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1. 发明申请

WO2004029673A8 IMPROVED DIAGNOSTIC FLUORESCENCE AND REFLECTANCE 审中-公开
标题翻译：改进的诊断荧光和反射
公开(公告)号：WO2004029673A8
公开(公告)日：2005-05-19
申请号：PCT/US0331036
申请日：2003-09-30
申请人： UNIV TEXAS , CHANG SUNG K , MIRABAL YVETTE , FOLLEN MICHELE , MALPICA ANAIS , UTZINGER URS , STAERKEL GREGG , COX DENNIS , ATKINSON E NEELY , MACAULAY CALUM , RICHARDS-KORTUM REBECCA , BC CANCER AGENCY
发明人： CHANG SUNG K , MIRABAL YVETTE , FOLLEN MICHELE , MALPICA ANAIS , UTZINGER URS , STAERKEL GREGG , COX DENNIS , ATKINSON E NEELY , MACAULAY CALUM , RICHARDS-KORTUM REBECCA
IPC分类号： A61B5/00 , G01N21/47 , G01N21/64
CPC分类号： G01N21/6486 , A61B5/0071 , A61B5/0075 , A61B5/0084 , A61B5/4331 , G01N21/474 , G01N2021/1734 , G01N2021/174 , G01N2021/4745 , G01N2021/6419 , G01N2021/6423 , G01N2021/6484
摘要： Systems and methods are described for improved diagnostic fluorescence and reflectance. A method of detecting tissue abnormality in a tissue sample in vivo detects a set of reflectance spectra emitted from a tissue sample as a result of illumination with an excitation light from a fiber optic probe that has at least one collection fiber positioned at a source-detector separation, and determining if the tissue sample is normal or abnormal based on the resulting reflectance spectra. Another method of detecting tissue abnormality in a tissue sample in vivo includes illuminating the tissue sample in vivo with at least one electromagnetic radiation wavelength selected to cause the tissue sample to produce a set of fluorescence intensity spectra indicative of tissue abnormality, detecting the resulting fluorescence intensity spectra, and determining if the tissue sample is normal or abnormal based on the resulting fluorescence intensity spectra. Yet another method of detecting tissue abnormality in a tissue sample in vivo includes combining the two methods described above.
摘要翻译：描述了用于改善诊断荧光和反射率的系统和方法。一种在体内检测组织样本中的组织异常的方法，检测由组织样本发射的一组反射光谱，该组由来自光纤探针的激发光照射而成，该光纤探针具有至少一个收集光纤位于源检测器分离，并根据所得的反射光谱确定组织样本是正常还是异常。在体内检测组织样本中的组织异常的另一种方法包括以选择的至少一个电磁辐射波长在体内照射组织样本，以使组织样品产生指示组织异常的一组荧光强度光谱，检测所得到的荧光强度光谱，并且基于所得荧光强度光谱确定组织样品是正常还是异常。在体内检测组织样本中的组织异常的另一种方法包括组合上述两种方法。

2. 发明申请

WO1991015867A1 RESERVOIR FIBER OPTIC CHEMICAL SENSORS 审中-公开
标题翻译：储存光纤化学传感器
公开(公告)号：WO1991015867A1
公开(公告)日：1991-10-17
申请号：PCT/US1991002181
申请日：1991-03-28
申请人： FIBERCHEM, INC.
发明人： FIBERCHEM, INC. , KLAINER, Stanley, M. , FRANK, Chet, A. , DANDGE, Dileep, K. , GOSWAMI, Kisholoy
IPC分类号： H01J05/16
CPC分类号： G01N21/7703 , G01N21/80 , G01N2021/0385 , G01N2021/1734 , G01N2021/1738 , G01N2021/174
摘要： Single and multi-cell reservoir FOCS configurations, with single or dual fibers (6) with optional optical elements (12), have a cross-flow arrangement of the sample relative to the fiber. A wide variety of sensors, including pH, arsenic, benzene cyanide, hydrazine, cupric ion, TCE, mercuric ion, and iron (2+) are provided.

3. 发明申请

WO2016083416A1 INTERGRATION OF FLUORESCENCE DETECTION CAPABILITY INTO LIGHT ABSORBANCE MEASUREMENT APPARATUS 审中-公开
标题翻译：荧光检测能力融入光吸收测量装置
公开(公告)号：WO2016083416A1
公开(公告)日：2016-06-02
申请号：PCT/EP2015/077567
申请日：2015-11-24
申请人： GE HEALTHCARE BIO-SCIENCES AB
发明人： EHRING, Hanno
IPC分类号： G01N21/05 , G01N21/64 , G01N21/31
CPC分类号： G01N21/645 , G01J3/42 , G01J3/4406 , G01J2003/421 , G01N21/05 , G01N21/33 , G01N2021/1736 , G01N2021/1738 , G01N2021/174 , G01N2021/6482 , G01N2021/6484 , G01N2021/6491 , G01N2201/0696
摘要： Disclosed is apparatus (1) for measuring fluorescence and absorbance of a substance in a sample, said apparatus (1) comprising: a flow cell (2) for containing a sample, a first light source (3), a first conductor (5) for transmitting light from the first light source (3) to the flow cell (2) for irradiating a sample contained therein, a second conductor (7) for transmitting light from the flow cell (2) to a sample detector (9) arranged to detect an electromagnetic radiation that has passed through said cell (2), and a processing unit (16) arranged to receive a first signal (31) from a reference detector (15) and a second signal (32) from the sample detector (9) and to determine an absorbance based on said first and second signals (31,32), said apparatus (1) further comprising a second light source (4), a third conductor (6) for transmitting light from the second light source (4) to the cell (2) and wherein the sample detector (9) is further arranged to also detect fluorescence signals in the light that has passed through the flow cell (2). The invention also relates to a method for measuring the absorbance and the fluorescence of a substance in a sample.
摘要翻译：公开了一种用于测量样品中物质的荧光和吸光度的装置（1），所述装置（1）包括：用于容纳样品的流动池（2），第一光源（3），第一导体（5）用于将来自第一光源（3）的光透射到用于照射其中所含样品的流通池（2），用于将来自流动池（2）的光传输到样品检测器（9）的第二导体（7）检测已经通过所述单元（2）的电磁辐射;以及处理单元（16），其布置成从参考检测器（15）接收第一信号（31）和从所述样本检测器（9）接收第二信号（32）），并且基于所述第一和第二信号（31,32）确定吸光度，所述设备（1）还包括第二光源（4），用于从第二光源（4）传输光的第三导体（6））到细胞（2），并且其中样品检测器（9）还被布置成还检测荧光信号在已经通过流通池（2）的光中。本发明还涉及一种用于测量样品中物质的吸光度和荧光的方法。

4. 发明申请

WO2015138044A1 COMBINED CHEMILUMINESCENCE AND ELISA AUTOMATED SAMPLE READER 审中-公开
标题翻译：组合型荧光素酶和ELISA自动样品阅读器
公开(公告)号：WO2015138044A1
公开(公告)日：2015-09-17
申请号：PCT/US2015/000037
申请日：2015-03-13
申请人： GOLD STANDARD DIAGNOSTICS
发明人： VAN PRAET, Peter , GRIFFITHS, John , ROTH, Jennifer , BENJAMIN, Karl
IPC分类号： G01N33/53 , G01N33/543
CPC分类号： G01N21/253 , G01N21/5907 , G01N21/76 , G01N35/109 , G01N2021/174 , G01N2035/0418
摘要： The automated reader operates within an enclosure also containing a sample rack and reagent rack, as well as a microtiter plate with multiple wells therein. The machine automatically loads sample and reagent into a well of the microtiter plate according to a testing protocol. The specimen can then be moved along with the microtiter plate into a slot of the reader and aligned with either a light source and detector for an optical density read or aligned with a photon counter for a chemiluminescence read. The reader includes a shroud assembly which can be raised and lowered by a lift assembly to occlude a read point from photons other than those emanating from the sample.
摘要翻译：自动读取器在还包含样品架和试剂架的外壳内以及其中具有多个孔的微量滴定板操作。机器根据测试方案自动将样品和试剂加载到微量滴定板的孔中。然后可以将样品与微量滴定板一起移动到读取器的狭槽中，并与光源和检测器对准，用于光密度读取或与用于化学发光读取的光子计数器对准。阅读器包括一个护罩组件，该护罩组件可由电梯组件升高和降低，从而从除样品之外的光子以外的光子中遮挡读点。

5. 发明申请

WO2007123555A3 TIME AND SPACE RESOLVED STANDOFF HYPERSPECTRAL IED EXPLOSIVES LIDAR DETECTOR 审中-公开
标题翻译：时间和空间分辨率高分辨率高分辨率激光雷达探测器
公开(公告)号：WO2007123555A3
公开(公告)日：2008-01-31
申请号：PCT/US2006022647
申请日：2006-06-09
申请人： CHEMIMAGE CORP , TREADO PATRICK J , NELSON MATTHEW P , HUBBLE HUGH W II , NEISS JASON
发明人： TREADO PATRICK J , NELSON MATTHEW P , HUBBLE HUGH W II , NEISS JASON
IPC分类号： G01N21/00 , G01J3/30 , G01J3/44
CPC分类号： G01J3/36 , G01J3/02 , G01J3/0221 , G01J3/0264 , G01J3/2823 , G01J3/44 , G01N21/359 , G01N21/6456 , G01N21/65 , G01N21/718 , G01N2021/1738 , G01N2021/174 , G01N2021/1744
摘要： A system and method for standoff detection of explosives and explosive residue. A laser light source illuminates a target area having an unknown sample producing luminescence emitted photons, scattered photons and plasma emitted photons. A first optical system directs light to the target area. A video capture device outputs a dynamic image of the target area. A second optical system collects photons, and directs collected photons to a first two-dimensional array of detection elements and/or to a fiber array spectral translator device which device includes a two-dimensional array of optical fibers drawn into a one-dimensional fiber stack. A spectrograph is coupled to the one-dimensional fiber stack of the fiber array spectral translator device, wherein the entrance slit of the spectrograph is coupled to the one dimensional fiber stack.
摘要翻译：爆炸物和爆炸物残留物检测的系统和方法。激光源照射具有未知样品的目标区域，产生发光的光子，散射的光子和等离子体发射的光子。第一光学系统将光引导到目标区域。视频采集装置输出目标区域的动态图像。第二光学系统收集光子，并将收集的光子引导到检测元件的第一二维阵列和/或光纤阵列光谱转换器装置，该装置包括被拉入一维光纤堆叠的光纤的二维阵列。光谱仪耦合到光纤阵列光谱转换器装置的一维光纤堆叠，其中光谱仪的入口狭缝耦合到一维光纤堆叠。

6. 发明申请

WO2018098260A1 DUAL FUNCTION FLUOROMETER-ABSORBANCE SENSOR 审中-公开
公开(公告)号：WO2018098260A1
公开(公告)日：2018-05-31
申请号：PCT/US2017/062991
申请日：2017-11-22
申请人： YSI, INC.
发明人： FLANAGAN, Kevin
IPC分类号： G01N1/10 , G01N21/00
CPC分类号： G01N21/64 , G01J3/42 , G01J3/4406 , G01N21/17 , G01N21/643 , G01N21/645 , G01N33/18 , G01N2021/174 , G01N2021/6419 , G01N2021/6491 , G01N2201/0627 , G02B5/20
摘要： A dual function fluorometer-absorbance sensor features an absorbance- based sensor configured to receive one part of an optical signal transmitted through a body of water of interest along an optical beam transmission path, and determine absorbance-based sensor signaling containing information about an absorbance of the optical signal by one or more absorbance species of interest present in the body of water; and a fluorescence-based sensor configured to receive another part of the optical signal transmitted through the body of water of interest along a corresponding optical beam transmission path that is perpendicular to the optical beam transmission path, and determine fluorescence-based sensor signaling containing information about a fluorescence transmitted by one or more fluorophore species of interest present in the body of water.

7. 发明申请

WO2011099137A1 食品の品質測定装置审中-公开
标题翻译：食品质量测量装置
公开(公告)号：WO2011099137A1
公开(公告)日：2011-08-18
申请号：PCT/JP2010/052027
申请日：2010-02-12
申请人：株式会社ユニソク , 長村俊彦 , 田村守
发明人：長村　俊彦 , 田村　守
IPC分类号： G01N21/17 , G01N21/64
CPC分类号： G01N21/6456 , G01N21/314 , G01N21/6486 , G01N2021/174
摘要：　本発明に係る食品の品質測定装置は、食品に対して波長域の異なる２種類の光を切り替えて照射する照明部と、前記食品からの反射光を受光して電気信号に変換することにより、前記２種類の光に対応する２種類の反射画像をそれぞれ取得する撮像部と、前記撮像部が取得した前記２種類の反射画像について、画素ごとに濃度の差分または蛍光強度を演算して濃度差画像または蛍光強度画像を取得する画像演算部と、前記濃度差画像または前記蛍光強度画像を可視像として出力する出力部と、を備えるものである。
摘要翻译：食品质量测量装置设置有照射单元，其在具有不同波长范围的两种类型的光之间切换并将光照射到食物上; 成像单元，用于通过接收来自食物的反射光并将光转换成电信号来分别获得与两种类型的光对应的两种类型的反射图像; 图像处理单元，用于通过对由所述摄像单元获得的两种类型的反射图像处理每个像素的浓度差或荧光强度来获得浓度差图像或荧光强度图像; 以及输出单元，用于作为可见图像输出浓度差图像或荧光强度图像。

8. 发明申请

WO1995022058A1 METHOD AND APPARATUS FOR DETECTION OF FLUORESCENTLY LABELED MATERIALS 审中-公开
标题翻译：用于检测荧光标签材料的方法和装置
公开(公告)号：WO1995022058A1
公开(公告)日：1995-08-17
申请号：PCT/US1995001886
申请日：1995-02-09
申请人： AFFYMAX TECHNOLOGIES N.V. , STERN, David , FIEKOWSKY, Peter , TRULSON, Mark
发明人： AFFYMAX TECHNOLOGIES N.V.
IPC分类号： G01N33/552
CPC分类号： G01N21/6458 , B01J2219/00605 , B01J2219/00612 , B01J2219/00659 , B01J2219/00702 , G01N21/6428 , G01N2021/174
摘要： Fluorescently marked targets bind to a substrate (230) synthesized with polymer sequences at known locations. The substrate (230) is mounted on an x-y-z translation table (240) during detection. The targets are detected by exposing selected regions of the substrate (230) to light from a light source (100) and detecting the light photons fluoresced therefrom, moving the substrate (230) position, and repeating the exposure and detection steps until the substrate (230) has been completely examined. The device includes a controller (190) for controlling the x-y-z translation table (240) movement for exposure of the selected regions of the substrate (230), the detection of the fluoresced light, and positioning of the substrate (230) to provide proper focusing of the light on the substrate (230) for maximum sensitivity. The resulting data can be used to determine binding affinity of the targets to the specific polymer sequences.
摘要翻译：荧光标记的靶结合到在已知位置处与聚合物序列合成的底物（230）。在检测期间，将衬底（230）安装在x-y-z平移台（240）上。通过将衬底（230）的选定区域暴露于来自光源（100）的光并检测从其发荧光的光子，移动衬底（230）位置并重复曝光和检测步骤直到衬底（ 230）已经完全检查。该装置包括控制器（190），用于控制用于曝光衬底（230）的选定区域的xyz平移台（240）运动，荧光灯的检测和衬底（230）的定位以提供适当的聚焦的基板（230）上的光以获得最大的灵敏度。所得数据可用于确定靶向特定聚合物序列的结合亲合力。

9. 发明申请

WO1992004606A1 COLORIMETER 审中-公开
标题翻译：比色计
公开(公告)号：WO1992004606A1
公开(公告)日：1992-03-19
申请号：PCT/US1991006315
申请日：1991-09-04
申请人： SEQUEL IMAGING
发明人： SEQUEL IMAGING , LUTZ, Carl, David , LIANZA, Thomas, A.
IPC分类号： G01J03/50
CPC分类号： G01J3/02 , G01J3/0272 , G01J3/0291 , G01J3/50 , G01J3/513 , G01N2021/174 , G01N2201/024
摘要： A colorimeter for measuring transmitted, reflected, emitted and incident light comprises a pod that is demountably attached to a base and that contains a color-responsive detector and associated processing electronics. The detector mates with one of several detachable heads that are selectable to establish precise measuring conditions for the various measurements to be made. The colorimeter enables common and consistent calibration across all elements of the pre-press industry, from checking color proofs or color transparencies, to calibrating video color monitors.
摘要翻译：用于测量透射，反射，发射和入射光的色度计包括可拆卸地附接到基座并且包含颜色响应检测器和相关联的处理电子器件的盒。检测器与可选择的几个可拆卸头中的一个配合，以建立用于进行各种测量的精确测量条件。色度计可以对印前行业的所有元件进行常规和一致的校准，从检查色彩校样或彩色透明胶片到校准视频彩色显示器。

10. 发明申请

WO2011088014A2 SYSTEMS AND METHODS FOR COUNTING CELLS AND BIOMOLECULES 审中-公开
标题翻译：用于计数细胞和生物分子的系统和方法
公开(公告)号：WO2011088014A2
公开(公告)日：2011-07-21
申请号：PCT/US2011020766
申请日：2011-01-11
申请人： NEXCELOM BIOSCIENCE LLC , CHAN LEO L , LI PETER
发明人： CHAN LEO L , LI PETER
CPC分类号： G01N21/6486 , G01J3/10 , G01J3/4406 , G01J5/10 , G01N15/1463 , G01N21/3581 , G01N21/64 , G01N21/6428 , G01N21/6456 , G01N21/6458 , G01N33/5005 , G01N2015/1486 , G01N2021/1736 , G01N2021/174 , G01N2021/6419 , G01N2021/6441 , G01N2021/6491 , G01N2201/0627
摘要： The invention generally relates to analytical and monitoring systems useful for analyzing and measuring cells and biological samples. More particularly, the invention relates to systems and methods for imaging, measuring, counting, analyzing, and monitoring microscopic particles such as cells and biological molecules in solution samples.
摘要翻译：本发明一般涉及用于分析和测量细胞和生物样品的分析和监测系统。更具体地，本发明涉及用于在溶液样品中成像，测量，计数，分析和监测微观颗粒如细胞和生物分子的系统和方法。

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