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    • 5. 发明申请
    • METHOD AND SYSTEM FOR ISOLATING ADIPOSE-DERIVED STEM CELLS
    • 用于分离ADIPOSE衍生的干细胞的方法和系统
    • WO2017007426A1
    • 2017-01-12
    • PCT/SG2016/050311
    • 2016-07-04
    • AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH
    • KE, LinZHANG, Nan
    • C12N5/0775
    • C12N5/0667C12N13/00C12N2529/00C12N2529/10
    • The present invention refers to a non -invasive method for isolating adipose-derived stem cells from adipose tissue by illuminating the adipose tissue with at least one laser having a wavelength of between 360nm to 480nm or between 800nm to 2pm for a predetermined time for dissociating fat cells and blood vessels of the adipose tissue to release intact stem cells from the adipose tissue while maintaining the viability of the stem cells. In the preferred embodiment, the adipose tissue is illuminated with pulsed near infra-red (NIR) laser and a continuous wave (CW) diode blue laser. The present invention also contains a system adapted for isolating adipose -derived stem cells from adipose tissue using the method of the present invention.
    • 本发明涉及通过用波长为360nm至480nm或800nm至2pm之间的至少一种激光照射脂肪组织一段预定时间以解离脂肪来从脂肪组织分离脂肪来源的干细胞的非侵入性方法。 细胞和血管,以从脂肪组织释放完整的干细胞,同时保持干细胞的活力。 在优选实施例中,用脉冲近红外(NIR)激光和连续波(CW)二极管蓝色激光照射脂肪组织。 本发明还包含适于使用本发明的方法从脂肪组织分离脂肪来源的干细胞的系统。
    • 9. 发明申请
    • SPATIO-TEMPORAL CONTROL OF PROTEIN INTERACTIONS USING PHYTOCHROMES
    • 使用生物色素蛋白质相互作用的时空控制
    • WO2009151948A2
    • 2009-12-17
    • PCT/US2009/045204
    • 2009-05-26
    • THE REGENTS OF THE UNIVERSITY OF CALIFORNIAVOIGT, Christopher, A.LEVSKAYA, AnselmLIM, Wendell
    • VOIGT, Christopher, A.LEVSKAYA, AnselmLIM, Wendell
    • A01H5/00C12N5/04
    • C12N5/00C12N2529/10
    • The invention provides methods, materials and systems of regulating association between proteins of interest using light. In an aspect, the invention takes advantage of the ability of phytochromes to change conformation upon exposure to appropriate light conditions, and to bind in a conformation-dependent manner to cognate proteins called phytochrome -interacting factors. The invention comprises a method of regulating interaction between a first protein of interest and second protein within a cell by light. Such a method optionally comprises providing in the cell (1) a first protein construct which comprises the first protein, a phytochrome domain (PHD), and (2) providing in the cell a second protein construct which comprises the second protein and a phytochrome domain- interacting peptide (PIP) that can bind selectively to the Pfr state, but not to the Pr state, of the phytochrome domain.
    • 本发明提供了使用光调节感兴趣的蛋白质之间的关联的方法,材料和系统。 在一方面,本发明利用植物色素在暴露于合适的光条件下改变构象的能力,并且以构象依赖性方式结合称为植物色素 - 相互作用因子的同源蛋白质。 本发明包括通过光调节细胞内第一种目的蛋白质和第二种蛋白质之间的相互作用的方法。 这种方法任选地包括在细胞(1)中提供包含第一蛋白质,植物色素结构域(PHD)的第一蛋白质构建体,和(2)在细胞中提供包含第二蛋白质和植物色素结构域的第二蛋白质构建体 - 可以选择性结合植物色素结构域的Pfr状态而不是Pr状态的相互作用肽(PIP)。
    • 10. 发明申请
    • PHOTOVOLTAIC DEVICE FOR STIMULATION OF CELLS AND/OR ELECTROCHEMICAL REACTIONS
    • 用于刺激细胞和/或电化学反应的光伏装置
    • WO2017157874A1
    • 2017-09-21
    • PCT/EP2017/055886
    • 2017-03-14
    • UNIVERSITÄT HAMBURG ARBEITSSTELLE FÜR WISSENS- UND TECHNOLOGIETRANSFER
    • DORN, AugustDIEDRICH, DanielBLICK, Robert
    • A61N1/20A61K41/00A61N1/32C12M1/42C12N5/0793C12N13/00B82Y5/00B82Y40/00C12M1/12H01L21/02H01L31/0392H01L31/07
    • A61N1/205A61L27/50A61L2400/12A61N1/326A61N5/0616A61N5/062A61N5/0622A61N5/0624A61N2005/0659A61N2005/0662A61N2005/067C12M25/08C12M35/02C12N5/0619C12N2529/10H01L24/00H01L31/035281H01L31/07H01L2924/12032
    • Device (1) for stimulation of at least one cell (2), and/or for stimulation of at least one electrochemical reaction, comprising at least one semiconductor (3) that is configured to convert electromagnetic radiation (4) into a charge separation (5), wherein the semiconductor (3) is planar and the device further comprises a planar metal layer (6), wherein the metal layer (6) forms a Schottky barrier (7), and/or a metal-insulator-semiconductor junction, with the semiconductor layer (3), the semiconductor and/or the metal layer is configured to bind to a cell (2) on contact, and/or configured to repel the cell (2) on contact in order to promote oriented or non-oriented binding to the cell, and/or configured to promote the electrochemical reaction when the device (1) is in contact with a solvent (11). The semiconductor (3) comprises at least one platelet (31) having a planar top face, a planar bottom face, and a circumferential side face that is more or less line-shaped or band-shaped, wherein either the top face or the bottom face of the platelet (31) is coated with the metal layer (6). A system (10) for the stimulation of a plurality of points in a network of cells, comprising a plurality of devices (1) according to the invention dispersed in a solvent (11). Methods (100-140, 210-240) for the fabrication of a plurality of devices (1) according to the invention. A disinfecting or sterilizing agent, and a medicament, with a plurality of devices according to the invention as its active ingredient.
    • (1),其用于刺激至少一个电池(2),和/或用于刺激至少一个电化学反应,包括至少一个半导体(3),其被配置为将电磁辐射 (6)形成肖特基势垒(7),和/或其中所述金属层 金属 - 绝缘体 - 半导体结,所述半导体层(3),所述半导体和/或所述金属层被配置为在接触时结合到单元(2),和/或被配置为在接触时排斥所述单元 以便促进定向或非定向结合到细胞,和/或被配置成当装置(1)与溶剂(11)接触时促进电化学反应。 半导体(3)包括至少一个具有平面顶面,平面底面和周向侧面的小板(31),该周面或多或少为线形或带形,其中顶面或底面 用金属层(6)涂覆片状物(31)的表面。 一种用于刺激细胞网络中的多个点的系统(10),包括分散在溶剂(11)中的多个根据本发明的装置(1)。 用于制造根据本发明的多个装置(1)的方法(100-140,210-240)。 一种消毒剂或消毒剂以及一种药剂,其具有多个根据本发明的装置作为其活性成分。