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1. 发明申请

WO2009021750A3 BENZOXAZOLE, BENZIMIDAZOLE AND BENZOTHIAZOLE DERIVATIVES AND THEIR USE IN THE TREATMENT OF DUCHENNE MUSCULAR DYTROPHY 审中-公开
标题翻译：苯并噻唑，苯并咪唑和苯并噻唑衍生物及其在治疗杜邦肌肉DYTROPHY中的应用
公开(公告)号：WO2009021750A3
公开(公告)日：2014-02-20
申请号：PCT/EP2008006720
申请日：2008-08-14
申请人： BIOMARIN IGA LTD , WYNNE GRAHAM MICHAEL , DE MOOR OLIVIER , LECCI CRISTINA , VAN WELL RENATE , JOHNSON PETER DAVID , STORER RICHARD , POIGNANT SEVERINE , WREN STEPHEN PAUL
发明人： WYNNE GRAHAM MICHAEL , DE MOOR OLIVIER , LECCI CRISTINA , VAN WELL RENATE , JOHNSON PETER DAVID , STORER RICHARD , POIGNANT SEVERINE , WREN STEPHEN PAUL
IPC分类号： C07D209/48 , A61K31/4184 , A61K31/423 , A61P21/00 , A61P21/06 , C07D235/18 , C07D265/16 , C07D403/04 , C07D405/04 , C07H7/06
CPC分类号： C07D413/04 , C07D209/12 , C07D263/57 , C07D277/66 , C07D417/14 , C07F9/65324 , C07H15/00
摘要： There are disclosed compounds of Formula (1). Pharmaceutical compositions containing the compounds are also provided. Methods of treatment of Duchenne muscular dystrophy, Becker muscular dystrophy and cachexia using the compounds and compositions are also provided.
摘要翻译：公开了式（1）的化合物。还提供了含有这些化合物的药物组合物。还提供了使用化合物和组合物治疗杜氏肌营养不良症，贝克肌营养不良症和恶病质的方法。

2. 发明申请

WO2009150022A2 ENZYMATISCHE SYNTHESE VON SPHINGOLIPIDEN 审中-公开
标题翻译：鞘脂的酶法合成
公开(公告)号：WO2009150022A2
公开(公告)日：2009-12-17
申请号：PCT/EP2009/056206
申请日：2009-05-22
申请人： EVONIK GOLDSCHMIDT GMBH , HOLLMANN, Frank , THUM, Oliver , TÖLLE, Christoph , PROVINZANO, Angelo , KOREVAAR, Cornelis Gerrit Nijs
发明人： HOLLMANN, Frank , THUM, Oliver , TÖLLE, Christoph , PROVINZANO, Angelo , KOREVAAR, Cornelis Gerrit Nijs
IPC分类号： C12P13/02 , C07H15/00 , A61K31/133 , A61K8/68
CPC分类号： C12P13/02 , A61K8/68 , A61Q19/00 , C07H15/00
摘要： Gegenstand der Erfindung ist die enzymatische Synthese von Sphingolipiden und Zusammensetzungen enthaltend Sphingolipide aus Lysosphingolipiden und Carbonsäureestern, sowie kosmetische, dermatologische oder pharmazeutische Formulierungen, die diese Sphingolipide oder Zusammensetzungen enthalten.
摘要翻译：本发明涉及鞘脂和包含来自lysosphingolipids和羧酸酯，以及化妆品的，皮肤病学或含有这些鞘脂类或组合物的药物制剂鞘脂组合物的酶促合成。

3. 发明申请

WO2008052077B1 PROCESS FOR THE PREPARATION OF SUCROSE-6-ESTER BY ESTERIFICATION IN THE PRESENCE OF SOLID SUPERACID CATALYST 审中-公开
标题翻译：通过在固体超级催化剂存在下制备SUCROSE-6-ESTER的方法
公开(公告)号：WO2008052077B1
公开(公告)日：2008-09-18
申请号：PCT/US2007082424
申请日：2007-10-24
申请人： MAMTEK INT LTD , HO DAVID LOSAN , WAN ZHENGHAO
发明人： HO DAVID LOSAN , WAN ZHENGHAO
IPC分类号： C07H1/00 , C07H13/02
CPC分类号： C07H15/00 , C07H13/04 , C13K13/00
摘要： One embodiment of the present inventionis a process of making sucrose-6-ester from sucrose by transesterification in the presence of a solid super acid catalyst such as SO 4 2-
摘要翻译：本发明的一个实施方案是在固体超酸催化剂如SO 2 SO 2 - 的存在下通过酯交换从蔗糖制备蔗糖-6-酯的方法，

4. 发明申请

WO2008082156A1 ALPHA-GALACTOSYLCERAMIDE DERIVATIVES, PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF, PREPARATION METHOD AND PHARMACEUTICAL COMPOSITION FOR THE IMMUNE ADJUVANT CONTAINING THE SAME AS AN ACTIVE INGREDIENT 审中-公开
标题翻译： ALPHA-GALACTOSYLCERAMIDE衍生物，其药学上可接受的盐，其含有作为活性成分的免疫调节剂的制备方法和药物组合物
公开(公告)号：WO2008082156A1
公开(公告)日：2008-07-10
申请号：PCT/KR2007/006889
申请日：2007-12-27
申请人： SEOUL NATIONAL UNIVERSITY INDUSTRY FOUNDATION , KANG, Chang-Yuil , KIM, SangHee , YOUN, Hyun-Jun , LEE, Yoon-Sook , LEE, Kyoo-A , LEE, Taeho , BAEK, Dong Jae , CHO, Minjae
发明人： KANG, Chang-Yuil , KIM, SangHee , YOUN, Hyun-Jun , LEE, Yoon-Sook , LEE, Kyoo-A , LEE, Taeho , BAEK, Dong Jae , CHO, Minjae
IPC分类号： C07H15/00
CPC分类号： C07H15/00 , Y02P20/55
摘要： Disclosed are novel α-galactosylceramide derivatives, pharmaceutically acceptable salts thereof, preparation methods thereof, and pharmaceutical compositions for use in an immune adjuvant containing the same as an active ingredient. The derivatives, in which the amide moiety of α-GalCer is bioisosterically replaced with a triazole moiety, direct cytokine secretion toward IL-4 rather than IFN-y and thus can be used as a therapeutic for autoimmune diseases regulated by IL-4, such as type 1 diabetes and multiple sclerosis.
摘要翻译：公开了新颖的α-半乳糖神经酰胺衍生物，其药学上可接受的盐，其制备方法和用于含有其作为活性成分的免疫佐剂的药物组合物。其中a-GalCer的酰胺部分被三唑部分生物电化学取代的衍生物直接导致IL-4的细胞因子分泌而不是IFN-γ，因此可以用作IL-4调节的自身免疫疾病的治疗剂，例如作为1型糖尿病和多发性硬化。

5. 发明申请

WO2007050668A1 ANALOGS OF ALPHA GALACTOSYLCERAMIDE AND USES THEREOF 审中-公开
标题翻译：阿尔法胶乳酰胺的模拟物及其用途
公开(公告)号：WO2007050668A1
公开(公告)日：2007-05-03
申请号：PCT/US2006/041592
申请日：2006-10-25
申请人： LUDWIG INSTITUTE FOR CANCER RESEARCH , CERUNDOLO, Vincenzo , SCHMIDT, Richard , REDDY, Gopal , BALAMURUGAN, Rengarajan , RITTER, Gerd , BESRA, Gurdyal , SALIO, Mariolina , SILK, Jonathan
发明人： CERUNDOLO, Vincenzo , SCHMIDT, Richard , REDDY, Gopal , BALAMURUGAN, Rengarajan , RITTER, Gerd , BESRA, Gurdyal , SALIO, Mariolina , SILK, Jonathan
IPC分类号： C07H15/00 , A61K31/70 , A61K35/28
CPC分类号： C07H15/00
摘要： There are disclosed compound of formula I, in which R 1 represents a hydrophobic moiety adapted to occupy the C’ channel of human CDId, R 2 represents a hydrophobic moiety adapted to occupy the A' channel of human CDId, such that R 1 fills at least at least 30% of the occupied volume of the C’ channel compared to the volume occupied by the terminal nC 14 H 29 of the sphingosine chain of α-galactosylceramide when bound to human CDId and R 2 fills at least 30% of the occupied volume of the A' channel compared to the volume occupied by the terminal nC 25 H 51 of the acyl chain of α-galactosylceramide when bound to human CDId R 3 represents hydrogen or OH, R a and R b each represent hydrogen and in addition, when R 3 represents hydrogen, R a and R b together may form a single bond, X represents or -CHA(CHOH) n Y or - P(=0)(0 - )0CH 2 (CH0H) m Y, in which Y represents CHB 1 B 2 , n represents an integer from 1 to 4, m represents 0 or 1, A årepresents hydrogen, one of B 1 and B 2 represents H, OH or phenyl, and the other represents hydrogen or one of B 1 and B 2 represents hydroxyl and the other represents phenyl, in addition, when n represents 4, then A together with one of B 1 and B 2 together forms a single bond and the other of B 1 and B 2 represents H, OH or OSO 3 H and pharmaceutically acceptable salts thereof; the compounds of formula I are indicted for use in the treatment of a virus, microbial infection, parasite, an autoimmune disease, cancer, allergy or asthma
摘要翻译：公开了式I化合物，其中R 1代表适于占据人CD1'的C'通道的疏水部分，R 2代表适于占据的疏水部分人类CDID的A'通道，使得R 1填充C'通道的占用体积的至少30％，与终端nC 14所占据的体积相比，当与人CD1d和R22结合时，α-半乳糖神经酰胺的鞘氨醇链的亚基29位填充了A'通道的占据体积的至少30％，与当与人CD1R33结合时，α-半乳糖神经酰胺的酰基链的末端nC 25 51位所占的体积代表氢或OH ，R a a和R b各自表示氢，此外，当R 3表示氢时，R a a和一起可以形成单键，X表示或-CHA（CHOH）n Y或-P（= O）（= O））0CH _{2（CH 2）m Y，其中Y表示CHB 1 B 2，n表示1〜4的整数， m表示0或1，A a表示氢，B 1和B 2之一表示H，OH或苯基，另一个表示氢或B < 1和B 2代表羟基，另一个代表苯基，此外，当n表示4时，则A与B 1和B之一 > 2 <！ - SIPO - >一起形成单键，B 1和B 2中的另一个表示H，OH或OSO 3 H，其药学上可接受的盐; 式I的化合物被指示用于治疗病毒，微生物感染，寄生虫，自身免疫疾病，癌症，变态反应或哮喘}

6. 发明申请

WO2006111783A1 MONOSACCHARIDE DERIVATIVES AS ANTI-INFLAMMATORY AND/OR ANTI-CANCER AGENTS 审中-公开
标题翻译：单抗衍生物作为抗炎和/或抗癌剂
公开(公告)号：WO2006111783A1
公开(公告)日：2006-10-26
申请号：PCT/IB2005/001039
申请日：2005-04-19
申请人： RANBAXY LABORATORIES LIMITED , SATTIGERI, Vishwajanani, Jitendra , ARORA, Sudershan, K. , SALMAN, Mohammad , PALLE, Venkata, P. , MUKHERJEE, Ashis , RAY, Abhijit , SHIRUMALLA, Raj, Kumar
发明人： SATTIGERI, Vishwajanani, Jitendra , ARORA, Sudershan, K. , SALMAN, Mohammad , PALLE, Venkata, P. , MUKHERJEE, Ashis , RAY, Abhijit , SHIRUMALLA, Raj, Kumar
IPC分类号： C07H9/04 , C07H15/00 , C07H3/02 , A61K31/70 , A61K31/7004 , A61K31/7028 , A61K31/7042 , A61P37/00 , A61P35/00 , A61P17/00 , A61P11/06
CPC分类号： C07H9/04 , C07H3/02 , C07H15/00
摘要： The present invention relates to monosaccharide derivatives as anti-inflammatory agents. The compounds disorder herein can be useful for inhibition and prevention of inflammation and associated pathologies including inflammatory and autoimmune diseases such as bronchial asthma, rheumatoid arthritis, type I diabetes, multiple sclerosis, allograft rejection, psoriasis, inflammatory bowel disease, ulcerative colitis, acne, atherosclerosis, cancer, pruritis and allergic rhinitis. Pharmacological compositions containing compounds disclosed herein and the methods of treating bronchial asthma, chronic obstructive pulmonary disease, rheumatoid arthritis, multiple sclerosis, type I diabetes, psoriasis, allograft rejection, inflammatory bowel disease, ulcerative colitis, acne, atherosclerosis, cancer, pruritis, allergic rhinitis and other inflammatory and/or autoimmune disorders, using the compounds are also provided.
摘要翻译：本发明涉及作为抗炎剂的单糖衍生物。本文中的化合物障碍可用于抑制和预防炎症和相关病理，包括炎症和自身免疫性疾病，例如支气管哮喘，类风湿性关节炎，I型糖尿病，多发性硬化，同种异体移植排斥，牛皮癣，炎性肠病，溃疡性结肠炎，痤疮，动脉粥样硬化，癌症，瘙痒和过敏性鼻炎。含有本文公开的化合物的药理学组合物和治疗支气管哮喘，慢性阻塞性肺病，类风湿性关节炎，多发性硬化，I型糖尿病，牛皮癣，同种异体移植排斥，炎性肠病，溃疡性结肠炎，痤疮，动脉粥样硬化，癌症，瘙痒，过敏还提供使用该化合物的鼻炎和其它炎性和/或自身免疫性疾病。

7. 发明申请

WO2005116041A3 NEW AMINOGLYCOSIDE COMPOUNDS AND DERIVATIVES THEREOF 审中-公开
标题翻译：新的氨基甲酸酯化合物及其衍生物
公开(公告)号：WO2005116041A3
公开(公告)日：2006-08-24
申请号：PCT/GB2005002133
申请日：2005-05-27
申请人： UNIV LEEDS , NELSON ADAM , STOCKLEY PETER
发明人： NELSON ADAM , STOCKLEY PETER
IPC分类号： C07H15/22 , C07H15/00
CPC分类号： C07H15/00
摘要： New amino glycoside compounds or derivatives thereof having at least one sugar moiety and which comprise two or more cyclic structures capable of forming "charmed" structural features at physiological pH, and which have binding affinities for RNA and protein structures and may be used as therapeutic or screening or diagnostic agents and the like.
摘要翻译：新的氨基糖苷化合物或其衍生物具有至少一个糖部分，并且包含两个或更多个能够在生理pH下形成“有魅力”结构特征的环状结构，并且其具有对RNA和蛋白质结构的结合亲和力并可用作治疗或筛选或诊断剂等。

8. 发明申请

WO2006071848A9 GLYCOLIPIDS AND ANALOGUES THEREOF AS ANTIGENS FOR NK T CELLS 审中-公开
公开(公告)号：WO2006071848A9
公开(公告)日：2006-08-17
申请号：PCT/US2005047017
申请日：2005-12-27
申请人： UNIV ROCKEFELLER , SCRIPPS CLINIC RES , WONG CHI-HUEY , WU DOUG , FUJIO MASAKAZU , TSUJI MORIYA , HO DAVID
发明人： WONG CHI-HUEY , WU DOUG , FUJIO MASAKAZU , TSUJI MORIYA , HO DAVID
IPC分类号： A61K31/4706
CPC分类号： C07H15/06 , C07H15/00 , C07H15/18 , C07H15/26
摘要： This invention relates to immunogenic compounds which may serve as ligands for NKT (natural killer T) cells and to methods of use thereof in modulating immune responses.

9. 发明申请

WO2005033100A1 NOVEL HYPOCHOLESTEROLEMIC COMPOUNDS 审中-公开
标题翻译：新型高效液相色谱
公开(公告)号：WO2005033100A1
公开(公告)日：2005-04-14
申请号：PCT/CH2004/000584
申请日：2004-09-15
申请人： LIPIDEON BIOTECHNOLOGY AG , CARREIRA, Erick , HAUSER, Helmut , KVAERNO, Lisbet , RITTER, Tobias , WERDER, Moritz
发明人： CARREIRA, Erick , HAUSER, Helmut , KVAERNO, Lisbet , RITTER, Tobias , WERDER, Moritz
IPC分类号： C07D405/04
CPC分类号： C07D215/14 , C07D205/04 , C07D205/08 , C07H15/00
摘要： The present invention relates to novel hypocholesterolemic compounds of formula (I) useful in the treatment and prevention of atherosclerosis and for the reduction of cholesterol levels as well as to pharmaceutical compositions comprising said compounds alone or in combination with other active agents.
摘要翻译：本发明涉及用于治疗和预防动脉粥样硬化和降低胆固醇水平的式（I）的新型低胆固醇血症化合物以及包含所述化合物单独或与其它活性剂组合的药物组合物。

10. 发明申请

WO2004058787A3 FLUOROGENIC ENZYME SUBSTRATES AND METHODS OF PREPARATION 审中-公开
标题翻译：荧光酶基质及其制备方法
公开(公告)号：WO2004058787A3
公开(公告)日：2005-01-20
申请号：PCT/EP0351105
申请日：2003-12-26
申请人： TIBOTEC BVBA , GOEMAN JAN LUDWIG , VAN ACKER KOENRAAD LODEWIJK AU , VAN DER EYCKEN JOHAN THEO ANDR , DIERYNCK INGE
发明人： GOEMAN JAN LUDWIG , VAN ACKER KOENRAAD LODEWIJK AU , VAN DER EYCKEN JOHAN THEO ANDR , DIERYNCK INGE
IPC分类号： C07D239/91 , C07F9/6512 , C07H15/00 , C07H15/26
CPC分类号： C07H15/00
摘要： This invention relates to hydrolase fluorogenic substrates with improved cell permeability, methods for the preparation thereof, and methods of measuring activities of hydrolases, particularly in cell-based assays. The substrates easily diffuse into the cells, where they are enzymatically processed to yield photostable fluorescent products, and are particularly fitted for visualising enzyme-derived activities in cell-based assays.
摘要翻译：本发明涉及具有改善的细胞渗透性的水解酶荧光底物，其制备方法和测量水解酶活性的方法，特别是在基于细胞的测定中。底物容易扩散到细胞中，在那里它们被酶处理以产生光稳定荧光产物，并且特别适用于在基于细胞的测定中可视化酶来源的活性。

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