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1. 发明申请

WO2017112542A1 PROCESSES FOR IMPROVING FERMENTATION PRODUCT YIELD USING PHOSPHOLIPASE C 审中-公开
标题翻译：用磷脂酶改进发酵产物产量的方法C
公开(公告)号：WO2017112542A1
公开(公告)日：2017-06-29
申请号：PCT/US2016/067183
申请日：2016-12-16
申请人： NOVOZYMES A/S , KREEL, Nathaniel Edward
发明人： KREEL, Nathaniel Edward
IPC分类号： C12P7/06 , C12N9/20 , C12P19/14
CPC分类号： C12P7/06 , C12N9/16 , C12N9/20 , C12N9/2414 , C12N9/2428 , C12N9/2437 , C12N9/2457 , C12N9/50 , C12P19/14 , C12Y301/03008 , C12Y301/04 , C12Y302/01001 , C12Y302/01003 , C12Y302/01004 , C12Y302/01008 , C12Y302/01041 , C12Y304/21062 , C12Y304/23023 , C12Y304/24039 , Y02E50/17
摘要： The present disclosure relates to processes for producing fermentation products from starch-containing material, wherein a thermostable phospholipase C is present and/or added during liquefaction to increase fermentation product yield, such as ethanol yield. The disclosure also relates to the use of a thermostable phospholipase C in processes of the disclosure, for example, to increase fermentation product yield, such as ethanol yield.
摘要翻译：本发明涉及用于由含淀粉材料生产发酵产物的方法，其中在液化过程中存在和/或加入热稳定磷脂酶C以增加发酵产物产量，例如乙醇产量。本公开还涉及在本公开的方法中使用热稳定性磷脂酶C，例如用于增加发酵产物产量，例如乙醇产量。

2. 发明申请

WO2016044956A1 NOVEL BACTERIAL ENDOPHYTE WITH ANTIFUNGAL ACTIVITY 审中-公开
标题翻译：具有抗真菌活性的新型细菌内含子
公开(公告)号：WO2016044956A1
公开(公告)日：2016-03-31
申请号：PCT/CA2015/050972
申请日：2015-09-28
申请人： UNIVERSITY OF GUELPH
发明人： RAIZADA, Manish N. , MOUSA, Walaa , SCHEARER, Charles
IPC分类号： C12N15/31 , A01C1/06 , A01H17/00 , A01H5/00 , A01N63/02 , A01P3/00 , C07K14/265 , C12N1/20 , C12N15/63 , C12N15/82 , C12N5/10 , C12Q1/68
CPC分类号： A01N63/00 , A01C1/06 , A01H3/00 , C07K14/265 , C12N1/20 , C12N9/0071 , C12N9/1241 , C12N9/16 , C12N9/2442 , C12N9/93 , C12N15/8282 , C12R1/01 , C12Y114/14009 , C12Y207/07065 , C12Y301/04 , C12Y302/01014 , C12Y602/01003 , A01N25/00
摘要： An Enterobacter species isolated from finger millet, characterized by 16S rRNA gene analysis and the identification of genes that prevent or inhibit the growth of fungal plant pathogens, is disclosed for use with agricultural plants.
摘要翻译：公开了与农业植物一起使用的特征在于通过16S rRNA基因分析和鉴定预防或抑制真菌植物病原体生长的基因的从小米分离的肠杆菌属物种。

3. 发明申请

WO2013176772A1 METHODS AND COMPOSITIONS FOR RNA-DIRECTED TARGET DNA MODIFICATION AND FOR RNA-DIRECTED MODULATION OF TRANSCRIPTION 审中-公开
标题翻译：用于RNA指导的目标DNA修饰和RNA指导调节的转录的方法和组合物
公开(公告)号：WO2013176772A1
公开(公告)日：2013-11-28
申请号：PCT/US2013/032589
申请日：2013-03-15
申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA , UNIVERSITY OF VIENNA , DOUDNA, Jennifer A. , JINEK, Martin , CHARPENTIER, Emmanuelle , CHYLINSKI, Krzysztof , DOUDNA CATE, James Harrison , LIM, Wendell , QI, Lei
发明人： JINEK, Martin , CHARPENTIER, Emmanuelle , CHYLINSKI, Krzysztof , DOUDNA CATE, James Harrison , LIM, Wendell , QI, Lei
IPC分类号： C12N15/11 , C12N15/63 , C07K19/00 , C12N5/10
CPC分类号： C12N15/907 , A61K38/465 , A61K48/00 , C12N9/22 , C12N15/102 , C12N15/111 , C12N15/113 , C12N15/63 , C12N15/70 , C12N15/746 , C12N15/90 , C12N15/902 , C12N2310/11 , C12N2310/13 , C12N2310/14 , C12N2310/20 , C12N2310/31 , C12N2310/32 , C12N2310/33 , C12N2310/3519 , C12N2310/531 , C12N2800/80 , C12Y301/04
摘要： The present disclosure provides a DNA-targeting RNA that comprises a targeting sequence and, together with a modifying polypeptide, provides for site-specific modification of a target DNA and/or a polypeptide associated with the target DNA. The present disclosure further provides site-specific modifying polypeptides. The present disclosure further provides methods of site-specific modification of a target DNA and/or a polypeptide associated with the target DNA The present disclosure provides methods of modulating transcription of a target nucleic acid in a target cell, generally involving contacting the target nucleic acid with an enzymatically inactive Cas9 polypeptide and a DNA-targeting RNA. Kits and compositions for carrying out the methods are also provided. The present disclosure provides genetically modified cells that produce Cas9; and Cas9 transgenic non-human multicellular organisms.
摘要翻译：本公开提供了包含靶向序列的DNA靶向RNA，并且与修饰多肽一起提供靶DNA和/或与靶DNA相关的多肽的位点特异性修饰。本公开进一步提供了位点特异性修饰多肽。本公开进一步提供了靶DNA和/或与靶DNA相关的多肽的位点特异性修饰的方法。本公开提供了调节靶细胞中靶核酸的转录的方法，通常涉及使目标核酸具有酶非活性的Cas9多肽和DNA靶向RNA。还提供了用于实施方法的试剂盒和组合物。本公开提供产生Cas9的转基因细胞; 和Cas9转基因非人多细胞生物。

4. 发明申请

WO2009059195A2 RATIONALLY-DESIGNED SINGLE-CHAIN MEGANUCLEASES WITH NON-PALINDROMIC RECOGNITION SEQUENCES 审中-公开
标题翻译：具有非光滑识别序列的原理设计的单链大分子
公开(公告)号：WO2009059195A2
公开(公告)日：2009-05-07
申请号：PCT/US2008082072
申请日：2008-10-31
申请人： PREC BIOSCIENCES , SMITH JAMES JEFFERSON , JANTZ DEREK
发明人： SMITH JAMES JEFFERSON , JANTZ DEREK
IPC分类号： C12N9/22
CPC分类号： C12N9/22 , C12N9/16 , C12N15/8509 , C12N15/902 , C12N15/907 , C12N2800/80 , C12Y301/00 , C12Y301/04
摘要： Disclosed are rationally-designed, non-naturally-occurring meganucleases in which a pair of enzyme subunits having specificity for different recognition sequence half-sites are joined into a single polypeptide to form a functional heterodimer with a non- palindromic recognition sequence. The invention also relates to methods of producing such meganucleases, and methods of producing recombinant nucleic acids and organisms using such meganucleases.
摘要翻译：公开了合理设计的非天然存在的大范围核酸酶，其中对不同识别序列半位点具有特异性的一对酶亚基连接成单一多肽以形成具有非回文识别序列的功能性异二聚体。本发明还涉及生产这种大范围核酸酶的方法，以及使用这种大范围核酸酶生产重组核酸和生物体的方法。

5. 发明申请

WO1995020673A1 ORGANO-PHOSPHORUS COMPOUNDS AS ACTIVATORS OF GAMMA DELTA T CELLS 审中-公开
标题翻译：有机磷化合物作为GAMMA DELTA T细胞的激活剂
公开(公告)号：WO1995020673A1
公开(公告)日：1995-08-03
申请号：PCT/FR1995000092
申请日：1995-01-26
申请人： CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (C.N.R.S.) , INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE , BONNEVILLE, Marc , CONSTANT, Patricia, Marie-Claude , FOURNIE, Jean-Jacques , PUZO, Germain
发明人： CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (C.N.R.S.) , INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
IPC分类号： C12P01/04
CPC分类号： A61K39/04 , A61K31/66 , A61K31/7072 , A61K38/46 , A61K38/465 , C07F9/091 , C07F9/113 , C07F9/3891 , C07F9/65586 , C07G17/00 , C07H19/10 , C12P1/06 , C12R1/32 , C12Y301/03 , C12Y301/04 , C12Y306/01009 , Y02A50/412 , A61K2300/00
摘要： Non-peptide hydrosoluble organo-phosphorus containing compound for use as a human T gamma 9 delta 2 cell activator, comprising at least one acidolabile ester bond of phosphoric acid. The activating properties of said compound in relation to lymphocytes are lost when it is placed in the presence of an enzymatic mixture comprising at least one phosphoric phosphohydrolase monoester and at least one phosphoric phosphohydrolase diester. The invention also concerns a method for the preparation, isolation or characterization of such a compound and compositions and pharmaceutical uses thereof.
摘要翻译：用作人Tγ9Δ2细胞活化剂的非肽可溶性有机磷化合物，其包含磷酸的至少一种酸不溶性酯键。所述化合物相对于淋巴细胞的活化性质在其包含至少一种磷酸磷酸酯单酯和至少一种磷酸磷酸二酯酯的酶混合物存在时丧失。本发明还涉及这种化合物及其组合物及其药物用途的制备，分离或表征的方法。

6. 发明申请

WO2017112533A1 PROCESS OF EXTRACTING OIL FROM THIN STILLAGE 审中-公开
标题翻译：从沉淀物中提取油的过程
公开(公告)号：WO2017112533A1
公开(公告)日：2017-06-29
申请号：PCT/US2016/067080
申请日：2016-12-16
申请人： NOVOZYMES A/S , JUMP, Joseph
发明人： JUMP, Joseph , VIDAL, Bernardo Jr. , SOONG, Chee-Leong , ROBERTS, Madison , HOOSS, Melissa Carrie , SHEN, Xinyu , KREEL, Nathaniel Edward
IPC分类号： C12P7/06 , C12P7/64
CPC分类号： C12P7/06 , C12N9/16 , C12N9/20 , C12N9/2414 , C12N9/2428 , C12N9/2437 , C12N9/2457 , C12N9/50 , C12P19/14 , C12Y301/03008 , C12Y301/04 , C12Y302/01001 , C12Y302/01003 , C12Y302/01004 , C12Y302/01008 , C12Y302/01041 , C12Y304/21062 , C12Y304/23023 , C12Y304/24039 , Y02E50/17
摘要： A process of recovering oil, comprising (a) converting a starch-containing material into dextrins with an alpha-amylase; (b) saccharifying the dextrins using a carbohydrate source generating enzyme to form a sugar; (c) fermenting the sugar in a fermentation medium into a fermentation product using a fermenting organism; (d) recovering the fermentation product to form a whole stillage; (e) separating the whole stillage into thin stillage and wet cake; (e') optionally concentrating the thin stillage into syrup; (f) recovering oil from the thin stillage and/or optionally the syrup, wherein a protease and a phospholipase are present and/or added during steps (a) to (c). Use of a protease and a phospholipase for increasing oil recovery yields from thin stillage and/or syrup in a fermentation product production process.
摘要翻译：一种回收油的方法，其包括（a）用α-淀粉酶将含淀粉材料转化为糊精; （b）使用产生碳水化合物源的酶糖化糊精以形成糖; （c）使用发酵生物将发酵培养基中的糖发酵成发酵产物; （d）回收发酵产物以形成酒糟; （e）将酒糟分离成酒糟和湿饼; （e'）任选地将稀釜馏物浓缩成糖浆; （f）从所述稀酒糟和/或任选的所述糖浆中回收油，其中在步骤（a）至（c）期间存在和/或加入蛋白酶和磷脂酶。在发酵产物生产过程中使用蛋白酶和磷脂酶来提高来自酒糟和/或糖浆的油回收率。

7. 发明申请

WO2014131113A1 THERMOSTABLE NUCLEASE 审中-公开
标题翻译：热稳定核
公开(公告)号：WO2014131113A1
公开(公告)日：2014-09-04
申请号：PCT/CA2014/000156
申请日：2014-02-27
申请人： UNIVERSITE LAVAL
发明人： BOISSINOT, Maurice , BOISSINOT, Karel , ISABEL, Sandra , SHI, Lu-E
IPC分类号： C12N15/55 , A23L1/229 , A61K31/7088 , C12N9/22 , C12P19/40
CPC分类号： C12N9/22 , A23L27/23 , A61K31/7088 , C12P19/32 , C12P19/34 , C12Y301/04
摘要： The present invention provides a heat-stable nuclease found in Y. enterocolitica subsp. palearctica that is active in broad spectrum conditions. Using the genome sequences of Y. enterocolitica subsp. enterocolitica , we identified one nuclease named Nucyep . This gene was sequenced in a strain Y. enterocolitica subsp. palearctica , cloned, and expressed in E. coli , and then purified and characterized. The molecular weight of this enzyme is about 30 to 32 kDa. The translation product, a nuclease referred to as "Nucyep" is biologically active. The purified Nucyep1 exhibits non-specific nuclease activity, being able to degrade various nucleic acids, including RNA, single-stranded DNA (ssDNA) and linear or circular double-stranded DNA (dsDNA). This enzyme is active in a wide range of temperatures, from 0 to 100°C. The enzyme is active in a wide range of pH values from 3.6 to 9.9, and keeps greater than 75% of the activity at pH 7.24. This enterobacterial nuclease has unique levels of intrinsic resistance to heat, and is active under a large spectrum of conditions.
摘要翻译：本发明提供了一种在小肠结肠炎小肠亚种中发现的热稳定核酸酶。在广谱条件下活跃的棕榈属。使用小肠结肠炎亚种的基因组序列我们确定了一种名叫Nucyep的核酸酶。该基因在小肠结肠炎菌株亚种中测序。在大肠杆菌中克隆并表达，然后纯化和表征。该酶的分子量为约30至32kDa。翻译产品，称为“Nucyep”的核酸酶具有生物活性。纯化的Nucyep1显示非特异性核酸酶活性，能够降解各种核酸，包括RNA，单链DNA（ssDNA）和线性或环状双链DNA（dsDNA）。该酶在0至100℃的宽范围的温度范围内是有活性的。该酶在宽范围的3.6至9.9的pH范围内是有活性的，并且在pH 7.24下保持大于活性的75％。这种肠杆菌核酸酶具有独特的固有抗热性，并且在大范围的条件下是有活性的。

8. 发明申请

WO2012010593A1 PROCESS FOR PRODUCING A BAKED PRODUCT HAVING INCREASED FLAVOR STABILITY WITH CATALASE AND PHOSPHOLIPASE 审中-公开
标题翻译：用催化剂和磷脂酶生产具有较高稳定性的烘烤产品的方法
公开(公告)号：WO2012010593A1
公开(公告)日：2012-01-26
申请号：PCT/EP2011/062342
申请日：2011-07-19
申请人： NOVOZYMES A/S , BENNEDBÆK-JENSEN, Sidsel Langballe , ØSTDAL, Henrik
发明人： BENNEDBÆK-JENSEN, Sidsel Langballe , ØSTDAL, Henrik
IPC分类号： A21D8/04 , A23L1/03 , C12N9/08
CPC分类号： A21D8/042 , C12N9/0065 , C12N9/16 , C12Y111/01006 , C12Y301/04
摘要： The present invention relates to a process for producing a baked product having increased flavor stability comprising the steps of: (a) preparing a dough comprising flour, water, an enzyme preparation having catalase activity and an enzyme preparation having phospholipase activity; and (b) baking the dough to obtain the baked product.
摘要翻译：本发明涉及一种具有增加风味稳定性的焙烤产品的生产方法，包括以下步骤：（a）制备包含面粉，水，具有过氧化氢酶活性的酶制剂和具有磷脂酶活性的酶制剂的生面团; 和（b）烘烤面团以获得烘焙产品。

9. 发明申请

WO2017112540A1 PROCESSES FOR PRODUCING FERMENTATION PRODUCTS 审中-公开
标题翻译：生产发酵产品的过程
公开(公告)号：WO2017112540A1
公开(公告)日：2017-06-29
申请号：PCT/US2016/067177
申请日：2016-12-16
申请人： NOVOZYMES A/S , KANG, Zhengfang
发明人： KANG, Zhengfang , STRAHLER, Christie Lynn , HUFFMAN, James Ron , KROGH, Kristian Bertel Romer M.
IPC分类号： C12P7/06 , C12P19/14
CPC分类号： C12P7/06 , C12N9/16 , C12N9/20 , C12N9/2414 , C12N9/2428 , C12N9/2437 , C12N9/2457 , C12N9/50 , C12P19/14 , C12Y301/03008 , C12Y301/04 , C12Y302/01001 , C12Y302/01003 , C12Y302/01004 , C12Y302/01008 , C12Y302/01041 , C12Y304/21062 , C12Y304/23023 , C12Y304/24039 , Y02E50/17
摘要： The present invention relates to processes for producing fermentation products from starch-containing material, wherein an alpha-amylase and a thermostable hemicellulase is present and/or added during liquefaction. The invention also relates to compositions suitable for use in processes of the invention.
摘要翻译：本发明涉及由含淀粉材料生产发酵产物的方法，其中α-淀粉酶和热稳定半纤维素酶在液化过程中存在和/或加入。本发明还涉及适用于本发明方法的组合物。

10. 发明申请

WO2017112539A1 PROCESS OF EXTRACTING OIL FROM THIN STILLAGE 审中-公开
标题翻译：从沉淀物中提取油的过程
公开(公告)号：WO2017112539A1
公开(公告)日：2017-06-29
申请号：PCT/US2016/067154
申请日：2016-12-16
申请人： NOVOZYMES A/S , AKERMAN, Michael, John
发明人： AKERMAN, Michael, John , HOOSS, Melissa, Carrie , KREEL, Nathaniel, Edward , SHEN, Xinyu
IPC分类号： C12P7/06 , C12N9/20 , C12P19/14
CPC分类号： C12P7/06 , C12N9/16 , C12N9/20 , C12N9/2414 , C12N9/2428 , C12N9/2437 , C12N9/2457 , C12N9/50 , C12P19/14 , C12Y301/03008 , C12Y301/04 , C12Y302/01001 , C12Y302/01003 , C12Y302/01004 , C12Y302/01008 , C12Y302/01041 , C12Y304/21062 , C12Y304/23023 , C12Y304/24039 , Y02E50/17
摘要： A process of recovering oil, comprising (a) converting a starch-containing material into dextrins with an alpha-amylase; (b) saccharifying the dextrins using a carbohydrate source generating enzyme to form a sugar; (c) fermenting the sugar in a fermentation medium into a fermentation product using a fermenting organism; (d) recovering the fermentation product to form a whole stillage; (e) separating the whole stillage into thin stillage and wet cake; (e') optionally concentrating the thin stillage into syrup; (f) recovering oil from the thin stillage and/or optionally the syrup, wherein a phospholipase is present and/or added during steps (a) to (c). Use of phospholipase for increasing oil recovery yields from thin stillage and/or syrup in a fermentation product production process.
摘要翻译：一种回收油的方法，其包括（a）用α-淀粉酶将含淀粉材料转化为糊精; （b）使用产生碳水化合物源的酶糖化糊精以形成糖; （c）使用发酵生物将发酵培养基中的糖发酵成发酵产物; （d）回收发酵产物以形成酒糟; （e）将酒糟分离成酒糟和湿饼; （e'）任选地将稀釜馏物浓缩成糖浆; （f）从所述稀酒糟和/或任选的所述糖浆中回收油，其中在步骤（a）至（c）期间存在和/或加入磷脂酶。在发酵产品生产过程中使用磷脂酶提高来自酒糟和/或糖浆的油回收量。

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