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1. 发明申请

WO9421240A3 SUPERPARAMAGNETIC PARTICLES, PROCESS FOR PRODUCING THE SAME AND THEIR USE 审中-公开
标题翻译：超级颗粒，其生产方法及其用途
公开(公告)号：WO9421240A3
公开(公告)日：1994-10-13
申请号：PCT/DE9400314
申请日：1994-03-17
申请人： SILICA GEL GMBH , PILGRIMM HERBERT
发明人： PILGRIMM HERBERT
IPC分类号： A61N1/40 , A61K9/50 , A61K31/395 , A61K31/66 , A61K31/77 , A61K35/12 , A61K35/74 , A61K35/76 , A61K38/43 , A61K39/395 , A61K41/00 , A61K47/02 , A61K49/00 , A61K49/18 , A61N2/00 , A61P35/00 , A61P37/00 , B03C1/01 , C07F9/09 , C07H21/00 , C12N11/14 , C12Q1/68 , G01N33/543 , G01R33/28 , H01F1/00 , H01F1/36 , H01F1/44
CPC分类号： C07F9/091 , A61K9/5094 , A61K41/0052 , A61K49/186 , A61K49/1887 , B03C1/01 , B82Y5/00 , B82Y25/00 , B82Y30/00 , C07H21/00 , C12N11/14 , C12Q1/6834 , G01N33/5434 , G01N2446/20 , G01N2446/84 , G01N2446/86 , G01R33/281 , H01F1/0054 , H01F1/36 , H01F1/44 , H01F1/445
摘要： New superparamagnetic particles useful in medicine for destroying tumors, increasing immunity and diagnosing conditions are disclosed. For that purpose, very small superparamagnetic single-domain particles are aggregated and protected against further aggregation by chemical bonding of reactive stabilizer substances on the surface of the superparamagnetic particles. These new particles thus consist of stable, decomposable aggregates with a particle size in a range between 10 and 1000 nanometres and a defined behaviour in a magnetic field. The aggregates consist of several small superparamagnetic single-domain particles of iron oxide, iron mixed oxide or iron, with a particle size in a range between 3 and 20 nanometres, bearing on their surface chemically bound organic substances from the group comprising the phosphate, diphosphate, polyphosphate, thiophosphate, phosphonate or group containing polyalkylene glycols, phosphate group containing nucleotides, their oligomers or polymers, as well as phosphate group containing carbohydrates, which may present further binding sites. Both the new disclosed superparamagnetic aggregates and reactive stabilizer substances may be active substances.

2. 发明申请

WO2013149265A1 MAGNETIC NANOCOMPOSITIONS FOR HIGHLY SENSITIVE MOLECULAR AND CELLULAR ENRICHMENT, PURIFICATION AND DETECTION 审中-公开
标题翻译：用于高敏感分子和细胞增殖，净化和检测的磁性纳米生物
公开(公告)号：WO2013149265A1
公开(公告)日：2013-10-03
申请号：PCT/US2013/034865
申请日：2013-04-01
申请人： NVIGEN, INC.
发明人： FU, Aihua , MENG, Zheng
IPC分类号： G01N33/483 , G01N33/53 , G01N33/553
CPC分类号： G01N33/587 , G01N33/54326 , G01N33/54346 , G01N2446/86
摘要： The present invention relates to a nanocomposition capable of capturing or enriching an analyte at a sub-nanogram level and methods thereof. The nanocomposition can comprise a nanostructure operably linked to an analyte-capturing member.
摘要翻译：本发明涉及能够捕获或富集亚纳米级分析物的纳米组合物及其方法。纳米组分可以包含可操作地连接到分析物捕获构件的纳米结构。

3. 发明申请

WO99035500A1 IMPROVED MAGNETIC PARTICLES, METHOD FOR OBTAINING SAME AND USES FOR SEPARATING MOLECULES 审中-公开
标题翻译：改进的磁性颗粒，其获得方法和用于分离分子的用途
公开(公告)号：WO99035500A1
公开(公告)日：1999-07-15
申请号：PCT/FR1999/000011
申请日：1999-01-06
IPC分类号： G01N33/553 , B03C1/00 , B03C1/01 , G01N33/543 , H01F1/11
CPC分类号： H01F1/111 , B03C1/01 , G01N33/5434 , G01N2446/20 , G01N2446/86 , Y10S428/90 , Y10T428/2991 , Y10T428/2998
摘要： The invention concerns magnetic and heat-sensitive particles having a predetermined size between 0.05 and 10 mu m, each particle comprising: an inner composite core consisting of a solid organic or inorganic particle, containing within it a magnetic filler; an outer coating based on a polymer capable of interacting with at least a biological molecule, the outer polymer is heat-sensitive and has a predetermined low critical solubility temperature (LCST) ranging between 10 and 100 DEG C and preferably between 20 and 60 DEG C. The invention also concerns methods for obtaining said particles and their uses. The particles are characterised in that there is an intermediate layer between the inner core and the outer layer isolating said inner core magnetic filler with respect to said functionalised outer layer. Said invention is particularly useful for separating proteins and/or nucleic acids.
摘要翻译：本发明涉及具有0.05-10μm的预定尺寸的磁性和热敏颗粒，每个颗粒包括：由固体有机或无机颗粒组成的内复合芯，其中含有磁性填料; 基于能够与至少一种生物分子相互作用的聚合物的外部涂层，外部聚合物是热敏感的并且具有在10至100℃之间，优选在20至60℃之间的预定的低临界溶解温度（LCST）本发明还涉及获得所述颗粒及其用途的方法。颗粒的特征在于，在内芯和外层之间存在相对于所述官能化外层隔离所述内芯磁性填料的中间层。所述发明对于分离蛋白质和/或核酸特别有用。

4. 发明申请

WO1997045202A1 SUPERPARAMAGNETIC MONODISPERSED PARTICLES 审中-公开
标题翻译：超级粒子单体颗粒
公开(公告)号：WO1997045202A1
公开(公告)日：1997-12-04
申请号：PCT/FR1997000912
申请日：1997-05-23
申请人： BIO MERIEUX , ELAISSARI, Abdelhamid , PICHOT, Christian , MANDRAND, Bernard , SAUZEDDE, Florence
发明人： BIO MERIEUX
IPC分类号： B03C01/01
CPC分类号： H01F1/37 , B03C1/01 , G01N33/5375 , G01N33/5434 , G01N2446/10 , G01N2446/40 , G01N2446/84 , G01N2446/86 , H01F1/44 , Y10S436/806 , Y10S436/824 , Y10T428/2982 , Y10T428/2989 , Y10T428/2991 , Y10T428/2998 , Y10T436/24
摘要： The invention discloses superparamagnetic monodispersed particles, their method of preparation and their uses. These particles comprise: a core of a first polymer, an internal layer of a second polymer coating the core, and in which is distributed a magnetic material, and an external layer of a third polymer coating the magnetic layer, and capable of interacting with at least one biological molecule, at least the second polymer being heat sensitive and having a predetermined lower critical solubility temperature (LCST) of 15 to 65 DEG C.
摘要翻译：本发明公开了超顺磁单分散颗粒，其制备方法及其用途。这些颗粒包括：第一聚合物的芯，涂覆芯的第二聚合物的内层，其中分布有磁性材料，以及涂覆磁性层的第三聚合物的外层，并且能够与至少一个生物分子，至少第二聚合物是热敏感的并具有15至65℃的预定的较低临界溶解温度（LCST）。

5. 发明申请

WO2015095398A1 METHOD AND APPARATUS FOR MANUFACTURING ISOTROPIC MAGNETIC NANOCOLLOIDS 审中-公开
标题翻译：制造等离子体磁性纳米粒子的方法和装置
公开(公告)号：WO2015095398A1
公开(公告)日：2015-06-25
申请号：PCT/US2014/070961
申请日：2014-12-17
申请人： HAGEDORN, Kevin , MALIZIA, Henrietta
发明人： HAGEDORN, Kevin , MALIZIA, Henrietta
IPC分类号： B82B1/00 , B22F9/02 , B22F3/115 , B82B3/00 , B23K26/122
CPC分类号： H01F41/205 , B82Y15/00 , C22C45/008 , C22C45/02 , C22C45/04 , G01N33/54326 , G01N2446/00 , G01N2446/86 , Y10T428/2982
摘要： Disclosed herein are systems, methods, and apparatuses for manufacturing highly isotropic magnetic nanoparticles 910. In particular, manufacturing of spherical and amorphous particles 910 suspended in a solvent 904 by irradiating alloy targets 902 submerged in a solvent 904 using nanosecond-scale laser pulses 906 is disclosed. The absence of shape and crystalline anisotropy in the particles 910 yields a colloidal suspension 900 with excellent soft magnetic properties which can be used to improve the performance of various medical diagnostic devices and consumer electronics.
摘要翻译：本文公开了用于制造高度各向同性的磁性纳米粒子910的系统，方法和装置。特别地，通过用纳秒级激光脉冲906照射浸没在溶剂904中的合金靶902来制造悬浮在溶剂904中的球形和无定形颗粒910，披露。在颗粒910中不存在形状和晶体各向异性产生具有优异软磁性质的胶体悬浮液900，其可用于改善各种医疗诊断装置和消费电子产品的性能。

6. 发明申请

WO1998012717A1 SPHERICAL MAGNETIC PARTICLES 审中-公开
标题翻译：球形磁粉
公开(公告)号：WO1998012717A1
公开(公告)日：1998-03-26
申请号：PCT/EP1997004828
申请日：1997-09-05
申请人： MERCK PATENT GMBH , ANSELMANN, Ralf , PELLATT, Martin, Geoffrey
发明人： MERCK PATENT GMBH
IPC分类号： H01F01/11
CPC分类号： H01F1/112 , B03C1/01 , G01N33/5434 , G01N2446/10 , G01N2446/40 , G01N2446/84 , G01N2446/86
摘要： Monodisperse magnetic particles with a particle size from 50 to 1500 nm have a spherical silicium dioxide core punctually coated with magnetite particles with a particle size below 60 nm and a silicium dioxide covering layer. The particles are used for isolating nucleic acids and biotin, biotinylated nucleic acids and proteins or other biotin-marked molecules from aqueous solutions.
摘要翻译：从50的颗粒尺寸至1500nm具有由二氧化硅制成的球形芯，其为点涂有磁铁矿的小于60nm的粒径和二氧化硅的覆盖层的单分散的磁性粒子。所述颗粒用于核酸和生物素，生物素化的核酸和生物素化的蛋白质或从水溶液中其它生物素标记的分子中分离。

7. 发明申请

WO9611054A3 PROCESS FOR THE PREPARATION OF MICROSPHERES AND MIPROCESS FOR THE PREPARATION OF MICROSPHERES AND MICROSPHERES MADE THEREBY CROSPHERES MADE THEREBY 审中-公开
标题翻译：制备微球和制备微球和微球的方法及其制备方法
公开(公告)号：WO9611054A3
公开(公告)日：1996-05-23
申请号：PCT/US9512988
申请日：1995-10-05
申请人： UNIV BAR ILAN , LICHTENSTEIN JOSEPH , MARGEL SHLOMO , BAMNOLKER HANNA
发明人： MARGEL SHLOMO , BAMNOLKER HANNA
IPC分类号： A61K47/48 , B01J13/14 , G01N33/543 , G01N33/552 , B01J13/04 , A61K9/50 , A61K49/00
CPC分类号： G01N33/54346 , A61K47/6923 , A61K47/6929 , B01J13/14 , G01N33/5434 , G01N33/552 , G01N2446/10 , G01N2446/80 , G01N2446/86 , G01N2446/90
摘要： A process for the preparation of a microsphere comprising a coating composed of one or more silica nanoparticles layers, comprises the steps of: a) providing a microsphere of polymeric material, the said microsphere having adsorbed on its surface one or more surfactants; and b) causing a layer of silica nanoparticles to coat the surface of the said microsphere by means of seeded polymerization of alkyl silicates onto the surface of said microsphere.

8. 发明申请

WO1996011054A2 PROCESS FOR THE PREPARATION OF MICROSPHERES AND MICROSPHERES MADE THEREBY 审中-公开
标题翻译：制备微生物和微生物的方法
公开(公告)号：WO1996011054A2
公开(公告)日：1996-04-18
申请号：PCT/US1995012988
申请日：1995-10-05
申请人： BAR-ILAN UNIVERSITY , LICHTENSTEIN, Joseph , MARGEL, Shlomo , BAMNOLKER, Hanna
发明人： BAR-ILAN UNIVERSITY , LICHTENSTEIN, Joseph
IPC分类号： B01J13/04
CPC分类号： G01N33/54346 , A61K47/6923 , A61K47/6929 , B01J13/14 , G01N33/5434 , G01N33/552 , G01N2446/10 , G01N2446/80 , G01N2446/86 , G01N2446/90
摘要： A process for the preparation of a microsphere comprising a coating composed of one or more silica nanoparticles layers, comprises the steps of: a) providing a microsphere of polymeric material, the said microsphere having adsorbed on its surface one or more surfactants; and b) causing a layer of silica nanoparticles to coat the surface of the said microsphere by means of seeded polymerization of alkyl silicates onto the surface of said microsphere.
摘要翻译：一种制备微球的方法，包括由一个或多个二氧化硅纳米粒子层组成的涂层，包括以下步骤：a）提供聚合物材料的微球，所述微球吸附在其表面上一个或多个表面活性剂; 以及b）使二氧化硅纳米颗粒层通过硅烷烷基硅烷聚合到所述微球表面上来涂覆所述微球的表面。

9. 发明申请

WO1991009141A1 MAGNETICALLY RESPONSIVE FLUORESCENT POLYMER PARTICLES AND APPLICATION THEREOF 审中-公开
标题翻译：磁性有效荧光聚合物颗粒及其应用
公开(公告)号：WO1991009141A1
公开(公告)日：1991-06-27
申请号：PCT/US1990007369
申请日：1990-12-12
申请人： BAXTER DIAGNOSTICS, INC.
发明人： BAXTER DIAGNOSTICS, INC. , WANG, Chao-Huei, J. , SHAH, Dinesh, O.
IPC分类号： C12Q01/68
CPC分类号： H01F1/111 , B03C1/01 , C08F257/02 , C08F285/00 , C12Q1/6834 , G01N33/54326 , G01N33/5434 , G01N33/582 , G01N33/585 , G01N2446/10 , G01N2446/40 , G01N2446/86 , C12Q2563/143 , C12Q2563/107
摘要： This invention provides a novel process of producing magnetically responsive fluorescent polymer particles comprising polymeric core particles coated evenly with a layer of polymer containing magnetically responsive metal oxide. A wide variety of polymeric particles with sizes ranging from 1 to 100 microns can be used as core particles and transformed into magnetically responsive polymer particles. The surface of these magnetically responsive polymer particles can be coated further with another layer of functionalized polymer. These magnetically responsive fluorescent polymer particles can be used for passive or covalent coupling of biological material such as antigens, antibodies, enzymes or DNA/RNA hybridization and used as solid phase for various types of immunoassays, DNA/RNA hybridization probes assays, affinity purification, cell separation and other medical, diagnostic, and industrial applications.
摘要翻译：本发明提供了一种制备磁响应荧光聚合物颗粒的新方法，其包括均匀地涂覆有含有磁响应金属氧化物的聚合物层的聚合物芯颗粒。尺寸范围为1至100微米的多种聚合物颗粒可用作核心颗粒并转化为磁响应聚合物颗粒。这些磁响应聚合物颗粒的表面可以进一步被另一层官能化聚合物涂覆。这些磁响应荧光聚合物颗粒可用于生物材料如抗原，抗体，酶或DNA / RNA杂交的被动或共价偶联，并用作各种类型的免疫测定的固相，DNA / RNA杂交探针测定，亲和纯化，细胞分离等医疗，诊断和工业应用。

10. 发明申请

WO2004042397A1 免疫反応測定に用いられる高感度磁性マーカー审中-公开
标题翻译：用于免疫应答测量的高灵敏度磁标记
公开(公告)号：WO2004042397A1
公开(公告)日：2004-05-21
申请号：PCT/JP2003/005733
申请日：2003-05-08
申请人：科学技術振興事業団 , 吉永耕二 , 円福敬二
发明人：吉永耕二 , 円福敬二
IPC分类号： G01N33/541
CPC分类号： G01N33/5434 , G01N2446/84 , G01N2446/86
摘要： SQUID磁気センサーによる免疫反応の測定に用いられるのに好適な高感度の磁性マーカーとその作製に関する新しい技術を開示している。磁性微粒子とその周りを被覆するポリマーとから構成され、SQUID磁気センサーにより免疫反応を測定するのに用いられる磁性マーカーにおいて、磁性微粒子(好ましくはフェライトFe 3 O 4 )の粒子径が20～40nmであり、磁性マーカーの外径が40～100nmであり、さらに、ポリマーの表面にカルボキシル基を有するようにする。このSQUID磁気センサー用磁性マーカーは、磁性微粒子の表面に、末端に重合性ビニル基を有し親水性で分子量が500～1000のマクロモノマー(好ましくは、ポリビニルピロリドン)を吸着させた後、カルボキシル基を有し親水性のビニル化合物から成るモノマーと架橋剤とを加えて共重合させることによって作製することができる。
摘要翻译：公开了一种优选用于通过使用SQUID磁传感器测量免疫应答的高灵敏度磁性标记和关于生产的新技术。由磁性粒子和聚合物组成的磁性标记物，其表面用SQUID磁性传感器测量免疫应答。磁性粒子（优选铁氧体Fe 3 O 4）的粒径为20〜40nm。磁标记的外径为40〜100nm。聚合物的表面含有羧基。磁性标记是通过使磁性颗粒的表面吸收具有可聚合乙烯基并具有500至1,000的分子量的亲水性大分子单体（优选聚乙烯吡咯烷酮），加入具有羧基的单体并包含亲水性乙烯基化合物和交联剂，并使它们共聚。

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