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1. 发明申请

WO0178893A9 FLUIDIC IMPEDANCES IN MICROFLUIDIC SYSTEM 审中-公开
标题翻译：微流控系统中的流体阻碍
公开(公告)号：WO0178893A9
公开(公告)日：2002-07-04
申请号：PCT/US0112244
申请日：2001-04-13
申请人： NANOSTREAM INC , O'CONNOR STEPHEN D , DANTSKER GENE , PEZZUTO MARCI
发明人： O'CONNOR STEPHEN D , DANTSKER GENE , PEZZUTO MARCI
IPC分类号： G01N37/00 , B01J19/00 , B01L3/00 , B81B1/00 , B81C1/00 , F15C1/02 , F15C5/00 , F15D1/02 , F16K99/00
CPC分类号： B01L3/502738 , B01L3/502746 , B01L2200/0605 , B01L2200/0621 , B01L2300/0816 , B01L2300/0864 , B01L2300/0874 , B01L2300/0887 , B01L2400/0415 , B01L2400/0487 , B01L2400/0688 , F15C1/02 , F15D1/02 , F16K99/0001 , F16K99/0017 , F16K99/0028 , F16K99/0049 , F16K99/0055 , F16K99/0057 , F16K2099/008 , Y10T137/0491 , Y10T137/2191 , Y10T137/2224 , Y10T137/598 , Y10T137/8242 , Y10T137/86035
摘要： The invention provides microfluidic devices with embedded fluidic impedances. Such impedancesdo not allow fluid to pass at a low differential pressure, but allow fluid to flow at a higher differential pressure. Impedances are formed by the three dimensional overlap of two or more channels contained within layers of the device. Such devices can be rapidly protyped and can be assembled to contain multiple fluidic impedances to perform complex fluid handling tasks, including metering defined volumes of samples and dividing samples into aliquots.
摘要翻译：本发明提供具有嵌入式流体阻抗的微流体装置。这种阻抗不允许流体在低压差下通过，而是允许流体以较高的压差流动。通过包含在器件的层内的两个或更多个沟道的三维重叠形成阻抗。这样的装置可以快速制成并且可以被组装成包含多个流体阻抗以执行复杂的流体处理任务，包括计量定义的体积的样品并将样品分成等分试样。

2. 发明申请

WO02094441A3 FLUIDIC SYSTEMS WITH NON-PLANAR MICROFLUIDIC DEVICES 审中-公开
标题翻译：具有非平面微流体装置的流体系统
公开(公告)号：WO02094441A3
公开(公告)日：2003-04-10
申请号：PCT/US0218357
申请日：2002-05-14
申请人： NANOSTREAM INC , KARP CHRISTOPH D , GUSTAFSON VINCENT K , O'CONNOR STEPHEN D , HOBBS STEVEN E
发明人： KARP CHRISTOPH D , GUSTAFSON VINCENT K , O'CONNOR STEPHEN D , HOBBS STEVEN E
IPC分类号： B01L3/00 , B01L3/02 , B81B1/00 , G01N35/10 , B01J19/00 , G01N27/447
CPC分类号： B01L3/0217 , B01L3/5027 , B01L3/502707 , B01L2300/0816 , B01L2300/0861 , B01L2300/0887 , B01L2300/123 , B01L2400/0487 , G01N2035/1062 , Y10T436/11 , Y10T436/117497 , Y10T436/118339 , Y10T436/2575
摘要： A fluidic system includes a vessel 250 having at least one nonplanar wall 253 defining a first aperture 252 therein and a microfluidic device having a port 220, wherein at least a portion of the microfluidic device 200 conforms to at least a portion of the nonplanar wall 253, with the port being co-located with the aperture 252to fluidically couple the device to the vessel. Various embodiments are directed to coupling microfluidic devices with syringes, vials, and pipes. Microfluidic devices may be fabricated constructed with stencil layers. Flexible materials are preferred, including materials having one or self-adhesive surfaces including adhesive tapes. Certain embodiments provide continuously wrapped, rewindable, and/or detachable microfluidic devices.
摘要翻译：流体系统包括容器250，容器250具有至少一个在其中限定第一孔252的非平面壁253和具有端口220的微流体装置，其中微流体装置200的至少一部分符合非平面壁253的至少一部分，其中端口与孔252共同定位，以将装置流体地耦合到容器。各种实施例涉及将微流体装置与注射器，小瓶和管道连接。微流体装置可以用模板层制造。柔性材料是优选的，包括具有一个或自粘表面的材料，包括胶带。某些实施例提供连续包裹的，可重新缠绕的和/或可拆卸的微流体装置。

3. 发明申请

WO02055198A3 MICROFLUIDIC FLOW CONTROL DEVICES 审中-公开
标题翻译：微流控流量装置
公开(公告)号：WO02055198A3
公开(公告)日：2003-03-13
申请号：PCT/US0142981
申请日：2001-11-06
申请人： NANOSTREAM INC , O'CONNOR STEPHEN D , KARP CHRISTOPH D , DANTSKER EUGENE
发明人： O'CONNOR STEPHEN D , KARP CHRISTOPH D , DANTSKER EUGENE
IPC分类号： B01L3/00 , B81B3/00 , F15C5/00 , F16K99/00 , B01J19/00 , F16K7/17
CPC分类号： B01L3/5025 , B01L3/502707 , B01L3/50273 , B01L3/502738 , B01L2200/0689 , B01L2300/0816 , B01L2300/0874 , B01L2300/0887 , B01L2300/123 , B01L2300/14 , B01L2400/0481 , B01L2400/0487 , B01L2400/0622 , B01L2400/0638 , B01L2400/0655 , F16K99/0001 , F16K99/0015 , F16K99/0028 , F16K99/0044 , F16K99/0046 , F16K99/0051 , F16K99/0055 , F16K99/0059 , F16K99/0061 , F16K2099/0074 , F16K2099/0076 , F16K2099/0078 , F16K2099/008 , Y10T137/2496 , Y10T137/2559 , Y10T137/2663 , Y10T137/87249
摘要： Various microfluidic flow control devices are provided. In one embodiment, a regulating device includes overlapping channel segments (139,143) separated by a deformable membrane (133) in fluid communication with one another. In another embodiment, a normally open microfluidic valve provides latching valve operation with at least one adhesive surface. A stencil-based microfluidic valve may be operated by deforming a membrane against a seating surface to prevent flow through an aperture. Configurable microfluidic devices permit flow control among an interconnected microfluidic channel network. Magnetic elements may be integrated into flexible membranes to provide magnetically actuated microfluidic flow control device.
摘要翻译：提供各种微流控流量控制装置。在一个实施例中，调节装置包括由可变形膜（133）分开的彼此流体连通的重叠通道段（139,143）。在另一个实施例中，常开微流体阀提供至少一个粘合剂表面的闭锁操作。基于模板的微流体阀可以通过使膜抵靠阀座表面变形来防止流过孔。可配置的微流体装置允许在互连的微流体通道网络之间进行流量控制。磁性元件可以集成到柔性膜中以提供磁致动微流体流量控制装置。

4. 发明申请

WO2005062340A3 HIGH THROUGHPUT SYSTEMS AND METHODS FOR PARALLEL SAMPLE ANALYSIS 审中-公开
标题翻译：高通量系统和并行样品分析方法
公开(公告)号：WO2005062340A3
公开(公告)日：2006-07-06
申请号：PCT/US2004023980
申请日：2004-07-23
申请人： NANOSTREAM INC , HOBBS STEVEN E , O'CONNOR STEPHEN D , GAMBLE RONALD C
发明人： HOBBS STEVEN E , O'CONNOR STEPHEN D , GAMBLE RONALD C
IPC分类号： H01J49/00 , B01J19/00 , B01L3/00 , G01N30/60 , G01N30/72 , H01J49/02 , H01J49/04
CPC分类号： G01N30/6043 , B01L3/5027 , G01N30/6095 , G01N30/72 , H01J49/009 , H01J49/04
摘要： Systems and methods for analyzing multiple samples in parallel using mass spectrometry preferably coupled with fluid phase separation techniques are provided. A modular mass spectrometer includes a vacuum enclosure, multiple sample inlets, multiple common vacuum pumping elements, and multiple mass analysis modules disposed substantially within the enclosure, with each module preferably including a mass analyzer and a transducer. In one embodiment, the modules mate with the vacuum enclosure to define multiple sequential vacuum regions, with each vacuum region having an associated common vacuum pumping element. At least one multi-pole ion transfer optic element is preferably associated with each module. Fluid phase separation devices for use with a multi-analyzer spectrometer may include microfluidic devices utilizing chromatographic, electrophoretic, or other separation methods to process raw samples into prepared samples to be ionized and injected into a multi-channel mass spectrometer.
摘要翻译：提供了使用优选与流体相分离技术结合的质谱分析多个样品并行的系统和方法。模块化质谱仪包括真空外壳，多个样品入口，多个共同的真空抽吸元件和基本上设置在外壳内的多个质量分析模块，每个模块优选地包括质量分析器和换能器。在一个实施例中，模块与真空外壳配合以限定多个连续的真空区域，每个真空区域具有相关联的共同真空泵送元件。至少一个多极离子转移光学元件优选地与每个模块相关联。用于多分析仪光谱仪的流体相分离装置可以包括利用色谱，电泳或其它分离方法的微流体装置，以将原始样品处理成待离子化并注入多通道质谱仪的制备样品。

5. 发明申请

WO0211888A3 FLUIDIC MIXER IN MICROFLUIDIC SYSTEM 审中-公开
标题翻译：微流控系统中的流体混合器
公开(公告)号：WO0211888A3
公开(公告)日：2003-01-03
申请号：PCT/US0124521
申请日：2001-08-03
申请人： NANOSTREAM INC
发明人： O'CONNOR STEPHEN D , KARP CHRISTOPH
IPC分类号： B01D17/00 , B01F5/06 , B01F13/00 , B01L3/00 , B81B1/00 , G01N35/00
CPC分类号： B01D17/00 , B01D17/0208 , B01D17/08 , B01F5/0604 , B01F13/0059 , B01L3/5027 , B01L3/502707 , B01L2300/0816 , B01L2300/0864 , B01L2300/0867 , B01L2300/0874 , B01L2300/0887 , B01L2300/165 , B01L2400/0406 , B01L2400/0487 , B81B1/002 , B81B2201/051 , G01N2035/00237 , G01N2035/00544 , Y10T137/2191 , Y10T137/2224 , Y10T137/8122 , Y10T428/24562 , Y10T428/24744
摘要： Microfluidic devices capable of efficiently mixing one or more fluids are described. Two or more microfluidic channels within the device meet at an overlap region. The overlap region may be in fluid communication with an outlet channel. The inlet channels are disposed within different layers of a three dimension device. Microfluidic separators for separating multiphase fluids are also described. In this case, a multiphase fluid flows through an inlet channel into an overlap region from where the separated phases can be withdrawn through outlet channels. Also provided are methods for mixing and separating fluids in such devices.
摘要翻译：描述了能够有效混合一种或多种流体的微流体装置。装置内的两个或更多个微流体通道在重叠区域处相遇。重叠区域可以与出口通道流体连通。入口通道布置在三维装置的不同层中。还描述了用于分离多相流体的微流体分离器。在这种情况下，多相流体通过入口通道流入重叠区域，从重叠区域分离的相可以通过出口通道取出。还提供了用于在这种装置中混合和分离流体的方法。

6. 发明申请

WO0171311A3 ELECTROSTATIC SYSTEMS AND METHODS FOR DISPENSING DROPLETS 审中-公开
标题翻译：静电系统和分配方法
公开(公告)号：WO0171311A3
公开(公告)日：2002-05-02
申请号：PCT/US0108677
申请日：2001-03-16
申请人： NANOSTREAM INC
发明人： O'CONNOR STEPHEN D , DANTSKER GENE , GAMBLE RONALD C
IPC分类号： B01F15/02 , B01J19/00 , B01L3/02 , B05B5/025 , C40B60/14 , G01N35/10
CPC分类号： B01L3/0268 , B01F15/0241 , B01F2015/0221 , B01J19/0046 , B01J2219/00317 , B01J2219/00358 , B01J2219/00369 , B01J2219/00371 , B01J2219/00378 , B01J2219/00527 , B01J2219/00585 , B01J2219/00596 , B01J2219/00605 , B01J2219/00612 , B01J2219/00621 , B01J2219/00628 , B01J2219/00637 , B01J2219/00653 , B01J2219/00659 , B01J2219/00713 , B01J2219/0072 , B05B5/0255 , C40B60/14 , G01N35/1074 , G01N2035/1034 , G01N2035/1041
摘要： In accordance with the present invention there is provided an apparatus for electrostatically dispensing small volumes of biological or chemical material from a dispensing tip or array of dispensing tips. The apparatus includes a voltage generator, a dispensing head containing the liquid to be dispensed, and an electrode that is in electrical communication with the liquid such that when a voltage pulse is applied to the electrode, the liquid is dispensed from the dispensing head onto a receptacle. The apparatus also can include an electrostatically charged counterplane and can include a guard shield. The invention also provides for means for movement of the dispensing apparatus and the receptacle relative to each other. The invention also provides methods for dispensing fluids onto a receptacle surface, including 96-, 384- and 1536-well plates.
摘要翻译：根据本发明，提供了一种用于从分配尖端或分配尖端阵列静电分配小体积的生物或化学材料的设备。该装置包括电压发生器，包含待分配液体的分配头和与液体电连通的电极，使得当电压脉冲施加到电极时，液体从分配头分配到容器。该装置还可以包括静电充电的对面板，并且可以包括防护罩。本发明还提供了用于使分配装置和容器相对于彼此移动的装置。本发明还提供了将流体分配到容器表面上的方法，包括96孔，384孔和1536孔板。

7. 发明申请

WO02083310A8 MICROFLUIDIC METERING SYSTEMS AND METHODS 审中-公开
标题翻译：微流量计系统及方法
公开(公告)号：WO02083310A8
公开(公告)日：2003-05-01
申请号：PCT/US0131790
申请日：2001-10-12
申请人： NANOSTREAM INC , O'CONNOR STEPHEN D , KARP CHRISTOPH D , PEZZUTO MARCI , DANTSKER EUGENE
发明人： O'CONNOR STEPHEN D , KARP CHRISTOPH D , PEZZUTO MARCI , DANTSKER EUGENE
IPC分类号： B01L3/00 , B01L3/02 , B81B1/00 , C40B60/14 , G01N35/08
CPC分类号： G01N35/08 , B01J2219/00315 , B01L3/0241 , B01L3/5027 , B01L3/502707 , B01L3/502738 , B01L2200/0605 , B01L2200/0621 , B01L2200/0673 , B01L2300/0816 , B01L2300/0864 , B01L2300/0874 , B01L2300/0887 , B01L2400/0406 , B01L2400/0487 , C40B60/14
摘要： Microfluidic devices capable of metering fluid flow are provided. Devices and methods for trunk-branch metering of fluid plugs in which one or more branch channels of defined volume are metered from a bulk fluid are described. Also described are the metering of at least one discrete plug by selecting the supply conditions of a first and a second fluid to a microfluidic channel. The first fluid may be a liquid and the second fluid a gas. Reduced-area channel segments are provided to assist with metering one or more discrete fluid plugs. In another aspect, a microfluidic volume is metered by filling a microfluidic chamber with fluid, sealing an inlet channel, and then extracting the fluid.
摘要翻译：提供了能够计量流体流量的微流体装置。描述了流体塞的中继分支计量的装置和方法，其中从体积流体计量一个或多个限定体积的分支通道。还描述了通过选择第一和第二流体对微流体通道的供应条件来测量至少一个离散塞。第一流体可以是液体，第二流体是气体。提供减小区域通道段以帮助计量一个或多个离散流体塞。在另一方面，通过用流体填充微流体室，密封入口通道，然后提取流体来计量微流体体积。

8. 发明申请

WO0230560A3 FLUIDIC COUPLERS AND MODULAR MICROFLUIDIC SYSTEMS 审中-公开
标题翻译：流体耦合器和模块化微流体系统
公开(公告)号：WO0230560A3
公开(公告)日：2003-01-16
申请号：PCT/US0131563
申请日：2001-10-11
申请人： NANOSTREAM INC , O'CONNOR STEPHEN D , DANTSKER EUGENE , KARP CHRISTOPH D , PEZZUTO MARCI
发明人： O'CONNOR STEPHEN D , DANTSKER EUGENE , KARP CHRISTOPH D , PEZZUTO MARCI
IPC分类号： B01L3/00 , B81B1/00 , G01N35/00 , G01N35/10 , B81B7/00 , B81C3/00
CPC分类号： B01L3/5027 , B01L3/502707 , B01L2200/027 , B01L2300/0887 , B01L2400/0487 , G01N35/10 , G01N2035/00326 , Y10T137/2224
摘要： A modular microfluidic system including a plurality of discrete microfluidic modules and at least one microfluidic coupling device for communicating fluid between the modules is described. The microfluidic modules and coupling devices may be constructed according to various techniques. Each coupling device is fabricated from multiple layers and includes a fluidic inlet port, a fluidic outlet port, and at least one sandwiched stencil layer having a microfluidic channel formed therein. Also described are integrated microfluidic systems capable of performing various functions.
摘要翻译：描述了包括多个离散微流体模块和用于在模块之间连通流体的至少一个微流体耦合装置的模块化微流体系统。微流体模块和耦合装置可以根据各种技术构造。每个联接装置由多个层制成并且包括流体入口端口，流体出口端口以及在其中形成有微流体通道的至少一个夹层模板层。还描述了能够执行各种功能的集成微流体系统。

9. 发明申请

WO02083310A2 MICROFLUIDIC METERING SYSTEMS AND METHODS 审中-公开
标题翻译：微流量计系统及方法
公开(公告)号：WO02083310A2
公开(公告)日：2002-10-24
申请号：PCT/US0131790
申请日：2001-10-12
申请人： NANOSTREAM INC , O'CONNOR STEPHEN D , KARP CHRISTOPH D , PEZZUTO MARCI , DANTSKER EUGENE
发明人： O'CONNOR STEPHEN D , KARP CHRISTOPH D , PEZZUTO MARCI , DANTSKER EUGENE
IPC分类号： B01L3/00 , B01L3/02 , B81B1/00 , C40B60/14 , G01N35/08
CPC分类号： G01N35/08 , B01J2219/00315 , B01L3/0241 , B01L3/5027 , B01L3/502707 , B01L3/502738 , B01L2200/0605 , B01L2200/0621 , B01L2200/0673 , B01L2300/0816 , B01L2300/0864 , B01L2300/0874 , B01L2300/0887 , B01L2400/0406 , B01L2400/0487 , C40B60/14
摘要： Microfluidic devices capable of metering fluid flow are provided. Devices and methods for trunk-branch metering of fluid plugs in which one or more branch channels of defined volume are metered from a bulk fluid are described. Also described are the metering of at least one discrete plug by selecting the supply conditions of a first and a second fluid to a microfluidic channel. The first fluid may be a liquid and the second fluid a gas. Reduced-area channel segments are provided to assist with metering one or more discrete fluid plugs. In another aspect, a microfluidic volume is metered by filling a microfluidic chamber with fluid, sealing an inlet channel, and then extracting the fluid.
摘要翻译：提供了能够计量流体流量的微流体装置。描述了流体塞的中继分支计量的装置和方法，其中从体积流体计量一个或多个限定体积的分支通道。还描述了通过选择第一和第二流体对微流体通道的供应条件来测量至少一个离散塞。第一流体可以是液体，第二流体是气体。提供减小区域通道段以帮助计量一个或多个离散流体塞。在另一方面，通过用流体填充微流体室，密封入口通道，然后提取流体来计量微流体体积。

10. 发明申请

WO0228160A3 MICROFLUIDIC DEVICES FOR HEAT TRANSFER 审中-公开
标题翻译：用于传热的微流体装置
公开(公告)号：WO0228160A3
公开(公告)日：2002-06-27
申请号：PCT/US0130659
申请日：2001-09-28
申请人： NANOSTREAM INC
发明人： O'CONNOR STEPHEN D , DANTSKER EUGENE
IPC分类号： B81B1/00 , G11B33/14 , H01L23/473 , H05K7/20
CPC分类号： H01L23/473 , B81B1/00 , F28F2260/02 , G11B33/1413 , H01L2924/0002 , H01L2924/00
摘要： In accordance with the present invention there is provided a microfluidic heat exchange system for cooling heat-generating components of electronic equipment, computers, lasers, analytical instruments, medical equipment and the like. Both direct contact and indirect contact microfluidic systems are described. Also described are microfluidic systems that incorporate remote heat rejection systems that may be located outside the body of the equipment that contains the heat generating components that need cooling.
摘要翻译：根据本发明，提供了一种用于冷却电子设备，计算机，激光器，分析仪器，医疗设备等的发热部件的微流体热交换系统。描述了直接接触和间接接触微流体系统。还描述了包含远程排热系统的微流体系统，所述远程排热系统可以位于包含需要冷却的发热部件的设备主体的外部。

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