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1. 发明申请

WO2015028541A1 ANTIGEN DELIVERY DEVICE AND METHOD 审中-公开
标题翻译：抗原递送装置和方法
公开(公告)号：WO2015028541A1
公开(公告)日：2015-03-05
申请号：PCT/EP2014/068236
申请日：2014-08-28
申请人： PCI BIOTECH AS
发明人： HØGSET, Anders , WALDAY, Per Edvard , EIVINDVIK, Kristin
IPC分类号： A61N5/06 , A61K39/00 , A61K9/00
CPC分类号： A61N5/062 , A61B2017/00172 , A61K39/00 , A61K2039/55555 , A61M37/0015 , A61M2037/0023 , A61N2005/0626 , A61N2005/0627 , A61N2005/0629 , A61N2005/0645
摘要： A device (1) for activating light-induced rupture of endocytic vesicles in target cells of a patient so as to effect delivery of an administered antigen to cytosol in the target cells, is described. The device is adapted to be worn by a patient over a region of skin where an antigen and a photosensitising agent have been or are to be administered. The device comprises a rear surface (11) that is rounded or otherwise configured to be worn against the patient's skin. It has a retaining part for retaining the device in place over the region of the patient's skin during an activation cycle, which may be a strap (3a, 3b) or an adhesive layer. A light source, such as an LED, is arranged to illuminate the patient's skin from the rear of the device. A control system is configured to vary the output of the light source with respect to time in accordance with a pre-configured output sequence, which includes an initial stage where the output of the light source is set to be zero or generally below that which could deliver a light dose that can activate light-induced rupture of endocytic vesicles (so as to allow time for the antigen and photosensitising agent to reach the target cells), and a later stage where the output is set to deliver a light dose which can activate light-induced rupture of the endocytic vesicles (for effecting the delivery of the administered antigen to the cytosol of the target cells).
摘要翻译：描述了用于在患者的靶细胞中激活内源性囊泡的光诱导破裂以便将施用的抗原递送到靶细胞中的细胞质的装置（1）。该装置适于在已经或将要施用抗原和光敏剂的皮肤区域上由患者佩戴。该装置包括后表面（11），其被倒圆或以其它方式构造成与患者皮肤相对地佩戴。它具有保持部件，用于在激活循环期间将装置保持在患者皮肤区域上的适当位置，激活循环可以是带（3a，3b）或粘合剂层。诸如LED的光源被布置成从装置的后部照亮患者的皮肤。控制系统被配置为根据预先配置的输出序列来改变光源相对于时间的输出，其包括初始阶段，其中光源的输出被设置为零或大致低于可能提供可以激活光诱导的内吞囊泡破裂的轻剂量（从而允许抗原和光敏剂到达靶细胞的时间），以及输出被设置为递送可以激活的光剂量的后期内吞细胞的光诱导破裂（用于将所施用的抗原递送至靶细胞的胞质溶胶）。

2. 发明申请

WO2023073116A1 METHOD 审中-公开
公开(公告)号：WO2023073116A1
公开(公告)日：2023-05-04
申请号：PCT/EP2022/080106
申请日：2022-10-27
申请人： PCI BIOTECH AS
发明人： HØGSET, Anders , JOHANSEN, Pål
IPC分类号： A61K39/04 , A61K41/00 , A61P31/06
摘要： The present invention concerns a method of generating an immune response to bacteria in a subject, in which live bacteria (such as BCG) and a photosensitizing agent are administered to cells of the subject and the cells are irradiated with light of a wavelength effective to activate the photosensitizing agent to generate an immune response to the bacteria. Pharmaceutical compositions, products and kits for this purpose are also provided.

3. 发明申请

WO2019145419A1 METHOD 审中-公开
公开(公告)号：WO2019145419A1
公开(公告)日：2019-08-01
申请号：PCT/EP2019/051749
申请日：2019-01-24
申请人： PCI BIOTECH AS
发明人： HØGSET, Anders
IPC分类号： A61K41/00 , A61K31/00 , A61K33/00 , A61P31/00 , A61P35/00
摘要： The present invention concerns an in vivo method for introducing an mRNA molecule (which is not associated with a carrier) into the cytosol of a cell(s) in a subject, by the use of photochemical internalization, wherein the photosensitising agent is a sulphonated meso-tetraphenyl chlorin, sulfonated tetraphenylporphine or a di- or tetrasulfonated aluminium phthaiocyanine used in an amount of 0.0001 to 1µg. The method may be used to express a polypeptide in the subject. The invention is also directed to pharmaceutical compositions containing the photosensitising agents and the mRNA and uses of the molecules in therapy, e.g. to treat or prevent cancer or an infection.

4. 发明申请

WO2016139362A1 METHOD 审中-公开
标题翻译：方法
公开(公告)号：WO2016139362A1
公开(公告)日：2016-09-09
申请号：PCT/EP2016/054714
申请日：2016-03-04
申请人： PCI BIOTECH AS
发明人： HØGSET, Anders
IPC分类号： A61K39/00 , A61K39/12 , A61K39/39 , A61K47/48 , A61K41/00 , C12N5/0784
CPC分类号： A61K41/0057 , A61K9/0019 , A61K31/713 , A61K35/17 , A61K39/0011 , A61K39/12 , A61K39/39 , A61K39/39541 , A61K39/3955 , A61K41/00 , A61K47/6901 , A61K2039/505 , A61K2039/507 , A61K2039/5158 , A61K2039/545 , A61K2039/55561 , A61K2039/575 , A61K2039/585 , C07K16/2818 , C07K2317/76 , C12N5/0639 , C12N5/0645 , C12N7/00 , C12N13/00 , C12N2501/50 , C12N2501/599 , C12N2502/1114 , C12N2710/20034 , C12N2710/20071 , A61K2300/00
摘要： The invention concerns a method of generating an immune response in a subject, comprising administering to the subject an antigenic molecule, a photosensitizing agent, a checkpoint inhibitor, and irradiating said subject with light of a wavelength effective to activate the photosensitizing agent to generate an immune response. Preferably the method is a method of vaccination. The invention also provides related methods, compositions, cells, uses, products and kits.
摘要翻译：本发明涉及在受试者中产生免疫应答的方法，其包括对受试者施用抗原分子，光敏剂，检查点抑制剂，并用有效激活光敏剂的光的光照射所述受试者以产生免疫响应。优选地，该方法是接种疫苗的方法。本发明还提供了相关方法，组合物，细胞，用途，产品和试剂盒。

5. 发明申请

WO2011018635A2 PHOTOSENSITIZING COMPOSITIONS 审中-公开
标题翻译：光敏组合物
公开(公告)号：WO2011018635A2
公开(公告)日：2011-02-17
申请号：PCT/GB2010/001547
申请日：2010-08-16
申请人： PCI BIOTECH AS , KLAVENESS, Jo , HOGSET, Anders , GOLDING, Louise
发明人： KLAVENESS, Jo , HOGSET, Anders
IPC分类号： A61K41/00
CPC分类号： A61K41/0071
摘要： The invention relates to pharmaceutically acceptable salts of amphiphilic photosensitizing agents which have a water solubility of at least 0.5 mg/ml and to their use in methods of photochemical internalization. Such salts may be formed from a pharmaceutically acceptable base, for example an organic amine such as an amino alcohol, or from a pharmaceutically acceptable acid, for example a sulphonic acid or a sulphonic acid derivative. Due to their increased water solubility, such salts are particularly suitable for use in the preparation of parenteral pharmaceutical preparations, e.g. for use as solutions for injection or infusion.
摘要翻译：本发明涉及水溶性为至少0.5mg / ml的两亲性光敏剂的药学上可接受的盐及其在光化学内化方法中的用途。这样的盐可以由药学上可接受的碱形成，例如有机胺如氨基醇，或者来自药学上可接受的酸，例如磺酸或磺酸衍生物。由于它们水溶性增加，这些盐特别适用于制备胃肠外药物制剂，例如，用作注射或输液的溶液。

6. 发明申请

WO2015028575A1 IMMUNISATION METHOD BY PHOTOCHEMICAL INTERNALISATION 审中-公开
标题翻译：光化学分析的免疫方法
公开(公告)号：WO2015028575A1
公开(公告)日：2015-03-05
申请号：PCT/EP2014/068314
申请日：2014-08-28
申请人： PCI BIOTECH AS
发明人： HØGSET, Anders , JOHANSEN, Pål
IPC分类号： A61K39/02
CPC分类号： A61K39/02 , A61K2039/54 , A61K2039/545
摘要： The present invention relates to a method of vaccination or immunisation involving the use of a photosensitizing agent, an antigenic molecule, e.g. a vaccine component, and irradiation with light of a wavelength effective to activate the photosensitizing agent. The invention also provides the photosensitizing agent and antigenic molecule for use in such a method. The invention lies in the identification of specific advantageous protocols for achieving enhanced PCI-mediated immunisation e.g. vaccination, in particular in relation to the time at which irradiation is performed after administration of the antigenic molecule and the photosensitizing agent.
摘要翻译：本发明涉及一种疫苗接种或免疫的方法，涉及使用光敏剂，抗原分子，例如，疫苗组分和用有效激活光敏剂的波长的光照射。本发明还提供了用于这种方法的光敏剂和抗原分子。本发明在于鉴定用于实现增强的PCI介导的免疫的特定有利方案，例如特别是在给予抗原分子和光敏剂后进行照射的时间。

7. 发明申请

WO2015028574A1 COMPOUND AND METHOD FOR VACCINATION AND IMMUNISATION 审中-公开
标题翻译：用于疫苗接种和免疫的化合物和方法
公开(公告)号：WO2015028574A1
公开(公告)日：2015-03-05
申请号：PCT/EP2014/068313
申请日：2014-08-28
申请人： PCI BIOTECH AS
发明人： HØGSET, Anders , JOHANSEN, Pål
IPC分类号： A61K31/409 , A61K39/00 , A61K39/12 , A61K41/00 , A61K31/437 , A61K31/7115 , A61K35/14 , C12N5/0784 , A61P35/00
CPC分类号： A61K39/12 , A61K31/409 , A61K31/437 , A61K31/7115 , A61K35/74 , A61K39/0011 , A61K39/39 , A61K41/00 , A61K41/0057 , A61K47/6901 , A61K2039/5154 , A61K2039/5156 , A61K2039/54 , A61K2039/55511 , A61K2039/55561 , A61K2039/55572 , A61K2039/572 , A61N5/062 , C12N7/00 , C12N2710/20034 , A61K2300/00
摘要： The present invention relates to a method of vaccination or immunisation involving the use of a photosensitizing agent, an antigenic molecule, e.g. a vaccine component, and an agent which enhances the effect of photochemical internalization (PCI)-mediated vaccination wherein the agent is a ligand for a Toll-like receptor (TLR) as defined herein, and irradiation with light of a wavelength effective to activate the photosensitizing agent. The invention also relates to antigenic, e.g. vaccine compositions, useful in such a method. The invention also provides a method of generating antigen presenting cells which may be used to generate an immune response, e.g. for vaccination, which involves using the same components as above to introduce antigenic molecules, e.g. vaccine components, into cells to achieve antigen presentation, and to antigenic compositions useful in such a method. The invention also provides use of cells generated in vitro by such methods for administration to a patient in vivo to elicit an immune response, e.g. to achieve vaccination. A method of internalising an antigenic molecule into a cell is also provided.
摘要翻译：本发明涉及一种疫苗接种或免疫的方法，涉及使用光敏剂，抗原分子，例如，疫苗组分和增强光化学内化（PCI）介导的疫苗接种效果的试剂，其中所述试剂是如本文所定义的Toll样受体（TLR）的配体，并且用有效激活波长的波长的光照射光敏剂。本发明还涉及抗原性，例如疫苗组合物，可用于这种方法。本发明还提供了可用于产生免疫应答的抗原呈递细胞的方法，例如，用于疫苗接种，其涉及使用与上述相同的组分引入抗原性分子，例如，疫苗组分进入细胞以实现抗原呈递，以及可用于这种方法的抗原组合物。本发明还提供了通过这样的方法在体外产生的细胞在体内给予患者以引发免疫应答的用途，例如，实现疫苗接种。还提供了将抗原性分子内化为细胞的方法。

8. 发明申请

WO2013189663A1 CONJUGATE OF A PHOTOSENSITISER AND CHITOSAN AND USES THEREOF 审中-公开
标题翻译：光合剂和壳聚糖的结合及其用途
公开(公告)号：WO2013189663A1
公开(公告)日：2013-12-27
申请号：PCT/EP2013/059968
申请日：2013-05-14
申请人： PCI BIOTECH AS
发明人： BERG, Kristian , HØGSET, Anders , MÁSSON, Már , GAWARE, Vivek S.
IPC分类号： A61K41/00 , A61K47/48 , A61P35/00
CPC分类号： A61K41/0057 , A61K41/0076 , A61K47/61 , C08B37/003
摘要： The present invention relates to novel chitosan-based conjugates, e.g. nanocarriers, comprising a derivative of the biocompatible polymer chitosan conjugated to a photosensitising agent, and uses thereof in photochemical internalisation (PCI) and photodynamic therapy (PDT). The invention also relates to the use of the novel conjugates of the invention in treatment or prevention of diseases, particularly cancer, and for vaccination purposes.
摘要翻译：本发明涉及新颖的基于壳聚糖的缀合物，例如纳米载体，其包含与光敏剂缀合的生物相容性聚合物壳聚糖的衍生物，以及其在光化学内化（PCI）和光动力疗法（PDT）中的用途。本发明还涉及本发明的新型缀合物在治疗或预防疾病，特别是癌症以及疫苗接种目的中的用途。

9. 发明申请

WO2010001102A2 METHOD 审中-公开
标题翻译：方法
公开(公告)号：WO2010001102A2
公开(公告)日：2010-01-07
申请号：PCT/GB2009/001618
申请日：2009-06-26
申请人： PCI BIOTECH AS , HØGSET, Anders , WEYERGANG, Anette , SELBO, Pål, Kristian , BERG, Kristian , JONES, Elizabeth, Louise
发明人： HØGSET, Anders , WEYERGANG, Anette , SELBO, Pål, Kristian , BERG, Kristian , JONES, Elizabeth, Louise
IPC分类号： A61K41/00 , A61P35/00 , A61P43/00 , A61K31/00
CPC分类号： A61K41/0071 , A61K31/00
摘要： The present invention relates to a method for enhancing the activity of kinase inhibitors in target cells, and more specifically for enhancing the activity of tyrosine kinase inhibitors (TKIs), said method comprising contacting a cell with a kinase inhibitor and a photosensitizing agent and irradiating said cell with light of a wavelength effective to activate the photosensitizing agent, and to the use of this method for enhancing the effects of kinase inhibitors or kinase inhibitor-based drugs in particular to achieve cell death, for example, in cancer treatment and other diseases or conditions in which kinase inhibitors, such as TKIs, have a beneficial effect.
摘要翻译：本发明涉及一种增强靶细胞中激酶抑制剂活性的方法，更具体地涉及提高酪氨酸激酶抑制剂（TKIs）活性的方法，所述方法包括使细胞与激酶抑制剂和光敏剂接触并照射所述具有有效激活光敏剂的波长的光的细胞，以及用于增强激酶抑制剂或基于激酶抑制剂的药物特别是用于实现细胞死亡（例如在癌症治疗和其它疾病中）或激酶抑制剂如TKIs具有有益效果的条件。

10. 发明申请

WO2019092215A1 COMPOSITION FOR THE TREATMENT OF INTRACELLULAR BACTERIAL INFECTION 审中-公开
公开(公告)号：WO2019092215A1
公开(公告)日：2019-05-16
申请号：PCT/EP2018/080832
申请日：2018-11-09
申请人： PCI BIOTECH AS , ACADEMISCH MEDISCH CENTRUM
发明人： HØGSET, Anders , ZAAT, Sebastian A.J. , ZHANG, Xiaolin
IPC分类号： A61K45/06 , A61K31/7036 , A61P31/04 , A61K41/00
摘要： The present invention provides a method of treating or preventing an intracellular bacterial infection, comprising contacting the cell(s) which are infected with an antibacterial agent and a photosensitizing agent and irradiating the cell(s) with light of a wavelength effective to activate the photosensitizing agent, wherein the antibacterial agent is released into the cytosol of the cell(s) and kills, damages or prevents the replication of bacteria in said cell(s). The invention also provides related uses, and compositions, products and kits for the same.

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