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1. 发明申请

WO2016115048A8 PRODUCTION OF RHAMNOLIPID COMPOSITIONS 审中-公开
标题翻译：生产卷状脂质组合物
公开(公告)号：WO2016115048A8
公开(公告)日：2017-04-20
申请号：PCT/US2016012901
申请日：2016-01-11
申请人： LOGOS TECH LLC
发明人： LOHITHARN NATTAPORN , DERR DANIEL
IPC分类号： C12P19/44 , C07H15/06 , C12P7/64
CPC分类号： C07H15/06 , C07H1/00
摘要： Provided are organic solvent free methods for obtaining compositions comprising one or more rhamnolipids as well as compositions obtainable from said methods.
摘要翻译：提供了用于获得包含一种或多种鼠李糖脂的组合物的无有机溶剂方法以及可从所述方法获得的组合物。

2. 发明申请

WO2014017928A1 ORGANIC COMPOUNDS 审中-公开
标题翻译：有机化合物
公开(公告)号：WO2014017928A1
公开(公告)日：2014-01-30
申请号：PCT/NZ2013/000133
申请日：2013-07-26
申请人： CALLAGHAN INNOVATION RESEARCH LIMITED , COMPTON, Benjamin Jason , HAYMAN, Colin Malcolm , HERMANS, Ian Francis , LARSEN, David Samuel , PAINTER, Gavin Frank , ANDERSON, Regan James
发明人： COMPTON, Benjamin Jason , HAYMAN, Colin Malcolm , HERMANS, Ian Francis , LARSEN, David Samuel , PAINTER, Gavin Frank , ANDERSON, Regan James
IPC分类号： C07H15/04 , A61K31/7028 , A61P3/10 , A61P11/06 , A61P31/04 , A61P35/00 , A61P37/02 , A61P37/08
CPC分类号： C07H15/04 , A61K39/39 , A61K2039/55511 , C07H15/06
摘要： This invention relates to sphingoglycolipid analogues, compositions comprising these compounds, processes for preparing the compounds, and methods of treating or preventing diseases or conditions using the compounds, such as diseases or conditions relating to infection, atopic disorders, autoimmune disease, diabetes or cancer.
摘要翻译：本发明涉及鞘糖脂类似物，包含这些化合物的组合物，制备该化合物的方法，以及使用该化合物治疗或预防疾病或病症的方法，例如与感染，特应性障碍，自身免疫性疾病，糖尿病或癌症有关的疾病或病症。

3. 发明申请

WO2013119857A1 GLYCOSPHINGOLIPIDS FOR USE IN MODULATING IMMUNE RESPONSES 审中-公开
标题翻译：用于调节免疫应答的谷氨酸蛋白酶
公开(公告)号：WO2013119857A1
公开(公告)日：2013-08-15
申请号：PCT/US2013/025205
申请日：2013-02-07
申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA , BROWN, Laura , CLARDY, Jon
发明人： BROWN, Laura , CLARDY, Jon , FISCHBACH, Michael, A. , BLUESTONE, Jeffrey, A. , PENARANDA, Cristina
IPC分类号： A01N43/04 , C07H15/00 , C07G3/00 , C07H5/04
CPC分类号： C07C235/08 , A61K35/26 , A61K2035/122 , C07F9/1411 , C07H15/04 , C07H15/06 , C12P13/02 , C12P19/44
摘要： Provided herein are sphingolipid compounds that are useful for activating natural killer T cells. Also provided are methods for treating or preventing a disease or disorder that is treatable by activating the immune system by stimulating natural killer T cells. The compounds are therefore useful for treating or reducing the likelihood of occurrence of an immune diseases and disorders, such as autoimmune diseases or disorders. The compounds may also be used for treating or reducing the likelihood of occurrence of a microbial infection or for treating or reducing the likelihood of occurrence of a cancer in a subject by administering the sphingolipid compounds described herein.
摘要翻译：本文提供了可用于激活天然杀伤T细胞的鞘脂化合物。还提供了通过刺激天然杀伤T细胞来激活免疫系统来治疗或预防可治疗的疾病或病症的方法。因此，这些化合物可用于治疗或降低发生免疫疾病和病症（例如自身免疫性疾病或病症）的可能性。化合物还可以用于治疗或降低发生微生物感染的可能性或通过施用本文所述的鞘脂化合物来治疗或降低受试者中癌症发生的可能性。

4. 发明申请

WO2009101475A2 COMPOSITIONS FOR AND METHODS OF ENHANCING THE IMMUNE RESPONSE TO ANTIGENS 审中-公开
标题翻译：组合物和增强对抗原免疫应答的方法
公开(公告)号：WO2009101475A2
公开(公告)日：2009-08-20
申请号：PCT/IB2008/003945
申请日：2008-12-05
申请人： WITTYCELL S.A.S. , SERRA, Vincent
发明人： SERRA, Vincent
IPC分类号： A61K31/7032 , A61K39/00 , A61P37/04
CPC分类号： C07D309/10 , A61K31/35 , A61K39/39 , A61K2039/55511 , C07H5/06 , C07H15/04 , C07H15/06 , C07H15/10
摘要： Compositions comprising the compound of formula are provided herein. Also provided are methods of enhancing an immune response of a subject to an antigen by administering the antigen and the composition. The enhanced immune response may be an humoral immune response, a CD4+ T cell response, a CD8+ T cell response or result in activation of antigen presenting cells. Methods of enhancing the immune response by intramuscular administration of an antigen and the composition including the compound of formula I are also provided.
摘要翻译：本文提供了包含式的化合物的组合物。还提供了通过施用抗原和组合物来增强受试者对抗原的免疫应答的方法。增强的免疫应答可以是体液免疫应答，CD4 + T细胞应答，CD8 + T细胞应答或导致抗原呈递细胞的活化。还提供了通过肌内施用抗原来增强免疫应答的方法和包括式I化合物的组合物。

5. 发明申请

WO2008124729A1 ONE-POT SYNTHESIS OF ALPHA/BETA-O-GLYCOLIPIDS 审中-公开
标题翻译： ALPHA / BETA-O-甘氨酸的一步合成
公开(公告)号：WO2008124729A1
公开(公告)日：2008-10-16
申请号：PCT/US2008/059666
申请日：2008-04-08
申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA , GERVAY-HAGUE, Jacquelyn , DU, Wenjun , KULKARNI, Suvarn S. , SCHOMBS, Matthew
发明人： GERVAY-HAGUE, Jacquelyn , DU, Wenjun , KULKARNI, Suvarn S. , SCHOMBS, Matthew
IPC分类号： C07H5/00 , C07H5/06 , A61K31/70
CPC分类号： C07H1/00 , C07H5/00 , C07H5/06 , C07H15/04 , C07H15/06 , C07H15/10 , C07J17/005
摘要： The present invention provides a one-pot method of preparing an unprotected α- O -glycolipid. The first step involves contacting a protected α-iodo sugar with a catalyst and a lipid comprising a hydroxy group, under conditions sufficient to prepare a protected α- O -glycolipid. The second step involves deprotecting the protected α- O -glycolipid under conditions sufficient to prepare the unprotected α- O -glycolipid, wherein the contacting and deprotecting steps are performed in a single vessel. The present invention also provides a one-pot method of preparing an unprotected β- O -glycolipid following the steps for the preparation of the unprotected α- O -glycolipid.
摘要翻译：本发明提供一种制备未保护的α-O-糖脂的一锅法。第一步包括在足以制备受保护的α-糖脂的条件下使受保护的碘碘与催化剂和包含羟基的脂质接触。第二步包括在足以制备未保护的α-O-糖脂的条件下将受保护的a-O-糖脂脱保护，其中接触和脱保护步骤在单个容器中进行。本发明还提供了一种制备未保护的β-O-糖脂的一锅法，其中所述步骤用于制备未保护的α-O-糖脂。

6. 发明申请

WO2007118234A2 MODIFIED -GALACTOSYL CERAMIDES FOR STAINING AND STIMULATING NATURAL KILLER T CELLS 审中-公开
标题翻译：用于染色和刺激天然杀伤细胞的改性的乳糖凝胶
公开(公告)号：WO2007118234A2
公开(公告)日：2007-10-18
申请号：PCT/US2007/066250
申请日：2007-04-09
申请人： THE SCRIPPS RESEARCH INSTITUTE , BRIGHAM YOUNG UNIVERSITY , THE UNIVERSITY OF CHICAGO , SAVAGE, Paul, B. , TEYTON, Luc , BENDELAC, Albert
发明人： SAVAGE, Paul, B. , TEYTON, Luc , BENDELAC, Albert
IPC分类号： A61K31/739
CPC分类号： C07H15/06
摘要： Modified glycolipid compounds are provided. Also disclosed are methods for activating an NKT cell, methods of stimulating an immune response in a subject, and methods suitable for labeling NKT cells.
摘要翻译：提供改良的糖脂化合物。还公开了用于激活NKT细胞的方法，刺激受试者中的免疫应答的方法和适于标记NKT细胞的方法。

7. 发明申请

WO2007048974A2 HETEROOLIGOMERES DE D-GLUCOSAMINE ET N-ACETYL-D-GLUCOSAMINE, LEUR PROCEDE DE PREPARATION ET LEUR UTILISATION 审中-公开
标题翻译： D-葡萄糖胺和N-乙酰-D-葡糖胺的杂多寡核苷酸，其制备方法及其用途
公开(公告)号：WO2007048974A2
公开(公告)日：2007-05-03
申请号：PCT/FR2006/051102
申请日：2006-10-24
申请人： UNIVERSITE CLAUDE BERNARD LYON I , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE , DOMARD, Alain , BARROCA, Nadine , TROMBOTTO, Stéphane
发明人： DOMARD, Alain , BARROCA, Nadine , TROMBOTTO, Stéphane
CPC分类号： C07H15/06 , C07H13/12 , C07H15/04 , C07H15/12
摘要： La présente invention a pour objet de nouveaux oligomères glycosidiques, des monomères utiles pour leur préparation, ainsi qu'un procédé de préparation de tels oligomères et en particulier d'hétéro-oligomères de D-glucosamine et N -acétyl-D-glucosamine, permettant de contrôler la taille, le degré d'acétylation et l'architecture des oligomères obtenus.
摘要翻译：本发明的主题是新型糖苷寡聚物，可用于其制备的单体，以及制备它们的方法。制备此类寡聚物，特别是D-葡糖胺和N-乙酰基-D-葡糖胺的寡聚物 - 寡聚物以防治大小，程度和oacute; 的乙酰化和低聚体系结构。

8. 发明申请

WO2007023583A1 糖脂質誘導体合成中間体及びその製造方法、並びに糖脂質誘導体及びその製造方法审中-公开
标题翻译：合成GLYCOLIPID衍生物的中间体及其生产方法及其衍生物及其生产方法
公开(公告)号：WO2007023583A1
公开(公告)日：2007-03-01
申请号：PCT/JP2006/303538
申请日：2006-02-21
申请人：国立大学法人名古屋大学 , エムバイオテック株式会社 , 西田芳弘 , 中村高典 , 新宮佑子 , 松田和洋
发明人：西田芳弘 , 中村高典 , 新宮佑子 , 松田和洋
IPC分类号： C07H15/04 , C07C247/04
CPC分类号： C07H15/06 , Y02P20/55
摘要： To synthesize a glycolipid derivative typified by GGPL-III, it is required to efficiently synthesize an intermediate in synthesizing the glycolipid derivative represented by the general formula (VIII). For this purpose, it is needed to control both of the formation of an a-glycoside bond and the stereostructure of the glycerol moiety. A method characterized by involving the step of reacting a donor compound, which is a saccharide having a protective group introduced into an OH group other than the one at the 1-position thereof, with a phosphonium halogen compound and an optically active glycidol, which is employed as an acceptor compound, in the presence of a basic solvent to thereby control both of the formation of an a-glycoside bond and the stereostructure of the glycerol moiety. (VIII) In the general formula (VIII), R's may be independently selected from among hydrocarbon groups; and Y's may be independently selected from among protective groups of OH group and a hydrogen atom.
摘要翻译：为了合成由GGPL-III代表的糖脂衍生物，需要合成由通式（VIII）表示的糖脂衍生物的合成中间体。为此，需要控制α-糖苷键的形成和甘油部分的立体结构。一种方法，其特征在于包括使供体化合物（其是具有引入至其1-位上除OH基之外的保护基的糖类）与卤化鏻化合物和光学活性缩水甘油反应的步骤，其为在碱性溶剂的存在下用作受体化合物，从而控制α-糖苷键的形成和甘油部分的立体结构。（VIII）在通式（VIII）中，R可以独立地选自烃基; 并且Y可以独立地选自OH基和氢原子的保护基。

9. 发明申请

WO2006026389A2 CERAMIDE DERIVATIVES AS MODULATORS OF IMMUNITY AND AUTOIMMUNITY 审中-公开
标题翻译：陶瓷衍生物作为免疫和自动调节剂的调节剂
公开(公告)号：WO2006026389A2
公开(公告)日：2006-03-09
申请号：PCT/US2005/030330
申请日：2005-08-26
申请人： ALBERT EINSTEIN COLLEGE OF MEDICINE OF YESHIVA UNIVERSITY , PORCELLI, Steven, A.
发明人： PORCELLI, Steven, A.
IPC分类号： A61K39/00
CPC分类号： A61K39/39 , A61K2039/55511 , C07H15/06
摘要： α-Galactosylceramides and glycosylceramides ("ceramide-like glycolipids") that modulate NK T cells. The ceramide-like glycolipids vary in the cytokines induced in NK T cells and vary in the antigen-presenting cells that are capable of efficiently presenting the compounds to NK T cells. Pharmaceutical compositions of the ceramide-like glycolipids are provided, as are pharmaceutical compositions of the ceramide-like glycolipids combined with dendritic cells. Methods utilizing the ceramide-like glycolipids in vaccines, to activate NK T cells, to stimulate the immune system, and to treat mammals are also provided. The invention also provides methods of evaluating a compound for its ability to activate an NK T cell in the presence of a cell expressing a CD 1 d protein.
摘要翻译： α-半乳糖神经酰胺和调节NK T细胞的糖基神经酰胺（“神经酰胺样糖脂”）。神经酰胺样糖脂在NK T细胞中诱导的细胞因子变化，并且能够有效地将化合物呈递给NK T细胞的抗原呈递细胞中变化。提供神经酰胺样糖脂的药物组合物，以及神经酰胺样糖脂与树突状细胞组合的药物组合物。还提供了在疫苗中利用神经酰胺样糖脂，激活NK T细胞，刺激免疫系统和治疗哺乳动物的方法。本发明还提供了在存在表达CD1d蛋白的细胞的情况下评价化合物活化NK T细胞能力的方法。

10. 发明申请

WO1995033758A1 NOVEL GLYCEROGLYCOPHOSPHOLIPID, ANTIBODY THERE AGAINST, AND METHOD OF DETECTING MYCOPLASMA 审中-公开
标题翻译：新型甘氨酸磷脂酰胆碱，抗体抗体及检测MYCOPLASMA的方法
公开(公告)号：WO1995033758A1
公开(公告)日：1995-12-14
申请号：PCT/JP1995001091
申请日：1995-06-02
申请人： SEIKAGAKU CORPORATION , MATSUDA, Kazuhiro , YAMAMOTO, Naoki
发明人： SEIKAGAKU CORPORATION
IPC分类号： C07H11/04
CPC分类号： C07H15/06 , C07H15/10 , C07K16/1253 , C12P19/44 , G01N33/56933
摘要： A hybridoma that produces a monoclonal antibody having a reaction specificity for GGPL-III, which is a phosphocholine-containing glyceroglycolipid specific for Mycoplasma fermentans, is selected from among the hybridomas prepared by immunizing a mouse with a lipid fraction of M. fermentans as an antigen and fusing mouse myeloma cells with splenocytes. M. fermentans is detected by using the produced antibody.
摘要翻译：产生对具有针对发酵支原体特异性的含有磷酸胆碱的甘油糖脂对GGPL-III具有反应特异性的单克隆抗体的杂交瘤选自通过用发酵杆菌的脂质部分作为抗原免疫小鼠而制备的杂交瘤并将小鼠骨髓瘤细胞与脾细胞融合。通过使用产生的抗体检测发酵菌。

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