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1. 发明申请

WO2013036493A1 ORTHOGONALLY REDUNDANT SENSOR SYSTEMS AND METHODS 审中-公开
标题翻译：正交冗余传感器系统和方法
公开(公告)号：WO2013036493A1
公开(公告)日：2013-03-14
申请号：PCT/US2012/053707
申请日：2012-09-04
申请人： MEDTRONIC MINIMED, INC. , SHAH, Rajiv , KRISTENSEN, Jesper Svenning , WOLFE, Katherine T. , AASMUL, Soren , BANSAL, Anubhuti
发明人： SHAH, Rajiv , KRISTENSEN, Jesper Svenning , WOLFE, Katherine T. , AASMUL, Soren , BANSAL, Anubhuti
IPC分类号： A61B5/00 , A61B5/1459 , A61B5/1473 , A61B5/1455 , G01N21/77
CPC分类号： A61B5/14532 , A61B5/0002 , A61B5/0004 , A61B5/14556 , A61B5/1459 , A61B5/1473 , A61B5/4839 , A61B5/6848 , A61B5/6849 , A61B5/742 , A61M5/1723 , A61M2230/201 , G01N21/6408 , G01N21/6428 , G01N21/7703 , G01N33/66 , G01N2021/6441 , G01N2021/6484 , G01N2021/772 , G01N2021/7733 , G01N2021/775 , G01N2021/7759 , G01N2021/7786 , G01N2333/4724
摘要： A continuous glucose monitoring system may include a hand-held monitor, a transmitter, an insulin pump, and an orthogonally redundant glucose sensor, which may comprise an optical glucose sensor and a non-optical glucose sensor. The former may be a fiber optical sensor, including a competitive glucose binding affinity assay with a glucose analog and a fluorophore-labeled glucose receptor, which is interrogated by an optical interrogating system, e.g., a stacked planar integrated optical system. The non-optical sensor may be an electrochemical sensor having a plurality of electrodes distributed along the length thereof. Proximal portions of the optical and electrochemical sensors may be housed inside the transmitter and operationally coupled with instrumentation for, e.g., receiving signals from the sensors, converting to respective glucose values, and communicating the glucose values. The sensors' distal portions may be inserted into a user's body via a single delivery needle and may be co-located inside the user's body.
摘要翻译：连续葡萄糖监测系统可以包括手持监视器，发射器，胰岛素泵和正交冗余葡萄糖传感器，其可以包括光学葡萄糖传感器和非光学葡萄糖传感器。前者可以是纤维光学传感器，其包括具有葡萄糖类似物和荧光团标记的葡萄糖受体的竞争性葡萄糖结合亲和力测定，其通过光学询问系统例如堆叠的平面集成光学系统进行询问。非光学传感器可以是具有沿其长度分布的多个电极的电化学传感器。光学和电化学传感器的近端部分可以容纳在发射器内部并且可操作地与仪器耦合，以便例如从传感器接收信号，转换成相应的葡萄糖值并传达葡萄糖值。传感器的远端部分可以经由单个输送针插入使用者的身体，并且可以位于使用者的身体内。

2. 发明申请

WO2012045046A2 ANALYTE SENSING SYSTEM AND METHOD UTILIZING SEPARATE EQUILIBRIUM AND MEASUREMENT CHAMBERS 审中-公开
标题翻译：分析感测系统和使用分离式均衡器和测量座的方法
公开(公告)号：WO2012045046A2
公开(公告)日：2012-04-05
申请号：PCT/US2011/054434
申请日：2011-09-30
申请人： UNIVERSITY OF MARYLAND BALTIMORE COUNTY , RAO, Govind , KOSTOV, Yordan , GE, Xudong , TOLOSA, Leah , LAM, Hung , HENDERSON, Robert
发明人： RAO, Govind , KOSTOV, Yordan , GE, Xudong , TOLOSA, Leah , LAM, Hung , HENDERSON, Robert
IPC分类号： G01N21/64 , A61B5/1455
CPC分类号： G01N21/643 , G01N21/77 , G01N21/78 , G01N31/223 , G01N33/1886 , G01N2021/7733 , G01N2021/7786 , G01N2201/0612 , G01N2201/062
摘要： An analyte sensing system is provided that utilizes separate and decoupled equilibrium and measurement chambers for improved sensitivity and stability. The system and method are particularly suited for monitoring of CO 2 levels in oceans or other bodies of water.
摘要翻译：提供了分析物传感系统，其利用分离的和去耦的平衡和测量室来提高灵敏度和稳定性。该系统和方法特别适用于监测海洋或其他水体中的二氧化碳水平。

3. 发明申请

WO2013036492A1 GLUCOSE SENSOR 审中-公开
标题翻译：葡萄糖传感器
公开(公告)号：WO2013036492A1
公开(公告)日：2013-03-14
申请号：PCT/US2012/053704
申请日：2012-09-04
申请人： MEDTRONIC MINIMED, INC. , AASMUL, Soren , KRISTENSEN, Jesper, Svenning , EJLERSEN, Henning, Munk
发明人： AASMUL, Soren , KRISTENSEN, Jesper, Svenning , EJLERSEN, Henning, Munk
IPC分类号： G01N21/64 , G01N21/77 , A61B5/145 , A61B5/1459
CPC分类号： A61B5/14532 , A61B5/0002 , A61B5/0004 , A61B5/14556 , A61B5/1459 , A61B5/1473 , A61B5/4839 , A61B5/6848 , A61B5/6849 , A61B5/742 , A61M5/1723 , A61M2230/201 , G01N21/6408 , G01N21/6428 , G01N21/7703 , G01N33/66 , G01N2021/6441 , G01N2021/6484 , G01N2021/772 , G01N2021/7733 , G01N2021/775 , G01N2021/7759 , G01N2021/7786 , G01N2333/4724
摘要： An optical glucose sensor may include an optical fiber and a glucose-permeable membrane having a hollow interior and being coupled to the optical fiber's distal end. The membrane's hollow interior provides a compartment to house a competitive glucose binding affinity assay. The assay may include a glucose analog that may be labeled with a dye, and a glucose receptor that may be labeled with a fluorophore. The optical fiber may include a compound parabolic concentrator tip, and the compartment may additionally house a reflector disposed so as to face the optical fiber's tip. A fluorophore-labeled assay may be interrogated by an optical interrogating system including a light source and a filter substrate having one or more coatings to effect, e.g., an excitation filter and/or an emission filter. The interrogating system may be manufactured as a stacked planar integrated optical system and diced into smaller units.
摘要翻译：光学葡萄糖传感器可以包括具有中空内部并耦合到光纤远端的光纤和葡萄糖透过膜。膜的中空内部提供了一个容纳竞争性葡萄糖结合亲和力测定的隔室。该测定可以包括可用染料标记的葡萄糖类似物和可用荧光团标记的葡萄糖受体。光纤可以包括复合抛物面聚光器尖端，并且隔室可另外容纳设置成面对光纤尖端的反射器。荧光团标记的测定可以由包括光源和具有一个或多个涂层的过滤器衬底的光学询问系统询问，以实现例如激发过滤器和/或发射过滤器。询问系统可以被制造为堆叠的平面集成光学系统并且被切成更小的单元。

4. 发明申请

WO2004090519A1 穀粒及び豆類の新鮮度測定方法及びその装置审中-公开
标题翻译：测量谷物和豆类及其食品的食品的方法
公开(公告)号：WO2004090519A1
公开(公告)日：2004-10-21
申请号：PCT/JP2003/004405
申请日：2003-04-07
申请人：株式会社サタケ , 三上隆司 , 川上晃司 , 越智龍彦
发明人：三上隆司 , 川上晃司 , 越智龍彦
IPC分类号： G01N21/78
CPC分类号： G01N21/314 , G01N21/78 , G01N21/80 , G01N33/10 , G01N2021/1751 , G01N2021/3166 , G01N2021/7733 , G01N2021/7783 , G01N2021/8466 , G01N2021/8592
摘要：　特定の試薬液が入った試験管内に穀粒を入れて撹拌して、出来た反応溶液をセルに入れる。そのセルに光を照射して、吸光度ピーク値を示す波長での吸光度と、吸光度がほとんど変化しない波長領域の吸光度とを検出する。そして、これら二つの吸光度の差に基づいて穀類及び豆類の新鮮度を判定する。
摘要翻译：将谷粒放入含有特定试剂溶液的试管中并搅拌。将由此获得的反应溶液引入电池。然后用光照射细胞，并检测出在吸光度几乎不变化的波长内的峰值吸光度和吸光度的波长处的吸光度。基于这些吸光度值之间的差异，判断谷物或豆的新鲜度。

5. 发明申请

WO1991003730A1 FLOW OPTRODE 审中-公开
标题翻译：流动门
公开(公告)号：WO1991003730A1
公开(公告)日：1991-03-21
申请号：PCT/US1990005054
申请日：1990-09-06
申请人： THE WASHINGTON RESEARCH FOUNDATION
发明人： THE WASHINGTON RESEARCH FOUNDATION , BURGESS, Lloyd, W., Jr.
IPC分类号： G01N21/63
CPC分类号： G01N21/643 , G01N21/75 , G01N21/76 , G01N21/7703 , G01N21/80 , G01N2021/0385 , G01N2021/1738 , G01N2021/174 , G01N2021/6434 , G01N2021/754 , G01N2021/7733 , G01N2021/7786 , G01N2201/06126 , G01N2201/0622 , G01N2201/08 , G01N2201/082 , Y10T436/117497 , Y10T436/25375 , Y10T436/255
摘要： There is disclosed a device capable of continuously measuring the presence and concentration of an analyte or analytes and a method for using said device in a liquid and/or a gas phase reaction volume. The inventive device comprises a sensor probe, a reservoir, and a detection means. The inventive device delivers reagent to the sensor probe in a flow method to directly and continuously renew reagent, thereby allowing the continuous measurement of the presence and the concentration of an analyte or analytes.
摘要翻译：公开了能够连续地测量分析物或分析物的存在和浓度的装置以及在液体和/或气相反应体积中使用所述装置的方法。本发明的装置包括传感器探针，储存器和检测装置。本发明的装置以流动方法将试剂递送到传感器探针，以直接和连续更新试剂，从而允许连续测量分析物或分析物的存在和浓度。

6. 发明申请

WO1990014590A1 DEVICES FOR USE IN CHEMICAL TEST PROCEDURES 审中-公开
标题翻译：用于化学测试程序的设备
公开(公告)号：WO1990014590A1
公开(公告)日：1990-11-29
申请号：PCT/GB1990000764
申请日：1990-05-17
申请人： ARES-SERONO RESEARCH & DEVELOPMENT LIMITED ... , ATTRIDGE, John, Worthington , SMITH, Alan, Martin
发明人： ARES-SERONO RESEARCH & DEVELOPMENT LIMITED ...
IPC分类号： G01N21/77
CPC分类号： G01N21/7703 , B01L3/5027 , B01L2300/0822 , B01L2300/168 , B01L2400/0406 , G01N21/6428 , G01N21/648 , G01N33/54373 , G01N2021/0346 , G01N2021/7733 , G01N2021/7786
摘要： The invention relates to a device for use in methods of assay, for example those involving fluorescent moieties. The device possesses a cavity or cavities into which sample liquid may be drawn by capillary action. Each cavity is formed from two transparent solid plates (35, 36): one (36) is adapted to act as a waveguide and carries a suitable immobilised reagent on its surface within the cavity; the other (35) carries on its external surface and optionally also on part only of its internal surface a layer of light-absorbing material (37). The invention also relates to a method of manufacturing devices according to the invention, and to a method of assaying for a ligand in a sample using a device according to the invention.

7. 发明申请

WO2016207361A1 METHOD AND DEVICE FOR DETECTING METAL ION RELEASE 审中-公开
标题翻译：用于检测金属离子释放的方法和装置
公开(公告)号：WO2016207361A1
公开(公告)日：2016-12-29
申请号：PCT/EP2016/064686
申请日：2016-06-24
申请人： DANMARKS TEKNISKE UNIVERSITET , HERLEV OG GENTOFTE HOSPITAL
发明人： JELLESEN, Morten, S. , THYSSEN, Jacob, Pontoppidan , OLSEN, Christian, Bang
IPC分类号： G01N31/22 , G01N27/42
CPC分类号： G01N31/22 , G01N21/78 , G01N2021/7733 , G01N2021/7766 , G01N2201/0221
摘要： The present invention relates to a method and a device for colorimetric detection of metal ion release from a metallic item.
摘要翻译：本发明涉及一种用于金属物质的金属离子释放的比色检测方法和装置。

8. 发明申请

WO2012090919A1 光センサ用チップ、光センサ、測定システムおよびそれを用いた測定方法审中-公开
标题翻译：光传感器，光传感器，测量系统和使用相同的测量方法的芯片
公开(公告)号：WO2012090919A1
公开(公告)日：2012-07-05
申请号：PCT/JP2011/080032
申请日：2011-12-26
申请人：ローム株式会社 , 国立大学法人東京医科歯科大学 , 浜地健次 , 三林浩二 , 工藤寛之
发明人：浜地　健次 , 三林　浩二 , 工藤　寛之
IPC分类号： G01N21/78 , C12M1/34
CPC分类号： G01N21/7703 , G01N2021/772 , G01N2021/7733
摘要：　本発明は、光ファイバー（１）と連結して使用される光センサ用チップ（２）であって、上記光ファイバー（１）の先端を覆う第１ガス透過性膜（２２）を備え、該第１ガス透過性膜（２２）の光ファイバー（１）と連結される側とは反対側の表面に液体が流れるようにするための液体チャンバ（２１）を備えることを特徴とする、光センサ用チップである。
摘要翻译：本发明是一种用于光传感器的芯片（2），该光传感器耦合到光纤（1）并与其一起使用，该光传感器芯片的特征在于包括：第一透气膜（22），用于覆盖光纤（1），并且包括用于使液体在与耦合到光纤（1）的一侧相反的一侧流到第一透气膜（22）的表面的液体室（21）。

9. 发明申请

WO1994000761A1 OPTICAL MEASUREMENT INSTRUMENT 审中-公开
标题翻译：光学测量仪器
公开(公告)号：WO1994000761A1
公开(公告)日：1994-01-06
申请号：PCT/JP1993000873
申请日：1993-06-25
申请人： DAIKIN INDUSTRIES, LTD. , TOSA, Kaori , HAMA, Yoshiyuki , YAMAMOTO, Kouichi , AKIYAMA, Ryuuji , YOSHIDA, Masakazu , YAGI, Hiroshi , SHIGEMORI, Kazuhisa , SAKAMOTO, Tomomi
发明人： DAIKIN INDUSTRIES, LTD.
IPC分类号： G01N33/543
CPC分类号： G01N21/648 , B01L3/508 , G01N21/03 , G01N2021/7733
摘要： A reaction vessel (24) and pre-treating vessels (21, 22, 23) are formed, and at least a part of partitioning walls of both of them is constituted as an optical waveguide body (11). An optical absorbent container (25) is formed adjacent to the reaction vessel (24) so that an optical measurement instrument can be formed integrally and a production process can be simplified. Because the optical absorbent is accommodated in the optical absorbent container (25), reflection components of excitation beams propagating through the optical waveguide body (11) and other optical noise components can be sufficiently reduced, and an S/N of optical measurement can be improved.
摘要翻译：形成反应容器（24）和预处理容器（21,22,23），并且它们的至少一部分分隔壁构成为光波导体（11）。与反应容器（24）相邻地形成光学吸收容器（25），从而能够整体地形成光学测量仪器，并且可以简化制造工序。由于光吸收剂容纳在光吸收容器25中，所以能够充分地减少通过光波导体11传播的激发光束的反射成分和其他光噪声成分，能够提高光学测量的S / N 。

10. 发明申请

WO1992008966A1 FLUORESCENCE ASSAY APPARATUS 审中-公开
标题翻译：荧光测定装置
公开(公告)号：WO1992008966A1
公开(公告)日：1992-05-29
申请号：PCT/US1991008390
申请日：1991-11-08
申请人： BLOCK, Myron, J.
发明人： LACKIE, Steve, J.
IPC分类号： G01N21/00
CPC分类号： G01N21/648 , G01N21/6428 , G01N21/7703 , G01N33/54373 , G01N2021/7733 , G01N2021/7786
摘要： A system for use with a totally internally reflecting fiber-optic fluorescent assay apparatus (20) overcomes the problems of discriminating against internally generated fluorescence arising in polymeric fibers. The system includes a disc (50) that can be moved to alternately block and unblock a central colinear conical portion of an input cone of excitation radiation directed into an input end (28) of the fiber (30), thereby periodically varying the numerical aperture at the sensing region of the fiber surface. By analyzing the signal values received when that numerical aperture is relatively high with respect to those received when that numerical aperture is relatively low, one can determine what portion of the fluorescence at the sensing region (44) on the fiber surface as distinguished from various background fluorescence.
摘要翻译：与全内反射光纤荧光测定装置（20）一起使用的系统克服了在聚合物纤维中产生的内部产生的荧光的区别问题。该系统包括盘（50），其可以被移动以交替地阻挡和解锁引导到光纤（30）的输入端（28）的激励辐射的输入锥的中心共弧锥形部分，从而周期性地改变数值孔径在纤维表面的感测区域。通过分析当该数值孔径相对于在该数值孔径相对较低时接收到的数值孔径相对较高时所接收到的信号值，可以确定纤维表面上的感测区域（44）的哪些部分与各种背景不同荧光。

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