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1. 发明申请

WO2012078470A2 METHODS OF SMALL MOLECULE DIRECTED REGENERATION FROM PLURIPOTENT STEM CELLS 审中-公开
标题翻译：小分子靶向从细胞干细胞再生的方法
公开(公告)号：WO2012078470A2
公开(公告)日：2012-06-14
申请号：PCT/US2011063101
申请日：2011-12-02
申请人： PARSONS XUEJUN H
发明人： PARSONS XUEJUN H
IPC分类号： C12N5/0735 , C12Q1/68
CPC分类号： C12N5/0619 , A61K35/30 , C12N5/0618 , C12N5/0657 , C12N2500/38 , C12N2501/115 , C12N2501/33 , C12N2501/385 , C12N2501/40 , C12N2502/02 , C12N2506/02 , C12N2533/50 , C12N2533/90 , G01N33/5044 , G01N33/5058 , G01N33/5073
摘要： This instant invention is based on the discovery that pluripotent human stem cells maintained under the defined culture conditions can be uniformly converted into a specific lineage by small molecule induction. Retinoic acid induces the specification of neuroectoderm direct from the pluripotent state of human stem cells and triggers progression to neuronal progenitors and neurons efficiently. Similarly, nicotinamide induces the specification of cardiomesoderm direct from the pluripotent state of human stem cells and triggers progression to cardiac precursors and cardiomyocytes efficiently. This technology provides a large supply of clinically-suitable human neuronal or cardiac therapeutic products for CNS or myocardium repair. This invention enables well-controlled efficient induction of pluripotent human stem cells exclusively to a specific clinically-relevant lineage for tissue and organ engineering and regeneration, cell-based therapy, and drug discovery.
摘要翻译：本发明基于这样的发现，即通过定义的培养条件维持的多能人干细胞可以通过小分子诱导被均匀地转化成特定谱系。视黄酸从人类干细胞的多能性直接诱导神经外胚层的规范，并有效地引发神经元祖细胞和神经元的进展。类似地，烟酰胺从人干细胞的多能性直接诱导心肌细胞的规范，并且有效地触发心脏前体和心肌细胞的进展。该技术为CNS或心肌修复提供了大量临床合适的人类神经元或心脏治疗产品。本发明使得能够完全控制有效诱导多能人干细胞专门用于组织和器官工程和再生，基于细胞的治疗和药物发现的特定临床相关谱系。

2. 发明申请

WO2012027474A1 NON-STATIC SUSPENSION CULTURE OF CELL AGGREGATES 审中-公开
标题翻译：细胞聚集体的非静止悬浮培养
公开(公告)号：WO2012027474A1
公开(公告)日：2012-03-01
申请号：PCT/US2011/048972
申请日：2011-08-24
申请人： REGENTS OF THE UNIVERSITY OF MINNESOTA , KATHOLIEKE UNIVERSITEIT LEUVEN , SUBRAMANIAN, Kartik , HU, Wei-Shou , VERFAILLIE, Catherine, M. , PARK, Yonsil
发明人： SUBRAMANIAN, Kartik , HU, Wei-Shou , VERFAILLIE, Catherine, M. , PARK, Yonsil
IPC分类号： C12N5/07
CPC分类号： C12N5/0607 , C12N5/0606 , C12N5/0662 , C12N5/0692 , C12N5/0695 , C12N5/0696 , C12N2500/02 , C12N2501/602 , C12N2501/603 , C12N2502/02 , C12N2513/00
摘要： The invention is directed to compositions of cell aggregates and methods for making and using the cell aggregates where the aggregates comprise cells that are not embryonic stem cells but can differentiate into cell types of at least two of ectodermal, endodermal, and mesodermal embryonic germ layers, e.g., stem cells.
摘要翻译：本发明涉及细胞聚集体的组合物和用于制备和使用细胞聚集体的方法，其中聚集体包含不是胚胎干细胞但可分化为外胚层，内胚层和中胚层胚胎胚层中的至少两种的细胞类型的细胞，例如，干细胞。

3. 发明申请

WO2011162826A2 GROUP CULTURE SYSTEM AND METHOD WITH HELPER EMBRYOS 审中-公开
标题翻译：组织文化系统和方法与帮助EMBRYOS
公开(公告)号：WO2011162826A2
公开(公告)日：2011-12-29
申请号：PCT/US2011/001135
申请日：2011-06-24
申请人： INGURAN, LLC , DU, Fuliang , PRESICCE, Giorgio, Antonio , MORENO, Juan , XU, Jie , WU, Shinn-Chin
发明人： DU, Fuliang , PRESICCE, Giorgio, Antonio , MORENO, Juan , XU, Jie , WU, Shinn-Chin
IPC分类号： C12N5/073
CPC分类号： C12M21/06 , C12M23/12 , C12N5/0012 , C12N5/0604 , C12N2502/02 , C12N2533/76
摘要： Methods and systems for physically separating helper embryos from desired embryos in a group culturing technique in order to maintain the pedigree and genetic information of the desired embryos from different species, including cattle and human, and to provide the developmental benefits of group culturing. The separation of the groups of embryos can be the result of embedding one group of embryos in a gel or solid, or the groups can be physically separated by a membrane or other structure.
摘要翻译：在组织培养技术中物理分离辅助胚胎与期望的胚胎的方法和系统，以便保持来自不同物种（包括牛和人）的所需胚胎的谱系和遗传信息，并提供组培养的发育益处。胚胎组的分离可以是将一组胚胎嵌入凝胶或固体中的结果，或者这些基团可以通过膜或其它结构物理分离。

4. 发明申请

WO2011064669A2 ADHERENT CELLS FROM PLACENTA AND USE OF SAME IN DISEASE TREATMENT 审中-公开
标题翻译：来自PLACENTA的附加细胞和在疾病治疗中使用相同的细胞
公开(公告)号：WO2011064669A2
公开(公告)日：2011-06-03
申请号：PCT/IB2010/003219
申请日：2010-11-29
申请人： PLURISTEM LTD. , ABERMAN, Zami
发明人： ABERMAN, Zami
IPC分类号： C12N5/073
CPC分类号： A61K35/50 , A61K2035/122 , C12N5/0605 , C12N2502/02
摘要： Methods for treating conditions by administration of placenta derived adherent stromal cells to a subject in thereof are provided. Such conditions include skeletal muscle defects, neuropathic pain, and myocardial infarction. Also provided are methods wherein the adherent stromal cells administered are cultured under 2 dimensional or 3 dimensional growth conditions. Also provided are methods in which the cells administered are at least 70 % adherent cells from a maternal or fetal portion of the placenta.
摘要翻译：提供了通过将胎盘衍生的粘附基质细胞施用于其中的受试者来治疗病症的方法。这些病症包括骨骼肌缺损，神经性疼痛和心肌梗死。还提供了其中所施用的贴壁基质细胞在2维或3维生长条件下培养的方法。还提供了这样的方法，其中施用的细胞是来自胎盘的母体或胎儿部分的至少70％的贴壁细胞。

5. 发明申请

WO2010138171A2 METHODS FOR CANCER TREATMENT USING STEM CELLS 审中-公开
标题翻译：使用干细胞治疗癌症的方法
公开(公告)号：WO2010138171A2
公开(公告)日：2010-12-02
申请号：PCT/US2010001526
申请日：2010-05-24
申请人： INCUBE LABS LLC
发明人： IMRAN MIR
IPC分类号： A61K39/395 , A61K35/12 , A61P35/00
CPC分类号： A61K39/0011 , A61K35/13 , A61K2039/5152 , C12N5/0695 , C12N2502/02
摘要： Various embodiments of the invention provide methods of treating cancer. Many embodiments provide methods of treating cancer using stem cells. In one embodiment the method comprises removing cancer cells from a patient and culturing the cancer cells in the presence of stem cells under conditions such that the stem cells differentiate into stem cell- derived cancer cells (SCDCC) which can comprise stem cell derived non-invasive and/or invasive cancer cells. An amount of the SCDCC is introduced into the patient sufficient to induce the patient's immune system to produce antibodies which inhibit or destroy the patient's cancer cells. The SCDCC may also be genetically modified to produce various immune stimulating proteins which enhance the patient's immune response to the cancer cells and improves the efficacy of the SCDNIC in treating the patient's cancer.
摘要翻译：本发明的各种实施方案提供了治疗癌症的方法。许多实施方案提供了使用干细胞治疗癌症的方法。在一个实施方案中，该方法包括从患者中除去癌细胞并在干细胞存在下培养癌细胞，使得干细胞分化成干细胞衍生的癌细胞（SCDCC），其可以包含干细胞来源的非侵入性和/或浸润性癌细胞。将足够的SCDCC量引入患者的免疫系统以产生抑制或破坏患者癌细胞的抗体。 SCDC也可以被遗传修饰以产生各种免疫刺激蛋白，增强患者对癌细胞的免疫应答，并提高SCDNIC治疗患者癌症的功效。

6. 发明申请

WO2010065546A3 MAINTENANCE/EXPANSION OF HSCs 审中-公开
标题翻译：维护/扩展HSC
公开(公告)号：WO2010065546A3
公开(公告)日：2010-09-16
申请号：PCT/US2009066271
申请日：2009-12-01
申请人： VERFAILLIE CATHERINE , BUCKLEY SHANNON MYCHEL
发明人： VERFAILLIE CATHERINE , BUCKLEY SHANNON MYCHEL
IPC分类号： C12N5/0789 , C07K14/52
CPC分类号： C12N5/0647 , C12N2502/02 , C12N2502/14
摘要： The invention is related to methods for culturing stem cells, more particularly hematopoietic stem cells (HSC). The invention relates to methods for HSC maintenance and/or expansion through the use of soluble factors. The invention is also directed to cells produced by the methods of the invention. The cells are useful, among other things, for treatment of disorders or diseases (e.g. leukemia). The invention also relates to the development of small molecules that may increase HSC self renewal in vitro and in vivo.
摘要翻译：本发明涉及用于培养干细胞，更特别是造血干细胞（HSC）的方法。本发明涉及通过使用可溶性因子进行HSC维持和/或扩增的方法。本发明还涉及通过本发明的方法生产的细胞。除其他之外，细胞用于治疗疾病或疾病（例如白血病）是有用的。本发明还涉及可在体外和体内增加HSC自我更新的小分子的开发。

7. 发明申请

WO2009151844A1 MULTIPOTENT STEM CELL CULTURES 审中-公开
标题翻译：多元干细胞培养
公开(公告)号：WO2009151844A1
公开(公告)日：2009-12-17
申请号：PCT/US2009/043426
申请日：2009-05-11
申请人： SAINT PETER'S COLLEGE , SCIORRA, Leonard
发明人： SCIORRA, Leonard
IPC分类号： C12N5/08 , C12N5/00
CPC分类号： C12N5/0662 , C12N5/0605 , C12N5/0607 , C12N2502/02 , C12N2506/1307
摘要： The invention provides methods for propagation of multipotent stem cells from human skin fibroblast samples using an appropriate medium, such as an amniotic fluid medium (AFM), and subsequent differentiation of the cells into cells of any of the three germ layers. The invention also provides methods of differentiating and making various tissues from multipotent cells in skin fibroblasts cultures that are capable of in vitro differentiation and that the cells are useful as a source of in vivo gene and/or autologist cell therapy. Isolated multipotent stem cells, culture of multipotent stem cells, and differentiated cells derived from the culture multipotent stem cells that are obtained by the methods disclosed herein also are provided. The methods, cells, cultures, media, banks, batches, and collections so provided can be used for various medical, research, diagnostic and therapeutic uses.
摘要翻译：本发明提供了使用适当培养基（例如羊水培养基（AFM））从人皮肤成纤维细胞样品繁殖多能干细胞的方法，以及随后将细胞分化成三个胚层中任何一个的细胞。本发明还提供了在皮肤成纤维细胞培养物中分化和制备来自多能细胞的各种组织的方法，其能够进行体外分化，并且该细胞可用作体内基因和/或自体细胞治疗的来源。还提供了通过本文公开的方法获得的分离的多能干细胞，多能干细胞的培养物和衍生自培养多潜能干细胞的分化细胞。如此提供的方法，细胞，培养物，媒体，银行，批次和收藏可用于各种医学，研究，诊断和治疗用途。

8. 发明申请

WO2008103462A2 HIGHLY EFFICIENT METHODS FOR REPROGRAMMING DIFFERENTIATED CELLS AND FOR GENERATING ANIMALS AND EMBRYONIC STEM CELLS FROM REPROGRAMMED CELLS 审中-公开
标题翻译：用于重组差异化细胞和用于从代谢细胞产生动物和胚胎干细胞的高效方法
公开(公告)号：WO2008103462A2
公开(公告)日：2008-08-28
申请号：PCT/US2008/002380
申请日：2008-02-22
申请人： ADVANCED CELL TECHNOLOGY, INC. , LANZA, Robert , CHUNG, Young
发明人： LANZA, Robert , CHUNG, Young
IPC分类号： C12N5/08
CPC分类号： C12N5/0606 , A01K67/0273 , A01K67/0275 , A01K2227/105 , A01K2267/0393 , C07K14/43595 , C12N5/0603 , C12N5/0604 , C12N5/0619 , C12N5/0621 , C12N5/0634 , C12N5/0657 , C12N2501/235 , C12N2501/998 , C12N2502/02 , C12N2506/02 , C12N2517/04 , C12N2533/52
摘要： The present invention relates generally to the field of somatic cell nuclear transfer (SCNT) and to the creation of cloned animals and cells. The disclosure relates to a method of cloning a mammal, obtaining pluripotent cells such as embryonic stem cells, or for reprogramming a mammalian cell using an oocyte and a fertilized embryo.
摘要翻译：本发明一般涉及体细胞核转移（SCNT）领域以及克隆的动物和细胞的产生。本公开涉及克隆哺乳动物，获得多能细胞如胚胎干细胞或用卵母细胞和受精胚胎重新编程哺乳动物细胞的方法。

9. 发明申请

WO2008016039A1 妊娠促進剤审中-公开
标题翻译：肥料代理
公开(公告)号：WO2008016039A1
公开(公告)日：2008-02-07
申请号：PCT/JP2007/064961
申请日：2007-07-31
申请人：日本ケミカルリサーチ株式会社 , 塩谷雅英 , 後藤栄
发明人：塩谷雅英 , 後藤栄
IPC分类号： A61K35/48 , A61P15/08
CPC分类号： A61K35/48 , C12N2502/02
摘要：　ヒトの胚盤胞移植をベースとし，それによる妊娠の確率を向上させるための手段が開示されている。当該手段は，ヒト胚を培地中で胚盤胞に至るまで培養して得られる培養物の培養上清を含有してなる，胚盤胞移植における妊娠促進剤を含む。当該薬剤の製造方法，及び，ヒトにおける妊娠促進のための方法であって，ヒト胚を培地中で胚盤胞に至るまで培養し，当該培養物の上清を含む組成物を，胚盤胞移植を受けることになっているヒト患者の子宮腔内に注射し，次いで当該患者に胚盤胞を移植することを含むものである方法も，開示されている。
摘要翻译：公开了一种改善基于人体胚胎移植的生殖力的方法。该方法包括在胚泡转移中的生育剂，其包含通过在培养物中培养人胚胎而获得的培养物上清液，直到发育成囊胚。还公开了制备该试剂的方法和增加人的生育力的方法，包括在培养基中培养人胚，直至发育成囊胚，将含有培养物上清液的组合物注入人的子宫腔将要进行胚泡移植的患者，并将囊胚转移到患者身上。

10. 发明申请

WO2007127975A2 METHOD FOR EXPANSION OF HUMAN CORNEAL ENDOTHELIAL CELLS 审中-公开
标题翻译：人角膜内皮细胞扩增方法
公开(公告)号：WO2007127975A2
公开(公告)日：2007-11-08
申请号：PCT/US2007067772
申请日：2007-04-30
申请人： TSAI RYAN TAO NIEN , TSAI RAY JU-FANG
发明人： TSAI RAY JU-FANG
IPC分类号： C12N5/071 , C12N5/0797
CPC分类号： C12N5/0623 , A61K35/12 , A61L27/3604 , A61L27/3808 , A61L27/3839 , A61L27/3895 , A61L2430/16 , C12N5/0621 , C12N2500/38 , C12N2501/11 , C12N2501/115 , C12N2502/02 , C12N2533/92 , Y10S977/904 , Y10S977/908 , Y10S977/913 , Y10S977/923
摘要： A method for expanding human corneal endothelial cells includes: (a) providing an amniotic membrane with or without amniotic cells, wherein the amniotic membrane has an extracellular matrix; (b) placing onto the amniotic membrane, a sheet of endothelial layer, or a cell suspension including human corneal endothelial stem cells; and (c) culturing the corneal endothelial cells on the amniotic membrane for a duration sufficient for the corneal endothelial stem cells to expand to an appropriate area. The invention also relates to a method for creating a surgical graft for a recipient site of a patient using the method for expanding human corneal endothelial cells, and the surgical graft prepared therefrom.
摘要翻译：用于扩张人角膜内皮细胞的方法包括：（a）提供具有或不具有羊膜细胞的羊膜，其中所述羊膜具有细胞外基质; （b）放置在羊膜上，一片内皮层或包含人角膜内皮干细胞的细胞悬浮液; 和（c）在羊膜上培养足够使角膜内皮干细胞扩张到适当区域的持续时间的角膜内皮细胞。本发明还涉及使用扩张人角膜内皮细胞的方法和由其制备的手术移植物来创建用于患者的受体部位的手术移植物的方法。

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