01N30/86 , G01N30/60 , B01D15/40 , G01N30/32
CPC分类号： B01D15/40 , B01D15/163 , G01N30/32 , G01N30/60 , G01N30/6039 , G01N30/8658 , G01N30/8668 , G01N30/8672 , G01N30/8693 , G01N2030/027 , G01N2030/8648
摘要： Methods for transferring a separation procedure from a first chromatographic system to a second one are disclosed that involve substantially matching a pressure profile. In some such methods, a length, an area, and a particle size of a first column in the first system and a flow rate in the first separation procedure are identifiable. Some such methods also involve selecting a combination of a length, an area, and a particle size of a second column in the second system and a flow rate for the second separation procedure. These methods may involve calculating a target length, a target area, or a target particle size for the second column in the second system or a target flow rate for the second separation procedure.

6. 发明申请

WO2005073713A3 A METHOD FOR STANDARDIZATION OF CHEMICAL AND THERAPEUTIC VALUES OF FOODS & MEDICINES USING ANIMATED CHROMATOGRAPHIC FINGERPRINTING 审中-公开
标题翻译：动物色谱指纹图谱标准化食品和药品化学和治疗价值的方法
公开(公告)号：WO2005073713A3
公开(公告)日：2005-10-13
申请号：PCT/IN2005000034
申请日：2005-01-28
申请人： COUNCIL SCIENT IND RES , DADALA VIJAYA KUMAR , RAGHAVAN KONDAPURAM VIJAYA
发明人： DADALA VIJAYA KUMAR , RAGHAVAN KONDAPURAM VIJAYA
IPC分类号： G01N30/86 , G01N30/88
CPC分类号： G01N30/8651 , G01N30/8672 , G01N30/8686 , G01N30/88 , G01N2030/8813 , G01N2030/8822 , G01N2030/8886 , Y02A90/26
摘要： The present invention provides a method of chromatographic fingerprinting facilitating assessment of chemical and therapeutic properties of foods and traditional medicines useful for chemical and therapeutic standardization. It provides the influence, of factors like pH, temperature, viscosity and ionic nature of the media along with atomic and molecular properties indicating the chemical and therapeutic values of the foods and medicines of natural and synthetic nature. The analysis of biological samples like blood indicated the utility of the method for the assessment of clinical pathological conditions of healthy and diseased and facilitates drug discovery, drug monitoring, drug targeting and drug profiling using different features of 3-D animated energy box created after analyzing the sample by different analysis, separation and detection methods.
摘要翻译：本发明提供了色谱指纹图谱的方法，其便于评估食品和用于化学和治疗标准化的传统药物的化学和治疗性质。它提供了介质的pH值，温度，粘度和离子性质以及原子和分子性质等因素的影响，表明了天然和合成性食品和药物的化学和治疗价值。生物样本如血液的分析表明该方法用于评估健康和患病的临床病理状况，并且利用分析后创建的三维动画能量盒的不同特征来促进药物发现，药物监测，药物靶向和药物分析该样品通过不同的分析，分离和检测方法。

7. 发明申请

WO2005073713A2 A METHOD FOR STANDARDIZATION OF CHEMICAL AND THERAPEUTIC VALUES OF FOODS & MEDICINES USING ANIMATED CHROMATOGRAPHIC FINGERPRINTING 审中-公开
标题翻译：食品和药物化学和治疗价值的标准化方法使用动画色彩指纹
公开(公告)号：WO2005073713A2
公开(公告)日：2005-08-11
申请号：PCT/IN2005/000034
申请日：2005-01-28
申请人： COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH , DADALA, Vijaya, Kumar , RAGHAVAN, Kondapuram, Vijaya
发明人： DADALA, Vijaya, Kumar , RAGHAVAN, Kondapuram, Vijaya
IPC分类号： G01N30/86
CPC分类号： G01N30/8651 , G01N30/8672 , G01N30/8686 , G01N30/88 , G01N2030/8813 , G01N2030/8822 , G01N2030/8886 , Y02A90/26
摘要： The present invention provides a method of standardization of chemical and therapeutic properties and quality of foods and medicines. The present invention provides a method of chromatographic finger printing facilitating correlation of traditional methods used for chemical and therapeutic standardization of medicines and humors in the living things with physico chemical properties of the medicines and their constituents. The method is used for the qualitative and quantitative analysis of the energy involved in the medicines and living things and to understand various bio chemical reactions in living things using an energy system. It provides a rational basis to understand the traditional methods of assessment of chemical and therapeutic qualities of materials used for the said purpose. The present invention also provides the influence, of factors like pH, temperature, viscosity and ionic nature of the media along with atomic and molecular properties indicating the chemical and therapeutic values of the foods and medicines of natural and synthetic nature. The analysis of biological samples like blood indicated the utility of the method for the assessment of clinical pathological conditions of healthy and diseased. This facilitates for a better drug discovery, drug monitoring, drug targeting and drug profiling using different features of 3-D animated energy box created after analyzing the sample by different analysis, separation and detection methods.
摘要翻译：本发明提供了一种色谱指纹图谱，便于评价用于化学和治疗标准化的食品和传统药物的化学和治疗性质。它提供了诸如pH，温度，粘度和离子性质等因素对原子和分子性质的影响，表明了天然和合成性质的食品和药物的化学和治疗价值。生物样本如血液的分析表明，该方法用于评估健康和患病的临床病理状况，并利用分析后创建的3-D动画能量盒的不同特征，促进药物发现，药物监测，药物靶向和药物分析样品通过不同的分析，分离和检测方法。

8. 发明申请

WO2013134862A1 RETENTION INDEX STANDARDS FOR LIQUID CHROMATOGRAPHY 审中-公开
标题翻译：液相色谱保留指标标准
公开(公告)号：WO2013134862A1
公开(公告)日：2013-09-19
申请号：PCT/CA2013/000252
申请日：2013-03-15
申请人： NATIONAL RESEARCH COUNCIL OF CANADA
发明人： QUILLIAM, Michael, Arthur
IPC分类号： G01N30/02 , C40B50/08 , G01N30/72 , G01N30/74
CPC分类号： G01N30/7233 , G01N21/33 , G01N30/04 , G01N30/8668 , G01N30/8672 , G01N2030/027 , G01N2030/042 , G01N2030/045 , Y10T436/10
摘要： A homologous series of neutrally charged compounds having at least one functional group bearing a positive charge and at least one functional group bearing a negative charge are advantageous retention index standards for liquid chromatography, especially for liquid chromatography-mass spectrometry (LC-MS) methods, more especially for LC-MS methods employing electrospray (ESI) or atmospheric pressure chemical ionization (APCI) ionization systems.
摘要翻译：具有至少一个具有正电荷的官能团和至少一个带有负电荷的官能团的中性带电化合物的同源系列是用于液相色谱，特别是液相色谱 - 质谱（LC-MS）方法的有利的保留指数标准，更特别的是使用电喷雾（ESI）或大气压化学电离（APCI）电离系统的LC-MS方法。

9. 发明申请

WO2013044401A1 METHOD FOR ANALYSIS OF SAMPLES IN TARGETED PROTEOMICS APPLICATIONS, COMPUTER PROGRAM PRODUCT AND SET OF REFERENCE PEPTIDES 审中-公开
标题翻译：目标保护应用样本分析方法，计算机程序产品和参考设置
公开(公告)号：WO2013044401A1
公开(公告)日：2013-04-04
申请号：PCT/CH2012/000217
申请日：2012-09-20
申请人： BiognoSYS AG , ESCHER, Claudia , OSSOLA, Reto , RINNER, Oliver , REITER, Lukas
发明人： ESCHER, Claudia , OSSOLA, Reto , RINNER, Oliver , REITER, Lukas
IPC分类号： G01N30/86 , G01N30/88
CPC分类号： G01N30/8675 , G01N30/8672 , G01N30/88 , G01N2030/042 , G01N2030/8831
摘要： The invention relates to the analysis of compounds with mass spectrometry and more particularly to instruments, substances, and methods for polypeptide analysis, in particular in targeted proteomics applications and based on indexed retention time as peptide specific property. The method of chemical analysis comprises the steps of: a) providing a first complex sample comprising a set of at least two reference peptides associated to an indexed retention time scale (iRT), as well as at least one further peptide; b) performing LC-MS on said complex sample and determining the empirical retention time values (RTe) of the reference peptides and of the at least one further peptide; c) translating the empirical retention time values (RTe) of the reference peptides and of the at least one further peptide into the indexed retention time scale and associating to each reference peptide a reference indexed retention time value (iRTr) and to the at least one further peptide an associated indexed retention time value (iRTa); d) providing a second complex sample comprising at least one polypeptide as well as said set of the at least two reference peptides; e) performing LC-MS on said second complex sample and determining the empirical retention time values (RTe) of the reference peptides; f) translating the empirical retention time values (RTe) of the reference peptides into the indexed retention time scale by numerically adapting the transformation function for the conversion of the retention time values (RTe) into indexed retention time values such that the calculated indexed retention time values (iRTe) calculated based on the measured retention time values (RTe) of the reference peptides match the assigned indexed retention time values (iRTr) of the reference peptides; g) determining the predicted empirical retention time value (RTp) of the at least one further peptide by using the numerically adapted transformation function determined in step f).
摘要翻译：本发明涉及通过质谱法分析化合物，更具体地涉及用于多肽分析的仪器，物质和方法，特别是在靶向蛋白质组学应用中，并且基于索引保留时间作为肽特异性。化学分析的方法包括以下步骤：a）提供第一复合物样品，其包含与索引的保留时间标度（iRT）相关的一组至少两个参考肽，以及至少一个其它肽; b）在所述复合物样品上进行LC-MS并确定参考肽和至少一种其它肽的经验性保留时间值（RTe）; c）将参考肽和至少一个另外的肽的经验保留时间值（RTe）翻译成索引保留时间标度，并将参考索引的保留时间值（iRTr）与至少一个进一步的肽相关的索引保留时间值（iRTa）; d）提供包含至少一种多肽以及所述至少两种参考肽组的第二复合物样品; e）在所述第二复合物样品上进行LC-MS并确定参考肽的经验保留时间值（RTe）; f）将参考肽的经验保留时间值（RTe）转化为索引保留时间标度，方法是使保留时间值（RTe）转化为指数保留时间值的转化函数，使得计算的指数保留时间基于所测量的参考肽的保留时间值（RTe）计算的值（iRTe）与参考肽的指定的指示保留时间值（iRTr）匹配; g）通过使用在步骤f）中确定的数字适应变换函数来确定所述至少一种另外的肽的预测经验保留时间值（RTp）。

10. 发明申请

WO2011091224A1 METHOD FOR DETERMINING EQUIVALENT THERMAL CONDITIONS BETWEEN LIQUID CHROMATOGRAPHY SYSTEMS 审中-公开
标题翻译：用于确定液相色谱系统之间等效热条件的方法
公开(公告)号：WO2011091224A1
公开(公告)日：2011-07-28
申请号：PCT/US2011/021999
申请日：2011-01-21
申请人： WATERS TECHNOLOGIES CORPORATION , ANDREWS, Richard, W. , BEALS, Peyton, C.
发明人： ANDREWS, Richard, W. , BEALS, Peyton, C.
IPC分类号： B01D15/10
CPC分类号： G01N30/04 , B01D15/424 , G01N30/8672 , G01N2030/047 , G01N2030/3007
摘要： Described is a method of transferring a chromatographic method between liquid chromatography (LC) systems. The method is based on a determination of an isoretention temperature at which two solutes co-elute. The method enables separations to be performed using different LC systems with reproducible and equivalent results. For example, the method allows for a chromatography method developed for HPLC to be more readily transferred to a UPLC system and for a chromatography method developed for a UPLC system to be more readily transferred to a HPLC system. The method addresses LC systems having column ovens of different design in which the internal column temperatures are not equal although the operating temperatures of the column ovens may be accurately controlled to equal values. The retention behavior and resolution of different LC systems is caused to be substantially the same so that equivalent separation results are obtained.
摘要翻译：描述了在液相色谱（LC）系统之间转移色谱方法的方法。该方法基于两个溶质共洗脱的等离子体停留温度的测定。该方法可以使用具有可重现性和等效结果的不同液相色谱系统进行分离。例如，该方法允许为HPLC开发的色谱方法更容易转移到UPLC系统中，并且为UPLC系统开发的色谱方法更容易转移到HPLC系统。该方法解决了具有不同设计的列炉的LC系统，其中内部柱温度不相等，尽管柱式炉的操作温度可以被精确地控制为相等的值。导致不同LC系统的保持行为和分辨率基本相同，从而获得等效的分离结果。

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