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1. 发明申请

WO1998005624A1 AMINO COMPOUNDS AND ANGIOTENSIN IV RECEPTOR AGONISTS 审中-公开
标题翻译：氨基化合物和血管紧张素Ⅱ受体激动剂
公开(公告)号：WO1998005624A1
公开(公告)日：1998-02-12
申请号：PCT/JP1997002716
申请日：1997-08-05
申请人： TAISHO PHARMACEUTICAL CO., LTD. , SAGAMI CHEMICAL RESEARCH CENTER , KOBORI, Takeo , GODA, Kenichi , SUGIMOTO, Kikuo , OTA, Tomomi , TOMISAWA, Kazuyuki
发明人： TAISHO PHARMACEUTICAL CO., LTD. , SAGAMI CHEMICAL RESEARCH CENTER
IPC分类号： C07C211/13
CPC分类号： C07D213/40 , C07C237/20 , C07D215/12
摘要： Amino compounds represented by general formula (1) or pharmaceutically acceptable salts thereof: (wherein X represents CH2NH or CONH; Y represents CH2NH or CONH, provided that X and Y do not represent CONH at the same time; Z represents CH=C(R )R , CH2CH(R )R or alkoxycarbonyl (wherein R and R independently represent each hydrogen or optionally substituted alkyl, aralkyl, aryl or heteroaryl); R represents hydrogen or optionally substituted lower alkyl, cycloalkyl, cycloalkyl-substituted alkyl, aralkyl or aryl; and R and R independently represent each optionally substituted lower alkyl or aralkyl); drugs composed of the amino compounds of general formula (1) or pharmaceutically acceptable salts thereof; and angiotensin receptor agonists containing the same as the active ingredient. These drugs are useful as remedies such as antagonists or agonists for various pathological states in which angiotensin IV participates, for example, accelerated renal blood flow, cerebral vasodilation, cell proliferation inhibition or hypermnesia.
摘要翻译：由通式（1）表示的氨基化合物或其药学上可接受的盐：（其中X表示CH 2 NH或CONH; Y表示CH 2 NH或CONH，条件是X和Y不同时表示CONH; Z表示CH = C R 5），CH 2 CH（R 4）R 5或烷氧基羰基（其中R 4和R 5独立地表示各个氢或任选取代的烷基，芳烷基，芳基或杂芳基）; R R 1和R 3独立地代表各个任选被取代的低级烷基或芳烷基）; R 2和R 3独立地表示任意取代的低级烷基或芳烷基。由通式（1）的氨基化合物或其药学上可接受的盐组成的药物; 和含有与活性成分相同的血管紧张素受体激动剂。这些药物可用作诸如血管紧张素IV参与的各种病理状态的拮抗剂或激动剂，例如加速肾血流量，脑血管扩张，细胞增殖抑制或高血症。

2. 发明申请

WO1997003093A1 PEPTIDE DERIVATIVES AND ANGIOTENSIN IV RECEPTOR AGONIST 审中-公开
标题翻译：肽衍生物和血管紧张素受体激动剂
公开(公告)号：WO1997003093A1
公开(公告)日：1997-01-30
申请号：PCT/JP1996001836
申请日：1996-07-03
申请人： SAGAMI CHEMICAL RESEARCH CENTER , TAISHO PHARMACEUTICAL CO., LTD. , KOBORI, Takeo , GODA, Kenichi , SUGIMOTO, Kikuo , OTA, Tomomi , TOMISAWA, Kazuyuki
发明人： SAGAMI CHEMICAL RESEARCH CENTER , TAISHO PHARMACEUTICAL CO., LTD.
IPC分类号： C07K05/062
CPC分类号： C07K5/06078 , A61K38/00 , C07K5/0202 , C07K5/06017 , C07K5/0804 , C07K5/0812 , C07K5/0815 , C07K5/0821
摘要： Short-chain peptide derivatives represented by general formula (1) which function as an angiotensin IV receptor agonist even in a low concentration and so are useful as a remedy for various diseases wherein angiotensin IV participates.
摘要翻译：由通式（1）表示的短链肽衍生物即使在低浓度下也起到血管紧张素IV受体激动剂的作用，因此可用作血管紧张素IV参与的各种疾病的治疗方法。

3. 发明申请

WO1992007840A1 THIAZOLE THIOESTER DERIVATIVE 审中-公开
标题翻译：噻唑衍生物
公开(公告)号：WO1992007840A1
公开(公告)日：1992-05-14
申请号：PCT/JP1991001482
申请日：1991-10-30
申请人： TAISHO PHARMACEUTICAL CO., LTD. , SAGAMI CHEMICAL RESEARCH CENTER , KOBORI, Takeo , YAMAMOTO, Rumi , FUJITA, Mikako , HIYAMA, Tamejiro , NAGATE, Takatoshi
发明人： TAISHO PHARMACEUTICAL CO., LTD. , SAGAMI CHEMICAL RESEARCH CENTER
IPC分类号： C07D277/74
CPC分类号： C07D501/00 , C07D277/74 , Y02P20/55
摘要： A compound represented by general formula (I), which is useful as an intermediate for the production of (Z)-2-(2-aminothiazol-4-yl)-2-hydroxyiminoacetamide-substituted cephalosporin derivatives having an excellent antibacterial activity, wherein R1 represents hydrogen or a hydroxyl protecting group.
摘要翻译：由通式（I）表示的化合物，其可用作制备具有优异抗菌活性的（Z）-2-（2-氨基噻唑-4-基）-2-羟基亚氨基乙酰胺取代的头孢菌素衍生物的中间体，其中 R 1表示氢或羟基保护基。

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