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1. 发明申请

WO2016037159A1 RETINAL GANGLION CELLS AND PROGENITORS THEREOF 审中-公开
标题翻译：后遗神经细胞及其前体细胞
公开(公告)号：WO2016037159A1
公开(公告)日：2016-03-10
申请号：PCT/US2015/048741
申请日：2015-09-05
申请人： OCATA THERAPEUTICS, INC. , WANG, Wei , LU, Shi-Jiang , LANZA, Robert, P.
发明人： WANG, Wei , LU, Shi-Jiang , LANZA, Robert, P.
IPC分类号： C12N5/0793 , C12N5/0797 , A61K35/30 , A61P27/02
CPC分类号： A61K35/30 , C12N5/00 , C12N5/0018 , C12N5/0621 , C12N2501/01 , C12N2501/13 , C12N2501/155 , C12N2501/33 , C12N2501/385 , C12N2501/42 , C12N2506/02
摘要： Methods are provided for the production of retinal ganglion (RG) progenitor cells and mature RG cells from pluripotent stem cells optionally under feeder- free conditions, and further optionally under xeno-free conditions. Additionally provided are compositions of RG progenitor cells and mature RG cells, as well as methods of use thereof including therapeutic use thereof. Exemplary methods may produce substantially pure populations and cultures of RG progenitor cells and mature RG cells.
摘要翻译：提供了用于任选地在无饲养条件下进一步任选地在无异种条件下从多能干细胞生产视网膜神经节（RG）祖细胞和成熟RG细胞的方法。另外提供了RG祖细胞和成熟RG细胞的组合物，以及其使用方法，包括其治疗用途。示例性的方法可以产生基本上纯的RG祖细胞和成熟RG细胞的群体和培养物。

2. 发明申请

WO2009137624A3 HEMANGIO COLONY FORMING CELLS AND NON-ENGRAFTING HEMANGIO CELLS 审中-公开
标题翻译： HEMANGIO COLONY成形细胞和非恒定HEMANGIO细胞
公开(公告)号：WO2009137624A3
公开(公告)日：2010-01-07
申请号：PCT/US2009043043
申请日：2009-05-06
申请人： ADVANCED CELL TECH INC , LANZA ROBERT , LU SHI-JIANG
发明人： LANZA ROBERT , LU SHI-JIANG
IPC分类号： C12N5/0789
CPC分类号： C12N5/0647 , A61K35/12 , A61K35/28 , A61K35/44 , A61K38/13 , A61K45/06 , A61K2035/124 , A61N5/10 , C12N2500/90 , C12N2501/115 , C12N2501/125 , C12N2501/14 , C12N2501/145 , C12N2501/155 , C12N2501/165 , C12N2501/26 , C12N2506/02 , C12N2506/45
摘要： Methods of generating and expanding human hemangio-colony forming cells and non-engrafting hemangio cells in vitro and methods of expanding and using such cells are disclosed. The methods permit the production of large numbers of hemangio-colony forming cells, non-engrafting hemangio cells as well as derivative cells, such as hematopoietic and endothelial cells. The cells obtained by the methods disclosed may be used for a variety of research, clinical, and therapeutic applications. Human non-engrafting hemangio cells are a novel progenitor cell population that is related to but distinct from the hemangioblast and human hemangio-colony forming cells. The invention also provides compositions, preparations, and solutions comprising hemangio-colony forming cells, non-engrafting hemangio cells or cells differentiated therefrom. The compositions, preparations, and solutions include cryopreserved preparations and substantially purified preparations, as well as mixed compositions formulated in combination with related hemangioblast progenitor cell types that can engraft into the bone marrow.
摘要翻译：公开了在体外产生和扩大人血管瘤集落形成细胞和非移植血管瘤细胞的方法以及扩增和使用这些细胞的方法。该方法允许生产大量的血管瘤集落形成细胞，非移植血管瘤细胞以及衍生细胞，如造血细胞和内皮细胞。通过所公开的方法获得的细胞可用于各种研究，临床和治疗应用。人类非移植血管瘤细胞是与成血管细胞和人血管瘤集落形成细胞相关但不同的新型祖细胞群。本发明还提供包含血管瘤集落形成细胞，非移植血管瘤细胞或与其分化的细胞的组合物，制剂和溶液。组合物，制剂和溶液包括冷冻保存的制剂和基本纯化的制剂，以及与可以移入骨髓的相关成血管细胞祖细胞类型组合配制的混合组合物。

3. 发明申请

WO2009137629A2 METHODS FOR PRODUCING ENUCLEATED ERYTHROID CELLS DERIVED FROM PLURIPOTENT STEM CELLS 审中-公开
标题翻译：用于生产从PLUIPOTETIC STEM CELLS衍生的已知的乳清细胞的方法
公开(公告)号：WO2009137629A2
公开(公告)日：2009-11-12
申请号：PCT/US2009/043050
申请日：2009-05-06
申请人： ADVANCED CELL TECHNOLOGY, INC. , LANZA, Robert , LU, Shi-Jiang
发明人： LANZA, Robert , LU, Shi-Jiang
IPC分类号： C12N5/08
CPC分类号： C12N5/0641 , A61K35/12 , C12N5/0644 , C12N5/0647 , C12N5/0692 , C12N2500/25 , C12N2500/38 , C12N2501/115 , C12N2501/125 , C12N2501/14 , C12N2501/145 , C12N2501/155 , C12N2501/165 , C12N2501/23 , C12N2501/26 , C12N2501/60 , C12N2502/1358 , C12N2502/1394 , C12N2506/02 , C12N2506/45 , C12N2533/78
摘要： Methods for generating enucleated erythroid cells using pluripotent stem cells are provided. The methods permit the production of large numbers of cells. The cells obtained by the methods disclosed may be used for a variety of research, clinical, and therapeutic applications. Methods for generating megakaryocyte and platelets are also provided.
摘要翻译：提供了使用多能干细胞产生去核的红细胞的方法。该方法允许生产大量的细胞。通过所公开的方法获得的细胞可用于各种研究，临床和治疗应用。还提供了产生巨核细胞和血小板的方法。

4. 发明申请

WO2007120811A3 HEMANGIO-COLONY FORMING CELLS 审中-公开
标题翻译： HEMANGIO-COLONY形成细胞
公开(公告)号：WO2007120811A3
公开(公告)日：2008-03-06
申请号：PCT/US2007009106
申请日：2007-04-13
申请人： ADVANCED CELL TECH INC , LANZA ROBERT , LU SHI-JIANG
发明人： LANZA ROBERT , LU SHI-JIANG
IPC分类号： C12N5/0789
CPC分类号： C12N5/0647 , A61K35/44 , A61K2035/124 , C12N2500/90 , C12N2500/99 , C12N2501/115 , C12N2501/125 , C12N2501/145 , C12N2501/155 , C12N2501/165 , C12N2501/20 , C12N2501/26 , C12N2501/998 , C12N2506/02
摘要： Methods of generating and expanding human hemangio-colony forming cells in vitro and methods of expanding and using such cells are disclosed. The methods permit the production of large numbers of hemangio-colony forming cells as well as derivative cells, such as hematopoietic and endothelial cells. The cells obtained by the methods disclosed may be used for a variety of research, clinical, and therapeutic applications.
摘要翻译：公开了在体外产生和扩大人血管瘤集落形成细胞的方法以及扩增和使用这些细胞的方法。该方法允许生产大量的血管瘤集落形成细胞以及衍生细胞，如造血细胞和内皮细胞。通过所公开的方法获得的细胞可用于各种研究，临床和治疗应用。

5. 发明申请

WO2002073188A1 METHOD FOR GENERATING REPLACEMENT CELLS AND/OR TISSUES 审中-公开
标题翻译：产生替代细胞和/或组织的方法
公开(公告)号：WO2002073188A1
公开(公告)日：2002-09-19
申请号：PCT/US2002/007394
申请日：2002-03-13
申请人： ADVANCED CELL TECHNOLOGY, INC. , LANZA, Robert
发明人： LANZA, Robert
IPC分类号： G01N33/00
CPC分类号： A01K67/0271 , A61K35/12 , A61K38/00 , C12N2517/02 , C12N2517/04
摘要： Disclosed are methods of isolaitng differentiated cells or adult stem cells for pluripotent cells and particularly ICM cells, by exposing such pluripotent cells to environmental cues in order to encourage development along a certain path.
摘要翻译：公开了通过将这种多能细胞暴露于环境线索以分散多能细胞，特别是ICM细胞的分化细胞或成体干细胞的分离方法，以促进沿某一途径的发育。

6. 发明申请

WO2002073187A1 METHOD FOR GENERATING REPLACEMENT CELLS AND/OR TISSUES 审中-公开
标题翻译：产生替代细胞和/或组织的方法
公开(公告)号：WO2002073187A1
公开(公告)日：2002-09-19
申请号：PCT/US2002/007109
申请日：2002-03-11
申请人： ADVANCED CELL TECHNOLOGY, INC. , LANZA, Robert
发明人： LANZA, Robert
IPC分类号： G01N33/00
CPC分类号： C12N5/0606 , A01K67/0271 , A61K35/12 , A61K38/00 , C12N2517/02 , C12N2517/04
摘要： Disclosed are methods of isolating differentiated cells or adult stem cells from pluripotent cells and particularly ICM cells, by exposing such pluripotent cells to environmental cues in order to encourage development along a certain path.
摘要翻译：公开了通过将这样的多能细胞暴露于环境线索以分散多能细胞，特别是ICM细胞中的分化细胞或成体干细胞的方法，以促进沿某一途径的发育。

7. 发明申请

WO0228164A3 CLONING ENDANGERED AND EXTINCT SPECIES 审中-公开
标题翻译：克隆濒危物种和除外物种
公开(公告)号：WO0228164A3
公开(公告)日：2002-07-18
申请号：PCT/US0131218
申请日：2001-10-05
申请人： ADVANCED CELL TECH INC , LANZA ROBERT , CIBELLI JOSE , DAMIANI PHILIP , WEST MICHAEL D
发明人： LANZA ROBERT , CIBELLI JOSE , DAMIANI PHILIP , WEST MICHAEL D
IPC分类号： A01K67/027 , C12N15/873 , G01N33/00 , C12N15/00
CPC分类号： C12N15/873
摘要： Approximately 100 species become extinct a day. Despite increasing interest in using cloning to rescue endangered species, successful interspecies nuclear transfer has not been previously described, and only a few report of in vitro embryo formation exist. Here it is shown that interspecies nuclear transfer can be used to clone an endangered species with normal karyo- and phenotypic development through implantation and the late stages of fetal growth, resulting in a newborn animal.
摘要翻译：每天约有100种物种灭绝。尽管越来越多的兴趣使用克隆来拯救濒危物种，但以前没有描述成功的种间核转移，只有少数的体外胚胎形成报告存在。这里表明，种间核转移可用于通过植入和胎儿生长的晚期阶段克隆具有正常核型和表型发育的濒危物种，导致新生儿动物。

8. 发明申请

WO2012174520A2 SEISMIC DEVICE WITH SEALED HOUSING AND RELATED METHODS 审中-公开
标题翻译：具有密封住房的地震装置及相关方法
公开(公告)号：WO2012174520A2
公开(公告)日：2012-12-20
申请号：PCT/US2012042929
申请日：2012-06-18
申请人： SCHLUMBERGER CA LTD , SCHLUMBERGER SERVICES PETROL , SCHLUMBERGER HOLDINGS , SCHLUMBERGER TECHNOLOGY BV , PRAD RES & DEV LTD , MINTO JAMES , LANZA ROBERT , BRYANS BRADLEY , DEKKERS MICHAEL , RAY SHANTONU
发明人： MINTO JAMES , LANZA ROBERT , BRYANS BRADLEY , DEKKERS MICHAEL , RAY SHANTONU
CPC分类号： G01V1/04 , G01V1/02 , G01V1/143 , G01V1/40 , G01V1/52 , G01V11/005
摘要： A seismic generation system may include an electrical source, a conductor coupled to the electrical source and to be positioned in a wellbore in a subterranean formation with a casing therein, and a seismic generation source assembly to be positioned in the wellbore and coupled to the conductor. The seismic generation source assembly may include a source element having a sealed housing, an armature within the sealed housing, source electromagnets coupled to the armature, and electromagnetic clamps coupled to the armature, each electromagnetic clamp having opposite magnetic poles. The sealed housing may include respective ferromagnetic portions adjacent the opposite magnetic poles of each electromagnetic clamp, and non-ferromagnetic portions between the opposite magnetic poles of each electromagnetic clamp.
摘要翻译：地震发生系统可以包括电源，耦合到电源的导体并且被定位在地下地层中的井眼中，其中壳体在其中;以及地震发生源组件，其被定位在井筒中并且耦合到导体。地震发生源组件可以包括具有密封壳体的源元件，密封壳体内的电枢，耦合到电枢的源电磁体和耦合到电枢的电磁夹具，每个电磁夹具具有相反的磁极。密封壳体可以包括与每个电磁夹具的相对磁极相邻的相应铁磁部分，以及每个电磁夹具的相对磁极之间的非铁磁部分。

9. 发明申请

WO2006080952A3 IMPROVED MODALITIES FOR THE TREATMENT OF DEGENERATIVE DISEASES OF THE RETINA 审中-公开
标题翻译：改善治疗退行性疾病的方法
公开(公告)号：WO2006080952A3
公开(公告)日：2009-04-30
申请号：PCT/US2005025860
申请日：2005-07-20
申请人： ADVANCED CELL TECH INC , KLIMANSKAYA IRINA , LANZA ROBERT
发明人： KLIMANSKAYA IRINA , LANZA ROBERT
IPC分类号： A01K67/00 , A01N63/00 , A61K48/00 , C12N5/071 , C12N5/0793
CPC分类号： C12N5/0621 , A61K35/12 , A61K35/30 , A61K35/36 , A61K35/44 , A61K35/545 , C12N5/062 , C12N2500/32 , C12N2500/44 , C12N2501/01 , C12N2501/115 , C12N2501/15 , C12N2501/155 , C12N2501/235 , C12N2501/33 , C12N2501/60 , C12N2506/02
摘要： This invention relates to methods for improved cell-based therapies for retinal degeneration and for differentiating human embryonic stem cells and human embryo-derived into retinal pigment epithelium (RPE) cells and other retinal progenitor cells.
摘要翻译：本发明涉及用于改善基于视网膜变性的基于细胞的疗法和用于分化人类胚胎干细胞和人类胚胎来源于视网膜色素上皮（RPE）细胞和其它视网膜祖细胞的细胞的治疗方法。

10. 发明申请

WO2007120811A2 HEMANGIO-COLONY FORMING CELLS 审中-公开
标题翻译： HEMANGIO-COLONY形成细胞
公开(公告)号：WO2007120811A2
公开(公告)日：2007-10-25
申请号：PCT/US2007/009106
申请日：2007-04-13
申请人： ADVANCED CELL TECHNOLOGY, INC. , LANZA, Robert , LU, Shi-Jiang
发明人： LANZA, Robert , LU, Shi-Jiang
IPC分类号： C12N5/00
CPC分类号： C12N5/0647 , A61K35/44 , A61K2035/124 , C12N2500/90 , C12N2500/99 , C12N2501/115 , C12N2501/125 , C12N2501/145 , C12N2501/155 , C12N2501/165 , C12N2501/20 , C12N2501/26 , C12N2501/998 , C12N2506/02
摘要： Methods of generating and expanding human hemangio-colony forming cells in vitro and methods of expanding and using such cells are disclosed. The methods permit the production of large numbers of hemangio-colony forming cells as well as derivative cells, such as hematopoietic and endothelial cells. The cells obtained by the methods disclosed may be used for a variety of research, clinical, and therapeutic applications.
摘要翻译：公开了在体外产生和扩大人血管瘤集落形成细胞的方法以及扩增和使用这些细胞的方法。该方法允许生产大量的血管瘤集落形成细胞以及衍生细胞，如造血细胞和内皮细胞。通过所公开的方法获得的细胞可用于各种研究，临床和治疗应用。

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