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1. 发明申请

WO1997003093A1 PEPTIDE DERIVATIVES AND ANGIOTENSIN IV RECEPTOR AGONIST 审中-公开
标题翻译：肽衍生物和血管紧张素受体激动剂
公开(公告)号：WO1997003093A1
公开(公告)日：1997-01-30
申请号：PCT/JP1996001836
申请日：1996-07-03
申请人： SAGAMI CHEMICAL RESEARCH CENTER , TAISHO PHARMACEUTICAL CO., LTD. , KOBORI, Takeo , GODA, Kenichi , SUGIMOTO, Kikuo , OTA, Tomomi , TOMISAWA, Kazuyuki
发明人： SAGAMI CHEMICAL RESEARCH CENTER , TAISHO PHARMACEUTICAL CO., LTD.
IPC分类号： C07K05/062
CPC分类号： C07K5/06078 , A61K38/00 , C07K5/0202 , C07K5/06017 , C07K5/0804 , C07K5/0812 , C07K5/0815 , C07K5/0821
摘要： Short-chain peptide derivatives represented by general formula (1) which function as an angiotensin IV receptor agonist even in a low concentration and so are useful as a remedy for various diseases wherein angiotensin IV participates.
摘要翻译：由通式（1）表示的短链肽衍生物即使在低浓度下也起到血管紧张素IV受体激动剂的作用，因此可用作血管紧张素IV参与的各种疾病的治疗方法。

2. 发明申请

WO1994015954A1 PYRROLIDINE AND THIAZOLIDINE DERIVATIVES, THEIR PREPARATION AND DRUGS CONTAINING SAME 审中-公开
标题翻译：吡咯啉和噻唑烷衍生物，其制备和含有的药物
公开(公告)号：WO1994015954A1
公开(公告)日：1994-07-21
申请号：PCT/FR1994000006
申请日：1994-01-03
申请人： RHONE-POULENC RORER S.A. , CAPET, Marc , DUBROEUCQ, Marie-Christine , MANFRE, Franco , MARTIN, Jean-Paul
发明人： RHONE-POULENC RORER S.A.
IPC分类号： C07K05/06
CPC分类号： C07K5/06017 , A61K38/00 , C07K5/06026 , C07K5/06191
摘要： Compounds of formula (I), their salts, the preparation thereof and drugs containing same. The compounds of formula (I) have interesting pharmacological properties. Said compounds have a high affinity for cholecystokinin (CCK) and gastrin receptors and are therefore useful in the treatment and prevention of CCK and gastrin-related disorders affecting the nervous system and gastrointestinal tract.
摘要翻译：式（I）化合物，其盐，其制备方法和含有它们的药物。式（I）化合物具有有趣的药理学性质。所述化合物对缩胆囊素（CCK）和胃泌素受体具有高亲和力，因此可用于治疗和预防影响神经系统和胃肠道的CCK和胃泌素相关病症。

3. 发明申请

WO2015000868A1 NOVEL COMPOUNDS 审中-公开
标题翻译：新型化合物
公开(公告)号：WO2015000868A1
公开(公告)日：2015-01-08
申请号：PCT/EP2014/063901
申请日：2014-07-01
申请人： GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED
发明人： CAMPOS, Sebastien, Andre , HARLING, John, David
IPC分类号： C07K5/078 , A61K31/427 , A61P35/00
CPC分类号： A61K38/06 , A61K45/06 , C07K5/06017 , C07K5/06043 , C07K5/06078 , C07K5/0812
摘要： A compound of formula (I) or a pharmaceutically acceptable salt thereof, compositions, combinations and medicaments containing said compounds and processes for their preparation. The invention also relates to the use of said compounds, combinations, compositions and medicaments, for example as inhibitors of the activity of the estrogen receptor, including degrading the estrogen receptor, the treatment of diseases and conditions mediated by the estrogen receptor.
摘要翻译：式（I）化合物或其药学上可接受的盐，含有所述化合物的组合物，组合和药物及其制备方法。本发明还涉及所述化合物，组合，组合物和药物的用途，例如作为雌激素受体活性的抑制剂，包括降解雌激素受体，治疗由雌激素受体介导的疾病和病症。

4. 发明申请

WO9708934A2 ARYL ACRYLIC ACID DERIVATIVES USEFUL AS PROTEIN TYROSINE PHOSPHATASE INHIBITORS 审中-公开
标题翻译： ARYL丙烯酸衍生物作为蛋白质酪氨酸磷酸酶抑制剂有用
公开(公告)号：WO9708934A2
公开(公告)日：1997-03-13
申请号：PCT/US9618401
申请日：1996-06-19
申请人： ONTOGEN CORP
发明人： MJALLI ADNAN M M , CAO XIAODONG , MORAN EDMUND J
IPC分类号： C07D317/60 , A61K31/00 , A61K31/19 , A61K31/195 , A61K31/33 , A61K31/34 , A61K31/357 , A61K31/36 , A61K31/38 , A61K31/39 , A61K31/40 , A61K31/403 , A61K31/404 , A61K31/405 , A61K38/00 , A61P3/02 , A61P7/00 , A61P35/00 , A61P37/08 , A61P43/00 , C07C59/52 , C07C59/84 , C07C59/88 , C07C69/732 , C07C69/738 , C07C69/92 , C07C235/12 , C07C235/34 , C07C235/78 , C07C235/80 , C07C237/22 , C07C323/60 , C07D207/337 , C07D209/14 , C07D209/20 , C07D209/26 , C07D213/81 , C07D215/14 , C07D233/54 , C07D233/90 , C07D241/42 , C07D263/34 , C07D277/30 , C07D307/52 , C07D307/54 , C07D307/68 , C07D307/71 , C07D333/32 , C07D333/38 , C07D401/04 , C07D403/04 , C07D405/04 , C07D405/14 , C07D409/04 , C07K5/06 , C07K5/062 , C07K5/065 , C07K5/083
CPC分类号： C07K5/0806 , A61K38/00 , C07C237/22 , C07C323/60 , C07C2601/14 , C07D209/26 , C07D233/64 , C07D233/90 , C07D241/42 , C07D263/34 , C07D277/30 , C07D307/54 , C07D307/71 , C07D317/60 , C07D401/04 , C07D403/04 , C07D405/04 , C07D405/14 , C07D409/04 , C07K5/06017 , C07K5/06034 , C07K5/06078 , C07K5/06191
摘要： The present invention provides novel protein tyrosine phosphatase modulating compounds having an aryl acrylic acid structure, compositions comprising the compounds, and methods of making and using the same.
摘要翻译：本发明提供具有芳基丙烯酸结构的新型蛋白质酪氨酸磷酸酶调节化合物，包含该化合物的组合物及其制备和使用方法。

5. 发明申请

WO2013064508A1 POLYETHYLENE GLYCOL BASED PRODRUG OF ADRENOMEDULLIN AND USE THEREOF 审中-公开
标题翻译：基于聚乙二醇的甘氨酸基因及其用途
公开(公告)号：WO2013064508A1
公开(公告)日：2013-05-10
申请号：PCT/EP2012/071507
申请日：2012-10-30
申请人： BAYER PHARMA AKTIENGESELLSCHAFT , BAYER INTELLECTUAL PROPERTY GMBH
发明人： FLAMME, Ingo , KÖBBERLING, Johannes , LERCHEN, Hans-Georg , GRIEBENOW, Nils , SCHOHE-LOOP, Rudolf , WITTROCK, Sven , KOELLNBERGER, Maria , WUNDER, Frank , REDLICH, Gorden , KNORR, Andreas , MARLEY, July , PRITCHARD, Iain
IPC分类号： A61K47/48 , A61K38/23 , A61P9/00 , A61P29/00 , A61P11/00
CPC分类号： C07K5/06017 , A61K9/007 , A61K38/22 , A61K45/06 , A61K47/60 , C07K5/02 , C07K5/06078 , C07K14/575
摘要： The invention relates to novel polyethylene glycol (PEG) based prodrug of Adrenomedullin, to processes for preparation thereof, to the use thereof for treatment and/or prevention of diseases, and to the use thereof for producing medicaments for treatment and/or prevention of diseases, especially of cardiovascular, edematous and/or inflammatory disorders.
摘要翻译：本发明涉及基于新型聚乙二醇（PEG）的肾上腺髓质素前药，其制备方法及其用于治疗和/或预防疾病的用途及其用于制备用于治疗和/或预防疾病的药物的用途，特别是心血管，水肿和/或炎症性疾病。

6. 发明申请

WO2012175554A1 PRODRUGS OF (1S,9S)-9-[[(1S)-1-CARBOXY-3-PHENYLPROPYL]AMINO]OCTAHYDRO-10-OXO-6H-PYRIDAZINO[1,2-A][1,2]DIAZEPINE-1-CARBOXYLIC ACID AND THEIR USE IN TRANSDERMAL THERAPEUTIC SYSTEMS 审中-公开
标题翻译：（1S，9S）-9 - [[（1S）-1-羧基-3-苯基丙基]氨基]亚甲基] -10-氧代-6H-吡啶并[1,2-A] [1,2]二氮杂- - 羧酸及其在转基因治疗系统中的应用
公开(公告)号：WO2012175554A1
公开(公告)日：2012-12-27
申请号：PCT/EP2012/061830
申请日：2012-06-20
申请人： HEXAL AG , BERNHARDT, Günther , ERTEL, Miriam , BUSCHAUER, Armin , NINK, Jörg
发明人： BERNHARDT, Günther , ERTEL, Miriam , BUSCHAUER, Armin , NINK, Jörg
IPC分类号： A61K47/48 , A61K9/70 , A61P9/12 , A61P9/04 , C07D487/04 , A61P9/02
CPC分类号： A61K9/703 , A61K9/7053 , A61K9/7061 , A61K47/54 , A61K47/545 , C07D487/04 , C07K5/06017
摘要： The present invention relates to diester prodrugs of cilazaprilate which undergo enzymatic cleavage to release the active metabolite cilazaprilate that is used for the treatment of hypertension and congestive heart failure. Furthermore the diester prodrugs of cilazaprilate possess all the properties necessary to be topically administered, preferably via transdermal therapeutic systems.
摘要翻译：本发明涉及经过酶裂解以释放用于治疗高血压和充血性心力衰竭的活性代谢物西拉普瑞拉的西拉普利的二酯前药。此外，西拉普利的二酯前药具有局部施用所需的所有特性，优选通过经皮给药系统。

7. 发明申请

WO98051687A1 PIPERIDINO DERIVATIVES WHICH PROMOTE GROWTH HORMONE RELEASE 审中-公开
标题翻译：促进生长激素释放的哌啶衍生物
公开(公告)号：WO98051687A1
公开(公告)日：1998-11-19
申请号：PCT/JP1998/001695
申请日：1998-04-14
IPC分类号： C07D211/60 , A61K31/438 , A61K31/4439 , A61K31/445 , A61P5/06 , C07D401/04 , C07D471/10 , C07K5/06
CPC分类号： C07K5/06017 , Y02P20/55
摘要： A pharmaceutically useful compound of formula (I) wherein R is hydrogen and X is a group of formula (II) in which R is esterified carboxy and R is ar(lower) alkyl; R is cyano and R is aryl; R is hydrogen and R is 2-oxo-1-benzimidazolinyl; or R and R are linked together to form formula (III) in which R is acyl, formula (a) is piperidino, and Y is lower alkanetriyl; or R is a group of formula (IV) in which R , R and formula (a) are each as defined above and X is bond, R is 3-azetidinyl, 4-piperidyl or a group of the formula: -Z-NHR in which R is hydrogen or amino protective group, and Z is lower alkylene or cyclo (lower) alkylene, and A is -(CH2)n-, in which n is 3, 4 or 5, or -CH=CH-(CH2)m-, in which m is 1, 2 or 3, and salts thereof. The compound or a salt thereof of the present invention has excellent promotion activity of growth hormone release for animals and human bodies.
摘要翻译：式（I）的药用有用化合物，其中R 1是氢，X是式（II）的基团，其中R 3是酯化的羧基，R 4是芳（低级）烷基; R 3是氰基，R 4是芳基; R 3是氢，R 4是2-氧代-1-苯并咪唑啉基; 或R 3和R 4连接在一起形成式（III），其中R 5是酰基，式（a）是哌啶子基，Y是低级烷酰基三烷基; 或R 1是式（Ⅳ）的基团，其中R 3，R 4和式（a）各自如上所定义，X是键，R 2是3-氮杂环丁烷基，4- 哌啶基或式-Z-NHR 6的基团，其中R 6是氢或氨基保护基，Z是低级亚烷基或环（低级）亚烷基，A是 - （CH 2）n - 其中n为3,4或5，或-CH = CH-（CH 2）m - ，其中m为1,2或3，及其盐。本发明的化合物或其盐对于动物和人体具有优异的生长激素释放的促进活性。

8. 发明申请

WO1994006824A1 OPTICALLY ACTIVE UREIDO-ACETAMIDE DERIVATIVE, ITS PREPARATION AND DRUGS CONTAINING SAME 审中-公开
标题翻译：光学活性尿嘧啶衍生物，其制备和含有药物
公开(公告)号：WO1994006824A1
公开(公告)日：1994-03-31
申请号：PCT/FR1993000846
申请日：1993-09-06
申请人： RHONE-POULENC RORER S.A. , DUBROEUCQ, Marie-Christine , GUYON, Claude
发明人： RHONE-POULENC RORER S.A.
IPC分类号： C07K05/06
CPC分类号： C07K5/06017 , A61K38/00
摘要： (((N-(methoxy-3 phenyl) N-(N-methyl N-phenyl-carboamoylmethyl) carbamoylmethyl)-3 ureido)-3 phenyl)-2 propionic acid dextrogyral isomer, salts thereof, its preparation and drugs containing same.
摘要翻译：（（N-（甲氧基-3-苯基）-N-（N-甲基N-苯基 - 氨甲酰基甲基）氨基甲酰基甲基）-3脲基）-3苯基）-2丙酸右旋糖醛酸异构体，其盐，其制备方法和含有它们的药物。

9. 发明申请

WO2018102006A1 COMPOUNDS FOR THE INHIBITION OF INDOLEAMINE-2,3-DIOXYGENASE ACTIVITY AND USE THEREOF 审中-公开
公开(公告)号：WO2018102006A1
公开(公告)日：2018-06-07
申请号：PCT/US2017/051837
申请日：2017-09-15
申请人： ENSEMBLE THERAPEUTICS CORPORATION
发明人： BRIGGS, Timothy, F. , CIPRIANI, Tyler, J. , DAVIS, Heather , DUVALL, Jeremy, R. , HALE, Stephen, P. , JIANG, Jun , LEE, Maurice, D. , MUNCIPINTO, Giovanni , OALMANN, Christopher, J. , SNEDEKER, Cheri
IPC分类号： C07D207/04 , A61K31/407 , A61K31/424 , A61P35/00 , C07D207/16 , C07D413/12 , C07D409/12 , C07D403/12 , C07D403/06 , C07D413/14 , C07D401/14
CPC分类号： A61P35/00 , A61K45/06 , C07D205/04 , C07D207/09 , C07D209/08 , C07D233/64 , C07D257/04 , C07D263/32 , C07D263/56 , C07D271/06 , C07D277/28 , C07D295/185 , C07D403/04 , C07D413/04 , C07D413/12 , C07D413/14 , C07D417/12 , C07K5/06017 , C07K5/06034 , C07K5/06043 , C07K5/06052 , C07K5/06078 , C07K5/06191 , C07K5/0808
摘要： The present invention relates to compounds, and pharmaceutically acceptable compositions thereof, useful as antagonists of indoleamine-2,3-dioxygenase (IDO) activity, and methods of treating IDO-related disorders.

10. 发明申请

WO2017138013A1 MOLECULAR GELATORS AND USES THEREOF 审中-公开
标题翻译：分子凝胶剂及其用途
公开(公告)号：WO2017138013A1
公开(公告)日：2017-08-17
申请号：PCT/IN2016/050424
申请日：2016-11-29
申请人： HINDUSTAN PETROLEUM CORPORATION LTD.
发明人： RAVISHANKAR, Raman , RAJU, Chinthalapati Sivakesava , PRAMANIK, Bhaskar , KAR, Tanmoy , RAO, Peddy Venkatachalapathi , CHOUDARY, Nettem Venkateswarlu
IPC分类号： C07K5/062 , C09K3/32
CPC分类号： C07K5/06052 , C07K5/06017 , C07K5/0606 , C07K5/06078 , C07K5/06165 , C09K3/32
摘要： In accordance with the present subject matter there is provided a compound of Formula I wherein, R 1 is substituted C 1 to C 10 alkyl; and R 2 is substituted C 1 to C 10 alkyl, a process for preparing a compound of Formula I, and a gel comprising a compound of Formula I. There is also provided a process for separating a hydrophobic material from a mixture of hydrophobic and hydrophilic material using a compound of Formula I.
摘要翻译：根据本主题，提供了式I的化合物，其中，R 1是被取代的C 1至C 1， 10烷基; 且R 2取代C 1至C 10烷基，制备式I化合物的方法和包含化合物式I还提供了使用式I化合物从疏水性和亲水性材料的混合物中分离疏水性材料的方法。

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