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1. 发明申请

WO2016066156A2 MOBILE PHOTOMETRISCHE MESSVORRICHTUNG UND VERFAHREN ZUR MOBILEN PHOTOMETRISCHEN MESSUNG AN MIKROTITIERPLATTEN 审中-公开
标题翻译：移动光度测量装置和方法MOBILE光度测量MIKROTITIERPLATTEN
公开(公告)号：WO2016066156A2
公开(公告)日：2016-05-06
申请号：PCT/DE2015/100425
申请日：2015-10-13
申请人： CHRISTIAN-ALBRECHTS-UNIVERSITÄT ZU KIEL
发明人： NAZIRIZADEH, Yousef , GERKEN, Martina , METZ, Philipp , KARROCK, Torben
IPC分类号： G01N21/64 , G01N21/77
CPC分类号： G01N21/253 , G01N21/6452 , G01N21/7743 , G01N2021/7776 , G01N2021/7786 , G01N2201/0221 , G01N2201/024 , G01N2201/0639
摘要： Die Erfindung betrifft eine mobile photometrische Messvorrichtung mit: mindestens einem Messmodul, bestehend aus einer Lichtquelle, einem Detektor und einem Optikgerüst mit einer Optik mit integrierten Filtereigenschaften oder einer Optik und mindestens einem Filter, wobei diese Komponenten auf einer Platine, in einem Gehäuse und/oder einem Baustein verschaltet angeordnet sind. Ferner betrifft die Erfindung ein mobiles photometrisches Messverfahren an Mikrotitierplatten mit Gittersensoren.
摘要翻译：本发明涉及一种移动光度测量设备，包括：至少一个测量模块，包括光源，检测器和一个光学框架与光学系统与内置滤波器特性或光学器件和至少一个过滤器，在电路板上的这些部件在壳体中和/或被布置为连接在一个块中。此外，本发明涉及Mikrotitierplatten与光栅传感器的移动光度测定方法。

2. 发明申请

WO2013165999A1 SELF-CLEANING OPTICAL SENSOR 审中-公开
标题翻译：自清洁光学传感器
公开(公告)号：WO2013165999A1
公开(公告)日：2013-11-07
申请号：PCT/US2013/038839
申请日：2013-04-30
申请人： ECOLAB USA INC. , TOKHTUEV, Eugene , OWEN, Christopher, J. , SKIRDA, Anatoly , CHRISTENSEN, William, M.
发明人： TOKHTUEV, Eugene , OWEN, Christopher, J. , SKIRDA, Anatoly , CHRISTENSEN, William, M.
IPC分类号： G01N21/15 , G01N21/64
CPC分类号： G01N21/15 , B08B3/02 , B08B5/02 , G01N21/05 , G01N21/645 , G01N2021/151 , G01N2021/6478 , G01N2021/6482 , G01N2201/0639 , G02B27/0006
摘要： An optical sensor may include a sensor head that has an optical window for directing light into a flow of fluid and/or receiving optical energy from the fluid. The optical sensor may also include a flow chamber that includes a housing defining a cavity into which the sensor head can be inserted. In some examples, the flow chamber includes an inlet port defining a flow nozzle that is configured to direct fluid entering the flow chamber against the optical window of the sensor head. In operation, the force of the incoming fluid impacting the optical window may prevent fouling materials from accumulating on the optical window.
摘要翻译：光学传感器可以包括传感器头，其具有用于将光引导到流体流和/或从流体接收光能的光学窗口。光学传感器还可以包括流动室，其包括限定腔的壳体，传感器头可插入该腔中。在一些示例中，流动室包括限定流动喷嘴的入口端口，该流动喷嘴被配置成将流体进入流动室的流体抵靠传感器头部的光学窗口。在操作中，冲击光学窗口的进入流体的力可以防止污垢物质积聚在光学窗口上。

3. 发明申请

WO2012087754A1 DEPTH-SELECTIVE FIBER-OPTIC PROBE 审中-公开
标题翻译：深度选择性光纤探头
公开(公告)号：WO2012087754A1
公开(公告)日：2012-06-28
申请号：PCT/US2011/065226
申请日：2011-12-15
申请人： UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION , LIU, Yang
发明人： LIU, Yang
IPC分类号： G02B23/26 , A61B1/07 , G01N21/55
CPC分类号： A61B5/0084 , A61B1/00096 , A61B1/00167 , A61B1/0017 , A61B1/00188 , A61B1/07 , A61B5/0075 , A61B5/1455 , A61B5/443 , A61B5/444 , A61B2560/0233 , G01N21/474 , G01N2021/4742 , G01N2201/0639 , G02B6/32 , Y10T29/49826
摘要： Systems and methods that facilitate analysis of superficial tissue based at least in part on a depth-selective fiber optic probe are discussed herein. The depth-selective fiber optic probe can include an illumination fiber for providing light to the superficial tissue, a collection fiber for collected reflected light, a ball lens that couples the fibers, and a protective overtube that houses the ball lens and fibers. The distances between the ball lens and fibers and between the fibers can be optimized based on several factors, such as by minimizing the illumination spot size, maximizing the overlap between the illumination and collection spots, and based on the angle between the illumination and collection beams.
摘要翻译：本文中讨论了至少部分地基于深度选择性光纤探针来促进浅表组织分析的系统和方法。深度选择性光纤探针可以包括用于向表面组织提供光的照明光纤，用于收集的反射光的收集光纤，耦合光纤的球形透镜以及容纳球透镜和光纤的保护外套管。可以基于几个因素来优化球透镜和纤维之间以及纤维之间的距离，例如通过使照明光点尺寸最小化，使照明和收集点之间的重叠最大化，并且基于照明和收集光束之间的角度。

4. 发明申请

WO2004053429A2 TURBIDITY SENSOR 审中-公开
标题翻译：涡轮传感器
公开(公告)号：WO2004053429A2
公开(公告)日：2004-06-24
申请号：PCT/US2003/038948
申请日：2003-12-10
申请人： APPRISE TECHNOLOGIES, INC. , TOKHTUEV, Eugene , OWEN, Christopher , SKIRDA, Anatoly , SLOBODYAN, Viktor , GOIN, Jose
发明人： TOKHTUEV, Eugene , OWEN, Christopher , SKIRDA, Anatoly , SLOBODYAN, Viktor , GOIN, Jose
IPC分类号： G01D
CPC分类号： G01N21/53 , G01N2201/0639
摘要： A turbidity sensor for underwater measurements is provided with a watertight housing, a light emitting diode, a first light focusing device for focusing a light emitted from the diode and passing the focused light into to-be-measured water, a second light focusing device for collecting at least one scattered light resulted form the focused light when passing the water, a photodiode for receiving the collected light thereby generating electronic signals, and an electronic board for processing the electronic signals.
摘要翻译：用于水下测量的浊度传感器设置有防水壳体，发光二极管，用于聚焦从二极管发射的光并将聚焦光聚焦到待测量水中的第一光聚焦装置，用于在通过水时收集至少一个散射光形成聚焦光，用于接收收集的光从而产生电子信号的光电二极管，以及用于处理电子信号的电子板。

5. 发明申请

WO2013131017A1 MULTICHANNEL ANALYTICAL INSTRUMENTS FOR USE WITH SPECIMEN HOLDERS 审中-公开
标题翻译：多用途分析仪器与样品夹持器一起使用
公开(公告)号：WO2013131017A1
公开(公告)日：2013-09-06
申请号：PCT/US2013/028693
申请日：2013-03-01
申请人： LAXCO, INC.
发明人： CHEN, Cong, Liang , CASSADY, Kevin
IPC分类号： G01N37/00 , G01N21/00
CPC分类号： G01N21/0303 , G01N21/01 , G01N21/17 , G01N21/253 , G01N21/27 , G01N21/6452 , G01N2201/0639 , G01N2201/08 , G01N2201/0826 , G02B6/006 , G02B6/04 , G02B6/29388 , G02B6/32
摘要： An analytical instrument may have multiple distinct channels. Such may include one or more illumination sources and sensors. Illumination may be delivered to specific locations of a specimen holder, and returned illumination may be delivered to specific locations of a sensor array. Illumination may first pass a specimen, and a mirror or reflector may then return the illumination past the specimen. Optical splitters may be employed to couple pairs of fiber optics proximate a specimen holder. Such channels may further include a plurality of illumination sources positioned on one side of a specimen holder and a plurality of sensors on the other side. The plurality of sensor may capture image of a specimen and a spectrophotometer may concurrently scan the specimen. A plurality of specimens may be imaged and scanned in a single pass of a plurality of passes. Spherical or ball lenses may be placed in an optical path of the illumination to achieve a desired illumination pattern.
摘要翻译：分析仪器可能具有多个不同的通道。这样可以包括一个或多个照明源和传感器。照明可以被传送到样本保持器的特定位置，并且返回的照明可以被传送到传感器阵列的特定位置。照明可以首先通过样本，然后镜子或反射器可以使照射通过样本。可以使用光分路器将靠近样本保持器的成对的光纤耦合。这样的通道还可以包括位于样品架一侧的多个照明源和另一侧的多个传感器。多个传感器可以捕获样本的图像，并且分光光度计可以同时扫描样本。可以在多次通过的单次通过中对多个样本进行成像和扫描。球形或球形透镜可以放置在照明的光路中以实现期望的照明图案。

6. 发明申请

WO2010120603A3 A HIGH PRESSURE AND HIGH TEMPERATURE OPTICAL SPECTROSCOPY CELL 审中-公开
标题翻译：高压和高温光学光谱细胞
公开(公告)号：WO2010120603A3
公开(公告)日：2011-01-20
申请号：PCT/US2010030165
申请日：2010-04-07
申请人： SCHLUMBERGER SERVICES PETROL , SCHLUMBERGER CA LTD , SCHLUMBERGER HOLDINGS , SCHLUMBERGER TECHNOLOGY BV , PRAD RES & DEV LTD , SCHROEDER ROBERT , GRANT BILL , ANGELESCU DAN
发明人： SCHROEDER ROBERT , GRANT BILL , ANGELESCU DAN
IPC分类号： G01N21/25 , G01N21/31 , G01N35/08
CPC分类号： G01J3/0291 , G01J3/02 , G01J3/0208 , G01J3/0218 , G01J3/0286 , G01N21/03 , G01N21/0303 , G01N21/0317 , G01N21/05 , G01N33/2823 , G01N2021/0346 , G01N2021/0392 , G01N2201/0639
摘要： Devices, methods and systems for making optical measurements of a fluid at elevated pressures and temperatures are disclosed. A cell is designed for the optical spectroscopic measurements of fluids or gas using light from ultra violet (UV) to far infrared wavelengths, among other wavelengths. A cell is described that is well suited for applications using very small fluid volumes, on the order of micro liters, such as microfluidic systems. Some described embodiments are suited for very high pressure and temperature environments (for example, 20kpsi or greater at 175 degree C or greater). Such conditions, for example, may be found in oilfield downhole environments. Some embodiments provide are inexpensive, and make use of replaceable lenses that are used as a pressure barrier and for collimation of the optical beam path for spectroscopic measurements.
摘要翻译：公开了用于在升高的压力和温度下对流体进行光学测量的装置，方法和系统。一个电池被设计用于使用从紫外线（UV）到远红外波长的光以及其他波长的流体或气体的光谱测量。描述了一种非常适合使用非常小的流体体积（微升量级）如微流体系统的应用的电池。一些描述的实施例适用于非常高的压力和温度环境（例如，在175℃或更高的温度下为20kpsi或更高）。例如，这些条件可以在油田井下环境中找到。一些实施例提供的是便宜的，并且使用用作压力屏障的可替换透镜和用于光束测量的光束路径的准直。

7. 发明申请

WO0004366A9 DETECTOR AND SCREENING DEVICE FOR ION CHANNELS 审中-公开
标题翻译：用于离子通道的检测器和筛选装置
公开(公告)号：WO0004366A9
公开(公告)日：2000-06-02
申请号：PCT/US9916170
申请日：1999-07-16
申请人： AURORA BIOSCIENCES CORP
发明人： TSIEN ROGER Y , COASSIN PETER J , PHAM ANDREW A , HAROOTUNIAN ALEC TATE , VUONG MINH
IPC分类号： G01N21/64 , G01N1/00 , G01N21/03 , G01N21/25 , G01N35/02 , G01N37/00 , G02B6/04 , G01N1/10 , G01N21/29 , G01N21/47
CPC分类号： G01N21/6452 , G01N2021/6419 , G01N2021/6421 , G01N2021/6478 , G01N2021/6484 , G01N2201/0639
摘要： The invention provides for a detector assembly, fiber assembly (204) and screening system for optical measurements. The invention includes a method of simultaneously measuring at least two optical properties of emitted light from at least one sample in a plurality of addressable wells (206) of a multiwell plate. The method including: aligning the wells of the plate to a plurality of ball lenses (205), directing electromagnetic radiation from an appropriate light source (201) coaxially through the symmetry axis of each ball lens, and detecting emitted light focused by the ball lenses from the sample.
摘要翻译：本发明提供了用于光学测量的检测器组件，光纤组件（204）和筛选系统。本发明包括同时测量来自多孔板的多个可寻址孔（206）中的至少一个样品的发射光的至少两种光学性质的方法。该方法包括：将板的孔与多个球透镜（205）对准，将来自适当光源（201）的电磁辐射同轴地穿过每个球透镜的对称轴线，并检测由球透镜聚焦的发射光从样品。

8. 发明申请

WO2017191118A1 SYSTEM AND METHOD FOR MONITORING REAGENT CONCENTRATIONS 审中-公开
标题翻译：监测试剂浓度的系统和方法
公开(公告)号：WO2017191118A1
公开(公告)日：2017-11-09
申请号：PCT/EP2017/060387
申请日：2017-05-02
申请人： VENTANA MEDICAL SYSTEMS, INC. , F. HOFFMANN-LA ROCHE AG
发明人： ALKANDRY, Emily S. , GILCHRIST, Collin Andrew , HERNANDEZ, Jamie L. , ILES, Shawn M. , JONES, Lisa A. , KOZIKOWSKI, III, Raymond Thomas , MOYA, Pete , TOTH, Tyler , WHITTIER, Danton Xixo
IPC分类号： G01N21/27 , G01N21/41 , G01N21/43 , G01N21/552 , G01N21/75
CPC分类号： G01N21/552 , G01N1/312 , G01N21/272 , G01N21/4133 , G01N21/43 , G01N21/75 , G01N2021/1731 , G01N2201/025 , G01N2201/0612 , G01N2201/0639
摘要： The present invention relates to a system and method for monitoring changes in reagent concentration, and in particular, to a system and method for monitoring for changes in reagent concentrations within small volumes of liquids in contact with a biological sample (908) disposed on a substrate such as a microscope slide (906) using a refractometer based on the reflection of a laser beam (900) coupled to the sample (908) via a prism (904).
摘要翻译：本发明涉及用于监测试剂浓度变化的系统和方法，具体涉及用于监测与生物体接触的少量液体内的试剂浓度变化的系统和方法基于经由棱镜（904）耦合到样本（908）的激光束（900）的反射，使用折射计设置在诸如显微镜载玻片（906）的衬底上的样本（908）。

9. 发明申请

WO2016066156A3 MOBILE PHOTOMETRIC MEASURING APPARATUS AND METHOD FOR MOBILE PHOTOMETRIC MEASUREMENT ON MICROTITER PLATES 审中-公开
标题翻译：移动式光度测量装置及微调板移动式光度测量方法
公开(公告)号：WO2016066156A3
公开(公告)日：2016-06-23
申请号：PCT/DE2015100425
申请日：2015-10-13
申请人： CHRISTIAN ALBRECHTS UNIVERSITÄT ZU KIEL
发明人： NAZIRIZADEH YOUSEF , GERKEN MARTINA , METZ PHILIPP , KARROCK TORBEN
IPC分类号： G01N21/64 , G01N21/77
CPC分类号： G01N21/253 , G01N21/6452 , G01N21/7743 , G01N2021/7776 , G01N2021/7786 , G01N2201/0221 , G01N2201/024 , G01N2201/0639
摘要： The invention relates to a mobile photometric measuring apparatus, comprising: at least one measuring module consisting of a light source, a detector and an optical structure comprising a lens system with integrated filter properties or a lens system and at least one filter, said components being arranged wired on a circuit board, in a housing and/or a component. The invention further relates to a mobile photometric measuring method on microtiter plates with grid sensors.
摘要翻译：本发明涉及一种移动光度测量设备，包括：至少一个测量模块，包括光源，检测器和一个光学框架与光学系统与内置滤波器特性或光学器件和至少一个过滤器，在电路板上的这些部件在壳体中和/或互相连接一块。此外，本发明涉及在具有光栅传感器的微量滴定板上的移动式光度测量方法。

10. 发明申请

WO2016020831A1 SYSTEM FOR OPTICAL DETECTION AND IMAGING OF SUB-DIFFRACTION-LIMITED NANO-OBJECTS 审中-公开
标题翻译：子衍射有限公司纳米对象的光学检测和成像系统
公开(公告)号：WO2016020831A1
公开(公告)日：2016-02-11
申请号：PCT/IB2015/055891
申请日：2015-08-03
申请人： ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE (EPFL)
发明人： YANG, Hui , CORNAGLIA, Matteo , GIJS, Martin
IPC分类号： G01N21/03 , G01N21/05 , G01N21/64 , B01L3/00 , G01N15/14
CPC分类号： G01N21/05 , B01L3/502715 , B01L3/502761 , B01L2200/0647 , B01L2300/0654 , G01N15/1434 , G01N15/1459 , G01N15/1484 , G01N21/0303 , G01N2015/0038 , G01N2021/0346 , G01N2021/6478 , G01N2201/0639
摘要： Nano-objects (8) with feature size smaller than the classical Abbe's diffraction limit can be optically detected via a microlens (4) array configured in a miniaturized microfluidic device. A hydrophilic microwell (3) array in a hydrophobic layer (2) is firstly fabricated by standard microfabrication processes. Dielectric microspheres (4) with high refractive index are used as microlenses and patterned inside the hydrophilic microwells (3) resulting in a microlens array format with high uniformity over a large surface area. These microlenses (4) focus the illuminating light into a region that is referred to as a photonic nanojet (6), which is characterized by a high optical intensity and sub-diffraction transverse dimension. The microlens array is integrated with a microfluidic channel (9), where a fluid medium (7) with nano-objects (8) is present. When the nano-objects (8) pass through the photonic nanojet (6), the retroreflected light from the microsphere-nano-object ensemble is highly enhanced and measured by an optical signal detection component (11) (conventional optical microscope, etc.), and the enhancement of the retroreflected light is very sensitive to the size of the nano-objects (8). Therefore, not only the existence of the nano-objects (8) can be qualitatively monitored, but also the size of these nano-objects can be quantitatively determined by the proposed technique.
摘要翻译：特征尺寸小于经典阿贝衍射极限的纳米物体（8）可以通过微型微流体装置中配置的微透镜（4）阵列进行光学检测。疏水层（2）中的亲水微孔（3）阵列首先通过标准微细加工工艺制造。具有高折射率的介电微球（4）用作微透镜并在亲水性微孔（3）内图案化，导致在大表面积上具有高均匀性的微透镜阵列格式。这些微透镜（4）将照明光聚焦到被称为光子纳米喷墨（6）的区域中，其特征在于高光强度和亚衍射横向尺寸。微透镜阵列与微流体通道（9）集成，其中存在具有纳米对象（8）的流体介质（7）。当纳米物体（8）通过光子纳米喷墨（6）时，通过光信号检测元件（11）（常规光学显微镜等）高度提高来自微球 - 纳米物体集合体的反射光，，并且反射光的增强对纳米物体的尺寸非常敏感（8）。因此，不仅可以定性地监测纳米物体（8）的存在，而且可以通过所提出的技术定量地确定这些纳米物体的尺寸。

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