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1. 发明申请

WO2006084705A3 NOVEL GENE STS 06 审中-公开
公开(公告)号：WO2006084705A3
公开(公告)日：2006-11-23
申请号：PCT/EP2006001197
申请日：2006-02-10
申请人： DSM IP ASSETS BV , CHEVREUX BASTIEN , MAYER ANNE FRANCOISE , MEURY ANJA , MOUNCEY NIGEL JOHN , SHINJOH MASAKO
发明人： CHEVREUX BASTIEN , MAYER ANNE FRANCOISE , MEURY ANJA , MOUNCEY NIGEL JOHN , SHINJOH MASAKO
IPC分类号： C12N15/11 , C07K14/705
CPC分类号： C07K14/195
摘要： The present invention relates to newly identified genes that encode proteins that are involved in the synthesis of L-ascorbic acid (hereinafter also referred to as Vitamin C). The invention also features polynucleotides comprising the full-length polynucleotide sequences of the novel genes and fragments thereof, the novel polypeptides encoded by the polynucleotides and fragments thereof, as well as their functional equivalents. The present invention also relates to the use of said polynucleotides and polypeptides as biotechnological tools in the production of Vitamin C from microorganisms, whereby a modification of said polynucleotides and/or encoded polypeptides has a direct or indirect impact on yield, production, and/or efficiency of production of the fermentation product in said microorganism. Also included are methods/processes of using the polynucleotides and modified polynucleotide sequences to transform host microorganisms. The invention also relates to genetically engineered microorganisms and their use for the direct production of Vitamin C.
摘要翻译：本发明涉及编码参与L-抗坏血酸合成的蛋白质（以下也称为维生素C）的新鉴定的基因。本发明的特征还在于包含新基因及其片段的全长多核苷酸序列的多核苷酸，由该多核苷酸及其片段编码的新多肽以及它们的功能等价物。本发明还涉及所述多核苷酸和多肽作为生物技术工具在由微生物生产维生素C中的用途，由此修饰所述多核苷酸和/或编码的多肽对产量，产量和/或所述微生物中发酵产物的生产效率。还包括使用多核苷酸和修饰的多核苷酸序列转化宿主微生物的方法/过程。本发明还涉及基因工程微生物及其用于直接生产维生素C的用途。

2. 发明申请

WO2006084749A3 RCS 02, A NOVEL GENE INVOLVED IN THE BIOSYNTHESIS OF VITAMIN C 审中-公开
公开(公告)号：WO2006084749A3
公开(公告)日：2006-08-17
申请号：PCT/EP2006/001257
申请日：2006-02-10
申请人： DSM IP ASSETS B.V. , CHEVREUX, Bastien , MAYER, Anne, Françoise , MEURY, Anja , MOUNCEY, Nigel, John , SHINJOH, Masako
发明人： CHEVREUX, Bastien , MAYER, Anne, Françoise , MEURY, Anja , MOUNCEY, Nigel, John , SHINJOH, Masako
IPC分类号： C12N9/02 , C12P17/04 , C12N15/00 , C07H21/00
摘要： The present invention relates to newly identified genes that encode proteins that are involved in the synthesis of L-ascorbic acid (hereinafter also referred to as Vitamin C), e.g. the RCS 02 gene coding for an οxidoreductase (EC 1.10) . The invention also features polynucleotides comprising the full-length polynucleotide sequences of the novel genes and fragments thereof, the novel polypeptides encoded by the polynucleotides and fragments thereof, as well as their functional equivalents. The present invention also relates to the use of said polynucleotides and polypeptides as biotechnological tools in the production of Vitamin C from microorganisms, whereby a modification of said polynucleotides and/or encoded polypeptides has a direct or indirect impact on yield, production, and/or efficiency of production of the fermentation product in said microorganism. Also included are methods/processes of using the polynucleotides and modified polynucleotide sequences to transform host microorganisms. The invention also relates to genetically engineered microorganisms and their use for the direct production of Vitamin C, e.g. from D-sorbitol or L-sorbose.

3. 发明申请

WO2006084732A3 NOVEL GENE RCS 07 审中-公开
公开(公告)号：WO2006084732A3
公开(公告)日：2006-08-17
申请号：PCT/EP2006/001227
申请日：2006-02-10
申请人： DSM IP ASSETS B.V. , CHEVREUX, Bastien , MAYER, Anne Francoise , MEURY, Anja , MOUNCEY, Nigel John , SHINJOH, Masako
发明人： CHEVREUX, Bastien , MAYER, Anne Francoise , MEURY, Anja , MOUNCEY, Nigel John , SHINJOH, Masako
IPC分类号： C12N9/02
摘要： The present invention relates to newly identified genes that encode proteins that are involved in the synthesis of L-ascorbic acid (hereinafter also referred to as Vitamin C). The invention also features polynucleotides comprising the full-length polynucleotide sequences of the novel genes and fragments thereof, the novel polypeptides encoded by the polynucleotides and fragments thereof, as well as their functional equivalents. The present invention also relates to the use of said polynucleotides and polypeptides as biotechnological tools in the production of Vitamin C from microorganisms, whereby a modification of said polynucleotides and/or encoded polypeptides has a direct or indirect impact on yield, production, and/or efficiency of production of the fermentation product in said microorganism. Also included are methods/processes of using the polynucleotides and modified polynucleotide sequences to transform host microorganisms. The invention also relates to genetically engineered microorganisms and their use for the direct production of Vitamin C.

4. 发明申请

WO2006084729A1 GENE RCS O1 审中-公开
公开(公告)号：WO2006084729A1
公开(公告)日：2006-08-17
申请号：PCT/EP2006/001224
申请日：2006-02-10
申请人： DSM IP ASSETS B.V. , CHEVREUX, Bastien , MAYER, Anne Françoise , MEURY, Anja , MOUNCEY, Nigel John , SHINJOH, Masako
发明人： CHEVREUX, Bastien , MAYER, Anne Françoise , MEURY, Anja , MOUNCEY, Nigel John , SHINJOH, Masako
IPC分类号： C12N9/02 , C12P17/04
CPC分类号： C12N9/0055 , C12N9/0006 , C12N9/0057 , C12P17/04
摘要： The present invention relates to newly identified genes that encode proteins that are involved in the synthesis of L-ascorbic acid (hereinafter also referred to as Vitamin C). The invention also features polynucleotides comprising the full-length polynucleotide sequences of the novel genes and fragments thereof, the novel polypeptides encoded by the polynucleotides and fragments thereof, as well as their functional equivalents. The present invention also relates to the use of said polynucleotides and polypeptides as biotechnological tools in the production of Vitamin C from microorganisms, whereby a modification of said polynucleotides and/or encoded polypeptides has a direct or indirect impact on yield, production, and/or efficiency of production of the fermentation product in said microorganism. Also included are methods/processes of using the polynucleotides and modified polynucleotide sequences to transform host microorganisms. The invention also relates to genetically engineered microorganisms and their use for the direct production of Vitamin C.
摘要翻译：本发明涉及编码参与L-抗坏血酸合成（以下也称为维生素C）的蛋白质的新鉴定的基因。本发明还涉及包含新基因及其片段的全长多核苷酸序列的多核苷酸，由多核苷酸及其片段编码的新多肽及其功能等同物。本发明还涉及所述多核苷酸和多肽在从微生物生产维生素C中作为生物技术工具的用途，其中所述多核苷酸和/或编码多肽的修饰对产量，产量和/或所述微生物中发酵产物的生产效率。还包括使用多核苷酸和修饰的多核苷酸序列转化宿主微生物的方法/方法。本发明还涉及基因工程微生物及其用于直接生产维生素C的用途。

5. 发明申请

WO2006084723A1 GENE STS 17 审中-公开
标题翻译：基因STS 17
公开(公告)号：WO2006084723A1
公开(公告)日：2006-08-17
申请号：PCT/EP2006/001218
申请日：2006-02-10
申请人： DSM IP ASSETS B.V. , CHEVREUX, Bastien , MAYER, Anne Françoise , MEURY, Anja , MOUNCEY, Nigel John , SHINJOH, Masako
发明人： CHEVREUX, Bastien , MAYER, Anne Françoise , MEURY, Anja , MOUNCEY, Nigel John , SHINJOH, Masako
IPC分类号： C12N9/00 , C12P17/04
CPC分类号： C12P17/04 , C07K14/195 , C12P7/60
摘要： The present invention relates to newly identified genes that encode proteins that are involved in the synthesis of L-ascorbic acid (hereinafter also referred to as Vitamin C). The invention also features polynucleotides comprising the full-length polynucleotide sequences of the novel genes and fragments thereof, the novel polypeptides encoded by the polynucleotides and fragments thereof, as well as their functional equivalents. The present invention also relates to the use of said polynucleotides and polypeptides as biotechnological tools in the production of Vitamin C from microorganisms, whereby a modification of said polynucleotides and/or encoded polypeptides has a direct or indirect impact on yield, production, and/or efficiency of production of the fermentation product in said microorganism. Also included are methods/processes of using the polynucleotides and modified polynucleotide sequences to transform host microorganisms. The invention also relates to genetically engineered microorganisms and their use for the direct production of Vitamin C.
摘要翻译：本发明涉及编码参与L-抗坏血酸合成（以下也称为维生素C）的蛋白质的新鉴定的基因。本发明还涉及包含新基因及其片段的全长多核苷酸序列的多核苷酸，由多核苷酸及其片段编码的新多肽及其功能等同物。本发明还涉及所述多核苷酸和多肽在从微生物生产维生素C中作为生物技术工具的用途，其中所述多核苷酸和/或编码多肽的修饰对产量，产量和/或所述微生物中发酵产物的生产效率。还包括使用多核苷酸和修饰的多核苷酸序列转化宿主微生物的方法/方法。本发明还涉及基因工程微生物及其用于直接生产维生素C的用途。

6. 发明申请

WO2006084701A1 PHOSPHOTRANSFERASE GENE FROM GLUCONOBACTER OXYDANS 审中-公开
标题翻译：来自葡萄糖氧化酶的磷酸酯酶基因
公开(公告)号：WO2006084701A1
公开(公告)日：2006-08-17
申请号：PCT/EP2006/001193
申请日：2006-02-10
申请人： DSM IP ASSETS B.V. , BEUZELIN OLLIVIER, Marie-Gabrielle , CHEVREUX, Bastien , DALLUEGE, Manuela , GOESE, Markus , LEE, Connie , MEURY, Anja , MOUNCEY, Nigel John , SHINJOH, Masako
发明人： BEUZELIN OLLIVIER, Marie-Gabrielle , CHEVREUX, Bastien , DALLUEGE, Manuela , GOESE, Markus , LEE, Connie , MEURY, Anja , MOUNCEY, Nigel John , SHINJOH, Masako
IPC分类号： C12N9/12 , C12P17/04
CPC分类号： C12P17/04 , C12N9/1223
摘要： The present invention relates to newly identified genes that encode proteins that are involved in the synthesis of L-ascorbic acid (hereinafter also referred to as Vitamin C). The invention also features polynucleotides comprising the full-length polynucleotide sequences of the novel genes and fragments thereof, the novel polypeptides encoded by the polynucleotides and fragments thereof, as well as their functional equivalents. The present invention also relates to the use of said polynucleotides and polypeptides as biotechnological tools in the production of Vitamin C from microorganisms, whereby a modification of said polynucleotides and/or encoded polypeptides has a direct or indirect impact on yield, production, and/or efficiency of production of the fermentation product in said microorganism. Also included are methods/processes of using the polynucleotides and modified polynucleotide sequences to transform host microorganisms. The invention also relates to genetically engineered microorganisms and their use for the direct production of Vitamin C.
摘要翻译：本发明涉及编码参与L-抗坏血酸合成（以下也称为维生素C）的蛋白质的新鉴定的基因。本发明还涉及包含新基因及其片段的全长多核苷酸序列的多核苷酸，由多核苷酸及其片段编码的新多肽及其功能等同物。本发明还涉及所述多核苷酸和多肽在从微生物生产维生素C中作为生物技术工具的用途，其中所述多核苷酸和/或编码多肽的修饰对产量，产量和/或所述微生物中发酵产物的生产效率。还包括使用多核苷酸和修饰的多核苷酸序列转化宿主微生物的方法/方法。本发明还涉及基因工程微生物及其直接生产维生素C的用途。

7. 发明申请

WO2008000416A1 BIOLOGICAL PROCESS USING A GLUCOSE-6-PHOSPHATE ISOMERASE 审中-公开
标题翻译：使用葡萄糖-6-磷酸异构体的生物过程
公开(公告)号：WO2008000416A1
公开(公告)日：2008-01-03
申请号：PCT/EP2007/005592
申请日：2007-06-25
申请人： DSM IP ASSETS B.V. , BREMUS, Christoph , BRINGER-MEYER, Stephanie , HERMANN, Ute , MOUNCEY, Nigel, John , SAHM, Hermann
发明人： BREMUS, Christoph , BRINGER-MEYER, Stephanie , HERMANN, Ute , MOUNCEY, Nigel, John , SAHM, Hermann
IPC分类号： C12N15/61 , C12N9/92 , C12P17/04 , C12P1/04 , C12N1/20
CPC分类号： C12P17/04 , C12N1/20 , C12N9/92 , C12P1/04
摘要： The present invention relates to microorganisms genetically engineered to reduce carbon source diversion throughout the bioconversion of a carbon source, such as e.g . sorbitol, into biomass. Processes for generating such microorganisms are also provided by the present invention. The invention also relates to polynucleotide sequences comprising genes that encode proteins that are involved in the bioconversion of a carbon source such as e.g. sorbitol, into biomass. The invention also features polynucleotides comprising the full-length polynucleotide sequences of the novel genes and fragments thereof, the novel polypeptides encoded by the polynucleotides and fragments thereof, as well as their functional equivalents. Also included are processes of using the polynucleotides and modified polynucleotide sequences to transform host microorganisms leading to a microorganism with reduced carbon source diversion, i.e. higher yield and/or efficiency of biomass production from a carbon source such as e.g. sorbitol.
摘要翻译：本发明涉及基因工程改造以减少在碳源的整个生物转化过程中碳源转移的微生物，例如，山梨醇，成为生物质。产生这种微生物的方法也由本发明提供。本发明还涉及包含编码参与碳源的生物转化的蛋白质的基因的多核苷酸序列，例如碳源。山梨醇，成为生物质。本发明还涉及包含新基因及其片段的全长多核苷酸序列的多核苷酸，由多核苷酸及其片段编码的新多肽及其功能等同物。还包括使用多核苷酸和修饰的多核苷酸序列来转化宿主微生物的方法，所述宿主微生物导致具有降低的碳源转移的微生物，即来自碳源的生物质产量的较高产量和/或效率，例如。山梨糖醇。

8. 发明申请

WO2006084713A3 NOVEL GENE VCS 03 审中-公开
标题翻译：新基因VCS 03
公开(公告)号：WO2006084713A3
公开(公告)日：2007-01-25
申请号：PCT/EP2006001208
申请日：2006-02-10
申请人： DSM IP ASSETS BV , CHEVREUX BASTIEN , GELDER VAN MARINA , HAUK CORINA , KOEKMAN BERTUS PIETER , MEURY ANJA , MOUNCEY NIGEL JOHN , SCHIPPER DICK , SHINJOH MASAKO , VOLLEBREGT ADRIANUS WILHELMUS
发明人： CHEVREUX BASTIEN , GELDER VAN MARINA , HAUK CORINA , KOEKMAN BERTUS PIETER , MEURY ANJA , MOUNCEY NIGEL JOHN , SCHIPPER DICK , SHINJOH MASAKO , VOLLEBREGT ADRIANUS WILHELMUS
IPC分类号： C12N9/02
CPC分类号： C12P17/04 , C12N9/0034 , C12Y105/03001
摘要： The present invention relates to newly identified genes that encode proteins that are involved in the synthesis of L-ascorbic acid (hereinafter also referred to as Vitamin C). The invention also features polynucleotides comprising the full-length polynucleotide sequences of the novel genes and fragments thereof, the novel polypeptides encoded by the polynucleotides and fragments thereof, as well as their functional equivalents. The present invention also relates to the use of said polynucleotides and polypeptides as biotechnological tools in the production of Vitamin C from microorganisms, whereby a modification of said polynucleotides and/or encoded polypeptides has a direct or indirect impact on yield, production, and/or efficiency of production of the fermentation product in said microorganism. Also included are methods/processes of using the polynucleotides and modified polynucleotide sequences to transform host microorganisms. The invention also relates to genetically engineered microorganisms and their use for the direct production of Vitamin C.
摘要翻译：本发明涉及编码参与L-抗坏血酸合成（以下也称为维生素C）的蛋白质的新鉴定的基因。本发明还涉及包含新基因及其片段的全长多核苷酸序列的多核苷酸，由多核苷酸及其片段编码的新多肽及其功能等同物。本发明还涉及所述多核苷酸和多肽作为生物技术工具在从微生物生产维生素C中的用途，其中所述多核苷酸和/或编码多肽的修饰对产量，产量和/或所述微生物中发酵产物的生产效率。还包括使用多核苷酸和修饰的多核苷酸序列转化宿主微生物的方法/方法。本发明还涉及基因工程微生物及其用于直接生产维生素C的用途。

9. 发明申请

WO2006084722A3 GENE STS 15 审中-公开
标题翻译：基因STS 15
公开(公告)号：WO2006084722A3
公开(公告)日：2006-09-28
申请号：PCT/EP2006001217
申请日：2006-02-10
申请人： DSM IP ASSETS BV , CHEVREUX BASTIEN , MAYER ANNE FRANCOISE , MEURY ANJA , MOUNCEY NIGEL JOHN , SHINJOH MASAKO
发明人： CHEVREUX BASTIEN , MAYER ANNE FRANCOISE , MEURY ANJA , MOUNCEY NIGEL JOHN , SHINJOH MASAKO
IPC分类号： C12N9/14 , C12P17/04
CPC分类号： C12P7/60 , C12N9/14 , C12P17/04
摘要： The present invention relates to newly identified genes that encode proteins that are involved in the synthesis of L-ascorbic acid (hereinafter also referred to as Vitamin C). The invention also features polynucleotides comprising the full-length polynucleotide sequences of the novel genes and fragments thereof, the novel polypeptides encoded by the polynucleotides and fragments thereof, as well as their functional equivalents. The present invention also relates to the use of said polynucleotides and polypeptides as biotechnological tools in the production of Vitamin C from microorganisms, whereby a modification of said polynucleotides and/or encoded polypeptides has a direct or indirect impact on yield, production, and/or efficiency of production of the fermentation product in said microorganism. Also included are methods/processes of using the polynucleotides and modified polynucleotide sequences to transform host microorganisms. The invention also relates to genetically engineered microorganisms and their use for the direct production of Vitamin C.
摘要翻译：本发明涉及编码参与L-抗坏血酸合成（以下也称为维生素C）的蛋白质的新鉴定的基因。本发明还涉及包含新基因及其片段的全长多核苷酸序列的多核苷酸，由多核苷酸及其片段编码的新多肽及其功能等同物。本发明还涉及所述多核苷酸和多肽在从微生物生产维生素C中作为生物技术工具的用途，其中所述多核苷酸和/或编码多肽的修饰对产量，产量和/或所述微生物中发酵产物的生产效率。还包括使用多核苷酸和修饰的多核苷酸序列转化宿主微生物的方法/方法。本发明还涉及基因工程微生物及其用于直接生产维生素C的用途。

10. 发明申请

WO2006084735A1 GENE FOR COENZYME PQQ SYNTHESIS PROTEIN B FROM GLUCONOBACTER OXYDANS 审中-公开
标题翻译：来自葡萄球菌OXYDANS的COENZYME PQQ合成蛋白B的基因
公开(公告)号：WO2006084735A1
公开(公告)日：2006-08-17
申请号：PCT/EP2006/001230
申请日：2006-02-10
申请人： DSM IP ASSETS B.V. , CHEVREUX, Bastien , MAYER, Anne Francoise , MEURY, Anja , MOUNCEY, Nigel John , SHINJOH, Masako
发明人： CHEVREUX, Bastien , MAYER, Anne Francoise , MEURY, Anja , MOUNCEY, Nigel John , SHINJOH, Masako
IPC分类号： C07K14/195 , C12P17/04
CPC分类号： C12P7/60 , C07K14/195 , C12P17/04
摘要： The present invention relates to a newly identified gene that encodes a protein that is involved in the synthesis of L-ascorbic acid (hereinafter also referred to a Vitamin C). The protein is coenzyme PQQ synthesis protein B. The invention also features polynucleotides comprising the full-length polynucleotide sequences of the novel genes and fragments thereof, the novel polypeptides encoded by the polynucleotides and fragments thereof, as well as their functional equivalents. The present invention also relates to the use of said polynucleotides and polypeptides as biotechnological tools in the production of Vitamin C from microorganisms, whereby a modification of said polynucleotides and/or encoded polypeptides has a direct or indirect impact on yield, production, and/or efficiency of production of the fermentation product in said microorganism. Also included are methods/processes of using the polynucleotides and modified polynucleotide sequences to transform host microorganisms. The invention also relates to genetically engineered microorganisms and their use for the direct production of Vitamin C.
摘要翻译：本发明涉及新鉴定的参与L-抗坏血酸合成的蛋白质的基因（以下也称为维生素C）。蛋白质是辅酶PQQ合成蛋白B.本发明还涉及包含新基因及其片段的全长多核苷酸序列的多核苷酸，由多核苷酸及其片段编码的新多肽及其功能等同物。本发明还涉及所述多核苷酸和多肽作为生物技术工具在从微生物生产维生素C中的用途，其中所述多核苷酸和/或编码多肽的修饰对产量，产量和/或所述微生物中发酵产物的生产效率。还包括使用多核苷酸和修饰的多核苷酸序列转化宿主微生物的方法/方法。本发明还涉及基因工程微生物及其用于直接生产维生素C的用途。

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